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14.03.2019 | Review

Novel PET tracers: added value for endocrine disorders

verfasst von: Sébastien Bergeret, Judith Charbit, Catherine Ansquer, Géraldine Bera, Philippe Chanson, Charlotte Lussey-Lepoutre

Erschienen in: Endocrine | Ausgabe 1/2019

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Summary

Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides ¹⁸F-FDG, which may be used in the management and follow-up of endocrine tumors, new tracers have emerged, such as ¹⁸F-DOPA for neuroendocrine tumors (NETs) (medullary thyroid carcinoma, pheochromocytomas and paragangliomas and well-differentiated NETs originating from the midgut) and ¹⁸F-Choline in the field of primary hyperparathyroidism. Moreover, some peptides such as somatostatin analogs can also be used for peptide receptor radionuclide therapy. In this context, Gallium-68 labeled somatostatin analogs (⁶⁸Ga-SSA) can help to tailor therapeutic choices and follow the response to treatment in the so-called “theranostic” approach. This review emphasizes the usefulness of these three novel PET tracers (¹⁸F-Choline, ¹⁸F-FDOPA, and ⁶⁸Ga-SSA) for primary hyperparathyroidism and neuroendocrine tumors.

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Titel: Novel PET tracers: added value for endocrine disorders
verfasst von: Sébastien Bergeret
Judith Charbit
Catherine Ansquer
Géraldine Bera
Philippe Chanson
Charlotte Lussey-Lepoutre
Publikationsdatum: 14.03.2019
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2019
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-019-01895-z

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