Introduction
Materials and methods
Evaluation
Measurement of fatty acids
Diagnosis of fatty liver and criterion for diagnosing “non-alcoholic” disease
Statistical analysis
Results
NAFLD presence | NAFLD absence | |z| or chi | p value | |
---|---|---|---|---|
N = 267 | N = 409 | |||
Age, years | 68 (60, 73) | 71 (65, 76) | 5.17 | < 0.0001 |
Male sex, n (%) | 184 (68.9%) | 245 (59.9%) | 5.71 | 0.0168 |
BMI, kg/m2 | 24.8 (22.3, 27) | 21.6 (19.5, 24.1) | 10.35 | < 0.0001 |
BH, cm | 165 (158, 170) | 163 (155, 168.3) | 3.17 | 0.0015 |
BW, kg | 67 (58.3, 77) | 58 (50, 66) | 9.56 | < 0.0001 |
Ischemic stroke, n (%) | 205 (76.8%) | 324 (79.2%) | 0.56 | 0.4536 |
AST, U/L | 24 (20, 31) | 22 (19, 28) | 3.14 | 0.0017 |
ALT, U/L | 23 (18, 30) | 17 (13, 22) | 8.92 | < 0.0001 |
AST/ALT ratio | 1.09 (0.86, 1.33) | 1.36 (1.10, 1.61) | 8.97 | < 0.0001 |
GGT, U/L | 32 (21, 59) | 24 (16, 42.5) | 4.82 | < 0.0001 |
Alb, g/L | 42 (40, 44) | 40 (37.3, 43) | 5.66 | < 0.0001 |
Glucose, mmol/L | 7.16 (6.0, 8.88) | 6.61 (5.77, 8.22) | 2.88 | 0.0039 |
HbA1c, % (NGSP) | 6 (5.7, 6.7) | 5.8 (5.5, 6.2) | 4.69 | < 0.0001 |
TC, mmol/L | 5.33 (4.58, 6.05) | 5.12 (4.43, 5.82) | 2.43 | 0.0150 |
LDL, mmol/L | 3.03 (2.38, 3.71) | 2.93 (2.32, 3.47) | 1.12 | 0.2640 |
HDL, mmol/L | 1.38 (1.12, 1.67) | 1.53 (1.26, 1.89) | 4.66 | < 0.0001 |
TG, mmol/L | 1.52 (0.93, 2.64) | 1.05 (0.78, 1.57) | 6.62 | < 0.0001 |
SBP, mmHg | 170.5 (151, 190.3) | 162 (141, 182) | 3.32 | 0.0009 |
DBP, mmHg | 97.5 (86, 109.3) | 89 (78, 102) | 4.96 | < 0.0001 |
MBP, mmHg | 120.7 (109.7, 133.2) | 113 (102, 128.7) | 4.59 | < 0.0001 |
A history of statin use, n (%) | 60 (22.5%) | 96 (23.5%) | 0.09 | 0.7627 |
NAFLD presence | NAFLD absence | |z| | p value | |
---|---|---|---|---|
N = 267 | N = 409 | |||
Saturated fatty acids | ||||
LaA μmol/L | 6.99 (3.49, 12.97) | 4.99 (2.99, 8.98) | 4.13 | < 0.0001 |
MyA μmol/L | 94.4 (59.9, 141.1) | 68.3 (52.1, 96.8) | 6.18 | < 0.0001 |
PA μmol/L | 2855 (2321, 3411) | 2447 (2127, 2812) | 6.63 | < 0.0001 |
StA μmol/L | 728.3 (601.7, 835.8) | 656.5 (550.5, 766.3) | 4.49 | < 0.0001 |
LaA % | 0.04 (0.03, 0.08) | 0.04 (0.02, 0.06) | 2.91 | 0.0036 |
MyA % | 0.71 (0.53, 0.92) | 0.58 (0.47, 0.76) | 5.19 | < 0.0001 |
PA % | 23.9 (22.9, 25.2) | 23.2 (22.2, 24.1) | 6.17 | < 0.0001 |
StA % | 6.68 (6.20, 7.22) | 6.84 (6.22, 7.44) | 2.17 | 0.0298 |
n-9 MUFA | ||||
OlA μmol/L | 2381 (1846, 3048) | 1993 (1650, 2509) | 6.60 | < 0.0001 |
OlA % | 22.4 (20.5, 24.6) | 20.9 (19.0, 23.0) | 6.06 | < 0.0001 |
n-6 PUFAs | ||||
LiA μmol/L | 2757 (2304, 3156) | 2607 (2220, 3080) | 2.14 | 0.0327 |
DGLA μmol/L | 111.2 (86.7, 136.6) | 86.4 (68.5, 110.1) | 7.76 | < 0.0001 |
AA μmol/L | 549.7 (468.7, 648.1) | 521.5 (435.7, 617.6) | 2.60 | 0.0092 |
LiA % | 25.3 (22.5, 27.6) | 26.9 (24.2, 29.4) | 5.90 | < 0.0001 |
DGLA % | 1.1 (0.88, 1.31) | 0.96 (0.81, 1.16) | 4.58 | < 0.0001 |
AA % | 5.45 (4.49, 6.32) | 5.88 (4.9, 6.74) | 3.30 | 0.0010 |
n-3 PUFAs | ||||
AlA μmol/L | 75.4 (54.9, 105.3) | 65.7 (49.5, 93.3) | 3.24 | 0.0012 |
EPA μmol/L | 209.2 (138.0, 306.2) | 196.3 (133.9, 298.9) | 0.61 | 0.5423 |
DHA μmol/L | 389.7 (315.9, 501.9) | 368.1 (286.1, 460.9) | 2.66 | 0.0078 |
AlA % | 0.69 (0.56, 0.85) | 0.66 (0.55, 0.86) | 0.58 | 0.5600 |
EPA % | 1.95 (1.33, 3.00) | 2.17 (1.44, 3.21) | 1.49 | 0.1369 |
DHA % | 4.30 (3.48, 5.13) | 4.49 (3.54, 5.29) | 1.43 | 0.1518 |
EPA/AA ratio | 0.36 (0.23, 0.56) | 0.36 (0.26, 0.57) | 0.46 | 0.6468 |
n-6/n-3 ratio | 4.4 (3.30, 5.56) | 4.43 (3.45, 5.56) | 0.48 | 0.6306 |
Odds ratio | p value | AUC | BIC | |
---|---|---|---|---|
< 0.0001 | 0.804 | 803 | ||
BMI | 1.17 (1.10–1.24) | < 0.0001 | ||
AST/ALT ratio | 0.39 (0.23–0.66) | 0.0003 | ||
Alb | 1.08 (1.03–1.14) | 0.0042 | ||
PA% | 1.19 (1.03–1.38) | 0.0147 | ||
DGLA | 1.01 (1.00–1.02) | 0.0193 | ||
DHA | 1.00 (0.99–1.00) | 0.1399 | ||
HbA1c | 1.10 (0.98–1.30) | 0.1432 | ||
HDL | 0.76 (0.45–1.23) | 0.3009 | ||
GGT | 1.00 (0.99–1.00) | 0.3987 | ||
DBP | 1.00 (0.99–1.01) | 0.4182 | ||
TG | 1.09 (0.88–1.37) | 0.4547 | ||
MyA% | 1.34 (0.59–3.10) | 0.4836 | ||
BH | 1.01 (0.98–1.03) | 0.5109 | ||
StA% | 0.96 (0.73–1.27) | 0.7937 | ||
AA% | 1.02 (0.88–1.18) | 0.8224 | ||
Age | 0.99 (0.97–1.02) | 0.8410 | ||
TC | 0.99 (0.80–1.24) | 0.9482 |
Sens (%) | Spec (%) | Odds ratio | p value | AUC | BIC | |
---|---|---|---|---|---|---|
BMI (≥ 23.7 vs. < 23.7) kg/m2 | 65.9 | 71.4 | 1.27 (1.21–1.34) | < 0.0001 | 0.735 | 808 |
AST/ALT ratio (≤ 1.25 vs. > 1.25) | 70.4 | 63.1 | 0.18 (0.11–0.28) | < 0.0001 | 0.703 | 848 |
Alb (≥ 41 vs. < 41) g/L | 67.0 | 52.9 | 1.11 (1.07–1.16) | < 0.0001 | 0.628 | 890 |
PA% (≥ 24.5 vs. < 24.5) | 37.6 | 84.5 | 1.39 (1.25–1.55) | < 0.0001 | 0.641 | 874 |
DGLA (≥ 97.1 vs. < 97.1) µmol/L | 64.0 | 67.7 | 1.02 (1.01–1.02) | < 0.0001 | 0.676 | 853 |