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02.06.2022 | Review

Molecular pathogenesis of Japanese encephalitis and possible therapeutic strategies

verfasst von: Sanjay Kumar, Akanksha Verma, Pardeep Yadav, Sumit Kumar Dubey, Esam Ibraheem Azhar, S. S. Maitra, Vivek Dhar Dwivedi

Erschienen in: Archives of Virology | Ausgabe 9/2022

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Abstract

Japanese encephalitis virus (JEV), a single-stranded, enveloped RNA virus, is a health concern across Asian countries, associated with severe neurological disorders, especially in children. Primarily, pigs, bats, and birds are the natural hosts for JEV, but humans are infected incidentally. JEV requires a few host proteins for its entry and replication inside the mammalian host cell. The endoplasmic reticulum (ER) plays a significant role in JEV genome replication and assembly. During this process, the ER undergoes stress due to its remodelling and accumulation of viral particles and unfolded proteins, leading to an unfolded protein response (UPR). Here, we review the overall strategy used by JEV to infect the host cell and various cytopathic effects caused by JEV infection. We also highlight the role of JEV structural proteins (SPs) and non-structural proteins (NSPs) at various stages of the JEV life cycle that are involved in up- and downregulation of different host proteins and are potentially relevant for developing efficient therapeutic drugs.

Graphical abstract

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Titel: Molecular pathogenesis of Japanese encephalitis and possible therapeutic strategies
verfasst von: Sanjay Kumar
Akanksha Verma
Pardeep Yadav
Sumit Kumar Dubey
Esam Ibraheem Azhar
S. S. Maitra
Vivek Dhar Dwivedi
Publikationsdatum: 02.06.2022
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 9/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-022-05481-z

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Immer mehr jüngere Menschen leiden unter Vorhofflimmern. Betroffene unter 65 Jahren haben viele Risikofaktoren und ein signifikant erhöhtes Sterberisiko verglichen mit Gleichaltrigen ohne die Erkrankung.

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Die Leitlinien für Ärztinnen und Ärzte, Digitale Mammographien links in kraniokaudaler Projektion./© Weigel, S. et al. / all rights reserved Springer Medizin Verlag GmbH, Operation bei Blasenkrebs/© anistidesign / Fotolia, Medizinische Fachangestellte sitzt erschöpft auf der Treppe/© Courtney Haas / peopleimages.com /stock.adobe.com (Symbolbild mit Fotomodell), Mann wird von Ärztin untersucht/© Tashi-Delek, Getty Images, iStock (Symbolbild mit Fotomodellen)

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