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Angiogenesis

Erschienen in:

01.06.2009 | Original Paper

Morphological and molecular aspects of physiological vascular morphogenesis

verfasst von: Domenico Ribatti, Beatrice Nico, Enrico Crivellato

Erschienen in: Angiogenesis | Ausgabe 2/2009

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Abstract

The cardiovascular system plays a crucial role in vertebrate development and homeostasis. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. During embryonal life, blood vessels first appear as the result of vasculogenesis, whereas remodeling of the primary vascular plexus occurs by angiogenesis. Many tissue-derived factors are involved in blood vessel formation and evidence is emerging that endothelial cells themselves represent a source of instructive signals to non-vascular tissue cells during organ development. This review article summarizes our knowledge concerning the principal factors involved in the regulation of vascular morphogenesis.

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Titel: Morphological and molecular aspects of physiological vascular morphogenesis
verfasst von: Domenico Ribatti
Beatrice Nico
Enrico Crivellato
Publikationsdatum: 01.06.2009
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 2/2009
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-008-9125-1

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