Mono- versus polyaxial locking plates in distal femur fractures – a biomechanical comparison of the Non-Contact-Bridging- (NCB) and the PERILOC-plate

Management of patients with articular distal femur fractures can often be difficult due to the complexity of the injury itself and to the often poor general condition of patients and their bones. Femur fractures are associated with complications that include malunion and implant failure[1]. Due to a relevant increase of elderly active patients with increased life expectancy and more hazardous sports more patients will present with femur fractures[2]. Two principle injury mechanisms are known: Either high energy trauma in younger patients e.g. after road traffic accidents or low energy trauma caused by falls in most elderly patients complicated through osteoporosis or even periprosthetic fractures[3]. The objectives in treatment include restoration of bone length, axis and rotation as well as a fixation that permits early full weight bearing to avoid immobilization and its associated complications[4].

As conservative treatment of distal femur fractures is obsolete, they used to be treated by (bicondylar) plate fixation in case of intact surrounding soft tissue or intramedullary nailing[5, 6]. However, the reported complication rate with non-union, loss of reduction and implant failure have been high[7‐9]. Recent developments in the last decade described the principle of ‘minimal invasive biological plate osteosynthesis’ showing reduced blood loss, lower infection rates and possibility of bridging the supracondylar fracture zone as an internal fixator, preserving the bone fragments and the periosteum[1, 10‐12]. The first and most famous of these products is the "Less Invasive Stabilizing System" (LISS®, Synthes Corp., Umkirch, Germany) showing improved biomechanical and clinical results[13]. Locking plates show advantages in osteoporotic bones for a lower rate of secondary dislocation as well as a definitely lower impairment of bone perfusion due to plate fixation with a small gap to the bone and the periosteum[3, 14]. The main downside of the monoaxial locking implants is that the existing thread in the plate pre-determines the perpendicular direction of the screw. That can often leads to positioning of screws in bone areas which intraoperatively have to be considered of minor quality. This may be associated with secondary loss of realignment and loosening of screws[15]. Ideas to avoid this and giving the surgeon more freedom in directing the screws through the bone lead to the introduction of polyaxial locking plates[16]. This implant (e.g. Non-Contact-Bridging-plate, Zimmer Inc., Winterthur, Switzerland) allows a locking screw placement in a range of 15° to the plate level. Additionally reduction of bony fragments (e.g. as lag screws) in the direction to the plate can be accomplished before the screws are locked. Angular stability is achieved by fixing the head of the screw with an additional cap turned into the plate thread covering the screw head (load to friction). Up to now, several clinical observations have been published concerning fixation of femur- and periprosthetic fractures with NCB plates[12, 16, 17] showing same or better results as compared to similar procedures with monoaxial implants. From the biomechanical point of view individual studies were published, comparing the available locking plates with synthetic bones only, but not on a cadaveric distal femur. As synthetic bone models will not capture interspecimen variability nor material inhomogeneity, both of which may affect relative performance of both implant systems, we performed the first cadaveric study to supply data that is closest to the real situation.

Seven pairs of cadaveric femora were used (2 male, 5 female donors). The mean donor age at the time of death was 75 years (range 45-92 years). The results for the biomechanical testing are shown in Table 1.Five constructs failed before reaching the maximum applied force of 2000 N. In 4 cases, failure was due to a distal loss of reduction (2 × PERILOC, 2 × NCB) due to a cutout of the screws as shown in Figure 2.One sample (PERILOC®) showed at 2000 N a complete failure in the shaft region, whereas the condyles were still stable (Figure 3). All other bones reached the test endpoint of 2000 N without any complication.Figure 4 presents the absolute values of plastic deformation of all samples in relation to the axial force. Both plates are compared for every bone pair. In most samples the curves have a very parallel or similar course.The overall plastic deformation in both groups was comparable. The measured differences were statistically not significant (Figure 5).

In the radiographs, we observed in all specimens of both groups no unexpected results (bone fissures or fractures, screw loosening/loss of locking mechanism, screw bending) despite the 5 described construct failures. No obvious permanent plate bending or deformation was found. Only one pullout failure of the proximal fragment as a complete burst fracture was observed as shown above.

Distal femur fractures especially in the elderly are dedicated to be the most problematic fractures in trauma surgery. These fractures can be complicated to treat and require advanced surgical skills and optimal implants. After nailing and conventional plating, monoaxial plating was suggested[9, 17, 22]. The newest device is the polyaxial locking plate.

From a clinical point of view, there are two main targets: first, that the fracture heals, and second, that the construct itself does not fail[8]. Stress tests have indicated that the locking plates of the first generation may provide improved distal fixation of distal femur fractures especially in osteoporotic bone, withstanding greater axial loads and requiring higher energy to failure, compared to the angled blade plates or intramedullary nails[23, 24]. In far distal fractures sufficient fixation of an intramedullary nail can be impossible, why in such cases plating should be preferred[4]. To maintain the osseous blood supply, pre-contoured plates are placed in an epiperiosteal position, and should have no direct contact with the bone. Several clinical and biomechanical studies evaluated such a system (LISS® - Less-Invasive stabilization System) which was introduced as an "internal fixator"[25]. However, this and other first-generation fixed-angle locking plates have screws that are inserted perpendicular to the plate, which limits their clinical applicability[4, 5, 20, 26‐28]. In the case of periprosthetic fractures with intramedullary stems or impossible bicortical screw placement, unicortical screw fixation was suggested. Unfortunately, several studies show high complication rates of up to 30% due to a break-out of the unicortical screws especially in osteoporotic bones[29‐31]. Polyaxial screw placement is suggested to be the clue.

Up to date only two authors published biomechanical series comparing the polyaxial NCB®-plate to monoaxial implants in the distal femur. Otto et al. compared the stability to axial loading to the LISS® plate in synthetic bones. There was no difference with regard to stiffness, load to failure, and peak force[32]. Wilkens et al. compared the NCB®-plate to another polyaxial plate and the LISS® furthermore in terms of parallel or angled screw placement[21]. They showed that the NCB® system outperformed the conventional plates in nearly all tested parameters. As limitation of their study Wilkens et al. stated that it was not conducted with cadaveric bones[33]. Investigations using synthetic bones can not adequately replace cadaveric studies due to the fact that synthetic bone models will not capture interspecimen variability nor material inhomogeneity, both of which may affect relative performance of both implant systems. Nevertheless these studies may need to be validated by further testing with a small cadaveric bone sample in order to produce conclusive results. The only two publications delivering biomechanical data with cadaveric femurs and NCB® plates are dealing with proximal periprosthetic fractures. Konstantinidis et al. compared bi- (NCB®)- and monocortical LISS®- fixation in formalin-fixed femora with Vancouver B1-fractures[34]. They concluded that bicortical screw placement should be preferred whenever possible and that fracture stabilization can be achieved equally well using either LISS®- or the NCB®-plate. Wähnert et al. published recently a biomechanical comparison with fresh-frozen cadavers of the same periprosthetic proximal femur fracture. They compared the NCB® system to another angular stable implant (fixed angle locking attachment plate, LAP®, DepuySynthes) and concluded that the non-contact bridging plate revealed significantly higher failure load and may be the preferred option[35].

There is no published data yet comparing NCB® plates to monoaxial plates in a cadaveric model of a distal femur fracture. The PERILOC® plate was chosen as monoaxial reference as it is from the biomechanical aspects as well as from the locking mechanism (thread in the head of the screw engaging in the hole of the plate) comparable to the LISS® plate. Both system simulates the concept of minimally invasive bridging of a comminuted fracture, and could be implanted via an aiming device with a limited approach. Concerning different available cadaveric bones a prior study showed, that formalin-fixed and fresh frozen femurs had similar characteristics in mechanical testing[36]. In the present study cadaveric formalin fixed femurs were used to mimic a realistic situation in such fractures in either osteoporotic as well as in younger individuals with higher bone density. The BMD in both groups showed samples either from osteoporotic as well as from younger and stronger bones. Both groups showed in regard of BMD no significant differences. The study design aimed at testing plate osteosynthesis at an open gap fracture model, which was biomechanically similar to a comminuted, inaccurately reduced, or non-consolidated fracture. A major challenge in real surgery is the direction of screws from a weak or comminuted region to a subjective ‘more stable’ bony region in internal fixation. Fixed angle monoaxial plates do not allow any angulation of the drill for screw placement, leading to a frequent suboptimal screw fixation in weak cancellous bone. Polyaxiality allows the surgeon to redirect the drill to find subjective ‘stronger’ bone for securer screw placement in the condylar region, as well as in the shaft (use of lag screws as a kind of hybrid system).

Concerning the locking mechanism of both systems, the above mentioned results showed no failure of locking mechanism or screw loosening. This is comparable to the published biomechanical data showing sufficient stability of the innovative frictional locking mechanism of the NCB® system with small caps locking the screw heads to the plate[21].

In our series, no implant failure as plate breakage or bending occurred. This may be due to the limited force applied on the samples with 2000 N and to the "physiological" loading with the axial force on the anatomical axis. There was no scientific interest in maximal loading like a "load-to failure" as the results up to a relevant high force were meaningful. Comparing both devices in both groups, no statistically significant differences were found regarding stability. The failure modes, which were observed in other biomechanical series with similar test designs at the femur shaft or proximal femur are analog to our results[37].

This study, as in several other clinical and composite bone trials[30‐32, 34], shows at least similar stability of tested poly- and monoaxial plates.

This study is limited by its inability to directly correlate biomechanical testing in a cadaveric system with clinical results. Another limitation results from using formalin-fixed specimen denuded of surrounding soft tissue. However, as shown by Topp et al. they have similar characteristics in mechanical testing as fresh frozen bones and are a good option for mechanical testing of orthopedic and trauma devices[36]. Moreover, the use of paired femora will likely limit any confounding effect of the formalin-related alterations of biomechanical properties of the specimen.

The test settings used in this study showed no statistical difference in the stability of PERILOC® and NCB® plates. No material fatigue under cyclical loading was observed. Thus, the NCB®-plate is comparable to the PERILOC®-plate in biomechanical aspects. Operative stabilization of distal femur fractures can be successfully and equally well achieved using either the PERILOC® plate or the NCB® plate. In complex supracondylar and periprosthetic fractures, the NCB® -plate might show superiority due to its higher flexibility and angulation in bicortical screw placement to regions with better bone stock.