Background
Methods
The characteristics of the dataset
Outcomes
Statistical analysis
Results
Group Aa (N = 740,675) | Group Ba (N = 38,402) | Group Ca (N = 9890) | p-value | |
---|---|---|---|---|
Age | 31.62 ± 3.96 | 33.87 ± 3.50 | 34.63 ± 3.42 | <.0001 |
Nulliparity | 385,663 (52.07) | 19,541 (50.89) | 5380 (54.40) | <.0001 |
Multiple pregnancy | 12,495 (1.69) | 1074 (2.80) | 432 (4.37) | <.0001 |
Cesarean section | 286,946 (38.74) | 17,547 (45.69) | 8447 (85.41) | <.0001 |
Preeclampsia | 16,033 (2.16) | 1063 (2.77) | 327 (3.31) | <.0001 |
PPH | 72,501 (9.79) | 3946 (10.28) | 1007 (10.18) | 0.0035 |
Placental abruption | 2728 (0.37) | 170 (0.44) | 40 (0.40) | 0.0572 |
Placenta previa | 9365 (1.26) | 848 (2.21) | 289 (2.92) | <.0001 |
Uterine rupture | 107 (0.01) | 12 (0.03) | 22 (0.22) | <.0001 |
Group Aa (N = 502,209) | Group Ba (N = 25,408) | Group Ca (N = 6642) | p-value | |
---|---|---|---|---|
Preterm birth | 13,470 (2.68) | 1018 (4.01) | 327 (4.92) | <.0001 |
Neonatal sex–male | 258,518 (51.48) | 13,066 (51.42) | 3430 (51.64) | <.0001 |
Birth weight (kg) | 3.20 ± 0.46 | 3.17 ± 0.50 | 3.11 ± 0.50 | <.0001 |
LBW | 20,203 (4.02) | 1452 (5.71) | 459 (6.91) | <.0001 |
LGA | 17,390 (3.46) | 885 (3.48) | 165 (2.48) | <.0001 |
Multivariate logistic regression analysis for adverse obstetric outcomes in pregnancies with myoma or following myomectomy
Obstetric outcomes | Odds ratio (95% confidence interval) | |
---|---|---|
Unadjusted | Adjusted b | |
Cesarean section | ||
Group Aa | 1 | 1 |
Group Ba | 1.312 (1.279–1.346) | 1.193 (1.163–1.224) |
Group Ca | 8.992 (8.408–9.617) | 7.985 (7.463–8.544) |
Preeclampsia | ||
Group A | 1 | 1 |
Group B | 1.326 (1.227–1.433) | 1.124 (1.123–1.313) |
Group C | 1.360 (1.175–1.574) | 1.159 (1.000–1.343) |
PPH | ||
Group A | 1 | 1 |
Group B | 1.048 (1.005–1.092) | 1.049 (1.006–1.094) |
Group C | 1.064 (0.983–1.152) | 1.062 (0.981–1.151) |
Placental abruption | ||
Group A | 1 | 1 |
Group B | 1.185 (0.970–1.448) | 1.118 (0.914–1.368) |
Group C | 1.156 (0.784–1.704) | 1.037 (0.703–1.532) |
Placenta previa | ||
Group A | 1 | 1 |
Group B | 1.797 (1.646–1.962) | 1.549 (1.418–1.692) |
Group C | 2.223 (1.912–2.584) | 1.772 (1.523–2.063) |
Uterine rupture | ||
Group A | 1 | 1 |
Group B | 2.421 (1.037–5.651) | 2.032 (0.865–4.777) |
Group C | 17.00 (8.836–32.708) | 13.674 (6.986–26.765) |
Obstetric outcomes | Odds ratio (95% confidence interval) | |
---|---|---|
Unadjusted | Adjusted b | |
Preterm birth | ||
Group Aa | 1 | 1 |
Group Ba | 1.514 (1.419–1.616) | 1.426 (1.336–1.523) |
Group Ca | 1.879 (1.679–2.103) | 1.698 (1.517–1.902) |
LBW | ||
Group A | 1 | 1 |
Group B | 1.446 (1.369–1.528) | 1.355 (1.282–1.432) |
Group C | 1.771 (1.609–1.949) | 1.580 (1.435–1.741) |
LGA | ||
Group A | 1 | 1 |
Group B | 1.006 (0.939–1.078) | 0.981 (0.916–1.051) |
Group C | 0.711 (0.609–0.830) | 0.688 (0.589–0.803) |
Multivariate logistic regression analysis for adverse obstetric outcomes in pregnancies with myoma or following myomectomy, in nulliparous women
Obstetric outcomes | Odds ratio (95% confidence interval) | |
---|---|---|
Unadjusted | Adjusted b | |
Cesarean section | ||
Group Aa | 1 | 1 |
Group Ba | 1.386(1.339–1.435) | 1.210(1.168–1.253) |
Group Ca | 8.194(7.502–8.949) | 6.908(6.320–7.551) |
Preeclampsia | ||
Group A | 1 | 1 |
Group B | 1.289(1.173–1.418) | 1.180(1.072–1.298) |
Group C | 1.353(1.139–1.607) | 1.180(0.992–1.403) |
PPH | ||
Group A | 1 | 1 |
Group B | 1.045(0.988–1.105) | 1.050(0.993–1.111) |
Group C | 1.037(0.934–1.151) | 1.046(0.942–1.162) |
Placental abruption | ||
Group A | 1 | 1 |
Group B | 1.113(0.863–1.435) | 1.054(0.816–1.361) |
Group C | 1.015(0.619–1.664) | 0.933(0.567–1.533) |
Placenta previa | ||
Group A | 1 | 1 |
Group B | 2.008(1.798–2.242) | 1.689(1.510–1.890) |
Group C | 2.672(2.236–3.193) | 2.059(1.720–2.466) |
Uterine rupture | ||
Group A | 1 | 1 |
Group B | 5.071(1.431–17.972) | 4.667(1.295–16.816) |
Group C | 54.783(23.070–130.090) | 48.206(19.239–120.789) |
Obstetric outcomes | Odds ratio (95% confidence interval) | |
---|---|---|
Unadjusted | Adjusted b | |
Preterm birth | ||
Group Aa | 1 | 1 |
Group Ba | 1.649(1.520–1.788) | 1.510(1.390–1.639) |
Group Ca | 2.145(1.876–2.452) | 1.874(1.636–2.145) |
LBW | ||
Group A | 1 | 1 |
Group B | 1.512(1.412–1.620) | 1.377(1.285–1.476) |
Group C | 1.883(1.678–2.114) | 1.631(1.451–1.833) |
LGA | ||
Group A | 1 | 1 |
Group B | 1.030(0.937–1.132) | 1.021(0.928–1.123) |
Group C | 0.676(0.546–0.838) | 0.667(0.538–0.827) |