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2015 | OriginalPaper | Buchkapitel

14. Molekulare Diagnostik der Gemüse- und Fruchtallergie

verfasst von : Prof. Dr. med. Barbara Ballmer-Weber, Univ.-Doz.Dr. rer. nat. Karin Hoffmann-Sommergruber

Erschienen in: Molekulare Allergiediagnostik

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Die häufigsten Nahrungsmittelallergien im Erwachsenenalter richten sich neben Nüssen und Leguminosen gegen Früchte und Gemüse. In einer Übersichtsarbeit aus dem Jahr 2011 (Ballmer-Weber u. Hoffmann-Sommergruber 2011) wurden die wichtigsten Forschungsergebnisse zur molekularen Diagnostik bei Frucht- und Gemüseallergie der Jahre 2009 und 2010 zusammengestellt. Das folgende Kapitel basiert auf dieser Zusammenfassung und wurde mit neuen Daten zum Thema ergänzt.

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Bublin M, Radauer C, Wilson IB, Kraft D, Scheiner O, Breiteneder H, Hoffmann-Sommergruber K (2003) Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients. Faseb J 17:1697–1699PubMed

Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K, Breiteneder H, Radauer C (2004) IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries. J Allergy Clin Immunol 114:1169–1175CrossRefPubMed

Bublin M, Pfister M, Radauer C, Oberhuber C, Bulley S, Dewitt AM, Lidholm J, Reese G, Vieths S, Breiteneder H, Hoffmann-Sommergruber K, Ballmer-Weber BK (2010) Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens. J Allergy Clin Immunol 125:687–694 (694 e681)CrossRefPubMed

Bublin M, Dennstedt S, Buchegger M, Antonietta Ciardiello M, Bernardi ML, Tuppo L, Harwanegg C, Hafner C, Ebner C, Ballmer-Weber BK, Knulst A, Hoffmann-Sommergruber K, Radauer C, Mari A, Breiteneder H (2011) The performance of a component-based allergen microarray for the diagnosis of kiwifruit allergy. Clin Exp Allergy 41(1):129–136CrossRefPubMed

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Burney PG, Potts J, Kummeling I, Mills EN, Clausen M, Dubakiene R, Barreales L, Fernandez-Perez C, Fernandez-Rivas M, Le TM, Knulst AC, Kowalski ML, Lidholm J, Ballmer-Weber BK, Braun-Fahlander C, Mustakov T, Kralimarkova T, Popov T, Sakellariou A, Papadopoulos NG, Versteeg SA, Zuidmeer L, Akkerdaas JH, Hoffmann-Sommergruber K, van Ree R (2014) The prevalence and distribution of food sensitization in European adults. Allergy 69:365–371CrossRefPubMed

Caimmi D, Barber D, Hoffmann-Sommergruber K, Amrane H, Bousquet PJ, Dhivert-Donnadieu H, Demoly P (2013) Understanding the molecular sensitization for Cypress pollen and peach in the Languedoc-Roussillon area. Allergy 68:249–251CrossRefPubMed

Ciardiello MA, D’Avino R, Amoresano A, Tuppo L, Carpentieri A, Carratore V, Tamburrini M, Giovane A, Pucci P, Camardella L (2008) The peculiar structural features of kiwi fruit pectin methylesterase: amino acid sequence, oligosaccharides structure, and modeling of the interaction with its natural proteinaceous inhibitor. Proteins 71:195–206CrossRefPubMed

Cuesta-Herranz J, Barber D, Blanco C, Cistero-Bahima A, Crespo JF, Fernandez-Rivas M, Fernandez-Sanchez J, Florido JF, Ibanez MD, Rodriguez R, Salcedo G, Garcia BE, Lombardero M, Quiralte J, Rodriguez J, Sanchez-Monge R, Vereda A, Villalba M, Alonso Diaz de Durana MD, Basagana M, Carrillo T, Fernandez-Nieto M, Tabar AI (2010) Differences among pollen-allergic patients with and without plant food allergy. Int Arch Allergy Immunol 153: 182–192

D’Avino R, Bernardi ML, Wallner M, Palazzo P, Camardella L, Tuppo L, Alessandri C, Breiteneder H, Ferreira F, Ciardiello MA, Mari A (2011) Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen. Allergy 66:870–877CrossRefPubMed

Eriksson N, Werner S, Foucard T, Möller C, Berg T, Kiviloog J (2003) Self-reportend hypersensitivity to exotic fruit in brich pollen-allergic patients. Allergology International 52:199–206CrossRef

Fernandez-Rivas M, Gonzalez-Mancebo E, Rodriguez-Perez R, Benito C, Sanchez-Monge R, Salcedo G, Alonso MD, Rosado A, Tejedor MA, Vila C, Casas ML (2003) Clinically relevant peach allergy is related to peach lipid transfer protein, Pru p 3, in the Spanish population. J Allergy Clin Immunol 112:789–795

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Gadermaier G, Hauser M, Egger M, Ferrara R, Briza P, Santos KS, Zennaro D, Girbl T, Zuidmeer-Jongejan L, Mari A, Ferreira F (2011) Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery. PloS one 6:e24150CrossRefPubMedPubMedCentral

Gaier S, Marsh J, Oberhuber C, Rigby NM, Lovegrove A, Alessandri S, Briza P, Radauer C, Zuidmeer L, van Ree R, Hemmer W, Sancho AI, Mills C, Hoffmann-Sommergruber K, Shewry PR (2008) Purification and structural stability of the peach allergens Pru p 1 and Pru p 3. Mol Nutr Food Res 52(Suppl 2):220–229

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Gao ZS, Yang ZW, Wu SD, Wang HY, Liu ML, Mao WL, Wang J, Gadermaier G, Ferreira F, Zheng M, van Ree R (2013) Peach allergy in China: a dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. J Allergy Clin Immunol 131:224–226 (e221–223)CrossRefPubMed

Gavrovic-Jankulovic M, cIrkovic T, Vuckovic O, Atanaskovic-Markovic M, Petersen A, Gojgic G, Burazer L, Jankov RM (2002) Isolation and biochemical characterization of a thaumatin-like kiwi allergen. J Allergy Clin Immunol 110:805–810CrossRefPubMed

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Grozdanovic M, Popovic M, Polovic N, Burazer L, Vuckovic O, Atanaskovic-Markovic M, Lindner B, Petersen A, Gavrovic-Jankulovic M (2012) Evaluation of IgE reactivity of active and thermally inactivated actinidin, a biomarker of kiwifruit allergy. Food Chem Toxicol 50:1013–1018CrossRefPubMed

Hoffmann-Sommergruber K, O’Riordain G, Ahorn H, Ebner C, Laimer Da Camara Machado M, Puhringer H, Scheiner O, Breiteneder H (1999) Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1. Clin Exp Allergy 29:840–847CrossRefPubMed

Hoffmann-Sommergruber K, Ferris R, Pec M, Radauer C, O’Riordain G, Laimer Da Camara Machado M, Scheiner O, Breiteneder H (2000) Characterization of Api g 1.0201, a new member of the Api g 1 family of celery allergens. Int Arch Allergy Immunol 122:115–123CrossRefPubMed

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Kummeling I, Mills EN, Clausen M, Dubakiene R, Perez CF, Fernandez-Rivas M, Knulst AC, Kowalski ML, Lidholm J, Le TM, Metzler C, Mustakov T, Popov T, Potts J, van Ree R, Sakellariou A, Tondury B, Tzannis K, Burney P (2009) The EuroPrevall surveys on the prevalence of food allergies in children and adults: background and study methodology. Allergy 64:1493–1497CrossRefPubMed

Larramendi CH, Ferrer A, Huertas AJ, Garcia-Abujeta JL, Andreu C, Tella R, Cerda MT, Bartra J, Lavin JR, Pagan JA, Lopez-Matas MA, Fernandez-Caldas E, Carnes J (2008) Sensitization to tomato peel and pulp extracts in the Mediterranean Coast of Spain: prevalence and co-sensitization with aeroallergens. Clin Exp Allergy 38:169–177PubMed

Le LQ, Mahler V, Scheurer S, Foetisch K, Braun Y, Weigand D, Enrique E, Lidholm J, Paulus KE, Sonnewald S, Vieths S, Sonnewald U (2010) Yeast profilin complements profilin deficiency in transgenic tomato fruits and allows development of hypoallergenic tomato fruits. Faseb J 24:4939–4947CrossRefPubMed

Le TM, Fritsche P, Bublin M, Oberhuber C, Bulley S, van Hoffen E, Ballmer-Weber BK, Knulst AC, Hoffmann-Sommergruber K (2011) Differences in the allergenicity of 6 different kiwifruit cultivars analyzed by prick-to-prick testing, open food challenges, and ELISA. J Allergy Clin Immunol 127(3):677–679 (e671–672)CrossRefPubMed

Lidholm J, Ballmer-Weber BK, Mari A, Vieths S (2006) Component-resolved diagnostics in food allergy. Curr Opin Allergy Clin Immunol 6:234–240CrossRefPubMed

Mattila L, Kilpelainen M, Terho EO, Koskenvuo M, Helenius H, Kalimo K (2003) Food hypersensitivity among Finnish university students: association with atopic diseases. Clin Exp Allergy 33:600–606CrossRefPubMed

Oberhuber C, Bulley SM, Ballmer-Weber BK, Bublin M, Gaier S, DeWitt AM, Briza P, Hofstetter G, Lidholm J, Vieths S, Hoffmann-Sommergruber K (2008) Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Mol Nutr Food Res 52(Suppl 2):230–240

Palacin A, Rodriguez J, Blanco C, Lopez-Torrejon G, Sanchez-Monge R, Varela J, Jimenez MA, Cumplido J, Carrillo T, Crespo JF, Salcedo G (2008) Immunoglobulin E recognition patterns to purified Kiwifruit (Actinidinia deliciosa) allergens in patients sensitized to Kiwi with different clinical symptoms. Clin Exp Allergy 38:1220–1228CrossRefPubMed

Palacin A, Tordesillas L, Gamboa P, Sanchez-Monge R, Cuesta-Herranz J, Sanz ML, Barber D, Salcedo G, Diaz-Perales A (2010) Characterization of peach thaumatin-like proteins and their identification as major peach allergens. Clin Exp Allergy 40:1422–1430CrossRefPubMed

Palacin A, Rivas LA, Gomez-Casado C, Aguirre J, Tordesillas L, Bartra J, Blanco C, Carrillo T, Cuesta-Herranz J, Bonny JA, Flores E, Garcia-Alvarez-Eire MG, Garcia-Nunez I, Fernandez FJ, Gamboa P, Munoz R, Sanchez-Monge R, Torres M, Losada SV, Villalba M, Vega F, Parro V, Blanca M, Salcedo G, Diaz-Perales A (2012) The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter study using a specific protein microarray. PloS one 7:e44088CrossRefPubMedPubMedCentral

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Titel: Molekulare Diagnostik der Gemüse- und Fruchtallergie
verfasst von: Prof. Dr. med. Barbara Ballmer-Weber
Univ.-Doz.Dr. rer. nat. Karin Hoffmann-Sommergruber
Verlag: Springer Berlin Heidelberg
Buch: Molekulare Allergiediagnostik
Print ISBN: 978-3-662-45220-2

Electronic ISBN: 978-3-662-45221-9

Copyright-Jahr: 2015
DOI: https://doi.org/10.1007/978-3-662-45221-9_14

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14. Molekulare Diagnostik der Gemüse- und Fruchtallergie

Zusammenfassung

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO

Springer Medizin

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO