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Erschienen in:

01.01.2008 | Therapy In Practice

Nonresponse to Treatment for Hepatitis C

Current Management Strategies

verfasst von: He-Jun Yuan, Dr William M. Lee

Erschienen in: Drugs | Ausgabe 1/2008

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Abstract

Chronic hepatitis C affects >170 million people worldwide, causing cirrhosis and liver cancer in a sizeable proportion of patients. Substantial progress has been made in the treatment of chronic hepatitis C. More than 50% of patients can achieve sustained virological response after 24–48 weeks of interferon and ribavirin combination therapy, making chronic hepatitis C a potentially curable disease. However, a large proportion of patients with chronic hepatitis C do not clear the virus after current standard therapy. Hepatitis C virus develops two pathways to counteract the antiviral effect of interferon. Some chronic hepatitis C patients may have a virus that is more resistant to interferon therapy, while other patients appear to have defective immune responses or poor tolerance or compliance to interferon-based antiviral therapy. The possible strategies to improve antiviral efficiency in these nonresponders are to increase the dosage, prolong the duration of treatment and improve the compliance of patients. A total of 6–15% of prior nonresponders to standard interferon plus ribavirin therapy will respond to re-treatment with peginterferon plus ribavirin, while 32–50% of patients who have relapsed will respond to re-treatment. New small molecules are under development to treat chronic hepatitis C and may be important particularly in the treatment of prior nonresponders to current standard therapy.

The use of trade names is for product identification purposes only and does not imply endorsement.

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Titel: Nonresponse to Treatment for Hepatitis C
Current Management Strategies
verfasst von: He-Jun Yuan
Dr William M. Lee
Publikationsdatum: 01.01.2008
Verlag: Springer International Publishing
Erschienen in: Drugs / Ausgabe 1/2008
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI: https://doi.org/10.2165/00003495-200868010-00003

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Nonresponse to Treatment for Hepatitis C

Current Management Strategies

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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