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01.10.2015 | Translational Neurosciences - Original Article

mRNA expression of dopamine receptors in peripheral blood lymphocytes of computer game addicts

verfasst von: Nasim Vousooghi, Seyed Zeinolabedin Zarei, Mitra-Sadat Sadat-Shirazi, Fatemeh Eghbali, Mohammad Reza Zarrindast

Erschienen in: Journal of Neural Transmission | Ausgabe 10/2015

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Abstract

Excessive playing of computer games like some other behaviors could lead to addiction. Addictive behaviors may induce their reinforcing effects through stimulation of the brain dopaminergic mesolimbic pathway. The status of dopamine receptors in the brain may be parallel to their homologous receptors in peripheral blood lymphocytes (PBLs). Here, we have investigated the mRNA expression of dopamine D3, D4 and D5 receptors in PBLs of computer game addicts (n = 20) in comparison to normal subjects (n = 20), using a real-time PCR method. The results showed that the expression level of D3 and D4 dopamine receptors in computer game addicts were not statistically different from the control group. However, the expression of the mRNA of D5 dopamine receptor was significantly down-regulated in PBLs of computer game addicts and reached 0.42 the amount of the control group. It is concluded that unlike with drug addiction, the expression levels of the D3 and D4 dopamine receptors in computer game addicts are not altered compared to the control group. However, reduced level of the D5 dopamine receptor in computer game addicts may serve as a peripheral marker in studies where the confounding effects of abused drugs are unwanted.

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Titel: mRNA expression of dopamine receptors in peripheral blood lymphocytes of computer game addicts
verfasst von: Nasim Vousooghi
Seyed Zeinolabedin Zarei
Mitra-Sadat Sadat-Shirazi
Fatemeh Eghbali
Mohammad Reza Zarrindast
Publikationsdatum: 01.10.2015
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 10/2015
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-015-1408-2

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