Background
Methods
Study design
Ethical approval
Sampling, extraction of nucleic acids, detection, and typing of HAdV
Sequence analysis
Data analysis
Results
HAdV genotyping
HAdV-associated factors
HAdV (231) | HAdV-A (1) | HAdV-B (108) | HAdV-C (47) | HAdV-D (1) | HAdV-E (5) | HAdV-F (6) | |
---|---|---|---|---|---|---|---|
Age | |||||||
< 2 Years | 153 | 1 (0,1) | 61 (7,5) | 31 (3,8) | 1 (0,12) | 4 (0,5) | 6 (0,7) |
2–5 Years | 20 | 0 (0) | 34 (4,2) | 16 (2) | 0 (0) | 0 (0) | 0 (0) |
5–15 Years | 56 | 0 (0) | 12 (1,5) | 0 (0) | 0 (0) | 1 (0,1) | 0 (0) |
NA | 2 | 0 (0) | 1 (0,1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
p-value | 0,4 | 0,9 | 0,4 | 0,04 | 0,9 | 0,6 | 0,3 |
Gender | |||||||
Female | 108 | 1 (0,1) | 49 (6) | 22 (2,7) | 1 (0,12) | 3 (0,4) | 3 (0,4) |
Male | 123 | 0 (0) | 59 (7,3) | 25 (3,1) | 0 (0) | 2 (0,2) | 3 (0,4) |
p-value | 0,9 | 0,3 | 0,7 | 1,0 | 0,3 | 0,6 | 0,9 |
Type | |||||||
ILI | 92 | 1 (0,1) | 31 (3,8) | 20 (2,5) | 0 (0) | 2 (0,2) | 1 (0,1) |
SARI | 139 | 0 (0) | 77 (9,5) | 27 (3,3) | 1 (0,1) | 3 (0,4) | 5 (0,6) |
p-value | 0,06 | 0,3 | < 0,001 | 0,7 | 0,4 | 0,8 | 0,2 |
Temporal distribution HAdV-positive samples
2011 | 2012 | 2013 | 2014 | Total | |
---|---|---|---|---|---|
HAdV-A | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (0,6) |
HAdV-B | 14 (70) | 32 (69,6) | 24 (58,5) | 38 (63,3) | 108 (64,3) |
HAdV-C | 6 (30) | 10 (21,7) | 13 (31,7) | 18 (30) | 47 (28) |
HAdV-D | 0 (0) | 0 (0) | 0 (0) | 1 (1,7) | 1 (0,6) |
HAdV-E | 0 (0) | 1 (2,2) | 2 (4,9) | 2 (3,3) | 5 (3) |
HAdV-F | 0 (0) | 3 (6,5) | 2 (4,9) | 1 (1,7) | 6 (3,6) |
Distribution of HAdV species mixed detections
HAdV-A | HAdV-B | HAdV-C | HAdV-D | HAdV-E | HAdV-F | Total = 137 | |
---|---|---|---|---|---|---|---|
HAdV-A | 0 | 1 | 0 | 0 | 0 | 0 | 1 (0.7) |
HAdV-B | – | 83 | 22 | 0 | 0 | 1 | 108 (78,8) |
HAdV-C | – | – | 23 | 0 | 0 | 1 | 47 (34,3) |
HAdV-D | – | – | – | 0 | 0 | 0 | 1 (0,7) |
HAdV-E | – | – | – | – | 1 | 4 | 5 (3,6) |
HAdV-F | – | – | – | – | – | 0 | 6 (4,4) |
Mono | O | 83 | 23 | 0 | 1 | 0 | 107 (78,1) |
Double | 1 | 24 | 23 | 0 | 4 | 6 | 29 (21,2) |
Triple | 0 | 1 | 1 | 1 | 0 | 0 | 1 (0,7) |