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Erschienen in:

12.07.2023 | original Article

Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy

verfasst von: Hiroki Kobayashi, Eiichiro Satake, Yusuke Murata, Hiromasa Otsuka, Akiko Tsunemi, Masaki Azuma, Yoshihiro Nakamura, Tomoyuki Saito, Masanori Abe

Erschienen in: Journal of Nephrology | Ausgabe 8/2023

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Abstract

Introduction

Recently, circulating neuroblastoma suppressor of tumorigenicity 1 (NBL1) was shown to be strongly associated with kidney disease progression and histological lesions in patients with diabetic kidney disease. This study aimed to examine whether serum NBL1 level was also associated with kidney function and renal histological findings in patients with IgA nephropathy.

Methods

We evaluated the levels of NBL1 in 109 patients with newly diagnosed biopsy-proven primary IgAN, between 2009 and 2018, at the Nihon University School of Medicine Itabashi Hospital, Tokyo, Japan, using serum obtained immediately before the renal biopsy, and examined the relationship between serum NBL1, renal function and renal histological findings assessed using the Oxford Classification (MEST score). Furthermore, we analyzed the association of serum NBL1 with kidney function decline over time in patients with IgA nephropathy who had follow-up data on the estimated glomerular filtration rate (n = 76).

Results

Serum NBL1 levels in patients with newly diagnosed IgA nephropathy were elevated, as compared to those in healthy individuals (n = 93). Logistic regression analysis demonstrated that the serum NBL1 level was independently and significantly associated with tubular atrophy/interstitial fibrosis. Immunohistochemical staining revealed that NBL1 was highly expressed in the tubulointerstitium. Furthermore, Spearman’s rank correlation identified a significant correlation between serum NBL1 level and estimated glomerular filtration rate slope.

Conclusions

The serum NBL1 level was significantly associated with the severity of renal interstitial fibrosis and kidney disease progression in patients with newly diagnosed IgA nephropathy. Thus, circulating NBL1 may serve as a good biomarker for evaluating renal interstitial fibrosis and the risk of kidney disease progression.

Graphical Abstract

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Titel: Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy
verfasst von: Hiroki Kobayashi
Eiichiro Satake
Yusuke Murata
Hiromasa Otsuka
Akiko Tsunemi
Masaki Azuma
Yoshihiro Nakamura
Tomoyuki Saito
Masanori Abe
Publikationsdatum: 12.07.2023
Verlag: Springer International Publishing
Erschienen in: Journal of Nephrology / Ausgabe 8/2023
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI: https://doi.org/10.1007/s40620-023-01704-x

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Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy