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Archives of Virology

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01.08.2014 | Original Article

Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin

verfasst von: Masayuki Shimojima, Atsushi Takenouchi, Hiroshi Shimoda, Naho Kimura, Ken Maeda

Erschienen in: Archives of Virology | Ausgabe 8/2014

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Abstract

Infection with West Nile virus and dengue virus, two mosquito-borne flaviviruses, is enhanced by two calcium-dependent lectins: dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and its related molecule (DC-SIGNR). The present study examined the relationship between Japanese encephalitis virus (JEV) infection and three lectins: DC-SIGN, DC-SIGNR, and liver sinusoidal endothelial cell lectin (LSECtin). Expression of DC-SIGNR resulted in robust JEV proliferation in a lymphoid cell line, Daudi cells, which was otherwise non-permissive to infection. DC-SIGN expression caused moderate JEV proliferation, with effects that varied according to the cells in which JEV was prepared. LSECtin expression had comparatively minor, but consistent, effects, in all cell types used in JEV preparation. While DC-SIGN/DC-SIGNR-mediated JEV infection was inhibited by yeast mannan, LSECtin-mediated infection was inhibited by N-acetylglucosamine β1-2 mannose. Although involvement of DC-SIGN/DC-SIGNR in infection seems to be a common characteristic, this is the first report on usage of LSECtin in mosquito-borne flavivirus infection.

Lindenbach BD, Murray CL, Thiel HJ, Rice CM (2013) Flaviviridae. In: Knipe DM, Howley PM (eds) Fields virology, 6th edn. Lippincott, Williams & Wilkins, Philadelphia, pp 712–746

McMinn PC, Dalgarno L, Weir RC (1996) A comparison of the spread of Murray Valley encephalitis viruses of high or low neuroinvasiveness in the tissues of Swiss mice after peripheral inoculation. Virology 220:414–423PubMedCrossRef

Monath TP, Cropp CB, Harrison AK (1983) Mode of entry of a neurotropic arbovirus into the central nervous system. Lab Invest 48:399–410PubMed

Mukherji AK, Biswas SK (1976) Histopathological studies of brains (and other viscera) from cases of JE virus encephalitis during 1973 epidemic at Bankura. Indian J Med Res 64:1143–1149PubMed

van Kooyk Y (2009) C-type lectin receptors on dendritic cells. In: Vasta GR, Ahmed H (eds) Animal lectins. CRC Press, Taylor & Francis Group, Florida, pp 351–361

van den Berg LM, Gringhuis SI, Geijtenbeek TBH (2012) An evolutionary perspective on C-type lectins in infection and immunity. Ann N Y Acad Sci 1253:149–158PubMedCrossRef

Soilleux EJ (2003) DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe? Clin Sci (Lond) 104:437–446CrossRef

Davis CW, Nguyen HY, Hanna SL, Sánchez MD, Doms RW, Pierson TC (2006) West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection. J Virol 80:1290–1301PubMedCentralPubMedCrossRef

Hacker K, White L, de Silva AM (2009) N-linked glycans on dengue viruses grown in mammalian and insect cells. J Gen Virol 90:2097–2106PubMedCentralPubMedCrossRef

10.

Navarro-Sanchez E, Altmeyer R, Amara A, Schwartz O, Fieschi F, Virelizier JL, Arenzana-Seisdedos F, Desprès P (2003) Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses. EMBO Rep 4:723–728PubMedCentralPubMedCrossRef

11.

Tassaneetrithep B, Burgess TH, Granelli-Piperno A, Trumpfheller C, Finke J, Sun W, Eller MA, Pattanapanyasat K, Sarasombath S, Birx DL, Steinman RM, Schlesinger S, Marovich MA (2003) DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J Exp Med 197:823–829PubMedCentralPubMedCrossRef

12.

Sakuntabhai A, Turbpaiboon C, Casadémont I, Chuansumrit A, Lowhnoo T, Kajaste-Rudnitski A, Kalayanarooj SM, Tangnararatchakit K, Tangthawornchaikul N, Vasanawathana S, Chaiyaratana W, Yenchitsomanus P, Suriyaphol P, Avirutnan P, Chokephaibulkit K, Matsuda F, Yoksan S, Jacob Y, Lathrop GM, Malasit P, Desprès P, Julier C (2005) A variant in the CD209 promoter is associated with severity of dengue disease. Nat Genet 37:507–513PubMedCrossRef

13.

Liu H, Chiou SS, Chen WJ (2004) Differential binding efficiency between the envelope protein of Japanese encephalitis virus variants and heparan sulfate on the cell surface. J Med Virol 72:618–624PubMedCrossRef

14.

Gramberg T, Hofmann H, Möller P, Lalor PF, Marzi A, Geier M, Krumbiegel M, Winkler T, Kirchhoff F, Adams DH, Becker S, Münch J, Pöhlmann S (2005) LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. Virology 340:224–236PubMedCrossRef

15.

Shimojima M, Ströher U, Ebihara H, Feldmann H, Kawaoka Y (2012) Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J Virol 86:2067–2078PubMedCentralPubMedCrossRef

16.

Shimojima M, Kawaoka Y (2012) Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein. J Vet Med Sci 74:1363–1366PubMedCrossRef

17.

Shimojima M, Nishimura Y, Miyazawa T, Kato K, Nakamura K, Izumiya Y, Akashi H, Tohya Y (2002) A feline CD2 homologue interacts with human red blood cells. Immunology 105:360–366PubMedCentralPubMedCrossRef

18.

Henchal EA, Gentry MK, McCown JM, Brandt WE (1982) Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence. Am J Trop Med Hyg 31:830–836PubMed

19.

Ohno Y, Sato H, Suzuki K, Yokoyama M, Uni S, Shibasaki T, Sashika M, Inokuma H, Kai K, Maeda K (2009) Detection of antibodies against Japanese encephalitis virus in raccoons, raccoon dogs and wild boars in Japan. J Vet Med Sci 71:1035–1039PubMedCrossRef

20.

Shimojima M, Ikeda Y, Kawaoka Y (2007) The mechanism of Axl-mediated Ebola virus infection. J Infect Dis 196:S259–S263PubMedCrossRef

21.

Kim JM, Yun SI, Song BH, Hahn YS, Lee CH, Oh HW, Lee YM (2008) A single N-linked glycosylation site in the Japanese encephalitis virus prM protein is critical for cell type-specific prM protein biogenesis, virus particle release, and pathogenicity in mice. J Virol 82:7846–7862PubMedCentralPubMedCrossRef

22.

Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y (2000) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100:587–597PubMedCrossRef

23.

Lozach PY, Lortat-Jacob H, de Lacroix de Lavalette A, Staropoli I, Foung S, Amara A, Houlès C, Fieschi F, Schwartz O, Virelizier JL, Arenzana-Seisdedos F, Altmeyer R (2003) DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J Biol Chem 278:20358–20366PubMedCrossRef

24.

Alvarez CP, Lasala F, Carrillo J, Muñiz O, Corbí AL, Delgado R (2002) C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol 76:6841–6844PubMedCentralPubMedCrossRef

25.

Han KK, Martinage AM (1992) Possible relationship between coding recognition amino acid sequence motif or residue(s) and post-translational chemical modification of proteins. Int J Biochem 24:1349–1363PubMedCrossRef

26.

Dejnirattisai W, Webb AI, Chan V, Jumnainsong A, Davidson A, Mongkolsapaya J, Screaton G (2011) Lectin switching during dengue virus infection. J Infect Dis 203:1775–1783PubMedCentralPubMedCrossRef

27.

Dube DH, Bertozzi CR (2005) Glycans in cancer and inflammation–potential for therapeutics and diagnostics. Nat Rev Drug Discov 4:477–488PubMedCrossRef

28.

Jeffers SA, Tusell SM, Gillim-Ross L, Hemmila EM, Achenbach JE, Babcock GJ, Thomas WD Jr, Thackray LB, Young MD, Mason RJ, Ambrosino DM, Wentworth DE, DeMartini JC, Holmes KV (2004) CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci USA 101:15748–15753PubMedCentralPubMedCrossRef

29.

Chaturvedi UC, Mathur A, Chandra A, Das SK, Tandon HO, Singh UK (1980) Transplacental infection with Japanese encephalitis virus. J Infect Dis 141:712–715PubMedCrossRef

30.

Bhonde RR, Wagh UV (1985) Susceptibility of human placenta to Japanese encephalitis virus in vitro. Indian J Med Res 82:371–373PubMed

31.

Thongtan T, Wikan N, Wintachai P, Rattanarungsan C, Srisomsap C, Cheepsunthorn P, Smith DR (2012) Characterization of putative Japanese encephalitis virus receptor molecules on microglial cells. J Med Virol 84:615–623PubMedCrossRef

Titel: Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin
verfasst von: Masayuki Shimojima
Atsushi Takenouchi
Hiroshi Shimoda
Naho Kimura
Ken Maeda
Publikationsdatum: 01.08.2014
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 8/2014
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-014-2042-2

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