Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Current Cardiovascular Imaging Reports
Erschienen in: Current Cardiovascular Imaging Reports 1/2010

01.02.2010

Molecular and Microstructural Imaging of the Myocardium

verfasst von: Shuning Huang, David E. Sosnovik

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 1/2010

Einloggen, um Zugang zu erhalten

Abstract

The past year has witnessed ongoing progress in the field of molecular MRI of the myocardium. In addition, several novel fluorescent agents have been introduced and used to image remodeling in the injured myocardium. New techniques to image myocardial microstructure, such as diffusion spectrum MRI, have also been introduced and have tremendous potential for integration and synergy with molecular MRI. In the current review we focus on these and other advances in the field that have occurred over the past year.
Literatur
1.
Zun Z, Wong E, Nayak K: Assessment of myocardial blood flow (MBF) in humans using arterial spin labeling (ASL): feasibility and noise analysis. Magn Reson Med 2009, 62:975–983.CrossRefPubMed
2.
Huang TY, Liu YJ, Stemmer A, Poncelet BP: T2 measurement of the human myocardium using a T2-prepared transient-state TrueFISP sequence. Magn Reson Med 2007, 57:960–966.CrossRefPubMed
3.
Weber OM, Speier P, Scheffler K, Bieri O: Assessment of magnetization transfer effects in myocardial tissue using balanced steady-state free precession (bSSFP) cine MRI. Magn Reson Med 2009, 62:699–705.CrossRefPubMed
4.
Sosnovik DE: Molecular imaging of myocardial injury: a magnetofluorescent approach. Curr Cardiovasc Imaging Rep 2009, 2:33–39.CrossRefPubMed
5.
Sosnovik DE, Nahrendorf M, Weissleder R: Molecular magnetic resonance imaging in cardiovascular medicine. Circulation 2007, 115:2076–2086.CrossRefPubMed
6.
Sosnovik DE, Nahrendorf M, Weissleder R: Targeted imaging of myocardial damage. Nat Clin Pract Cardiovasc Med 2008, 5(Suppl 2):S63–S70.CrossRefPubMed
7.
• Nahrendorf M, Sosnovik DE, French BA, et al.: Multimodality cardiovascular molecular imaging, part II. Circ Cardiovasc Imaging 2009, 2:56–70. This is a comprehensive review of cardiovascular molecular imaging. CrossRefPubMed
8.
Streeter DD Jr, Spotnitz HM, Patel DP, et al.: Fiber orientation in the canine left ventricle during diastole and systole. Circ Res 1969, 24:339–347.PubMed
9.
Streeter DD Jr, Hanna WT: Engineering mechanics for successive states in canine left ventricular myocardium. II. Fiber angle and sarcomere length. Circ Res 1973, 33:656–664.PubMed
10.
Reese TG, Weisskoff RM, Smith RN, et al.: Imaging myocardial fiber architecture in vivo with magnetic resonance. Magn Reson Med 1995, 34:786–791.CrossRefPubMed
11.
Scollan DF, Holmes A, Winslow R, Forder J: Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging. Am J Physiol 1998, 275:H2308–H2318.PubMed
12.
Holmes AA, Scollan DF, Winslow RL: Direct histological validation of diffusion tensor MRI in formaldehyde-fixed myocardium. Magn Reson Med 2000, 44:157–161.CrossRefPubMed
13.
Geerts L, Bovendeerd P, Nicolay K, Arts T: Characterization of the normal cardiac myofiber field in goat measured with MR-diffusion tensor imaging. Am J Physiol Heart Circ Physiol 2002, 283:H139.PubMed
14.
Chen J, Song S, Liu W, et al.: Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI. Am J Physiol Heart Circ Physiol 2003, 285:H946.PubMed
15.
Li W, Lu M, Banerjee S, et al.: Ex vivo diffusion tensor MRI reflects microscopic structural remodeling associated with aging and disease progression in normal and cardiomyopathic Syrian hamsters. NMR Biomed 2009, 22:819–825.CrossRefPubMed
16.
•• Strijkers GJ, Bouts A, Blankesteijn WM, et al.: Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse. NMR Biomed 2009, 22:182–190. This important article shows how changes in diffusion in the myocardium evolve over time after myocardial infarction in a mouse model. These changes are correlated with histological changes in the myocardium. CrossRefPubMed
17.
Wu Y, Chan CW, Nicholls JM, et al.: MR study of the effect of infarct size and location on left ventricular functional and microstructural alterations in porcine models. J Magn Reson Imaging 2009, 29:305–312.CrossRefPubMed
18.
Wu MT, Tseng WYI, Su MYM, et al.: Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction: correlation with viability and wall motion. Circulation 2006, 114:1036–1045.CrossRefPubMed
19.
•• Wu MT, Su MYM, Huang YL, et al.: Sequential changes of myocardial microstructure in patients postmyocardial infarction by diffusion-tensor cardiac MR: correlation with left ventricular structure and function. Circ Cardiovasc Imaging 2009, 2:32–40. This is the first study to perform sequential diffusion tensor MRI in patients after myocardial infarction. CrossRefPubMed
20.
•• Sosnovik DE, Wang R, Dai G, et al.: Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging 2009, 2:206–212. This article details application of a new technique, diffusion spectrum MRI tractography, in the myocardium. The technique allows myocardial tractography to be performed with an extremely high degree of accuracy. CrossRefPubMed
21.
• Sosnovik DE, Wang R, Dai G, et al.: Diffusion MR tractography of the heart. J Cardiovasc Magn Reson 2009, 11:47. This is a comprehensive review of diffusion tractography in the myocardium.CrossRefPubMed
22.
Hagmann P, Jonasson L, Maeder P, et al.: Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics 2006, 26(Suppl 1):S205–S223.CrossRefPubMed
23.
•• Schmitt M, Potthast A, Sosnovik DE, et al.: A 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3 Tesla. Magn Reson Med 2008, 59:1431–1439. This article provides a description of a 128–channel MRI system.CrossRefPubMed
24.
Reese TG, Benner T, Wang R, et al.: Halving imaging time of whole brain diffusion spectrum imaging and diffusion tractography using simultaneous image refocusing in EPI. J Magn Reson Imaging 2009, 29:517–522.PubMedCrossRef
25.
•• van den Borne SW, Isobe S, Verjans JW, et al.: Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction. J Am Coll Cardiol 2008, 52:2017–2028. This study describes molecular imaging of myofibroblasts in myocardial remodeling.CrossRefPubMed
26.
Verjans JWH, Lovhaug D, Narula N, et al.: Noninvasive imaging of angiotensin receptors after myocardial infarction. JACC Cardiovasc Imaging 2008, 1:354–362.CrossRefPubMed
27.
•• Sosnovik DE, Garanger E, Aikawa E, et al.: Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging 2009, 2:460–467. This article describes a strategy to image CM apoptosis and necrosis simultaneously with molecular MRI.CrossRefPubMed
28.
Helm PA, Caravan P, French BA, et al.: Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent. Radiology 2008, 247:788–796.CrossRefPubMed
29.
•• Spuentrup E, Ruhl KM, Botnar RM, et al.: Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model. Circulation 2009, 119:1768–1775. This article describes use of a collagen-binding small gadolinium chelate to image myocardial perfusion defects.CrossRefPubMed
30.
•• Sosnovik DE, Nahrendorf M, Panizzi P, et al.: Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging 2009, 2:468–475. This article demonstrates the ability of molecular MRI to image an extremely sparse target in the myocardium.CrossRefPubMed
31.
Kanno S, Wu YJ, Lee PC, et al.: Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation 2001, 104:934–938.CrossRefPubMed
32.
Christen T, Nahrendorf M, Wildgruber M, et al.: Molecular imaging of innate immune cell function in transplant rejection. Circulation 2009, 119:1925–1932.CrossRefPubMed
Metadaten
Titel
Molecular and Microstructural Imaging of the Myocardium
verfasst von
Shuning Huang
David E. Sosnovik
Publikationsdatum
01.02.2010
Verlag
Current Science Inc.
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 1/2010
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-010-9007-y

Weitere Artikel der Ausgabe 1/2010

Current Cardiovascular Imaging Reports 1/2010 Zur Ausgabe

OriginalPaper

Nanomedicine and Cardiovascular Disease

OriginalPaper

Optical Molecular Imaging of Inflammation and Calcification in Atherosclerosis

Clinical Trial Report

The ATHEROMA Study: Rapid Anti-inflammatory Effects of High-Dose Statin Pharmacotherapy Illuminated by Molecular MRI

OriginalPaper

Molecular Imaging of Thrombosis

OriginalPaper

Molecular MRI of Atherosclerosis

OriginalPaper

Ultrasound Molecular Imaging of Cardiovascular Disease

Neu im Fachgebiet Kardiologie

Vorsicht, erhöhte Blutungsgefahr nach PCI!

10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

Triglyzeridsenker schützt nicht nur Hochrisikopatienten

10.05.2024 Hypercholesterinämie Nachrichten

Patienten mit Arteriosklerose-bedingten kardiovaskulären Erkrankungen, die trotz Statineinnahme zu hohe Triglyzeridspiegel haben, profitieren von einer Behandlung mit Icosapent-Ethyl, und zwar unabhängig vom individuellen Risikoprofil.

Gibt es eine Wende bei den bioresorbierbaren Gefäßstützen?

10.05.2024 Periphere arterielle Verschlusskrankheit Nachrichten

In den USA ist erstmals eine bioresorbierbare Gefäßstütze – auch Scaffold genannt – zur Rekanalisation infrapoplitealer Arterien bei schwerer PAVK zugelassen worden. Das markiert einen Wendepunkt in der Geschichte dieser speziellen Gefäßstützen.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise