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22.09.2015 | Experimental

Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model

verfasst von: Alain Nchimi, Audrey Courtois, Mounia El Hachemi, Ziad Touat, Pierre Drion, Nadia Withofs, Geoff Warnock, Mohamed-Ali Bahri, Jean-Michel Dogné, Jean-Paul Cheramy-Bien, Laurent Schoysman, Julien Joskin, Jean-Baptiste Michel, Jean-Olivier Defraigne, Alain Plenevaux, Natzi Sakalihasan

Erschienen in: European Radiology | Ausgabe 7/2016

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Abstract

Objectives

To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence.

Methods

The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates.

Results

All of the following significantly increased with time post-induction (p < 0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion.

Conclusion

Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities.

Key Points

• ILT occurrence in AAA is associated with increasing FDG uptake and growth.

• MRI signalling changes in ILT reflect activities such as haemorrhage and RBC trapping.

• Monitoring ILT activities using MRI may require no exogenous contrast agent.

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Titel: Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model
verfasst von: Alain Nchimi
Audrey Courtois
Mounia El Hachemi
Ziad Touat
Pierre Drion
Nadia Withofs
Geoff Warnock
Mohamed-Ali Bahri
Jean-Michel Dogné
Jean-Paul Cheramy-Bien
Laurent Schoysman
Julien Joskin
Jean-Baptiste Michel
Jean-Olivier Defraigne
Alain Plenevaux
Natzi Sakalihasan
Publikationsdatum: 22.09.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 7/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-4010-y

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Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model