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Journal of Nuclear Cardiology
Erschienen in: Journal of Nuclear Cardiology 2/2009

01.04.2009 | From Bench to Imaging

Molecular imaging of platelet activation in thrombus

verfasst von: François Rouzet, MD, Laure Sarda-Mantel, MD, PhD, Jean-Baptiste Michel, MD, PhD, Dominique Le Guludec, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 2/2009

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Excerpt

Since its first use as a radiolabeled tracer for in vivo detection of platelet activation in an animal model of acute thrombosis in 1994,1 annexin V (Anx) generated a large body of literature. Because of its specific binding to phosphatidylserines (PS) externalized upon platelet activation and apoptosis, most of the work accomplished with radiolabeled Anx pertains to two domains: thrombus and programmed cell death. The latter is out of the scope of this review but contributed a lot to the improvement of Anx labeling with standardized procedures suitable for human utilization.2 …
Literatur
1.
Tait JF, Cerqueira MD, Dewhurst TA, Fujikawa K, Ritchie JL, Stratton JR. Evaluation of annexin V as a platelet-directed thrombus targeting agent. Thromb Res 1994;75:491-501.CrossRefPubMed
2.
Boersma HH, Kietselaer BL, Stolk LM, Bennaghmouch A, Hofstra L, Narula J, et al. Past, present, and future of annexin A5: From protein discovery to clinical applications. J Nucl Med 2005;46:2035-50.PubMed
3.
Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997;89:1121-32.PubMed
4.
Seigneuret M, Devaux PF. ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: Relation to shape changes. Proc Natl Acad Sci USA 1984;81:3751-5.CrossRefPubMed
5.
Bitbol M, Devaux PF. Measurement of outward translocation of phospholipids across human erythrocyte membrane. Proc Natl Acad Sci USA 1988;85:6783-7.CrossRefPubMed
6.
Andrick C, Broring K, Deuticke B, Haest CW. Fast translocation of phosphatidylcholine to the outer membrane leaflet after its synthesis at the inner membrane surface in human erythrocytes. Biochim Biophys Acta 1991;1064:235-41.CrossRefPubMed
7.
Comfurius P, Williamson P, Smeets EF, Schlegel RA, Bevers EM, Zwaal RF. Reconstitution of phospholipid scramblase activity from human blood platelets. Biochemistry 1996;35:7631-4.CrossRefPubMed
8.
Solum NO. Procoagulant expression in platelets and defects leading to clinical disorders. Arterioscler Thromb Vasc Biol 1999;19:2841-6.PubMed
9.
Thiagarajan P, Tait JF. Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. J Biol Chem 1990;265:17420-3.PubMed
10.
Pei G, Powers DD, Lentz BR. Specific contribution of different phospholipid surfaces to the activation of prothrombin by the fully assembled prothrombinase. J Biol Chem 1993;268:3226-33.PubMed
11.
Bevers EM, Comfurius P, Zwaal RF. Platelet procoagulant activity: Physiological significance and mechanisms of exposure. Blood Rev 1991;5:146-54.CrossRefPubMed
12.
Mann KG, Nesheim ME, Church WR, Haley P, Krishnaswamy S. Surface-dependent reactions of the vitamin K-dependent enzyme complexes. Blood 1990;76:1-16.PubMed
13.
Zwaal RF, Comfurius P, Bevers EM. Lipid-protein interactions in blood coagulation. Biochim Biophys Acta 1998;1376:433-53.PubMed
14.
Husten EJ, Esmon CT, Johnson AE. The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem 1987;262:12953-61.PubMed
15.
Lentz BR. Exposure of platelet membrane phosphatidylserine regulates blood coagulation. Prog Lipid Res 2003;42:423-38.CrossRefPubMed
16.
Dachary-Prigent J, Freyssinet JM, Pasquet JM, Carron JC, Nurden AT. Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: A flow cytometry study showing a role for free sulfhydryl groups. Blood 1993;81:2554-65.PubMed
17.
Dachary-Prigent J, Pasquet JM, Freyssinet JM, Nurden AT. Calcium involvement in aminophospholipid exposure and microparticle formation during platelet activation: A study using Ca2+-ATPase inhibitors. Biochemistry 1995;34:11625-34.CrossRefPubMed
18.
Dachary-Prigent J, Pasquet JM, Fressinaud E, Toti F, Freyssinet JM, Nurden AT. Aminophospholipid exposure, microvesiculation and abnormal protein tyrosine phosphorylation in the platelets of a patient with Scott syndrome: A study using physiologic agonists and local anaesthetics. Br J Haematol 1997;99:959-67.CrossRefPubMed
19.
Reutelingsperger CP, Hornstra G, Hemker HC. Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord. Eur J Biochem 1985;151:625-9.CrossRefPubMed
20.
Reutelingsperger CP, Kop JM, Hornstra G, Hemker HC. Purification and characterization of a novel protein from bovine aorta that inhibits coagulation. Inhibition of the phospholipid-dependent factor-Xa-catalyzed prothrombin activation, through a high-affinity binding of the anticoagulant to the phospholipids. Eur J Biochem 1988;173:171-8.CrossRefPubMed
21.
Thiagarajan P, Tait JF. Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles. J Biol Chem 1991;266:24302-7.PubMed
22.
van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 1998;31:1-9.CrossRefPubMed
23.
Stratton JR, Dewhurst TA, Kasina S, Reno JM, Cerqueira MD, Baskin DG, et al. Selective uptake of radiolabeled annexin V on acute porcine left atrial thrombi. Circulation 1995;92:3113-21.PubMed
24.
Sarda-Mantel L, Coutard M, Rouzet F, Raguin O, Vrigneaud JM, Hervatin F, et al. 99mTc-annexin-V functional imaging of luminal thrombus activity in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2006;26:2153-9.CrossRefPubMed
25.
Kazi M, Thyberg J, Religa P, Roy J, Eriksson P, Hedin U, et al. Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall. J Vasc Surg 2003;38:1283-92.CrossRefPubMed
26.
Kazi M, Zhu C, Roy J, Paulsson-Berne G, Hamsten A, Swedenborg J, et al. Difference in matrix-degrading protease expression and activity between thrombus-free and thrombus-covered wall of abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 2005;25:1341-6.CrossRefPubMed
27.
Tsai TT, Evangelista A, Nienaber CA, Myrmel T, Meinhardt G, Cooper JV, et al. Partial thrombosis of the false lumen in patients with acute type B aortic dissection. N Engl J Med 2007;357:349-59.CrossRefPubMed
28.
Fontaine V, Jacob MP, Houard X, Rossignol P, Plissonnier D, Angles-Cano E, et al. Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms. Am J Pathol 2002;161:1701-10.PubMed
29.
Fontaine V, Touat Z, Mtairag el M, Vranckx R, Louedec L, Houard X, et al. Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus. Am J Pathol 2004;164:2077-87.PubMed
30.
Wagner DD. New links between inflammation and thrombosis. Arterioscler Thromb Vasc Biol 2005;25:1321-4.CrossRefPubMed
31.
Touat Z, Ollivier V, Dai J, Huisse MG, Bezeaud A, Sebbag U, et al. Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution. Am J Pathol 2006;168:1022-30.CrossRefPubMed
32.
Anidjar S, Salzmann JL, Gentric D, Lagneau P, Camilleri JP, Michel JB. Elastase-induced experimental aneurysms in rats. Circulation 1990;82:973-81.PubMed
33.
Widmer E, Que YA, Entenza JM, Moreillon P. New concepts in the pathophysiology of infective endocarditis. Curr Infect Dis Rep 2006;8:271-9.CrossRefPubMed
34.
Fitzgerald JR, Foster TJ, Cox D. The interaction of bacterial pathogens with platelets. Nat Rev Microbiol 2006;4:445-57.CrossRefPubMed
35.
Yeaman MR. The role of platelets in antimicrobial host defense. Clin Infect Dis 1997;25:951-68. quiz 969-970.CrossRefPubMed
36.
Schwarz-Linek U, Werner JM, Pickford AR, Gurusiddappa S, Kim JH, Pilka ES, et al. Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Nature 2003;423:177-81.CrossRefPubMed
37.
Que YA, Haefliger JA, Piroth L, Francois P, Widmer E, Entenza JM, et al. Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis. J Exp Med 2005;201:1627-35.CrossRefPubMed
38.
39.
Herzberg MC, MacFarlane GD, Gong K, Armstrong NN, Witt AR, Erickson PR, et al. The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis. Infect Immun 1992;60:4809-18.PubMed
40.
Sullam PM, Bayer AS, Foss WM, Cheung AL. Diminished platelet binding in vitro by Staphylococcus aureus is associated with reduced virulence in a rabbit model of infective endocarditis. Infect Immun 1996;64:4915-21.PubMed
41.
Herzberg MC, Brintzenhofe KL, Clawson CC. Aggregation of human platelets and adhesion of Streptococcus sanguis. Infect Immun 1983;39:1457-69.PubMed
42.
Herzberg MC, Brintzenhofe KL, Clawson CC. Cell-free released components of Streptococcus sanguis inhibit human platelet aggregation. Infect Immun 1983;42:394-401.PubMed
43.
Erickson PR, Herzberg MC. The Streptococcus sanguis platelet aggregation-associated protein. Identification and characterization of the minimal platelet-interactive domain. J Biol Chem 1993;268:1646-9.PubMed
44.
Kerrigan SW, Douglas I, Wray A, Heath J, Byrne MF, Fitzgerald D, et al. A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation. Blood 2002;100:509-16.CrossRefPubMed
45.
Bhakdi S, Muhly M, Mannhardt U, Hugo F, Klapettek K, Mueller-Eckhardt C, et al. Staphylococcal alpha toxin promotes blood coagulation via attack on human platelets. J Exp Med 1988;168:527-42.CrossRefPubMed
46.
Arvand M, Bhakdi S, Dahlback B, Preissner KT. Staphylococcus aureus alpha-toxin attack on human platelets promotes assembly of the prothrombinase complex. J Biol Chem 1990;265:14377-81.PubMed
47.
Riba AL, Downs J, Thakur ML, Gottschalk A, Andriole VT, Zaret BL. Technetium-99m stannous pyrophosphate imaging of experimental infective endocarditis. Circulation 1978;58:111-9.PubMed
48.
Riba AL, Thakur ML, Gottschalk A, Andriole VT, Zaret BL. Imaging experimental infective endocarditis with indium-111-labeled blood cellular components. Circulation 1979;59:336-43.PubMed
49.
Stratton JR, Ritchie JL, Hamilton GW, Hammermeister KE, Harker LA. Left ventricular thrombi: In vivo detection by indium-111 platelet imaging and two dimensional echocardiography. Am J Cardiol 1981;47:874-81.CrossRefPubMed
50.
Ezekowitz MD, Wilson DA, Smith EO, Burow RD, Harrison LH Jr, Parker DE, et al. Comparison of Indium-111 platelet scintigraphy and two-dimensional echocardiography in the diagnosis of left ventricular thrombi. N Engl J Med 1982;306:1509-13.PubMedCrossRef
51.
Stratton JR, Ritchie JL. 111In platelet imaging of left ventricular thrombi. Predictive value for systemic emboli. Circulation 1990;81:1182-9.PubMed
52.
Bellotti P, Claudiani F, Chiarella F, Domenicucci S, Lupi G, Scopinaro G, et al. Activity of left ventricular thrombi of different ages. Assessment with indium-oxine platelet imaging and cross-sectional echocardiography. Eur Heart J 1987;8:855-60.PubMed
53.
Vandenberg BF, Seabold JE, Conrad GR, Kieso R, Johnson J, Fox-Eastham K, et al. 111In-labeled platelet scintigraphy and two-dimensional echocardiography for detection of left atrial appendage thrombi. Studies in a new canine model. Circulation 1988;78:1040-6.PubMed
54.
Stratton JR, Cerqueira MD, Dewhurst TA, Kohler TR. Imaging arterial thrombosis: Comparison of technetium-99m-labeled monoclonal antifibrin antibodies and indium-111-platelets. J Nucl Med 1994;35:1731-7.PubMed
55.
Rouzet F, Dominguez Hernandez M, Hervatin F, Sarda-Mantel L, Lefort A, Duval X, et al. Technetium 99m-labeled annexin V scintigraphy of platelet activation in vegetations of experimental endocarditis. Circulation 2008;117:781-9.CrossRefPubMed
56.
Shaw L, Golonka E, Potempa J, Foster SJ. The role and regulation of the extracellular proteases of Staphylococcus aureus. Microbiology 2004;150:217-28.CrossRefPubMed
57.
Lahteenmaki K, Edelman S, Korhonen TK. Bacterial metastasis: The host plasminogen system in bacterial invasion. Trends Microbiol 2005;13:79-85.CrossRefPubMed
58.
Sun H. The interaction between pathogens and the host coagulation system. Physiology (Bethesda) 2006;21:281-8.
59.
Rouzet F, Hernandez MD, Sarda-Mantel L, Lefort A, Duval X, Louedec L, et al. Functional imaging of experimental endocarditis vegetations by 99m Tc Annexin V scintigraphy. European Journal of Nuclear Medicine and Molecular Imaging 2007;34:S233-S233. [abstract].CrossRef
60.
Kietselaer BL, Narula J, Hofstra L. The Annexin code: Revealing endocarditis. Eur Heart J 2007;28:948.CrossRefPubMed
61.
Dai J, Louedec L, Philippe M, Michel JB, Houard X. Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model. J Vasc Surg 2008 (in press)
62.
Lindholt JS, Sorensen HT, Michel JB, Thomsen HF, Henneberg EW. Low-dose aspirin may prevent growth and later surgical repair of medium-sized abdominal aortic aneurysms. Vasc Endovascular Surg 2008;42:329-34.CrossRefPubMed
63.
Dasgupta SK, Guchhait P, Thiagarajan P. Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5. Transl Res 2006;148:19-25.CrossRefPubMed
64.
Andersen MH, Graversen H, Fedosov SN, Petersen TE, Rasmussen JT. Functional analyses of two cellular binding domains of bovine lactadherin. Biochemistry 2000;39:6200-6.CrossRefPubMed
65.
Francesconi LC, Zheng Y, Bartis J, Blumenstein M, Costello C, De Rosch MA. Preparation and characterization of [99TcO] apcitide: A technetium labeled peptide. Inorg Chem 2004;43:2867-75.CrossRefPubMed
66.
DeHoyos MJ, Rubal BJ, Bradley MY. Detection of acute atrial thrombus in a porcine model with atrial fibrillation with tc 99m-apcitide. Invest Radiol 2004;39:197-201.CrossRefPubMed
67.
Schaadt BK, Hendel HW, Gimsing P, Jonsson V, Pedersen H, Hesse B. 99mTc-aprotinin scintigraphy in amyloidosis. J Nucl Med 2003;44:177-83.PubMed
68.
Houard X, Rouzet F, Touat Z, Philippe M, Dominguez M, Fontaine V, et al. Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms. J Pathol 2007;212:20-8.CrossRefPubMed
Metadaten
Titel
Molecular imaging of platelet activation in thrombus
verfasst von
François Rouzet, MD
Laure Sarda-Mantel, MD, PhD
Jean-Baptiste Michel, MD, PhD
Dominique Le Guludec, MD, PhD
Publikationsdatum
01.04.2009
Verlag
Springer-Verlag
Erschienen in
Journal of Nuclear Cardiology / Ausgabe 2/2009
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-009-9053-5

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