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Erschienen in:

23.03.2018 | Clinical Study

Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study

verfasst von: Taeryool Koo, Do Hoon Lim, Ho Jun Seol, Chul-Kee Park, Il Han Kim, Jong Hee Chang, Jeongshim Lee, Shin Jung, Ho-Shin Gwak, Kwan Ho Cho, Chang-Ki Hong, Ik Jae Lee, El Kim, Jin Hee Kim, Yong-Kil Hong, Hong Seok Jang, Chae-Yong Kim, In Ah Kim, Sung Hwan Kim, Young Il Kim, Eun-Young Kim, Woo Chul Kim, Semie Hong

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2018

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Abstract

Introduction

We performed this study to identify the treatment patterns of patients with low-grade gliomas (LGG) in Korea.

Methods

A total of 555 patients diagnosed as WHO grade II gliomas between 2000 and 2010 at 14 Korean institutions were included. The patients were divided into four adjuvant treatment groups: adjuvant fractionated radiotherapy (RT, N = 204), adjuvant chemotherapy (N = 20), adjuvant fractionated RT and chemotherapy (N = 65), and non-adjuvant treatment (N = 266) groups. We examined differences among the groups and validated patient/tumor characteristics associated with the adjuvant treatments.

Results

Astrocytoma was diagnosed in 210 patients (38%), oligoastrocytoma in 85 patients (15%), and oligodendroglioma in 260 patients (47%). Gross total resection was performed in 200 patients (36%), subtotal resection in 153 (28%), partial resection in 71 patients (13%), and biopsy in 131 patients (24%). RT was most commonly applied as an adjuvant treatment. The use of chemotherapy with or without RT decreased after 2008 (from 38 to 4%). The major chemotherapeutic regimen was procarbazine, lomustine, and vincristine (PCV); however, the proportion of temozolomide increased since 2005 (up to 69%). Patient/tumor characteristics related with RT were male gender, non-seizure, multiple lobes involvement, and non-gross total resection. Chemotherapy was associated with non-gross total resection and non-astrocytoma.

Conclusions

A preference for RT and increased use of temozolomide was evident in the treatment pattern of LGG. The extent of resection was associated with a decision to perform RT and chemotherapy. To establish a robust guideline for LGG, further studies including molecular information are needed.

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Titel: Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study
verfasst von: Taeryool Koo
Do Hoon Lim
Ho Jun Seol
Chul-Kee Park
Il Han Kim
Jong Hee Chang
Jeongshim Lee
Shin Jung
Ho-Shin Gwak
Kwan Ho Cho
Chang-Ki Hong
Ik Jae Lee
El Kim
Jin Hee Kim
Yong-Kil Hong
Hong Seok Jang
Chae-Yong Kim
In Ah Kim
Sung Hwan Kim
Young Il Kim
Eun-Young Kim
Woo Chul Kim
Semie Hong
Publikationsdatum: 23.03.2018
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2018
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-2839-z

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