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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 6/2014

01.06.2014 | IMMUNOLOGIC/DIAGNOSTIC TESTS IN ALLERGY (JL SCHMITZ, SECTION EDITOR)

Metabolomics Approach in Allergic and Rheumatic Diseases

verfasst von: Rossana Scrivo, Luca Casadei, Mariacristina Valerio, Roberta Priori, Guido Valesini, Cesare Manetti

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2014

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Abstract

Metabolomics is the analysis of the concentration profiles of low molecular weight compounds present in biological fluids. Metabolites are nonpeptide molecules representing the end products of cellular activity. Therefore, changes in metabolite concentrations reveal the range of biochemical effects induced by a disease or its therapeutic intervention. Metabolomics has recently become feasible with the accessibility of new technologies, including mass spectrometry and high-resolution proton nuclear magnetic resonance, and has already been applied to several disorders. Indeed, it has the advantage of being a nontargeted approach for identifying potential biomarkers, which means that it does not require a preliminary knowledge of the substances to be studied. In this review, we summarize the main studies in which metabolomic approach was used in some allergic (asthma, atopic dermatitis) and rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus) to explore the feasibility of this technique as a novel diagnostic tool in these complex disorders.
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Metadaten
Titel
Metabolomics Approach in Allergic and Rheumatic Diseases
verfasst von
Rossana Scrivo
Luca Casadei
Mariacristina Valerio
Roberta Priori
Guido Valesini
Cesare Manetti
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 6/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-014-0445-5

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