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Cancer and Metastasis Reviews

Erschienen in:

01.12.2008

Non-invasive assessment of tumor neovasculature: techniques and clinical applications

verfasst von: Rodolfo Perini, Regine Choe, Arjun G. Yodh, Chandra Sehgal, Chaitanya R. Divgi, Mark A. Rosen

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 4/2008

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Abstract

The ability to induce and sustain angiogenesis is regarded as one of the hallmarks of cancer growth and metastasis. Marked advances in understanding vascular physiology and mechanisms of angiogenesis have led to the development of vascularly-targeted anti-cancer therapies. Two broad subclasses of agents are in clinical use currently: those with anti-angiogenic activity (i.e. those that target angiogenic pathways) and those that have direct cytotoxic activity against proliferating endothelial cells (i.e. vascular disruptive agents (VDAs)). This article reviews the various imaging modalities, including magnetic resonance imaging, computed tomography, photon emission imaging (positron emission tomography and single photon emission computed tomography), ultrasound and optical (near-infrared absorption and scattering) techniques that have been used in an attempt to assess the status of tumor neovasculature in vivo. In each case, we describe the basic imaging methodology, methods for image quantification, technical standardization and reproducibility, and current and potential clinical applications for monitoring the status of tumor neovasculature before and during treatment with vascular targeted agents.

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Titel: Non-invasive assessment of tumor neovasculature: techniques and clinical applications
verfasst von: Rodolfo Perini
Regine Choe
Arjun G. Yodh
Chandra Sehgal
Chaitanya R. Divgi
Mark A. Rosen
Publikationsdatum: 01.12.2008
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 4/2008
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-008-9147-6

Springer Medizin

Non-invasive assessment of tumor neovasculature: techniques and clinical applications

Abstract

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Springer Medizin

Abstract

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