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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Naturally acquired immune responses to malaria vaccine candidate antigens MSP3 and GLURP in Guahibo and Piaroa indigenous communities of the Venezuelan Amazon

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Andreas Baumann, Magda M Magris, Marie-Luz Urbaez, Sarai Vivas-Martinez, Rommy Durán, Tahidid Nieves, Meral Esen, Benjamin G Mordmüller, Michael Theisen, Luisana Avilan, Wolfram G Metzger
Wichtige Hinweise
Andreas Baumann, Magda M Magris contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

AB coordinated and conducted field and laboratory work, analysed and interpreted the data, and drafted and revised the manuscript. MM conceived the study, supervized field and laboratory work and interpreted the data. SVM conceived the study, facilitated the overall collaboration and revised the manuscript. MLU and TH coordinated and conducted field and laboratory work. RD collaborated as anthropologist. ME and BGM supervized the laboratory work, gave statistical input, interpreted the data and revised the manuscript. MT and LA were responsible for the conception of the work. WGM conceived the study, interpreted the data, and drafted and revised the manuscript. All authors revised and approved the final manuscript. WGM and MM are the guarantors of the paper.

Abstract

Background

Malaria transmission in most of Latin America can be considered as controlled. In such a scenario, parameters of baseline immunity to malaria antigens are of specific interest with respect to future malaria eradication efforts.

Methods

A cross-sectional study was carried out in two indigenous population groups in Amazonas/Venezuela. Data from the regional malaria documentation system were extracted and participants from the ethnic groups of the Guahibo (n = 180) and Piaroa (n = 295) were investigated for the presence of Plasmodium parasites and naturally acquired antibodies to Plasmodium falciparum antigens in serum. The GMZ2 vaccine candidate proteins MSP3 and GLURP were chosen as serological markers.

Results

The incidence of P. falcip arum in both communities was found to be less than 2%, and none of the participants harboured P. falciparum at the time of the cross-sectional. Nearly a quarter of the participants (111/475; 23,4%) had positive antibody titres to at least one of the antigens. 53/475 participants (11.2%) were positive for MSP3, and 93/475 participants (19.6%) were positive for GLURP. High positive responses were detected in 36/475 participants (7.6%) and 61/475 participants (12.8%) for MSP3 and GLURP, respectively. Guahibo participants had significantly higher antibody titres than Piaroa participants.

Conclusions

Considering the low incidence of P. falciparum, submicroscopical infections may explain the comparatively high anti-P. falciparum antibody concentrations.
Literatur
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