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Current Oncology Reports
Erschienen in: Current Oncology Reports 1/2014

01.01.2014 | Breast Cancer (B Overmoyer, Section Editor)

New HER2-Positive Targeting Agents in Clinical Practice

verfasst von: Sara Tolaney

Erschienen in: Current Oncology Reports | Ausgabe 1/2014

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Abstract

Overexpression of human epidermal growth factor occurs in approximately 20–25 % of invasive breast cancers. This subtype of breast cancer has been associated with poor clinical outcomes. The development of trastuzumab, a humanized monoclonal antibody that binds to the extracellular domain of human epidermal growth factor receptor 2 (HER2), revolutionized outcomes of patients with HER2-positive breast cancer; however, many patients with HER2-positive metastatic breast cancer eventually become resistant to it. Several newer anti-HER2 agents have been developed, including lapatinib, pertuzumab, and trastuzumab emtansine. These exciting advances in drug development for HER2-positive breast cancer have also led to many challenges, including how to optimally sequence and combine HER2-targeted agents.
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Metadaten
Titel
New HER2-Positive Targeting Agents in Clinical Practice
verfasst von
Sara Tolaney
Publikationsdatum
01.01.2014
Verlag
Springer US
Erschienen in
Current Oncology Reports / Ausgabe 1/2014
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-013-0359-8

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