Skip to main content
main-content

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Allergy, Asthma & Clinical Immunology 1/2017

Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment

Zeitschrift:
Allergy, Asthma & Clinical Immunology > Ausgabe 1/2017
Autoren:
Peng-peng Wang, Gui-xiang Wang, Wen-tong Ge, Li-xing Tang, Jie Zhang, Xin Ni
Wichtige Hinweise
Peng-peng Wang and Gui-xiang Wang contributed equally to this work

Abstract

Background

Nasal nitrous oxide (nNO) is increased in allergic rhinitis (AR), but not in asthma, and is a non-invasive marker for inflammation in the nasal passages.

Methods

Levels of nNO were measured and compared in healthy children and children with mild and moderate-to-severe AR. Levels of nNO before and after treatment with steroids and/or antihistamine were then compared in the 2 AR groups. Their relationship to quality of life and nasal symptom and reactivity to outdoor and outdoor allergens were examined.

Results

nNO levels were higher in mild AR than in healthy children and higher in moderate-to-severe AR than in mild AR. One month steroid and/or antihistamine treatment lowered nNO levels to control levels in mild AR and approximately halfway to control levels in moderate-to-severe AR. nNO levels had a weak correlation to quality of life questions and a fair correlation to nasal symptom scores before treatment. This correlation was weakened or lost after treatment, and no correlation was seen between nNO levels and responses to indoor or outdoor allergens.

Conclusion

nNO levels in children with AR may be useful for assessing the response to treatment. Their relationship to quality of life, nasal symptoms, and sensitivity to specific allergens needs further study.
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Allergy, Asthma & Clinical Immunology 1/2017 Zur Ausgabe

Neu im Fachgebiet HNO

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update HNO und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise