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01.03.2018 | Cardiac PET, CT, and MRI (F Pugliese and SE Petersen, Section Editors) | Ausgabe 3/2018 Open Access

Current Cardiology Reports 3/2018

Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography

Current Cardiology Reports > Ausgabe 3/2018
Paul R. Scully, Gorka Bastarrika, James C. Moon, Thomas A. Treibel
Wichtige Hinweise
This article is part of the Topical Collection on Cardiac PET, CT, and MRI


Purpose of review

This review article discusses the evolution of extracellular volume (ECV) quantification using both cardiovascular magnetic resonance (CMR) and computed tomography (CT).

Recent findings

Visualizing diffuse myocardial fibrosis is challenging and until recently, was restricted to the domain of the pathologist. CMR and CT both use extravascular, extracellular contrast agents, permitting ECV measurement. The evidence base around ECV quantification by CMR is growing rapidly and just starting in CT. In conditions with high ECV (amyloid, oedema and fibrosis), this technique is already being used clinically and as a surrogate endpoint. Non-invasive diffuse fibrosis quantification is also generating new biological insights into key cardiac diseases.


CMR and CT can estimate ECV and in turn diffuse myocardial fibrosis, obviating the need for invasive endomyocardial biopsy. CT is an attractive alternative to CMR particularly in those individuals with contraindications to the latter. Further studies are needed, particularly in CT.

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