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International Journal of Hematology

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24.02.2016 | Progress in Hematology

Novel chemical attempts at ex vivo hematopoietic stem cell expansion

verfasst von: Yu Zhang, Yingdai Gao

Erschienen in: International Journal of Hematology | Ausgabe 5/2016

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Abstract

Hematopoietic stem cells (HSCs) are the most extensively studied stem cell type in adults, and the only stem cell type with proof of clinical utility. However, the greatest challenge for the broader use of HSCs remains the true expansion of the stem cells ex vivo. The development of researches on small-molecule compounds that support the safe and efficient ex vivo expansion of HSCs would help to promote the clinical application of HSCs. In recent years, several novel small-molecule compounds have been reported to improve ex vivo HSC expansion by promoting self-renewal, delaying differentiation, increasing homing, and inhibiting apoptosis. Here, we review recent chemical developments in stem cell research and the mechanisms underlying these compounds’ effects.

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Titel: Novel chemical attempts at ex vivo hematopoietic stem cell expansion
verfasst von: Yu Zhang
Yingdai Gao
Publikationsdatum: 24.02.2016
Verlag: Springer Japan
Erschienen in: International Journal of Hematology / Ausgabe 5/2016
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-016-1962-x

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Novel chemical attempts at ex vivo hematopoietic stem cell expansion

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