Background
Methods
Case selection and TMA construction
MCT and CD147 immunohistochemistry
Immunohistochemical evaluation
Statistics
Ethics
Results
MCT, CD147 and gp70 expressions in prostate tissues
ISG (%) | HSG (%) | |||||
---|---|---|---|---|---|---|
n | (Score 4) |
p
| (Scores 5-6) |
p
| ||
MCT1
| 0.500 |
0.002
| ||||
NT
|
121
| 17.4 | 66.9 | |||
T
|
166
| 18.0 | 46.4 | |||
MCT2
|
0.048
|
< 0.001
| ||||
NT
|
132
| 37.9 | 16.7 | |||
T
|
166
| 26.0 | 53.0 | |||
MCT4
| 0.474 |
< 0.001
| ||||
NT
|
128
| 16.4 | 7.8 | |||
T
|
168
| 20.8 | 23.2 | |||
CD147
| 0.211 | 0.153 | ||||
NT
|
134
| 11.9 | 41.1 | |||
T
|
167
| 16.7 | 32.9 |
MCT1
|
MCT4
|
MCT2
| |||||||
---|---|---|---|---|---|---|---|---|---|
n | Positive (%) |
p
| n | Positive (%) |
p
| n | Positive (%) |
p
| |
CD147
|
< 0.001
|
< 0.001
| 0.184 | ||||||
Negative |
59
| 20.3 |
84
| 26.7 |
35
| 40.0 | |||
Positive |
107
| 64.5 |
83
| 63.0 |
131
| 50.4 |
Associations between MCTs and CD147 expressions and the clinic-pathological data
MCT1 | MCT2 | MCT4 | CD147 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable | n | ISG %(n) |
p
| HSG %(n) |
p
| ISG %(n) |
p
| HSG %(n) |
p
| ISG %(n) |
p
| HSG %(n) |
p
| ISG %(n) |
p
| HSG %(n) |
p
|
Age
| 0.391 | 0.073 |
0.023
| 0.117 | 0.247 |
< 0.001
| 0.518 |
< 0.001
| |||||||||
> 64 |
93
| 19.4 (18) | 40.9 (38) | 32.6 (30) | 48.4 (45) | 18.5 (17) | 8.6 (8) | 17.2 (16) | 16.1 (15) | ||||||||
> 64 |
73
| 16.4 (12) | 53.4 (39) | 17.8 (13) | 58.9 (43) | 24.0 (18) | 42.3 (31) | 16.2 (12) | 54.1 (40) | ||||||||
PSA (ng/ml)
| 0.414 |
0.016
| 0.085 | 0.250 | 0.060 |
< 0.001
| 0.529 |
< 0.001
| |||||||||
> 11 |
116
| 19 (22) | 40.5 (47) | 29.6 (34) | 50.9 (116) | 17.2 (20) | 11.1 (13) | 17.1 (20) | 16.2 (19) | ||||||||
> 11 |
50
| 16 (8) | 60.0 (30) | 18.0 (9) | 58.0 (50) | 29.4 (15) | 51.0 (26) | 16.0 (8) | 72.0 (36) | ||||||||
pT
| 0.511 | 0.145 | 0.528 | 0.297 | 0.210 |
< 0.001
| 0.396 |
< 0.001
| |||||||||
2 |
130
| 18.5 (24) | 43.8 (57) | 26.4 (34) | 51.5 (67) | 19.2 (25) | 14.5 (19) | 16.0 (21) | 24.4 (32) | ||||||||
3 |
36
| 16.7 (6) | 55.6 (20) | 25.0 (3) | 58.3 (21) | 27.0 (10) | 54.1 (20) | 19.4 (7) | 63.9 (23) | ||||||||
Gleason score
| 0.251 | 0.170 | 0.386 | 0.857 | 0.692 |
0.011
| 0.850 |
0.012
| |||||||||
< 7 |
57
| 15.8 (9) | 52.6 (30) | 31.6 (18) | 54.4 (31) | 24.6 (14) | 10.5 (6) | 15.8 (9) | 21.1 (12) | ||||||||
7 |
100
| 21.0 (21) | 41.0 (41) | 22.2 (22) | 53.0 (53) | 18.8 (19) | 28.4 (29) | 17.8 (18) | 36.6 (36) | ||||||||
> 7 |
9
| 0 (0) | 66.7 (6) | 33.3 (3) | 44.4 (4) | 22.2 (2) | 44.4 (4) | 11.1 (1) | 66.7 (6) | ||||||||
Perineural
| |||||||||||||||||
Invasion
| 0.525 |
0.036
| 0.503 | 0.259 | 0.397 |
0.011
| 0.531 |
0.021
| |||||||||
Absent |
52
| 17.3 (9) | 57.7 (30) | 26.9 (14) | 57.7 (30) | 23.1 (12) | 11.5 (6) | 17.3 (9) | 21.2 (11) | ||||||||
Present |
114
| 18.4 (21) | 41.2 (47) | 25.7 (29) | 50.9 (58) | 20.0 (23) | 28.4 (33) | 16.5 (19) | 38.3 (44) | ||||||||
Biochemical
| |||||||||||||||||
Recurrence
| 0.434 |
0.047
| 0.597 | 0.089 | 0.200 |
< 0.001
| 0.489 |
< 0.001
| |||||||||
Absent |
139
| 18.7 (26) | 43.2 (60) | 26.1 (36) | 50.4 (70) | 19.4 (27) | 17.1 (24) | 16.4 (23) | 26.4 (37) | ||||||||
Present |
27
| 14.8 (4) | 63.0 (17) | 25.9 (7) | 66.7 (18) | 28.6 (8) | 53.6 (15) | 18.5 (5) | 66.7 (18) |