9. Molekulare Allergiediagnostik im Multiplex-Verfahren

Zurück zum Zitat Asarnoj A, Nilsson C, Lidholm J, Glaumann S, Östblom E, Hedlin G, van Hage M, Lilja G, Wickman M (2012) Peanut component Ara h 8 sensitization and tolerance to peanut. J Allergy Clin Immunol 130:468–472CrossRefPubMed Asarnoj A, Nilsson C, Lidholm J, Glaumann S, Östblom E, Hedlin G, van Hage M, Lilja G, Wickman M (2012) Peanut component Ara h 8 sensitization and tolerance to peanut. J Allergy Clin Immunol 130:468–472CrossRefPubMed

Zurück zum Zitat Blackley CH (1880) Hay fever; its causes, treatment, and effective prevention. Ballière, London Blackley CH (1880) Hay fever; its causes, treatment, and effective prevention. Ballière, London

Zurück zum Zitat Breiteneder HI, Hassfeld W, Pettenburger K, Jarolim E, Breitenbach M, Rumpold H, Kraft D, Scheiner O (1988) Isolation and characterization of messenger RNA from male inflorescences and pollen of the white birch (Betula verrucosa). Int Arch Allergy Appl Immunol 87(1):19–24CrossRefPubMed Breiteneder HI, Hassfeld W, Pettenburger K, Jarolim E, Breitenbach M, Rumpold H, Kraft D, Scheiner O (1988) Isolation and characterization of messenger RNA from male inflorescences and pollen of the white birch (Betula verrucosa). Int Arch Allergy Appl Immunol 87(1):19–24CrossRefPubMed

Zurück zum Zitat Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, Melioli G, Nunes C, Passalacqua G, Rosenwasser L, Sampson H, Sastre J, Bousquet J, Zuberbier T, Allen K, Asero R, Bohle B, Cox L, de Blay F, Ebisawa M, Maximiliano-Gomez R, Gonzalez-Diaz S, Haahtela T, Holgate ST, Jakob T, Larche M, Matricardi PM, Oppenheimer J, Poulsen LK, Rosario N, Rothenberg M, Sanchez-Borges M, Scala E, Valenta R (2013) A WAO – ARIA – GA2LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J 136:17–34CrossRef Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, Melioli G, Nunes C, Passalacqua G, Rosenwasser L, Sampson H, Sastre J, Bousquet J, Zuberbier T, Allen K, Asero R, Bohle B, Cox L, de Blay F, Ebisawa M, Maximiliano-Gomez R, Gonzalez-Diaz S, Haahtela T, Holgate ST, Jakob T, Larche M, Matricardi PM, Oppenheimer J, Poulsen LK, Rosario N, Rothenberg M, Sanchez-Borges M, Scala E, Valenta R (2013) A WAO – ARIA – GA2LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J 136:17–34CrossRef

Zurück zum Zitat Constantin C, Quirce S, Poorafshar M, Touraev A, Niggemann B, Mari A, Ebner C, Akerström H, Heberle-Bors E, Nystrand M, Valenta R (2009) Micro-arrayed wheat seed and grass pollen allergens for component-resolved diagnosis. Allergy 64:1030–1037CrossRefPubMed Constantin C, Quirce S, Poorafshar M, Touraev A, Niggemann B, Mari A, Ebner C, Akerström H, Heberle-Bors E, Nystrand M, Valenta R (2009) Micro-arrayed wheat seed and grass pollen allergens for component-resolved diagnosis. Allergy 64:1030–1037CrossRefPubMed

Zurück zum Zitat Gadisseur R, Chapelle JP, Cavalier E (2011) A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP 250 with the ImmunoCAP ISAC. Clin Chem Lab Med 49:277–280CrossRefPubMed Gadisseur R, Chapelle JP, Cavalier E (2011) A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP 250 with the ImmunoCAP ISAC. Clin Chem Lab Med 49:277–280CrossRefPubMed

Zurück zum Zitat Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, Bergmann KE, Keil T, Hofmaier S, Rohrbach A, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Matricardi PM (2012) Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 130:894–901.e5CrossRefPubMed Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, Bergmann KE, Keil T, Hofmaier S, Rohrbach A, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Matricardi PM (2012) Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 130:894–901.e5CrossRefPubMed

Zurück zum Zitat Hiller R, Laffer S, Harwanegg C, Huber M, Schmidt WM, Twardosz A, Barletta B, Becker WM, Blaser K, Breiteneder H, Chapman M, Crameri R, Duchêne M, Ferreira F, Fiebig H, Hoffmann-Sommergruber K, King TP, Kleber-Janke T, Kurup VP, Lehrer SB, Lidholm J, Müller U, Pini C, Reese G, Scheiner O, Scheynius A, Shen HD, Spitzauer S, Suck R, Swoboda I, Thomas W, Tinghino R, Van Hage-Hamsten M, Virtanen T, Kraft D, Müller MW, Valenta R (2002) Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J16:414–416 Hiller R, Laffer S, Harwanegg C, Huber M, Schmidt WM, Twardosz A, Barletta B, Becker WM, Blaser K, Breiteneder H, Chapman M, Crameri R, Duchêne M, Ferreira F, Fiebig H, Hoffmann-Sommergruber K, King TP, Kleber-Janke T, Kurup VP, Lehrer SB, Lidholm J, Müller U, Pini C, Reese G, Scheiner O, Scheynius A, Shen HD, Spitzauer S, Suck R, Swoboda I, Thomas W, Tinghino R, Van Hage-Hamsten M, Virtanen T, Kraft D, Müller MW, Valenta R (2002) Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J16:414–416

Zurück zum Zitat Hofmann SC, Fischer J, Eriksson C, Bengtsson Gref O, Biedermann T, Jakob T (2012) IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis. Allergy 67:1457–1460CrossRefPubMed Hofmann SC, Fischer J, Eriksson C, Bengtsson Gref O, Biedermann T, Jakob T (2012) IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis. Allergy 67:1457–1460CrossRefPubMed

Zurück zum Zitat Ishizaka K, Ishizaka T (1967) Identification of gamma-E antibodies as a carrier of reaginic antibody. J Immunol 99:1187–1198PubMed Ishizaka K, Ishizaka T (1967) Identification of gamma-E antibodies as a carrier of reaginic antibody. J Immunol 99:1187–1198PubMed

Zurück zum Zitat Johansson SGO, Bennich H (1967) Immunological studies of an atypical (myeloma) immunoglobulin. Immunology 13:381–394PubMedCentralPubMed Johansson SGO, Bennich H (1967) Immunological studies of an atypical (myeloma) immunoglobulin. Immunology 13:381–394PubMedCentralPubMed

Zurück zum Zitat Lupinek C, Wollmann E, Baar A, Banerjee S, Breiteneder H, Broecker BM, Bublin M, Curin M, Flicker S, Garmatiuk T, Hochwallner H, Mittermann I, Pahr S, Resch Y, Roux KH, Srinivasan B, Stentzel S, Vrtala S, Willison LN, Wickman M, Lødrup-Carlsen KC, Antó JM, Bousquet J, Bachert C, Ebner D, Schlederer T, Harwanegg C, Valenta R (2014) Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip. Methods 66:106–119CrossRefPubMed Lupinek C, Wollmann E, Baar A, Banerjee S, Breiteneder H, Broecker BM, Bublin M, Curin M, Flicker S, Garmatiuk T, Hochwallner H, Mittermann I, Pahr S, Resch Y, Roux KH, Srinivasan B, Stentzel S, Vrtala S, Willison LN, Wickman M, Lødrup-Carlsen KC, Antó JM, Bousquet J, Bachert C, Ebner D, Schlederer T, Harwanegg C, Valenta R (2014) Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip. Methods 66:106–119CrossRefPubMed

Zurück zum Zitat Matricardi PM (2014) Allergen-specific immunoprophylaxis: Toward secondary prevention of allergic rhinitis? Pediatr Allergy Immunol 25:15–18CrossRefPubMed Matricardi PM (2014) Allergen-specific immunoprophylaxis: Toward secondary prevention of allergic rhinitis? Pediatr Allergy Immunol 25:15–18CrossRefPubMed

Zurück zum Zitat Melioli G, Spenser C, Reggiardo G, Passalacqua G, Compalati E, Rogkakou A, Riccio AM, Di Leo E, Nettis E, Canonica GW (2014) Allergenius, an expert system for the interpretation of allergen microarray results. World Allergy Organ J 7:15PubMedCentralCrossRefPubMed Melioli G, Spenser C, Reggiardo G, Passalacqua G, Compalati E, Rogkakou A, Riccio AM, Di Leo E, Nettis E, Canonica GW (2014) Allergenius, an expert system for the interpretation of allergen microarray results. World Allergy Organ J 7:15PubMedCentralCrossRefPubMed

Zurück zum Zitat Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G, Härlin A, Woodcock A, Ahlstedt S, Custovic A (2010) Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol 125:191–197.e1–13CrossRefPubMed Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G, Härlin A, Woodcock A, Ahlstedt S, Custovic A (2010) Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol 125:191–197.e1–13CrossRefPubMed

Zurück zum Zitat Palomba A, Maccari M, Baldracchini F, Mazzoleni G, Crisanti A, Marcucci F (2014) Evaluation of a new microarray based system for allergy testing. EAACI, Copenhagen (Abstract # 18) Palomba A, Maccari M, Baldracchini F, Mazzoleni G, Crisanti A, Marcucci F (2014) Evaluation of a new microarray based system for allergy testing. EAACI, Copenhagen (Abstract # 18)

Zurück zum Zitat Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J (2014) Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases – S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 23:282–319. doi:10.1007/s40629-014-0032-2PubMedCentralCrossRefPubMed Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J (2014) Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases – S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 23:282–319. doi:10.1007/s40629-014-0032-2PubMedCentralCrossRefPubMed

Zurück zum Zitat van Ree R (2002) Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases. Int Arch Allergy Immunol 129:189–197CrossRefPubMed van Ree R (2002) Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases. Int Arch Allergy Immunol 129:189–197CrossRefPubMed

Zurück zum Zitat Rosenfeld L, Shreffler W, Bardina L, Niggemann B, Wahn U, Sampson HA, Beyer K (2012) Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity. Int Arch Allergy Immunol 157:238–245CrossRefPubMed Rosenfeld L, Shreffler W, Bardina L, Niggemann B, Wahn U, Sampson HA, Beyer K (2012) Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity. Int Arch Allergy Immunol 157:238–245CrossRefPubMed

Zurück zum Zitat Sastre J, Landivar ME, Ruiz-García M, Andregnette-Rosigno MV, Mahillo I (2012) How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area. Allergy 67:709–711CrossRefPubMed Sastre J, Landivar ME, Ruiz-García M, Andregnette-Rosigno MV, Mahillo I (2012) How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area. Allergy 67:709–711CrossRefPubMed

Zurück zum Zitat Shreffler WG, Beyer K, Chu TH, Burks AW, Sampson HA (2004) Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 113:776–782CrossRefPubMed Shreffler WG, Beyer K, Chu TH, Burks AW, Sampson HA (2004) Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 113:776–782CrossRefPubMed

Zurück zum Zitat Stringari G, Tripodi S, Caffarelli C, Dondi A, Asero R, Di Rienzo Businco A, Bianchi A, Candelotti P, Ricci G, Bellini F, Maiello N, Miraglia del Giudice M, Frediani T, Sodano S, Dello Iacono I, Macrì F, Peparini I, Povesi Dascola C, Patria MF, Varin E, Peroni D, Comberiati P, Chini L, Moschese V, Lucarelli S, Bernardini R, Pingitore G, Pelosi U, Tosca M, Cirisano A, Faggian D, Travaglini A, Plebani M, Matricardi PM, Italian Pediatric Allergy Network (I-PAN) (2014) The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever. J Allergy Clin Immunol 134:75–81CrossRefPubMed Stringari G, Tripodi S, Caffarelli C, Dondi A, Asero R, Di Rienzo Businco A, Bianchi A, Candelotti P, Ricci G, Bellini F, Maiello N, Miraglia del Giudice M, Frediani T, Sodano S, Dello Iacono I, Macrì F, Peparini I, Povesi Dascola C, Patria MF, Varin E, Peroni D, Comberiati P, Chini L, Moschese V, Lucarelli S, Bernardini R, Pingitore G, Pelosi U, Tosca M, Cirisano A, Faggian D, Travaglini A, Plebani M, Matricardi PM, Italian Pediatric Allergy Network (I-PAN) (2014) The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever. J Allergy Clin Immunol 134:75–81CrossRefPubMed

Zurück zum Zitat Thermo Fisher Scientific (2011) ImmunoCAP ISAC 112 – performance characteristics, data on file, Oct 2011. Thermo Fisher Scientific, Uppsala, Sweden Thermo Fisher Scientific (2011) ImmunoCAP ISAC 112 – performance characteristics, data on file, Oct 2011. Thermo Fisher Scientific, Uppsala, Sweden

Zurück zum Zitat Tripodi S, Frediani T, Lucarelli S, Macrì F, Pingitore G, Di Rienzo Businco A, Dondi A, Pansa P, Ragusa G, Asero R, Faggian D, Plebani M, Matricardi PM (2012) Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: implications for specific immunotherapy. J Allergy Clin Immunol 129:834–839.e8CrossRefPubMed Tripodi S, Frediani T, Lucarelli S, Macrì F, Pingitore G, Di Rienzo Businco A, Dondi A, Pansa P, Ragusa G, Asero R, Faggian D, Plebani M, Matricardi PM (2012) Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: implications for specific immunotherapy. J Allergy Clin Immunol 129:834–839.e8CrossRefPubMed

Zurück zum Zitat van Vaerenbergh M, De Smet L, Rafei-Shamsabadi D, Blank S, Spillner E, Ebo DG, Devreese B, Jakob T, de Graaf DC (2015) IgE recognition of chimeric isoforms of the honeybee (Apis mellifera) venom allergen Api m 10 evaluated by protein array technology. Mol Immunol 63:449–455CrossRefPubMed van Vaerenbergh M, De Smet L, Rafei-Shamsabadi D, Blank S, Spillner E, Ebo DG, Devreese B, Jakob T, de Graaf DC (2015) IgE recognition of chimeric isoforms of the honeybee (Apis mellifera) venom allergen Api m 10 evaluated by protein array technology. Mol Immunol 63:449–455CrossRefPubMed

Zurück zum Zitat Valenta R (2002) The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol 2:446–453PubMed Valenta R (2002) The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol 2:446–453PubMed

Zurück zum Zitat Valenta R, Kraft D (2001) Recombinant allergen molecules: tools to study effector cell activation. Immunol Rev 179:119–127CrossRefPubMed Valenta R, Kraft D (2001) Recombinant allergen molecules: tools to study effector cell activation. Immunol Rev 179:119–127CrossRefPubMed

Zurück zum Zitat Westman M, Lupinek C, Bousquet J, Andersson N, Pahr S, Baar A, Bergström A, Holmström M, Stjärne P, Lødrup Carlsen KC, Carlsen K, Antó JM, Valenta R, van Hage M, Wickman M, Mechanisms for the Development of Allergies (MeDALL) consortium (2015) Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence. J Allergy Clin Immunol 135:1199-1206.e1-11CrossRefPubMed Westman M, Lupinek C, Bousquet J, Andersson N, Pahr S, Baar A, Bergström A, Holmström M, Stjärne P, Lødrup Carlsen KC, Carlsen K, Antó JM, Valenta R, van Hage M, Wickman M, Mechanisms for the Development of Allergies (MeDALL) consortium (2015) Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence. J Allergy Clin Immunol 135:1199-1206.e1-11CrossRefPubMed

Zurück zum Zitat Wide L, Bennich H, Johansson SG (1967) Diagnosis of allergy by an in vitro test for allergen antibodies. Lancet II:1105–1107CrossRef Wide L, Bennich H, Johansson SG (1967) Diagnosis of allergy by an in vitro test for allergen antibodies. Lancet II:1105–1107CrossRef

Zurück zum Zitat Zuberbier T, Bachert C, Bousquet PJ, Passalacqua G, Walter Canonica G, Merk H, Worm M, Wahn U, Bousquet J (2010) GA² LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma. Allergy 65:1525–1530CrossRefPubMed Zuberbier T, Bachert C, Bousquet PJ, Passalacqua G, Walter Canonica G, Merk H, Worm M, Wahn U, Bousquet J (2010) GA² LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma. Allergy 65:1525–1530CrossRefPubMed