Background
Methods
Ethics statement
SFTSV RNA load determination using quantitative real time PCR (qPCR)
Genetic analysis
Viral detection using the immunohistochemistry assays and indirect immunofluorescence assays
Expression and purification of recombinant NP and obtaining primary antibody
Sample preparation
Sampling labeling
Results
Case presentations
Day after admission | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ||
Days after onset | P1a | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
P2b | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
PLT (× 109/L) | P1 | 89 | 58 | 35 | 20 | 11 | 10 | 14 | 62 | 69 |
P2 | 83 | cND | 44 | 39 | 28 | 28 | 38 | 44 | 67 | |
WBC (×109/L) | P1 | 1.3 | 1.1 | 0.7 | 3 | 4.4 | 3.9 | 6.5 | 11 | 15.4 |
P2 | 4.1 | ND | 2 | 2 | 1.5 | 1.9 | 2.1 | 2.2 | 2.3 | |
HB (g/L) | P1 | 138 | 135 | 134 | 126 | 114 | 81 | 77 | 50 | 41 |
P2 | 130 | ND | 124 | 127 | 119 | 116 | 120 | 117 | 111 | |
AST (U/L) | P1 | 93 | 131 | 650 | 650 | 862 | 852 | 703 | 719 | 922 |
P2 | ND | ND | 45 | 48 | 49 | 39 | 38 | 31 | 40 | |
ALT (U/L) | P1 | 38 | 40 | 171 | 164 | 223 | 168 | 102 | 83 | 166 |
P2 | ND | ND | 17 | 24 | 27 | 25 | 24 | 23 | 26 | |
ALB (g/L) | P1 | 33.8 | 32.4 | 27.6 | 25.9 | 26.3 | 26.3 | 23.5 | 21.7 | 17.4 |
P2 | ND | ND | 37.1 | 37.7 | 35.8 | 37.4 | 39.3 | 43.9 | 40 | |
LDH (U/L) | P1 | 240 | 337 | 965 | 1134 | 1418 | 1649 | 2511 | – | 4840 |
P2 | ND | ND | 218 | 295 | 286 | 282 | 267 | 241 | 246 | |
CK (U/L) | P1 | 499 | 665 | 1151 | 1261 | 1451 | 1126 | 2337 | – | 3783 |
P2 | ND | ND | 217 | 255 | 207 | 149 | 97 | 62 | 52 | |
CKMBU/L) | P1 | 17 | 19 | 42 | 50 | 51 | 74 | 92 | – | 125 |
P2 | ND | ND | 8 | 11 | 8 | 11 | 8 | 6 | 5 | |
CR (umol/L) | P1 | 83.2 | 101.7 | 87 | 85 | 84 | 107 | 153.6 | 152 | 232 |
P2 | ND | ND | 75.2 | 65.7 | 57.7 | 52.9 | 68.2 | 54.1 | 55.7 | |
BUN (mmol/L) | P1 | 6.9 | 7.33 | 5.2 | 7.8 | 6.41 | 7.8 | 10.33 | 9.6 | 12.6 |
P2 | ND | ND | 4.43 | 3.23 | 2.68 | 2.12 | 2.51 | 3.17 | 3.89 | |
APTT (s) | P1 | ND | 41.6 | 49.3 | 54.7 | 90.5 | 97.9 | 116.2 | 78.1 | 76.4 |
P2 | ND | ND | 34.1 | 31.2 | 31.7 | 30.5 | 29.5 | 28.9 | 27.2 | |
PT (s) | P1 | ND | 12.3 | 13.3 | 11.8 | 11.4 | 10.4 | 10.8 | 11.7 | 14.2 |
P2 | ND | ND | 12.1 | 11.2 | 11.1 | 10.8 | 11.2 | 11.2 | 11.4 | |
D-D (ng/ml) | P1 | ND | 983 | 3110 | 4522 | 2581 | 1210 | 392 | 389 | 409 |
P2 | ND | ND | 608 | 572 | 412 | 401 | 418 | 415 | 390 | |
Potassium (mmol/l) | P1 | 3.88 | 3.71 | 3.28 | 3.4 | 3.36 | 3.48 | 3.62 | 3.9 | 4.13 |
P2 | ND | ND | 3.02 | 3.6 | 3.37 | 3.45 | 3.52 | 3.74 | 4.3 | |
Sodium (mmol/l) | P1 | 127 | 129.9 | 132.6 | 129.9 | 134.0 | 130.1 | 138.4 | 139.0 | 138 |
P2 | ND | ND | 132.6 | 140.6 | 139.4 | 142.4 | 142.1 | 137.4 | 143 |