Introduction
Methods
Patients
STAT3-HIES patient 1 (P1) | STAT3-HIES patient 2 (P2) | STAT3-HIES patient 3 (P3) | STAT3-HIES patient 4 (P4) | |
---|---|---|---|---|
Age | 9 years of age | 29 years of age | 53 years of age | 5 years of age |
Mutation | c.1144C > T p.R382W | c.1145C > A p.R382Q | c.1144C > T p.R382W | c.1825A > G p.R609G |
History of skin abscesses/eczema | + | + | + | + |
History of recurrent respiratory infections | − | + | + | + |
Antibiotic prophylaxis | Co-Trimoxazole Cephalexin | Co-Trimoxazole | − | Co-Trimoxazole |
S. aureus Isolate Collection, Whole Genome Sequencing, and Data Analysis
Patient | Sample | MLST ST | CC | spa type | mecA | pvl | Collection site | Collection date |
---|---|---|---|---|---|---|---|---|
P1 | P1.1 | 5 | 5 | t179 | + | − | Nose/throat, screening swab | 2011 |
P1.2 | 7 | - | t091 | − | − | Lymph node abscess | 2019 | |
P1.3 | 5 | 5 | t179 | − | − | Nose/throat, screening swab | 2019 | |
P1.4 | 5 | 5 | t179 | − | − | Perianal screening swab | 2019 | |
P2 | P2.1 | 97 | 97 | t521 | − | − | Nose/throat, screening swab | 2012 |
P3 | P3.1 | 582 | 15 | t084 | − | − | Skin lesion (left eyebrow) | 2011 |
P3.2 | 582 | 15 | t084 | − | − | Skin lesion (left arm) | 2011 | |
P3.3 | 582 | 15 | t084 | − | − | Skin lesion (left ear) | 2011 | |
P3.4 | 582 | 15 | t084 | − | − | Skin lesion (nose) | 2011 | |
P3.5 | 582 | 15 | t084 | − | − | Skin lesion (right ear) | 2011 | |
P4 | P4.1 | 45 | 45 | t015 | − | − | Nose/throat, screening swab | 2019 |
Results
Patient Characteristics and S. aureus Isolates
Epidemiology of S. aureus Strains and spa Typing Results
P1.1 | P1.2 | P1.3 | P1.4 | P2 | P3.1 | P3.2 | P3.3 | P3.4 | P3.5 | P4 | |
---|---|---|---|---|---|---|---|---|---|---|---|
agrIIB agrIIC agrIID | agrIB agrIC agrID | agrIIB agrIIC agrIID | agrIID | agrIB agrIC agrID | agrIIB agrIIC agrIID | agrIIB agrIID | agrIIB agrIIC agrIID | agrIIB agrIID | agrIIB agrIIC agrIID | agrIB agrID | |
Hemolysin α (hla) | + | + | + | + | + | + | + | + | + | + | + |
Hemolysin β (hlb) | − | − | − | − | − | − | − | − | − | − | − |
Hemolysin δ (hld) | + | + | + | + | + | + | + | + | − | + | + |
Hemolysin (hl) | + | + | − | − | + | + | + | + | + | + | + |
γ hemolysin component A (hlgA) | + | + | + | + | + | + | + | + | + | + | + |
γ hemolysin component B (hlgB) | + | + | + | + | − | + | + | + | + | + | + |
γ hemolysin component C (hlgC) | + | + | + | + | + | + | + | + | + | + | + |
Hemolysin (hlIII) | + | + | + | + | + | + | + | + | + | + | + |
saeS | + | + | + | + | + | + | + | + | + | + | + |
Transcriptional regulator (sarA) | + | + | + | + | + | + | + | + | + | + | + |
varS | + | + | + | + | + | + | + | + | + | + | + |
Enterotoxin A (sea) | + | − | + | + | − | − | − | − | − | − | − |
Chemotaxis inhibitoy protein (chp) | + | − | + | + | + | − | + | + | − | + | + |
Staphylococcal complement inhibitor (scn) | + | + | + | + | + | ? | + | + | + | + | + |
Staphylokinase (sak) | + | + | + | + | + | − | − | − | − | − | + |
Serine protease A (sspA) | + | − | + | − | + | + | − | + | − | + | + |
Serine protease B (sspB) | + | + | + | + | + | − | + | + | + | + | + |
Enterotoxin b (seb) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin c (sec) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin d (sed) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin e (see) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin g (seg) | + | − | + | + | − | − | − | − | − | − | − |
Enterotoxin h (seh) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin i (sei) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin j (sej) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin k (sek) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin l (sel) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin m (sem) | + | − | + | − | − | − | − | − | − | − | − |
Enterotoxin n (sen) | + | − | + | − | − | − | − | − | − | − | − |
Enterotoxin o (seo) | − | − | − | − | − | − | − | − | − | − | − |
Enterotoxin q (seq) | − | − | - | − | − | − | − | − | − | − | − |
Enterotoxin r (ser) | − | − | - | − | − | − | − | − | − | − | − |
Enterotoxin u (seu) | − | − | + | − | − | − | − | − | − | − | − |
Clumping factor B (clfB) | + | + | − | + | + | + | + | + | + | + | + |
Elastin-binding protein (ebpS) | + | + | + | + | + | + | + | + | + | + | + |
Fibronectin-binding protein (fnbA) | + | + | + | + | + | + | + | + | + | + | + |
Intracellular adhesion protein A (icaA) | + | + | + | + | + | + | + | + | + | + | + |
Intracellular adhesion protein C (icaC) | + | + | − | + | − | + | + | + | − | + | + |
Intracellular adhesion protein D (icaD) | + | + | + | + | + | + | + | + | + | + | + |
Exfoliative toxin A (etA) | − | − | − | − | + | + | − | − | − | − | − |
Exfoliative toxin B (etB) | − | − | − | − | − | − | − | − | − | − | − |
Exfoliative toxin D (etD) | − | − | − | − | − | − | − | − | − | − | − |
Toxic shock syndrome toxine (tst1) | − | − | − | − | − | − | − | − | − | − | − |
Leucotoxin D (lukD) | + | + | + | + | + | + | + | + | + | + | − |
Leucotoxin E (lukE) | + | + | + | + | + | + | + | + | + | + | − |