Erschienen in:
01.04.2011 | Invited Commentary
Neurodevelopmental Risks of Pediatric Anesthesia: What Do We Know, and What Should We Do?
verfasst von:
Stephen R. Hays, Jayant K. Deshpande
Erschienen in:
Current Urology Reports
|
Ausgabe 2/2011
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Excerpt
First demonstrated in 1846, general anesthesia remains a singular advance of modern medicine. Anesthesia for children has dramatically alleviated pain and stress in pediatric patients, and now permits surgical care of even the youngest and smallest infants. By the mid-20th century, however, it was first suggested adverse postoperative behaviors in children might be due, at least in part, to general anesthesia [
1]. Subsequent studies demonstrated abnormal neuropathology and adverse behavioral changes in rodents following in utero exposure to volatile agents, and in 1999, data demonstrating widespread neuronal apoptosis in rat pups following postnatal exposure to anesthetics were first published [
2]. The resultant debate in the medical literature regarding human relevance of such findings has been extensive, and dissemination of alarm over potential deleterious effects of pediatric anesthesia in the general media has been widespread. What do we know, and what should we do? …
