Ausgabe 1/2023
Inhalt (83 Artikel)
Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease
Deepak Prasad Gupta, Young-Sun Lee, Youngshik Choe, Kun-Tae Kim, Gyun Jee Song, Sun-Chul Hwang
14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson’s disease-like motor incoordination in mice
Eunsil Cho, Jinsil Park, Eun Mi Hwang, Hyung Wook Kim, Jae-Yong Park
Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex
Guanghao Sun, Michael McCartin, Weizhuo Liu, Qiaosheng Zhang, George Kenefati, Zhe Sage Chen, Jing Wang
Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice
Si-Bo Zhou, Man Xue, Weiqi Liu, Yu-Xin Chen, Qi-Yu Chen, Jing-Shan Lu, Jinjun Wang, Keqiang Ye, Xu-Hui Li, Min Zhuo
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Nicolette Schurhoff, Michal Toborek
Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology
Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen, Jürgen Götz
Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson’s disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy
Jieun Kim, Jung-Youn Han, Yujeong Lee, Kipom Kim, Young Pyo Choi, Sehyun Chae, Hyang-Sook Hoe
Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier
Hirosato Kanda, Koichi Noguchi, Yi Dai
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg
Role of Calcr expressing neurons in the medial amygdala in social contact among females
Kansai Fukumitsu, Arthur J. Huang, Thomas J. McHugh, Kumi O. Kuroda
PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain
Yuji Kurihara, Kotone Mitsunari, Nagi Mukae, Hirotaka Shoji, Tsuyoshi Miyakawa, Michiko Shirane
Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles
Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi, Naoya Oishi
Modulating and monitoring the functionality of corticostriatal circuits using an electrostimulable microfluidic device
Sukmin Han, Seokyoung Bang, Hong Nam Kim, Nakwon Choi, Sung Hyun Kim
Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective
Nelufar Yasmen, Madison N. Sluter, Lexiao Li, Ying Yu, Jianxiong Jiang
Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood–brain barrier model
Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga, Makoto Michikawa
G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses
Leigh Clements, Amy Alexander, Kirsty Hamilton, Andrew Irving, Jenni Harvey
Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus
Sang Hun Lee, Vadim Y. Bolshakov, Jie Shen
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus
Sara Yoshida, Yusuke Hamada, Michiko Narita, Daisuke Sato, Kenichi Tanaka, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Hideki Tamura, Kazunori Aoki, Naoko Kuzumaki, Minoru Narita
Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice
Kenichi Tanaka, Takashige Kondo, Michiko Narita, Takeru Muta, Sara Yoshida, Daisuke Sato, Yukari Suda, Yusuke Hamada, Takatsune Shimizu, Naoko Kuzumaki, Minoru Narita
The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain
Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki, Atsuo Nakayama
Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis
Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing, Tao Chen
The deficiency of Maged1 attenuates Parkinson's disease progression in mice
Jie Wang, Sheng-Ye Xu, Zhi-Yuan Ye, Zhou-Na Sun, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei-Yan You, Jun Gao
A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death
Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation
Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen, Bin Xue
Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide
Cristina Nuñez-Diaz, Dovilė Pocevičiūtė, Nina Schultz, Charlotte Welinder, Karl Swärd, Malin Wennström
The gut microbiota and metabolite profiles are altered in patients with spinal cord injury
Ganggang Kong, Wenwu Zhang, Siyun Zhang, Jiewen Chen, kejun He, Changming Zhang, Xi Yuan, Baoshu Xie
Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice
Akihiro Yamada, Ayaka I. Yamada, Jennifer Ling, Hidemasa Furue, Wenqin Luo, Jianguo G. Gu
Experience-dependent changes in affective valence of taste in male mice
Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase, Takashi Nagashima, Mikiyasu Yamamoto, Haruhiko Bito, Sayaka Takemoto-Kimura, Toshihisa Ohtsuka, Ayako M. Watabe
Correction: Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles
Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi, Naoya Oishi
Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases
Yanruo Huang, Qihang Wang, Yunsong Peng, Wenjie Du, Qi Wang, Jiangtao Qi, Zijian Hao, Yingwei Wang
Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates
Kimiko Shimizu, Ken-ichi Inoue, Takao Oishi, Masahiko Takada, Yoshitaka Fukada, Hiroo Imai
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice
Hirotaka Shoji, Kazutaka Ikeda, Tsuyoshi Miyakawa
FMRP binds Per1 mRNA and downregulates its protein expression in mice
Xiangrong Tang, Jing Zhang, Xin Li, Ying Hu, Dengfeng Liu, Jia-Da Li, Renbin Lu
Ablation of microglia does not alter circadian rhythm of locomotor activity
Futaba Matsui, Sho T. Yamaguchi, Riho Kobayashi, Shiho Ito, Sakimi Nagashima, Zhiwen Zhou, Hiroaki Norimoto
Increased social interaction in Shank2-deficient mice following acute social isolation
Ja Eun Choi, Bong-Kiun Kaang
Tibial fracture surgery in elderly mice caused postoperative neurocognitive disorder via SOX2OT lncRNA in the hippocampus
Zhibin Xiao, Xiajing Zhang, Guangyao Li, Li Sun, Jiangjing Li, Ziwei Jing, Qingya Qiu, Guangxiang He, Changjun Gao, Xude Sun
Towards multiplexed immunofluorescence of 3D tissues
Wonjin Cho, Sehun Kim, Young-Gyun Park
A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice
Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi, Noriaki Ohkawa
Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study
Bangbei Wan, Ning Ma, Zhi Zhou, Weiying Lu
A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice
Ke-Ming Zhang, Yan Shen, Chun-Hui Jia, Hao Wang, Guo-Qiang Bi, Pak-Ming Lau
Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells
Ji-Eun Bae, Soyoung Jang, Joon Bum Kim, Hyejin Hyung, Na Yeon Park, Yong Hwan Kim, So Hyun Kim, Seong Hyun Kim, Jin Min Ha, Gyeong Seok Oh, Kyuhee Park, Kwiwan Jeong, Jae Seon Jang, Doo Sin Jo, Pansoo Kim, Hyun-Shik Lee, Zae Young Ryoo, Dong-Hyung Cho
Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila
Silvia Schwartz, Sarah J Wilson, Tracy K Hale, Helen L Fitzsimons
Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus
Simo Ojanen, Tatiana Kuznetsova, Zoia Kharybina, Vootele Voikar, Sari E. Lauri, Tomi Taira
Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency
Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie, Keizo Takao
Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses
Yoonsub Kim, Sooyun Kim, Won-Kyung Ho, Suk-Ho Lee
Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
Melina Matthiesen, Abdessattar Khlaifia, Carl Frank David Steininger Jr, Maryam Dadabhoy, Unza Mumtaz, Maithe Arruda-Carvalho
Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels
Vinicius de Maria Gadotti, Flavia Tasmin Techera Antunes, Gerald W. Zamponi
Partial inactivation of songbird auditory cortex impairs both tempo and pitch discrimination
Gunsoo Kim, Miguel Sánchez-Valpuesta, Mimi H. Kao
Regulation of dendritic spine length in corticopontine layer V pyramidal neurons by autism risk gene β3 integrin
Lucia Celora, Fanny Jaudon, Carmela Vitale, Lorenzo A. Cingolani
A new AAV tool for highly preferentially targeting hippocampal CA2
Siqi Peng, Wenzhen Gu, Wenxiu Zhu, Yan Zhuang, Xiuqi Yang, Yaochen Lv, Sibie Meng, Wei Xie, Moyi Li
Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch
Chiwoo Lee, Jihae Oh, Jae-Hyung Lee, Bong-Kiun Kaang, Hyoung-Gon Ko
Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice
Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto, Koichi Tan-No
BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons
Shukui Zhang, Jinyue Zhao, Cheng Zhao, Libo Su, Jianwei Jiao
The lateral habenula nucleus regulates pruritic sensation and emotion
Rui Chen, Xiang Xu, Xin-Yue Wang, Wen-Bin Jia, De-Shan Zhao, Na Liu, Zhen Pang, Xiao-Qing Liu, Yan Zhang
mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
François-Xavier Michon, Isabel Laplante, Anthony Bosson, Richard Robitaille, Jean-Claude Lacaille
Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
Bobae Hyeon, Heeyoung Lee, Nury Kim, Won Do Heo
Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum
Kelly Ceyzériat, Alekos Nicolaides, Quentin Amossé, Christine Fossey, Thomas Cailly, Frédéric Fabis, Valentina Garibotto, Carole Escartin, Benjamin B. Tournier, Philippe Millet
Dynamic alteration of intrinsic properties of the cerebellar Purkinje cell during the motor memory consolidation
Dong Cheol Jang, Geehoon Chung, Sun Kwang Kim, Sang Jeong Kim
Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice
Siyao Li, Koki Sakurai, Masahiro Ohgidani, Takahiro A. Kato, Takatoshi Hikida
Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels
Daniel F. Martins, Victor Sorrentino, Leidiane Mazzardo-Martins, William R. Reed, Adair R. S. Santos, Vinícius M. Gadotti, Gerald W. Zamponi
C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity
Takahiro Aimi, Keiko Matsuda, Michisuke Yuzaki
Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress
Asako Onda-Ohto, Minami Hasegawa-Ogawa, Hiromasa Matsuno, Tomotaka Shiraishi, Keiko Bono, Hiromi Hiraki, Yumi Kanegae, Yasuyuki Iguchi, Hirotaka James Okano
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD
Hyun-ju Lee, Jeong-Woo Hwang, Jin-Hee Park, Yoo Joo Jeong, Ji-Yeong Jang, Hyang-Sook Hoe
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
Heloísa Alonso-Matielo, Zizhen Zhang, Eder Gambeta, Junting Huang, Lina Chen, Gabriel Oliveira de Melo, Camila Squarzoni Dale, Gerald W. Zamponi
Changes in oligodendroglial subpopulations in Parkinson’s disease
Eun-Jin Bae, Dayana Pérez-Acuña, Ka Hyun Rhee, Seung-Jae Lee
Recombinase-independent AAV for anterograde transsynaptic tracing
Islam Faress, Valentina Khalil, Haruka Yamamoto, Szilard Sajgo, Keisuke Yonehara, Sadegh Nabavi
Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
Si Han Li, Tash-Lynn L. Colson, Jingwei Chen, Khaled S. Abd-Elrahman, Stephen S. G. Ferguson
Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss
Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard, Norbert Weiss
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Kristoffer Højgaard, Bianka Szöllősi, Kim Henningsen, Natsumi Minami, Nobuhiro Nakanishi, Erik Kaadt, Makoto Tamura, Richard G.M. Morris, Tomonori Takeuchi, Betina Elfving
Rab11a in the spinal cord: an essential contributor to complete Freund’s adjuvant-induced inflammatory pain in mice
Jun-Xiang Gu, Jian Wang, Fu-Juan Ma, Miao-Miao Liu, Si-Hai Chen, Yi Wei, Yi-Fan Xiao, Pei-Yuan Lv, Xin Liu, Jian-Qiang Qu, Xian-Xia Yan, Tao Chen
Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Hyun Jung Jee, Elaine Zhu, Mengqi Sun, Weizhuo Liu, Qiaosheng Zhang, Jing Wang
α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis
Dayana Pérez-Acuña, Soo Jean Shin, Ka Hyun Rhee, Sang Jeong Kim, Seung-Jae Lee
AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo
Yeon Hee Kook, Hyoin Lee, Jinsu Lee, Yeonji Jeong, Jaerang Rho, Won Do Heo, Sangkyu Lee
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
Yanyan Tang, Quanhong Chu, Guanfeng Xie, Yafu Tan, Ziming Ye, Chao Qin
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Phoebe Valdes, Kenneth W. Henry, Michael Q. Fitzgerald, Koushik Muralidharan, Andrew B. Caldwell, Srinivasan Ramachandran, Lawrence S. B. Goldstein, William C. Mobley, Douglas R. Galasko, Shankar Subramaniam
Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
Stuart M. Cain, Sascha R. A. Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C. Yung, Andrew Bauman, Yi Yang, Glen B. Baker, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch
Impact of volume and expression time in an AAV-delivered channelrhodopsin
Sanaz Ansarifar, Gabija Andreikė, Milad Nazari, Rodrigo Labouriau, Sadegh Nabavi, Andrea Moreno
Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
Jun Yokose, Naoki Yamamoto, Sachie K. Ogawa, Takashi Kitamura
Effects of MAP4K inhibition on neurite outgrowth
Di Ja Lasham, Reza K. Arta, Abdul Fuad Hadi, Jun Egawa, Vance P. Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment
Qinghai Meng, Ying Chao, Shurui Zhang, Xue Ding, Han Feng, Chenyan Zhang, Bowen Liu, Weijie Zhu, Yu Li, Qichun Zhang, Huangjin Tong, Lixing Wu, Huimin Bian
Role of spinal astrocytes through the perisynaptic astrocytic process in pathological pain
Hyoung-Gon Ko, Heejung Chun, Seunghyo Han, Bong-Kiun Kaang
Pathophysiology of ion channels in amyotrophic lateral sclerosis
Robin N. Stringer, Norbert Weiss
Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics
Arjun Raha, Yuning Wu, Lily Zhong, Jatheeshan Raveenthiran, Minji Hong, Aftab Taiyab, Li Wang, Bill Wang, Fei Geng