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Metabolic Brain Disease

Erschienen in:

10.12.2019 | Original Article

Nuclear prelamin a recognition factor and iron dysregulation in multiple sclerosis

verfasst von: Di Ding, Anddre Osmar Valdivia, Sanjoy K. Bhattacharya

Erschienen in: Metabolic Brain Disease | Ausgabe 2/2020

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Abstract

Dysregulation of iron metabolism and aberrant iron deposition has been associated with multiple sclerosis. However, the factors that contribute to this pathological state remain to be understood. In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblot techniques, which demonstrated that iron deposition is associated with increased levels of nuclear prelamin A recognition factor (NARF). NARF is a protein associated with the mitochondria which has also been linked to mitochondrial defects in multiple sclerosis. We report NARF to be associated in multiple sclerosis pathology and aberrant iron deposition.

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Titel: Nuclear prelamin a recognition factor and iron dysregulation in multiple sclerosis
verfasst von: Di Ding
Anddre Osmar Valdivia
Sanjoy K. Bhattacharya
Publikationsdatum: 10.12.2019
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 2/2020
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-019-00515-z

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