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Erschienen in: Current Allergy and Asthma Reports 6/2014

01.06.2014 | RHINITIS (JJ OPPENHEIMER AND J CORREN, SECTION EDITORS)

Nonallergic Rhinitis

verfasst von: Phil Lieberman, Debendra Pattanaik

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2014

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Abstract

Rhinitis is normally defined by the symptoms of nasal congestion, postnasal drainage, rhinorrhea, and sneezing. It has been associated with various pathologic changes, but can occur in the absence of any inflammation. Thus, the diagnosis is based on the clinical presentation. There are no clear-cut criteria to distinguish when rhinitis becomes chronic, but in its chronic form, it can be complex. Chronic forms of rhinitis that occur in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis. This review will concentrate on chronic nonallergic rhinitis in its various forms, discussing the epidemiology, underlying mechanisms, and its therapy.
Literatur
1.
Zurück zum Zitat Wallace DV, Dykewicz MS. The diagnosis and management of rhinitis: An updated practice parameter. J Allergy Clin Immunol. 2008;122:S1–S84.PubMed Wallace DV, Dykewicz MS. The diagnosis and management of rhinitis: An updated practice parameter. J Allergy Clin Immunol. 2008;122:S1–S84.PubMed
2.
Zurück zum Zitat Blom HM, Godthelp T, Fokkens WJ, et al. Mast cells, eosinophils and IgE-positive cells in nasal mucosa of patients with vasomotor rhinitis. An immunohistochemical study. Eur Arch Otorhinolaryngol. 1995;252 Suppl 1:S33–9.PubMed Blom HM, Godthelp T, Fokkens WJ, et al. Mast cells, eosinophils and IgE-positive cells in nasal mucosa of patients with vasomotor rhinitis. An immunohistochemical study. Eur Arch Otorhinolaryngol. 1995;252 Suppl 1:S33–9.PubMed
3.
Zurück zum Zitat Powe DG, Huskisson RS, Carney AS, et al. Evidence for an inflammatory pathophysiology in idiopathic rhinitis. Clin Exp Allergy. 2001;31:864–72.PubMed Powe DG, Huskisson RS, Carney AS, et al. Evidence for an inflammatory pathophysiology in idiopathic rhinitis. Clin Exp Allergy. 2001;31:864–72.PubMed
4.
Zurück zum Zitat Middleton Jr E. Chronic rhinitis in adults. J Allergy Clin Immunol. 1988;81:971.PubMed Middleton Jr E. Chronic rhinitis in adults. J Allergy Clin Immunol. 1988;81:971.PubMed
5.
Zurück zum Zitat Mullarkey MF, Hill JS, Webb DR. Allergic and nonallergic rhinitis: their characterization with attention to the meaning of nasal eosinophilia. J Allergy Clin Immunol. 1980;65:122.PubMed Mullarkey MF, Hill JS, Webb DR. Allergic and nonallergic rhinitis: their characterization with attention to the meaning of nasal eosinophilia. J Allergy Clin Immunol. 1980;65:122.PubMed
6.
Zurück zum Zitat Enberg RN. Perennial nonallergic rhinitis: a retrospective review. Ann Allergy. 1989;63:513.PubMed Enberg RN. Perennial nonallergic rhinitis: a retrospective review. Ann Allergy. 1989;63:513.PubMed
7.
Zurück zum Zitat Leynaert B, Bousquet J, Neukirch C, et al. Perennial rhinitis: An independent risk factor for asthma in nonatopic subjects: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol. 1999;104:301.PubMed Leynaert B, Bousquet J, Neukirch C, et al. Perennial rhinitis: An independent risk factor for asthma in nonatopic subjects: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol. 1999;104:301.PubMed
8.
Zurück zum Zitat Togias A. Age relationships and clinical features of nonallergic rhinitis. J Allergy Clin Immunol. 1990;85:182. Togias A. Age relationships and clinical features of nonallergic rhinitis. J Allergy Clin Immunol. 1990;85:182.
9.
Zurück zum Zitat Settipane RA, Lieberman P. Update on nonallergic rhinitis. Ann Allergy Asthma Immunol. 2001;86:494.PubMed Settipane RA, Lieberman P. Update on nonallergic rhinitis. Ann Allergy Asthma Immunol. 2001;86:494.PubMed
10.
Zurück zum Zitat Bachert C, van Cauwenberge P, Olbrecht J, van Schoor J. Prevalence, classification and perception of allergic and nonallergic rhinitis in Belgium. Allergy. 2006;61:693.PubMed Bachert C, van Cauwenberge P, Olbrecht J, van Schoor J. Prevalence, classification and perception of allergic and nonallergic rhinitis in Belgium. Allergy. 2006;61:693.PubMed
11.
Zurück zum Zitat Mølgaard E, Thomsen SF, Lund T, et al. Differences between allergic and nonallergic rhinitis in a large sample of adolescents and adults. Allergy. 2007;62:1033.PubMed Mølgaard E, Thomsen SF, Lund T, et al. Differences between allergic and nonallergic rhinitis in a large sample of adolescents and adults. Allergy. 2007;62:1033.PubMed
12.
Zurück zum Zitat Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008;122:S1.PubMed Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008;122:S1.PubMed
13.
Zurück zum Zitat Dykewicz MS, Fineman S, Skoner DP, et al. Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology. Ann Allergy Asthma Immunol. 1998;81:478.PubMed Dykewicz MS, Fineman S, Skoner DP, et al. Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology. Ann Allergy Asthma Immunol. 1998;81:478.PubMed
14.
Zurück zum Zitat Togias AK. Nonallergic rhinitis. In: Allergic and nonallergic rhinitis: clinical aspects, Mygine N, Naclerio RM (Eds), Munksgaard, Copenhagen 1993; p.159. Togias AK. Nonallergic rhinitis. In: Allergic and nonallergic rhinitis: clinical aspects, Mygine N, Naclerio RM (Eds), Munksgaard, Copenhagen 1993; p.159.
15.
Zurück zum Zitat Settipane RA, Charnock DR. Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol. 2007;19(23):58. Settipane RA, Charnock DR. Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol. 2007;19(23):58.
16.
Zurück zum Zitat Berger WE, Schonfeld JE. Nonallergic rhinitis in children. Curr Allergy Asthma Rep. 2007;7:112.PubMed Berger WE, Schonfeld JE. Nonallergic rhinitis in children. Curr Allergy Asthma Rep. 2007;7:112.PubMed
17.
Zurück zum Zitat Chawes BL, Kreiner-Møller E, Bisgaard H. Objective assessments of allergic and nonallergic rhinitis in young children. Allergy. 2009;64:1547.PubMed Chawes BL, Kreiner-Møller E, Bisgaard H. Objective assessments of allergic and nonallergic rhinitis in young children. Allergy. 2009;64:1547.PubMed
18.
Zurück zum Zitat Erwin EA, Faust RA, Platts-Mills TA, Borish L. Epidemiological analysis of chronic rhinitis in pediatric patients. Am J Rhinol Allergy. 2011;25:327.PubMed Erwin EA, Faust RA, Platts-Mills TA, Borish L. Epidemiological analysis of chronic rhinitis in pediatric patients. Am J Rhinol Allergy. 2011;25:327.PubMed
19.
Zurück zum Zitat Westman M, Stjärne P, Asarnoj A, et al. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol. 2012;129:403. Chronic non-allergic rhinitis has been a well-recognized entity in adults, but until recently it was thought to be rare in children. This reference dispels that opinion and discusses the importance of non-allergic rhinitis in children.PubMed Westman M, Stjärne P, Asarnoj A, et al. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol. 2012;129:403. Chronic non-allergic rhinitis has been a well-recognized entity in adults, but until recently it was thought to be rare in children. This reference dispels that opinion and discusses the importance of non-allergic rhinitis in children.PubMed
20.
Zurück zum Zitat Settipane RA. Rhinitis: a dose of epidemiological reality. Allergy Asthma Proc. 2003;24:147.PubMed Settipane RA. Rhinitis: a dose of epidemiological reality. Allergy Asthma Proc. 2003;24:147.PubMed
21.
Zurück zum Zitat Settipane GA, Klein DE. Non allergic rhinitis: demography of eosinophils in nasal smear, blood total eosinophil counts and IgE levels. N Engl Reg Allergy Proc. 1985;6:363.PubMed Settipane GA, Klein DE. Non allergic rhinitis: demography of eosinophils in nasal smear, blood total eosinophil counts and IgE levels. N Engl Reg Allergy Proc. 1985;6:363.PubMed
22.
Zurück zum Zitat Powe DG, Huskisson RS, Carney AS, et al. Evidence for an inflammatory pathophysiology in idiopathic rhinitis. Clin Exp Allergy. 2001;31:864.PubMed Powe DG, Huskisson RS, Carney AS, et al. Evidence for an inflammatory pathophysiology in idiopathic rhinitis. Clin Exp Allergy. 2001;31:864.PubMed
23.
Zurück zum Zitat Berger G, Goldberg A, Ophir D. The inferior turbinate mast cell population of patients with perennial allergic and nonallergic rhinitis. Am J Rhinol. 1997;11:63.PubMed Berger G, Goldberg A, Ophir D. The inferior turbinate mast cell population of patients with perennial allergic and nonallergic rhinitis. Am J Rhinol. 1997;11:63.PubMed
24.
Zurück zum Zitat Canakcioglu S, Tahamiler R, Saritzali G, et al. Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. Am J Otolaryngol. 2009;30(5):312–7.PubMed Canakcioglu S, Tahamiler R, Saritzali G, et al. Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. Am J Otolaryngol. 2009;30(5):312–7.PubMed
25.
Zurück zum Zitat Schiavino D, Nucera E, Milani A, Della Corte AM, D'Ambrosio C, Pagliari G, et al. Nasal lavage cytometry in the diagnosis of nonallergic rhinitis with eosinophilia syndrome (NARES). Allergy Asthma Proc. 1997;18(6):363–6.PubMed Schiavino D, Nucera E, Milani A, Della Corte AM, D'Ambrosio C, Pagliari G, et al. Nasal lavage cytometry in the diagnosis of nonallergic rhinitis with eosinophilia syndrome (NARES). Allergy Asthma Proc. 1997;18(6):363–6.PubMed
26.
Zurück zum Zitat Maselli Del Giudice A, Barbara M, Russo GM, et al. Cell-mediated non-allergic rhinitis in children. Int J Pediatr Otorhinolaryngol. 2012;76:1741.PubMed Maselli Del Giudice A, Barbara M, Russo GM, et al. Cell-mediated non-allergic rhinitis in children. Int J Pediatr Otorhinolaryngol. 2012;76:1741.PubMed
27.
Zurück zum Zitat Matteo G, Luigi MG, Amelia L, et al. Nasal cytology in children: recent advances. Ital J Pediatr. 2012;38:51. Nasal cytology has become a lost art in the assessment of rhinitis, and yet it can give important insights into the pathogenesis underlying this disorder in any given patient and therefore assist in therapy. The importance of nasal cytology is demonstrated in children with rhinitis.PubMedCentral Matteo G, Luigi MG, Amelia L, et al. Nasal cytology in children: recent advances. Ital J Pediatr. 2012;38:51. Nasal cytology has become a lost art in the assessment of rhinitis, and yet it can give important insights into the pathogenesis underlying this disorder in any given patient and therefore assist in therapy. The importance of nasal cytology is demonstrated in children with rhinitis.PubMedCentral
28.
Zurück zum Zitat Mullarkey MF. Eosinophilic nonallergic rhinitis. J Allergy Clin Immunol. 1998;82(5):941–9. Mullarkey MF. Eosinophilic nonallergic rhinitis. J Allergy Clin Immunol. 1998;82(5):941–9.
29.
Zurück zum Zitat Rinne J, Simola M, Malmberg H, Haahtela T. Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long term outcome. J Allergy Clin Immunol. 2002;109:426–32.PubMed Rinne J, Simola M, Malmberg H, Haahtela T. Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long term outcome. J Allergy Clin Immunol. 2002;109:426–32.PubMed
30.
Zurück zum Zitat Brooms P, Malm L. Oral vasoconstrictors in perennial non-allergic rhinitis. Allergy. 1982;37:67–74. Brooms P, Malm L. Oral vasoconstrictors in perennial non-allergic rhinitis. Allergy. 1982;37:67–74.
31.
Zurück zum Zitat Lieberman P. The role of antihistamines in the treatment of vasomotor rhinitis. WAO J. 2009;2:156–61. Lieberman P. The role of antihistamines in the treatment of vasomotor rhinitis. WAO J. 2009;2:156–61.
32.
Zurück zum Zitat Purello-D’ Ambrosio F, Isola S, Ricciardi L, Gangemi S, Barresi L, Bagnato GF. A controlled study on the effectiveness of loratidine in combination with flunisolide in the treatment of nonallergic rhinitis with eosinophilia (NARES). Clin Exp Allergy. 1999;29:1143–7. Purello-D’ Ambrosio F, Isola S, Ricciardi L, Gangemi S, Barresi L, Bagnato GF. A controlled study on the effectiveness of loratidine in combination with flunisolide in the treatment of nonallergic rhinitis with eosinophilia (NARES). Clin Exp Allergy. 1999;29:1143–7.
33.
Zurück zum Zitat Scadding GK, Durham SR, Mirakian R, et al. BSACI guidelines for the treatment of allergic and non-allergic rhinitis. Clin Exp Allergy. 2008;38(1):19–42.PubMed Scadding GK, Durham SR, Mirakian R, et al. BSACI guidelines for the treatment of allergic and non-allergic rhinitis. Clin Exp Allergy. 2008;38(1):19–42.PubMed
34.
Zurück zum Zitat Powe DG, Jagger C, Kleinjan A, Carney AS, Jenkins D, Jones NS. “Entopy”: localized mucosal allergic disease in the absence of systemic responses for atopy. Clin Exp Allergy. 2003;33:1374–9.PubMed Powe DG, Jagger C, Kleinjan A, Carney AS, Jenkins D, Jones NS. “Entopy”: localized mucosal allergic disease in the absence of systemic responses for atopy. Clin Exp Allergy. 2003;33:1374–9.PubMed
35.
Zurück zum Zitat KleinJan A, Vinke JG, Severijnen LW, Fokkens WJ. Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients. Eur Respir J. 2000;15:491.PubMed KleinJan A, Vinke JG, Severijnen LW, Fokkens WJ. Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients. Eur Respir J. 2000;15:491.PubMed
36.
Zurück zum Zitat Rondón C, Romero JJ, López S, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol. 2007;119:899.PubMed Rondón C, Romero JJ, López S, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol. 2007;119:899.PubMed
37.
Zurück zum Zitat Rondón C, Fernández J, López S, et al. Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol. 2009;124:1005.PubMed Rondón C, Fernández J, López S, et al. Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol. 2009;124:1005.PubMed
38.
Zurück zum Zitat Rondón C, Campo P, Togias A, et al. Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol. 2012;129:1460.PubMed Rondón C, Campo P, Togias A, et al. Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol. 2012;129:1460.PubMed
39.
Zurück zum Zitat Smurthwaite L, Walker SN, Wilson DR, et al. Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur J Immunol. 2001;31:3422.PubMed Smurthwaite L, Walker SN, Wilson DR, et al. Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur J Immunol. 2001;31:3422.PubMed
40.
Zurück zum Zitat Smurthwaite L, Durham SR. Local IgE synthesis in allergic rhinitis and asthma. Curr Allergy Asthma Rep. 2002;2:231.PubMed Smurthwaite L, Durham SR. Local IgE synthesis in allergic rhinitis and asthma. Curr Allergy Asthma Rep. 2002;2:231.PubMed
41.
Zurück zum Zitat Rondón C, Campo P, Herrera R, et al. Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis. J Allergy Clin Immunol. 2011;128:1192. The local synthesis of specific IgE to aeroallergens (without the detection of systemic specific IgE) has been demonstrated to account for rhinitis symptoms in patients previously diagnosed as having nonallergic rhinitis. In this article, it is shown that nasal allergen provocation with multiple aeroallergens can be an effective means of detecting the production of local IgE in such patients.PubMed Rondón C, Campo P, Herrera R, et al. Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis. J Allergy Clin Immunol. 2011;128:1192. The local synthesis of specific IgE to aeroallergens (without the detection of systemic specific IgE) has been demonstrated to account for rhinitis symptoms in patients previously diagnosed as having nonallergic rhinitis. In this article, it is shown that nasal allergen provocation with multiple aeroallergens can be an effective means of detecting the production of local IgE in such patients.PubMed
42.
Zurück zum Zitat Rondón C, Campo P, Galindo L, et al. Prevalence and clinical relevance of local allergic rhinitis. Allergy. 2012;67:1282.PubMed Rondón C, Campo P, Galindo L, et al. Prevalence and clinical relevance of local allergic rhinitis. Allergy. 2012;67:1282.PubMed
43.
Zurück zum Zitat Wierzbicki DA, Majmundar AR, Schull DE, Khan DA. Multiallergen nasal challenges in nonallergic rhinitis. Ann Allergy Asthma Immunol. 2008;100:533.PubMed Wierzbicki DA, Majmundar AR, Schull DE, Khan DA. Multiallergen nasal challenges in nonallergic rhinitis. Ann Allergy Asthma Immunol. 2008;100:533.PubMed
44.
Zurück zum Zitat Hamilos DL. Chronic sinusitis. J Allergy Clin Immunol. 2000;106:213–27.PubMed Hamilos DL. Chronic sinusitis. J Allergy Clin Immunol. 2000;106:213–27.PubMed
45.
Zurück zum Zitat Yoon BN, Choi NG, Lee HS, Cho KS, Roh HJ. Induction of interleukin-8 from nasal epithelial cells during bacterial infection: the role of IL-8 for neutrophil recruitment in chronic rhinosinusitis. Mediators Inflamm 2010; 8136. Yoon BN, Choi NG, Lee HS, Cho KS, Roh HJ. Induction of interleukin-8 from nasal epithelial cells during bacterial infection: the role of IL-8 for neutrophil recruitment in chronic rhinosinusitis. Mediators Inflamm 2010; 8136.
46.
Zurück zum Zitat Calderón-Garcidueñas L, Valencia-Salazar G, Rodríguez-Alcaraz A, et al. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am J Respir Cell Mol Biol. 2001;24(2):132–8.PubMed Calderón-Garcidueñas L, Valencia-Salazar G, Rodríguez-Alcaraz A, et al. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am J Respir Cell Mol Biol. 2001;24(2):132–8.PubMed
47.
Zurück zum Zitat Einarsson O, Geba GP, Zhou Z, et al. Interleukin-11 in respiratory inflammation. Ann N Y Acad Sci. 1995;762:31–40. Einarsson O, Geba GP, Zhou Z, et al. Interleukin-11 in respiratory inflammation. Ann N Y Acad Sci. 1995;762:31–40.
48.
Zurück zum Zitat Baraniuk JN. Pathogenic mechanisms of idiopathic non allergic rhinitis. WAO J. 2009;2:106–14. Baraniuk JN. Pathogenic mechanisms of idiopathic non allergic rhinitis. WAO J. 2009;2:106–14.
49.
Zurück zum Zitat Bernstein JA, Hastings L, Boespflug EL, et al. Alteration of brain activation patterns in nonallergic rhinitis patients using functional magnetic resonance imaging before and after treatment with intranasal azelastine. Ann Allergy Asthma Immunol. 2011;106(527). This article gives an excellent insight into the neural mechanisms underlying symptoms in patients with chronic non-allergic rhinitis upon exposure to respiratory irritants. It also elucidates in part the mechanisms of action of azelastine in this condition. Bernstein JA, Hastings L, Boespflug EL, et al. Alteration of brain activation patterns in nonallergic rhinitis patients using functional magnetic resonance imaging before and after treatment with intranasal azelastine. Ann Allergy Asthma Immunol. 2011;106(527). This article gives an excellent insight into the neural mechanisms underlying symptoms in patients with chronic non-allergic rhinitis upon exposure to respiratory irritants. It also elucidates in part the mechanisms of action of azelastine in this condition.
50.
Zurück zum Zitat van Rijswijk J, Blom H, KleinJan A, Mulder P, Rijntjes E, Fokkens W. Inflammatory cells seem not to be involved in idiopathic rhinitis. Rhinology. 2002;40:1–6. van Rijswijk J, Blom H, KleinJan A, Mulder P, Rijntjes E, Fokkens W. Inflammatory cells seem not to be involved in idiopathic rhinitis. Rhinology. 2002;40:1–6.
51.
Zurück zum Zitat Braat J, Mulder P, Fokkens W, van Wijk R, Rijntjes E. Intranasal cold dry air is superior to histamine challenge in determining the presence and degree of nasal hyperreactivity in nonallergic noninfectiousperennial rhinitis. Am J Respir Crit Care Med. 1998;157:1748–55.PubMed Braat J, Mulder P, Fokkens W, van Wijk R, Rijntjes E. Intranasal cold dry air is superior to histamine challenge in determining the presence and degree of nasal hyperreactivity in nonallergic noninfectiousperennial rhinitis. Am J Respir Crit Care Med. 1998;157:1748–55.PubMed
52.
Zurück zum Zitat Garay R. Mechanisms of Vasomotor Rhinitis. Allergy. 2004;59 Suppl 76:4–10.PubMed Garay R. Mechanisms of Vasomotor Rhinitis. Allergy. 2004;59 Suppl 76:4–10.PubMed
53.
Zurück zum Zitat Lundblad L. Protective reflexes and vascular effects in the nasal mucosa elicited by activation of capsaicin sensitive substance P-immunoreactive neurons. Acta Physiol Scand. 1984;529:1–42. Lundblad L. Protective reflexes and vascular effects in the nasal mucosa elicited by activation of capsaicin sensitive substance P-immunoreactive neurons. Acta Physiol Scand. 1984;529:1–42.
54.
Zurück zum Zitat van Rijswijk J, Boeke E, Keizer J, Mulder P, Blom H, Fokkens W. Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis:a double-blind randomized application regimen study. Allergy. 2003;58:754–61.PubMed van Rijswijk J, Boeke E, Keizer J, Mulder P, Blom H, Fokkens W. Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis:a double-blind randomized application regimen study. Allergy. 2003;58:754–61.PubMed
55.
Zurück zum Zitat Lacroix J, Buvelot J, Polla B, Lundberg J. Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. Clin Exp Allergy. 1991;21:595–600.PubMed Lacroix J, Buvelot J, Polla B, Lundberg J. Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. Clin Exp Allergy. 1991;21:595–600.PubMed
56.
Zurück zum Zitat Blom H, Van Rijswijk J, Garrelds I, Mulder P, Timmermans T, Van Wijk R. Intranasal capsaicin is efficacious in non-allergic, noninfectious perennial rhinitis: a placebo-controlled study. Clin Exp Allergy. 1997;27:796–801.PubMed Blom H, Van Rijswijk J, Garrelds I, Mulder P, Timmermans T, Van Wijk R. Intranasal capsaicin is efficacious in non-allergic, noninfectious perennial rhinitis: a placebo-controlled study. Clin Exp Allergy. 1997;27:796–801.PubMed
57.
Zurück zum Zitat Sanico AM, Philip G, Lai G, Togias A. Hyperosmolar saline induces reflex nasal secretions, evincing neural hyperresponsiveness in allergic rhinitis. J Appl Physiol. 1999;86:1202–10.PubMed Sanico AM, Philip G, Lai G, Togias A. Hyperosmolar saline induces reflex nasal secretions, evincing neural hyperresponsiveness in allergic rhinitis. J Appl Physiol. 1999;86:1202–10.PubMed
58.
Zurück zum Zitat Baraniuk JN, Petrie KN, Le U, Tai CF, Park YJ, et al. Neuropathology in rhinosinusitis. Am J Respir Crit Care Med. 2005;171:5–11.PubMed Baraniuk JN, Petrie KN, Le U, Tai CF, Park YJ, et al. Neuropathology in rhinosinusitis. Am J Respir Crit Care Med. 2005;171:5–11.PubMed
59.
Zurück zum Zitat Naranch K, Park YJ, Repka-Ramirez MS, et al. A tender sinus does not always mean sinusitis. Otolaryngol Head Neck Surg. 2002;127:387–97.PubMed Naranch K, Park YJ, Repka-Ramirez MS, et al. A tender sinus does not always mean sinusitis. Otolaryngol Head Neck Surg. 2002;127:387–97.PubMed
60.
Zurück zum Zitat Wilkins BW, Chung LH, Tublitz NJ, Wong BJ, Minson CT. Mechanisms of vasoactive intestinal peptide-mediated vasodilation in human skin. J Appl Physiol. 2004;97:1291–8.PubMed Wilkins BW, Chung LH, Tublitz NJ, Wong BJ, Minson CT. Mechanisms of vasoactive intestinal peptide-mediated vasodilation in human skin. J Appl Physiol. 2004;97:1291–8.PubMed
61.
Zurück zum Zitat Fokkens WJ. Thoughts on the pathophysiology of nonallergic rhinitis. Curr Allergy Asthma Rep. 2002;2:203–9.PubMed Fokkens WJ. Thoughts on the pathophysiology of nonallergic rhinitis. Curr Allergy Asthma Rep. 2002;2:203–9.PubMed
62.
Zurück zum Zitat Silvers WS. The skier's nose: a model of cold induced rhinorrhea. Ann Allergy. 1991;67:32–6.PubMed Silvers WS. The skier's nose: a model of cold induced rhinorrhea. Ann Allergy. 1991;67:32–6.PubMed
63.
Zurück zum Zitat Waibel KH, Chang C. Prevalence and food avoidance behaviors for gustatory rhinitis. Ann Allergy Asthma Immunol. 2008;100:200–5.PubMed Waibel KH, Chang C. Prevalence and food avoidance behaviors for gustatory rhinitis. Ann Allergy Asthma Immunol. 2008;100:200–5.PubMed
64.
Zurück zum Zitat Vayisoglu Y, Ozcan C, Pekdemir H, Gorur K, Pata YS, Camsari A. Autonomic nervous system evaluation using heart rate variability parameters in vasomotor rhinitis patients. J Otolaryngol. 2006;35:338–42.PubMed Vayisoglu Y, Ozcan C, Pekdemir H, Gorur K, Pata YS, Camsari A. Autonomic nervous system evaluation using heart rate variability parameters in vasomotor rhinitis patients. J Otolaryngol. 2006;35:338–42.PubMed
65.
Zurück zum Zitat Wilde D, Cook JA, Jones AS. The nasal response to axillary pressure in non-eosinophilic intrinsic rhinitis. Clin Otolaryngol Allied Sci. 1997;22:219–21.PubMed Wilde D, Cook JA, Jones AS. The nasal response to axillary pressure in non-eosinophilic intrinsic rhinitis. Clin Otolaryngol Allied Sci. 1997;22:219–21.PubMed
66.
Zurück zum Zitat Jaradeh S, Smith T, Torrico L, Prieto T, Loehrl T, Darling R, et al. Autonomic nervous system evaluation of patients with vasomotor rhinitis. Laryngoscope. 2000;110:1828–31.PubMed Jaradeh S, Smith T, Torrico L, Prieto T, Loehrl T, Darling R, et al. Autonomic nervous system evaluation of patients with vasomotor rhinitis. Laryngoscope. 2000;110:1828–31.PubMed
67.
Zurück zum Zitat Elsheikh MN, Badran HM. Dysautonomia rhinitis: associated otolaryngological manifestations and characterization based on autonomic function tests. Acta Otolaryngol. 2006;126:1206–12.PubMed Elsheikh MN, Badran HM. Dysautonomia rhinitis: associated otolaryngological manifestations and characterization based on autonomic function tests. Acta Otolaryngol. 2006;126:1206–12.PubMed
68.
Zurück zum Zitat Molgaard E, Thomsen SF, Lund T, Pedersen L, Nolte H, Backer V. Differences between allergic and nonallergic rhinitis in a large sample of adolescents and adults. Allergy. 2007;62(9):1033–7.PubMed Molgaard E, Thomsen SF, Lund T, Pedersen L, Nolte H, Backer V. Differences between allergic and nonallergic rhinitis in a large sample of adolescents and adults. Allergy. 2007;62(9):1033–7.PubMed
69.
Zurück zum Zitat Wedback A, Enbom H, Eriksson NE, Moverare R, Malcus I. Seasonal nonallergic rhinitis (SNAR): a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent nonallergic rhinitis. Rhinology. 2005;43:86–92.PubMed Wedback A, Enbom H, Eriksson NE, Moverare R, Malcus I. Seasonal nonallergic rhinitis (SNAR): a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent nonallergic rhinitis. Rhinology. 2005;43:86–92.PubMed
70.
Zurück zum Zitat Lindberg S, Malm L. Comparison of allergic rhinitis and vasomotor rhinitis patients on the basis of a computer questionnaire. Allergy. 1993;48:602–7.PubMed Lindberg S, Malm L. Comparison of allergic rhinitis and vasomotor rhinitis patients on the basis of a computer questionnaire. Allergy. 1993;48:602–7.PubMed
71.
Zurück zum Zitat Di Lorenzo G, Pacor ML, Amodio E, et al. Differences and similarities between allergic and nonallergic rhinitis in a large sample of adult patients with rhinitis symptoms. Int Arch Allergy Immunol. 2011;155(3):263–70.PubMed Di Lorenzo G, Pacor ML, Amodio E, et al. Differences and similarities between allergic and nonallergic rhinitis in a large sample of adult patients with rhinitis symptoms. Int Arch Allergy Immunol. 2011;155(3):263–70.PubMed
72.
Zurück zum Zitat Stjarne P, Lundblad L, Lundberg JM, Anggard A. Capsaicin and nicotine sensitive afferent neurons and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis. Br J Pharmacol. 1989;96:693–701.PubMedCentralPubMed Stjarne P, Lundblad L, Lundberg JM, Anggard A. Capsaicin and nicotine sensitive afferent neurons and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis. Br J Pharmacol. 1989;96:693–701.PubMedCentralPubMed
73.
Zurück zum Zitat Scarupa MD, Kaliner MA. Non-allergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. WAO J. 2009;2(3):20–5. Scarupa MD, Kaliner MA. Non-allergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. WAO J. 2009;2(3):20–5.
74.
Zurück zum Zitat Chawes BL, Kreiner-Møller E, Bisgaard H. Objective assessments of allergic and nonallergic rhinitis in young children. Allergy. 2009;64(10):1547–53.PubMed Chawes BL, Kreiner-Møller E, Bisgaard H. Objective assessments of allergic and nonallergic rhinitis in young children. Allergy. 2009;64(10):1547–53.PubMed
75.
Zurück zum Zitat Erwin EA, Faust RA, Platts-Mills TA, Borish L. Epidemiological analysis of chronic rhinitis in pediatric patients. Am J Rhinol Allergy. 2011;25(5):327–32.PubMed Erwin EA, Faust RA, Platts-Mills TA, Borish L. Epidemiological analysis of chronic rhinitis in pediatric patients. Am J Rhinol Allergy. 2011;25(5):327–32.PubMed
76.
Zurück zum Zitat Brandt D, Bernstein JA. Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. Ann Allergy Asthma Immunol. 2006;96(4):526–32.PubMed Brandt D, Bernstein JA. Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. Ann Allergy Asthma Immunol. 2006;96(4):526–32.PubMed
77.
Zurück zum Zitat Bernstein JA. Characteristics of nonallergic vasomotor rhinitis. WAO J. 2009;2:102–5. Bernstein JA. Characteristics of nonallergic vasomotor rhinitis. WAO J. 2009;2:102–5.
78.
Zurück zum Zitat Bernstein JA, Levin LS, Al-Shuik E, Martin VT. Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. Ann Allergy Asthma Immunol. 2012;109:173–8.PubMed Bernstein JA, Levin LS, Al-Shuik E, Martin VT. Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. Ann Allergy Asthma Immunol. 2012;109:173–8.PubMed
79.
Zurück zum Zitat Segboer CL, Holland CT, Reinartz SM, Terreehorst I, Gevorgyan A, Hellings PW, et al. Nasal hyper-reactivity is a common feature in both allergic and nonallergic rhinitis. Allergy. 2013;68:1427–34. Hyperirritability of the upper airways is an important factor in patients who have abnormal responses to respiratory irritants and perhaps weather changes. It has been known that patients with non-allergic rhinitis exhibit such hyperactivity. This article demonstrates that such hyperactivity also occurs in patients with allergic rhinitis.PubMed Segboer CL, Holland CT, Reinartz SM, Terreehorst I, Gevorgyan A, Hellings PW, et al. Nasal hyper-reactivity is a common feature in both allergic and nonallergic rhinitis. Allergy. 2013;68:1427–34. Hyperirritability of the upper airways is an important factor in patients who have abnormal responses to respiratory irritants and perhaps weather changes. It has been known that patients with non-allergic rhinitis exhibit such hyperactivity. This article demonstrates that such hyperactivity also occurs in patients with allergic rhinitis.PubMed
80.
Zurück zum Zitat Kaliner MA. Classification of nonallergic rhinitis syndromes with a focus on vasomotor rhinitis, proposed to be known henceforth as nonallergic rhinopathy. WAO J. 2009;2:98–101. Kaliner MA. Classification of nonallergic rhinitis syndromes with a focus on vasomotor rhinitis, proposed to be known henceforth as nonallergic rhinopathy. WAO J. 2009;2:98–101.
81.
Zurück zum Zitat Settipane GA, Klein DE. Non allergic rhinitis: demography of eosinophils in nasal smear, blood total eosinophil counts and IgE levels. N Engl Reg Allergy Proc. 1985;6(4):363–6.PubMed Settipane GA, Klein DE. Non allergic rhinitis: demography of eosinophils in nasal smear, blood total eosinophil counts and IgE levels. N Engl Reg Allergy Proc. 1985;6(4):363–6.PubMed
82.
Zurück zum Zitat Dollner R, Taraldsrud E, Iversen K, Osnes T, Kristensen B, Kramer MF. Non-allergic, mastocytosis-associated rhinitis. Clin Exp Allergy. 2013;43:406–12.PubMed Dollner R, Taraldsrud E, Iversen K, Osnes T, Kristensen B, Kramer MF. Non-allergic, mastocytosis-associated rhinitis. Clin Exp Allergy. 2013;43:406–12.PubMed
83.
Zurück zum Zitat Dzieciolowska-Baran E, Teul-Swiniarska I, Gawlikowska-Sroka A, Poziomkowska-Gesicka I, Zietek Z. Rhinitis as a cause of respiratory disorders during pregnancy. Adv Exp Med Biol. 2013;755:213–20.PubMed Dzieciolowska-Baran E, Teul-Swiniarska I, Gawlikowska-Sroka A, Poziomkowska-Gesicka I, Zietek Z. Rhinitis as a cause of respiratory disorders during pregnancy. Adv Exp Med Biol. 2013;755:213–20.PubMed
84.
Zurück zum Zitat Reisacher WR. Prevalence of autoimmune thyroid disease in chronic rhinitis. Ear Nose Throat J. 2008;87(9):524–7.PubMed Reisacher WR. Prevalence of autoimmune thyroid disease in chronic rhinitis. Ear Nose Throat J. 2008;87(9):524–7.PubMed
85.
Zurück zum Zitat Varghese M, Glaum MC, Lockey RF. Drug-induced rhinitis. Clin Exp Allergy. 2010;40(3):381–4.PubMed Varghese M, Glaum MC, Lockey RF. Drug-induced rhinitis. Clin Exp Allergy. 2010;40(3):381–4.PubMed
86.
Zurück zum Zitat Graf P, Hallén H, Juto JE. Benzalkonium chloride in a decongestant nasal spray aggravates rhinitis medicamentosa in healthy volunteers. Clin Exp Allergy. 1995;25(5):395–400.PubMed Graf P, Hallén H, Juto JE. Benzalkonium chloride in a decongestant nasal spray aggravates rhinitis medicamentosa in healthy volunteers. Clin Exp Allergy. 1995;25(5):395–400.PubMed
87.
Zurück zum Zitat Baroody FM, Brown D, Gavanescu L, DeTineo M, Naclerio RM. Oxymetazoline adds ttheeffectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis. J Allergy Clin Immunol. 2011;127(4):927–34.PubMed Baroody FM, Brown D, Gavanescu L, DeTineo M, Naclerio RM. Oxymetazoline adds ttheeffectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis. J Allergy Clin Immunol. 2011;127(4):927–34.PubMed
88.
Zurück zum Zitat Rael EL, Ramey J, Lockey RF. Oxymetazoline hydrochloride combined with mometasone nasal spray for persistent nasal congestion (pilot study). WAO J. 2011;4(3):65–7. Rebound rhinitis due to the administration of topical nasal decongestants has been, for many years, a well-recognized side effect of the administration of these agents. This article demonstrates that short-term use of oxymetazoline does not produce this "rebound phenomenon" when the agent is administered in conjunction with mometasone, a topical nasal steroid. Rael EL, Ramey J, Lockey RF. Oxymetazoline hydrochloride combined with mometasone nasal spray for persistent nasal congestion (pilot study). WAO J. 2011;4(3):65–7. Rebound rhinitis due to the administration of topical nasal decongestants has been, for many years, a well-recognized side effect of the administration of these agents. This article demonstrates that short-term use of oxymetazoline does not produce this "rebound phenomenon" when the agent is administered in conjunction with mometasone, a topical nasal steroid.
89.
Zurück zum Zitat Meltzer EO, Nathan RA, Derebery J, et al. Physician perceptions of the treatment and management of allergic and nonallergic rhinitis. Allergy Asthma Proc. 2009;30(1):75–83.PubMed Meltzer EO, Nathan RA, Derebery J, et al. Physician perceptions of the treatment and management of allergic and nonallergic rhinitis. Allergy Asthma Proc. 2009;30(1):75–83.PubMed
90.
Zurück zum Zitat Blom HM, Godthelp T, Fokkens WJ, et al. The effect of nasal steroid aqueous spray on nasal complaint scores and cellular infiltrates in the nasal mucosa of patients with nonallergic, noninfectious perennial rhinitis. J Allergy Clin Immunol. 1997;100:739.PubMed Blom HM, Godthelp T, Fokkens WJ, et al. The effect of nasal steroid aqueous spray on nasal complaint scores and cellular infiltrates in the nasal mucosa of patients with nonallergic, noninfectious perennial rhinitis. J Allergy Clin Immunol. 1997;100:739.PubMed
91.
Zurück zum Zitat Philip G, Togias AG. Nonallergic rhinitis. Pathophysiology and models for study. Eur Arch Otorhinolaryngol. 1995;252 Suppl 1:S27.PubMed Philip G, Togias AG. Nonallergic rhinitis. Pathophysiology and models for study. Eur Arch Otorhinolaryngol. 1995;252 Suppl 1:S27.PubMed
92.
Zurück zum Zitat Mullarkey MF. Eosinophilic nonallergic rhinitis. J Allergy Clin Immunol. 1988;82:941.PubMed Mullarkey MF. Eosinophilic nonallergic rhinitis. J Allergy Clin Immunol. 1988;82:941.PubMed
93.
Zurück zum Zitat Rinne J, Simola M, Malmberg H, Haahtela T. Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long-term outcome. J Allergy Clin Immunol. 2002;109:426.PubMed Rinne J, Simola M, Malmberg H, Haahtela T. Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long-term outcome. J Allergy Clin Immunol. 2002;109:426.PubMed
94.
Zurück zum Zitat Kondo H, Nachtigal D, Frenkiel S, et al. Effect of steroids on nasal inflammatory cells and cytokine profile. Laryngoscope. 1999;109:91.PubMed Kondo H, Nachtigal D, Frenkiel S, et al. Effect of steroids on nasal inflammatory cells and cytokine profile. Laryngoscope. 1999;109:91.PubMed
95.
Zurück zum Zitat Malm L, Wihl JA. Intra-nasal beclomethasone dipropionate in vasomotor rhinitis. Acta Allergol. 1976;31:245.PubMed Malm L, Wihl JA. Intra-nasal beclomethasone dipropionate in vasomotor rhinitis. Acta Allergol. 1976;31:245.PubMed
96.
Zurück zum Zitat Wight RG, Jones AS, Beckingham E, et al. A double blind comparison of intranasal budesonide 400 micrograms and 800 micrograms in perennial rhinitis. Clin Otolaryngol Allied Sci. 1992;17:354.PubMed Wight RG, Jones AS, Beckingham E, et al. A double blind comparison of intranasal budesonide 400 micrograms and 800 micrograms in perennial rhinitis. Clin Otolaryngol Allied Sci. 1992;17:354.PubMed
97.
Zurück zum Zitat Small P, Black M, Frenkiel S. Effects of treatment with beclomethasone dipropionate in subpopulations of perennial rhinitis patients. J Allergy Clin Immunol. 1982;70:178.PubMed Small P, Black M, Frenkiel S. Effects of treatment with beclomethasone dipropionate in subpopulations of perennial rhinitis patients. J Allergy Clin Immunol. 1982;70:178.PubMed
98.
Zurück zum Zitat Banov CH, Lieberman P. Vasomotor Rhinitis Study Groups. Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Ann Allergy Asthma Immunol. 2001;86:28.PubMed Banov CH, Lieberman P. Vasomotor Rhinitis Study Groups. Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Ann Allergy Asthma Immunol. 2001;86:28.PubMed
99.
Zurück zum Zitat Scadding GK, Lund VJ, Jacques LA, Richards DH. A placebo-controlled study of fluticasone propionate aqueous nasal spray and beclomethasone dipropionate in perennial rhinitis: efficacy in allergic and non-allergic perennial rhinitis. Clin Exp Allergy. 1995;25:737.PubMed Scadding GK, Lund VJ, Jacques LA, Richards DH. A placebo-controlled study of fluticasone propionate aqueous nasal spray and beclomethasone dipropionate in perennial rhinitis: efficacy in allergic and non-allergic perennial rhinitis. Clin Exp Allergy. 1995;25:737.PubMed
100.
Zurück zum Zitat Pipkorn U, Berge T. Long-term treatment with budesonide in vasomotor rhinitis. Acta Otolaryngol. 1983;95:167.PubMed Pipkorn U, Berge T. Long-term treatment with budesonide in vasomotor rhinitis. Acta Otolaryngol. 1983;95:167.PubMed
101.
Zurück zum Zitat Takao A, Shimoda T, Matsuse H, et al. Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. Ann Allergy Asthma Immunol. 1999;82:390.PubMed Takao A, Shimoda T, Matsuse H, et al. Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. Ann Allergy Asthma Immunol. 1999;82:390.PubMed
102.
Zurück zum Zitat Ciprandi G, Pronzato C, Passalacqua G, et al. Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity. J Allergy Clin Immunol. 1996;98:1088.PubMed Ciprandi G, Pronzato C, Passalacqua G, et al. Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity. J Allergy Clin Immunol. 1996;98:1088.PubMed
103.
Zurück zum Zitat Yoneda K, Yamamoto T, Ueta E, Osaki T. Suppression by azelastine hydrochloride of NF-kappa B activation involved in generation of cytokines and nitric oxide. Jpn J Pharmacol. 1997;73:145.PubMed Yoneda K, Yamamoto T, Ueta E, Osaki T. Suppression by azelastine hydrochloride of NF-kappa B activation involved in generation of cytokines and nitric oxide. Jpn J Pharmacol. 1997;73:145.PubMed
104.
Zurück zum Zitat Tamaoki J, Yamawaki I, Tagaya E, et al. Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. Am J Physiol. 1999;276:L351.PubMed Tamaoki J, Yamawaki I, Tagaya E, et al. Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. Am J Physiol. 1999;276:L351.PubMed
105.
Zurück zum Zitat Bronsky EA, Druce H, Findlay SR, et al. A clinical trial of ipratropium bromide nasal spray in patients with perennial nonallergic rhinitis. J Allergy Clin Immunol. 1995;95:1117.PubMed Bronsky EA, Druce H, Findlay SR, et al. A clinical trial of ipratropium bromide nasal spray in patients with perennial nonallergic rhinitis. J Allergy Clin Immunol. 1995;95:1117.PubMed
106.
Zurück zum Zitat Hampel FC, Ratner PH, Van Bavel J, et al. Double-blind, placebo-controlled study of azelastine and flutica sone in a single nasal spray delivery device. Ann Allergy Asthma Immunol. 2010;105:168.PubMed Hampel FC, Ratner PH, Van Bavel J, et al. Double-blind, placebo-controlled study of azelastine and flutica sone in a single nasal spray delivery device. Ann Allergy Asthma Immunol. 2010;105:168.PubMed
107.
Zurück zum Zitat Blom HM, Godthelp T, Fokkens WJ, KleinJan A, Mulder PG, Rijntjes E. The effect of nasal steroid aqueous spray on nasal complaint scores and cellular infiltrates in the nasal mucosa of patients with nonallergic, noninfectious perennial rhinitis. J Allergy Clin Immunol. 1997;100:739–47.PubMed Blom HM, Godthelp T, Fokkens WJ, KleinJan A, Mulder PG, Rijntjes E. The effect of nasal steroid aqueous spray on nasal complaint scores and cellular infiltrates in the nasal mucosa of patients with nonallergic, noninfectious perennial rhinitis. J Allergy Clin Immunol. 1997;100:739–47.PubMed
108.
Zurück zum Zitat Small P, Black M, Frenkiel S. Effects of treatment with beclomethasone dipropionate in subpopulations of perennial rhinitis patients. J Allergy Clin Immunol. 1982;70:178–82.PubMed Small P, Black M, Frenkiel S. Effects of treatment with beclomethasone dipropionate in subpopulations of perennial rhinitis patients. J Allergy Clin Immunol. 1982;70:178–82.PubMed
109.
Zurück zum Zitat Lundblad L, Sipila P, Farstad T, Drozdziewicz D. Mometasone furoate nasal spray in the treatment of perennial non-allergic rhinitis: a Nordic, multicenter, randomized, double-blind, placebo-controlled study. Acta Otolaryngol. 2001;121:505–9.PubMed Lundblad L, Sipila P, Farstad T, Drozdziewicz D. Mometasone furoate nasal spray in the treatment of perennial non-allergic rhinitis: a Nordic, multicenter, randomized, double-blind, placebo-controlled study. Acta Otolaryngol. 2001;121:505–9.PubMed
110.
Zurück zum Zitat Webb DR, Meltzer EO, Finn Jr AF, et al. Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia. Ann Allergy Asthma Immunol. 2002;88:385.PubMed Webb DR, Meltzer EO, Finn Jr AF, et al. Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia. Ann Allergy Asthma Immunol. 2002;88:385.PubMed
111.
Zurück zum Zitat Jacobs R, Lieberman P, Kent E, et al. Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. Allergy Asthma Proc. 2009;30:120.PubMed Jacobs R, Lieberman P, Kent E, et al. Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. Allergy Asthma Proc. 2009;30:120.PubMed
112.
Zurück zum Zitat Pattanaik D, Lieberman P. Vasomotor rhinitis. Curr Allergy Asthma Rep. 2010;10(2):84–91.PubMed Pattanaik D, Lieberman P. Vasomotor rhinitis. Curr Allergy Asthma Rep. 2010;10(2):84–91.PubMed
113.
Zurück zum Zitat Smith PK, Collins J. Olopatadine 0.6 % nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis. Am J Rhinol Allergy. 2011;25:e149.PubMed Smith PK, Collins J. Olopatadine 0.6 % nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis. Am J Rhinol Allergy. 2011;25:e149.PubMed
114.
Zurück zum Zitat Lieberman P, Meltzer EO, LaForce CF, et al. Two-week comparison study of olopatadine hydrochloride nasal spray 0.6 % versus azelastine hydrochloride nasal spray 0.1 % in patients with vasomotor rhinitis. Allergy Asthma Proc. 2011;32:151.PubMed Lieberman P, Meltzer EO, LaForce CF, et al. Two-week comparison study of olopatadine hydrochloride nasal spray 0.6 % versus azelastine hydrochloride nasal spray 0.1 % in patients with vasomotor rhinitis. Allergy Asthma Proc. 2011;32:151.PubMed
115.
Zurück zum Zitat Lieberman P. Intranasal antihistamines for allergic rhinitis: mechanism of action. Allergy Asthma Proc. 2009;30:345.PubMed Lieberman P. Intranasal antihistamines for allergic rhinitis: mechanism of action. Allergy Asthma Proc. 2009;30:345.PubMed
116.
Zurück zum Zitat Carr W, Bernstein J, Lieberman P, et al. A novel intranasal therapy of azelastine with fluticasone for the treatment of allergic rhinitis. J Allergy Clin Immunol. 2012;129:1282.PubMed Carr W, Bernstein J, Lieberman P, et al. A novel intranasal therapy of azelastine with fluticasone for the treatment of allergic rhinitis. J Allergy Clin Immunol. 2012;129:1282.PubMed
117.
Zurück zum Zitat Raphael G, Raphael MH, Kaliner M. Gustatory rhinitis: a syndrome of food-induced rhinorrhea. J Allergy Clin Immunol. 1989;83:110.PubMed Raphael G, Raphael MH, Kaliner M. Gustatory rhinitis: a syndrome of food-induced rhinorrhea. J Allergy Clin Immunol. 1989;83:110.PubMed
118.
Zurück zum Zitat Georgalas C, Jovancevic L. Gustatory rhinitis. Curr Opin Otolaryngol Head Neck Surg. 2012;20:9.PubMed Georgalas C, Jovancevic L. Gustatory rhinitis. Curr Opin Otolaryngol Head Neck Surg. 2012;20:9.PubMed
119.
Zurück zum Zitat Hatton RC, Winterstein AG, McKelvey RP, et al. Efficacy and safety of oral phenylephrine: systematic review and meta-analysis. Ann Pharmacother. 2007;41:381.PubMed Hatton RC, Winterstein AG, McKelvey RP, et al. Efficacy and safety of oral phenylephrine: systematic review and meta-analysis. Ann Pharmacother. 2007;41:381.PubMed
120.
Zurück zum Zitat Horak F, Zieglmayer P, Zieglmayer R, et al. A placebo-controlled study of the nasal decongestant effect of phenylephrine and pseudoephedrine in the Vienna Challenge Chamber. Ann Allergy Asthma Immunol. 2009;102:116.PubMed Horak F, Zieglmayer P, Zieglmayer R, et al. A placebo-controlled study of the nasal decongestant effect of phenylephrine and pseudoephedrine in the Vienna Challenge Chamber. Ann Allergy Asthma Immunol. 2009;102:116.PubMed
121.
Zurück zum Zitat Lanier BQ, Meltzer EO, Gates D, Shekar T, Teper A. Onset and duration of action of concomitant administration of mometasone furoate nasal spray with oxymetazoline nasal spray versus either drug alone and placebo in subjects with seasonal allergic rhinitis. J Allergy Clin Immunol. 2010;4(2):AB173. Lanier BQ, Meltzer EO, Gates D, Shekar T, Teper A. Onset and duration of action of concomitant administration of mometasone furoate nasal spray with oxymetazoline nasal spray versus either drug alone and placebo in subjects with seasonal allergic rhinitis. J Allergy Clin Immunol. 2010;4(2):AB173.
122.
Zurück zum Zitat Gross G, Meltzer EO, Gates D, Shekar T, Teper A. Impact of concomitant administration of mometasone furoate and oxymetazoline nasal sprays vs either drug alone or placebo on quality of life in patients with seasonal allergic rhinitis. J Allergy Clin Immunol. 2010;4(2):AB174. Gross G, Meltzer EO, Gates D, Shekar T, Teper A. Impact of concomitant administration of mometasone furoate and oxymetazoline nasal sprays vs either drug alone or placebo on quality of life in patients with seasonal allergic rhinitis. J Allergy Clin Immunol. 2010;4(2):AB174.
123.
Zurück zum Zitat Nayak AS, Prenner B, Gates D, Shekar T, Teper A. Tolerability of concomitant administration of mometasone furoate and oxymetazoline nasal sprays administered once daily vs oxymetazoline twice daily, mometasone furoate once daily, and placebo in the treatment of subjects with seasonal allergic rhinitis. J Allergy Clin Immunol. 2010;4(2):AB175. Nayak AS, Prenner B, Gates D, Shekar T, Teper A. Tolerability of concomitant administration of mometasone furoate and oxymetazoline nasal sprays administered once daily vs oxymetazoline twice daily, mometasone furoate once daily, and placebo in the treatment of subjects with seasonal allergic rhinitis. J Allergy Clin Immunol. 2010;4(2):AB175.
124.
Zurück zum Zitat Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;137(4):532–4. CD006394. Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;137(4):532–4. CD006394.
125.
Zurück zum Zitat Tomooka LT, Murphy C, Davidson TM. Clinical study and literature review of nasal irrigation. Laryngoscope. 2000;110:1189.PubMed Tomooka LT, Murphy C, Davidson TM. Clinical study and literature review of nasal irrigation. Laryngoscope. 2000;110:1189.PubMed
126.
Zurück zum Zitat Spector SL. The placebo effect is nothing to sneeze at. J Allergy Clin Immunol. 1992;90:1042.PubMed Spector SL. The placebo effect is nothing to sneeze at. J Allergy Clin Immunol. 1992;90:1042.PubMed
127.
Zurück zum Zitat Pynnonen MA, Mukerji SS, Kim HM, et al. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Arch Otolaryngol Head Neck Surg. 2007;133:1115.PubMed Pynnonen MA, Mukerji SS, Kim HM, et al. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Arch Otolaryngol Head Neck Surg. 2007;133:1115.PubMed
128.
Zurück zum Zitat Blom HM, Van Rijswijk JB, Garrelds IM, Mulder PG, Timmermans T, Van Gerth WR. Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis: a placebo-controlled study. Clin Exp Allergy. 1997;27(7):796–801.PubMed Blom HM, Van Rijswijk JB, Garrelds IM, Mulder PG, Timmermans T, Van Gerth WR. Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis: a placebo-controlled study. Clin Exp Allergy. 1997;27(7):796–801.PubMed
129.
Zurück zum Zitat Van Rijswijk JB, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ. Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study. Allergy. 2003;58(8):754–61.PubMed Van Rijswijk JB, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ. Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study. Allergy. 2003;58(8):754–61.PubMed
130.
Zurück zum Zitat Marabini S, Ciabatti PG, Polli G, et al. Beneficial effects of intranasal applications of capsaicin in patients with vasomotor rhinitis. Eur Arch Otorhinolaryngol. 1991;248:191.PubMed Marabini S, Ciabatti PG, Polli G, et al. Beneficial effects of intranasal applications of capsaicin in patients with vasomotor rhinitis. Eur Arch Otorhinolaryngol. 1991;248:191.PubMed
131.
Zurück zum Zitat Bernstein JA, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis. Ann Allergy Asthma Immunol. 2011;107(2):171–8.PubMed Bernstein JA, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis. Ann Allergy Asthma Immunol. 2011;107(2):171–8.PubMed
132.
Zurück zum Zitat Erhan E, Külahli I, Kandemir O, Cemiloglu R, Yigitbasi OG, Cüreoglu S. Comparison of topical silver nitrate and flunisolide treatment in patients with idiopathic non-allergic rhinitis. Tokai J Exp Clin Med. 1996;21:103–11.PubMed Erhan E, Külahli I, Kandemir O, Cemiloglu R, Yigitbasi OG, Cüreoglu S. Comparison of topical silver nitrate and flunisolide treatment in patients with idiopathic non-allergic rhinitis. Tokai J Exp Clin Med. 1996;21:103–11.PubMed
133.
Zurück zum Zitat Samarrae SM. Treatment of 'vasomotor rhinitis' by the local application of silver nitrate. J Laryngol Otol. 1991;105:285–7. Samarrae SM. Treatment of 'vasomotor rhinitis' by the local application of silver nitrate. J Laryngol Otol. 1991;105:285–7.
134.
Zurück zum Zitat Bhargava KB, Shirali GN, Abhyankar US, Gadre KC. Treatment of allergic and vasomotor rhinitis by the local application of different concentrations of silver nitrate. J Laryngol Otol. 1992;106:699–701.PubMed Bhargava KB, Shirali GN, Abhyankar US, Gadre KC. Treatment of allergic and vasomotor rhinitis by the local application of different concentrations of silver nitrate. J Laryngol Otol. 1992;106:699–701.PubMed
135.
Zurück zum Zitat Davies A, Lewith G, Goddard J, Howarth P. The effect of acupuncture on nonallergic rhinitis: a controlled pilot study. Altern Ther Health Med. 1998;4(1):70–4.PubMed Davies A, Lewith G, Goddard J, Howarth P. The effect of acupuncture on nonallergic rhinitis: a controlled pilot study. Altern Ther Health Med. 1998;4(1):70–4.PubMed
136.
Zurück zum Zitat Fleckenstein J, Raab C, Gleditsch J, Ostertag P, Rasp G, Stör W, et al. Impact of acupuncture on vasomotor rhinitis: a randomized placebo-controlled pilot study. J Altern Complement Med. 2009;15:391–8.PubMed Fleckenstein J, Raab C, Gleditsch J, Ostertag P, Rasp G, Stör W, et al. Impact of acupuncture on vasomotor rhinitis: a randomized placebo-controlled pilot study. J Altern Complement Med. 2009;15:391–8.PubMed
137.
Zurück zum Zitat Mladina R, Risavi R, Subaric M. CO2 laser anterior turbinectomy in the treatment of non-allergic vasomotor rhinopathia. A prospective study upon 78 patients. Rhinology. 1991;29:267.PubMed Mladina R, Risavi R, Subaric M. CO2 laser anterior turbinectomy in the treatment of non-allergic vasomotor rhinopathia. A prospective study upon 78 patients. Rhinology. 1991;29:267.PubMed
138.
Zurück zum Zitat Fernandes CM. Bilateral transnasal vidian neurectomy in the management of chronic rhinitis. J Laryngol Otol. 1994;108:569.PubMed Fernandes CM. Bilateral transnasal vidian neurectomy in the management of chronic rhinitis. J Laryngol Otol. 1994;108:569.PubMed
139.
Zurück zum Zitat Prasanna A, Murthy PS. Vasomotor rhinitis and sphenopalatine ganglion block. J Pain Symptom Manag. 1997;13:332. Prasanna A, Murthy PS. Vasomotor rhinitis and sphenopalatine ganglion block. J Pain Symptom Manag. 1997;13:332.
Metadaten
Titel
Nonallergic Rhinitis
verfasst von
Phil Lieberman
Debendra Pattanaik
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 6/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-014-0439-3

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