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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

01.12.2007 | Article

No influence of atopic diseases on antibody titres following tetanus, diphtheria and hepatitis B immunisation among adults

verfasst von: N. Friedrich, A. Kramer, R. Mentel, L. Gürtler, U. John, H. Völzke

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 12/2007

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Abstract

Several studies have reported associations between reduced humoral immune response to vaccine antigens and diseases with modified reactions of the immune system. We have investigated the influence of atopic diseases on specific IgG levels to tetanus, diphtheria and hepatitis B (HB), following immunisation, in a general adult population. From the Study of Health in Pomerania, a total number of 3,920 subjects aged 20 to 79 years were included in the analyses. Information on immunisation history, as well as behavioural and socio-demographic characteristics were collected. Anti-tetanus IgG, anti-diphtheria IgG and anti-HBs IgG were measured by indirect enzyme-linked immunosorbent assay (ELISA). Odds ratios and 95% confidence intervals were calculated using logistic regression. Atopic diseases were reported by 14% of participants. Proportions of 67%, 34% and 10% had been vaccinated against tetanus, diphtheria and hepatitis B within the past ten years, respectively. Multi-variable analyses revealed no associations between the presence of atopic diseases and all of the three vaccine-specific antibody titres. We conclude that there is no reduced immune response related to antibody production following immunisations against tetanus, diphtheria and hepatitis B in adults with atopic diseases.

El Yousfi M, Mercier S, Breuillé D, Denis P, Papet I, Mirand PP et al (2005) The inflammatory response to vaccination is altered in the elderly. Mech Ageing Dev 126(8):874–881PubMedCrossRef

Malaspina A, Moir S, Orsega SM, Vasquez J, Miller NJ, Donoghue ET et al (2005) Compromised B cell responses to influenza vaccination in HIV-infected individuals. J Infect Dis 191(9):1442–1450PubMedCrossRef

Girndt M, Pietsch M, Köhler H (1995) Tetanus immunization and its association to hepatitis B vaccination in patients with chronic renal failure. Am J Kidney Dis 26(3):454–460PubMed

Kreft B, Klouche M, Kreft R, Kirchner H, Sack K (1997) Low efficiency of active immunization against diphtheria in chronic hemodialysis patients. Kidney Int 52(1):212–216PubMedCrossRef

Krüger S, Seyfarth M, Sack K, Kreft B (1999) Defective immune response to tetanus toxoid in hemodialysis patients and its association with diphtheria vaccination. Vaccine 17(9–10):1145–1150PubMedCrossRef

Eibl N, Spatz M, Fischer GF, Mayr WR, Samstag A, Wolf HM et al (2002) Impaired primary immune response in type-1 diabetes: results from a controlled vaccination study. Clin Immunol 103(3 Pt 1):249–259PubMedCrossRef

Muszkat M, Friedman G, Dannenberg HD, Greenbaum E, Lipo M, Heymann Y et al (2003) Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. Exp Gerontol 38(10):1199–1203PubMedCrossRef

Shirakawa T, Enomoto T, Shimazu S, Hopkin JM (1997) The inverse association between tuberculin responses and atopic disorder. Science 275(5296):77–79PubMedCrossRef

Csoma Z, Kemény L, Boda K, Dobozy A (2002) Investigation of the delayed type hypersensitivity reaction in atopic patients (in Hungarian). Orv Hetil 143(39):2235–2239PubMed

10.

Arkwright PD, Patel L, Moran A, Haeney MR, Ewing CI, David TJ (2000) Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine. Clin Exp Immunol 122(1):16–19PubMedCrossRef

11.

Prescott SL, Sly PD, Holt PG (1998) Raised serum IgE associated with reduced responsiveness to DPT vaccination during infancy. Lancet 351(9114):1489PubMedCrossRef

12.

Dunstan JA, Hale J, Breckler L, Lehmann H, Weston S, Richmond P et al (2005) Atopic dermatitis in young children is associated with impaired interleukin-10 and interferon-gamma responses to allergens, vaccines and colonizing skin and gut bacteria. Clin Exp Allergy 35(10):1309–1317PubMedCrossRef

13.

Holt PG, Rudin A, Macaubas C, Holt BJ, Rowe J, Loh R et al (2000) Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children. J Allergy Clin Immunol 105(6 Pt 1):1117–1122PubMedCrossRef

14.

Dannemann A, van Ree R, Kulig M, Bergmann RL, Bauer P, Forster J et al (1996) Specific IgE and IgG4 immune responses to tetanus and diphtheria toxoid in atopic and nonatopic children during the first two years of life. Int Arch Allergy Immunol 111(3):262–267PubMedCrossRef

15.

Masten B, McWilliams B, Lipscomb M, Archibeque T, Qualls C, Kelly HW et al (2003) Immune response to hepatitis B vaccine in asthmatic children. Pediatr Pulmonol 36(6):522–528PubMedCrossRef

16.

John U, Greiner B, Hensel E, Lüdemann J, Piek M, Sauer S et al (2001) Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Soz Praventivmed 46(3):186–194PubMedCrossRef

17.

Keil U, Stieber J, Doring A, Chambless L, Härtel U, Filipiak B et al (1988) The cardiovascular risk factor profile in the study area Augsburg. Results from the first MONICA survey 1984/85. Acta Med Scand Suppl 728:119–128PubMed

18.

Friedrich N, Völzke H, Schwahn C, Kramer A, Jünger M, Schäfer T et al (2006) Inverse association between periodontitis and respiratory allergies. Clin Exp Allergy 36(4):495–502PubMedCrossRef

19.

Brant R (1990) Assessing proportionality in the proportional odds model for ordinal logistic regression. Biometrics 46(4):1171–1178PubMedCrossRef

20.

Kreft B, Fischer A, Kruger S, Sack K, Kirchner H, Rink L (2000) The impaired immune response to diphtheria vaccination in elderly chronic hemodialysis patients is related to zinc deficiency. Biogerontology 1(1):61–66PubMedCrossRef

21.

Swan AM, De Vita MV (1997) Higher response rate to hepatitis B vaccination observed in chronic hemodialysis patients. Clin Nephrol 47(3):207–208PubMed

22.

Kara IH, Yilmaz ME, Suner A, Kadiroglu AK, Isikoglu B (2004) The evaluation of immune responses that occur after HBV infection and HBV vaccination in hemodialysis patients. Vaccine 22(29–30):3963–3967PubMedCrossRef

23.

Abu-Shakra M, Press J, Varsano N, Levy V, Mendelson E, Sukenik S et al (2002) Specific antibody response after influenza immunization in systemic lupus erythematosus. J Rheumatol 29(12):2555–2557PubMed

24.

Kanakoudi-Tsakalidou F, Trachana M, Pratsidou-Gertsi P, Tsitsami E, Kyriazopoulou-Dalaina V (2001) Influenza vaccination in children with chronic rheumatic diseases and long-term immunosuppressive therapy. Clin Exp Rheumatol 19(5):589–594PubMed

25.

Kasapçopur O, Çullu F, Kamburðglu-Goksel A, Çam H, Akdenizli E, Çalykan S et al (2004) Hepatitis B vaccination in children with juvenile idiopathic arthritis. Ann Rheum Dis 63(9):1128–1130PubMedCrossRef

26.

Maple PA, Efstratiou A, George RC, Andrews NJ, Sesardic D (1995) Diphtheria immunity in UK blood donors. Lancet 345(8955):963–965PubMedCrossRef

27.

Hasselhorn HM, Nübling M, Tiller FW, Hofmann F (1997) Diphtheria booster immunization for adults (in German). Dtsch Med Wochenschr 122(10):281–286PubMedCrossRef

28.

Kjeldsen K, Simonsen O, Heron I (1988) Immunity against diphtheria and tetanus in the age group 30–70 years. Scand J Infect Dis 20(2):177–185PubMed

29.

Morris CA, Oliver PR, Reynolds F, Selkon JB (1989) Intradermal hepatitis B immunization with yeast-derived vaccine: serological response by sex and age. Epidemiol Infect 103(2):387–394PubMed

30.

Morales JM, Jaqueti J, Viña C (1993) A meta-analytical review of the response by sex to vaccination against hepatitis B in hospital personnel (in Spanish). Aten Primaria 12(2):99–101PubMed

31.

Burns EA, Lum LG, Seigneuret MC, Giddings BR, Goodwin JS (1990) Decreased specific antibody synthesis in old adults: decreased potency of antigen-specific B cells with aging. Mech Ageing Dev 53(3):229–241PubMedCrossRef

32.

Hainz U, Jenewein B, Asch E, Pfeiffer KP, Berger P, Grubeck-Loebenstein B (2005) Insufficient protection for healthy elderly adults by tetanus and TBE vaccines. Vaccine 23(25):3232–3235PubMedCrossRef

33.

Bigl S, Drechsler R, Grosche A, Roch M (1998) Seroepidemiologische Studie zur Überwachung der Diphtherie-Immunität und Diphtherie-Schutzimpfung im Freistaat Sachsen 1996. Bundesgesundhbl 55–61

34.

Martin S, Giss A, Ackermann B, Russer S, Inderwisch U, Howe J et al (2005) Assessment of the tetanus immune status in plasma donors of the Blood Donor Service of the Bavarian Red Cross (in German). Dtsch Med Wochenschr 130(31–32):1810–1813PubMedCrossRef

35.

Stark K, Schönfeld C, Barg J, Molz B, Vornwald A, Bienzle U (1999) Seroprevalence and determinants of diphtheria, tetanus and poliomyelitis antibodies among adults in Berlin, Germany. Vaccine 17(7–8):844–850PubMedCrossRef

36.

Thierfelder W, Meisel H, Schreier E, Dortschy R (1999) Prevalence of antibodies to hepatitis A, hepatitis B and hepatitis C viruses in the German population (in German). Gesundheitswesen 61:S110–S114PubMed

Titel: No influence of atopic diseases on antibody titres following tetanus, diphtheria and hepatitis B immunisation among adults
verfasst von: N. Friedrich
A. Kramer
R. Mentel
L. Gürtler
U. John
H. Völzke
Publikationsdatum: 01.12.2007
Verlag: Springer-Verlag
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 12/2007
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-007-0374-5

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