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Current Hematologic Malignancy Reports

Erschienen in:

07.02.2020 | Myeloproliferative Neoplasms (B Stein, Section Editor)

Novel Therapies in Polycythemia Vera

verfasst von: Douglas Tremblay, John Mascarenhas

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 2/2020

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Abstract

Purpose of Review

Polycythemia vera is a myeloproliferative neoplasm characterized by increased erythrocyte count, thrombotic potential, and transformation to myelofibrosis. Older patients and those who have a history of thrombosis require cytoreductive therapy, most commonly with hydroxyurea. Other currently available therapies include pegylated interferon alfa-2a and the JAK1/2 inhibitor ruxolitinib. However, there are limitations to these agents, including potential detrimental adverse effects. In this review, we will describe current therapeutic options for the treatment of PV and then detail new agents with available clinical trial data.

Recent Findings

A number of novel investigational therapies including MDM2 inhibitors, histone deacetylase inhibitors, and long-acting pegylated interferon alfa-2b are in various stages of clinical development with encouraging efficacy data.

Summary

The therapeutic landscape for patients with PV is expanding. Novel agents are in development that not only reduce the thrombotic potential but also act directly on the malignant PV clone with the intention of significantly modifying disease progression.

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Titel: Novel Therapies in Polycythemia Vera
verfasst von: Douglas Tremblay
John Mascarenhas
Publikationsdatum: 07.02.2020
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 2/2020
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-020-00564-7

Springer Medizin

Novel Therapies in Polycythemia Vera

Abstract

Purpose of Review

Recent Findings

Summary

Neu im Fachgebiet Onkologie

Erhöhte Mortalität bei postpartalem Brustkrebs

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Bessere Prognose mit links- statt rechtsseitigem Kolon-Ca.

Update Onkologie

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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