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International Archives of Occupational and Environmental Health

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22.05.2021 | Original Article

Nurses’ internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study

verfasst von: Antoine Villa, Mathieu Molimard, Dunia Sakr, Régis Lassalle, Emmanuelle Bignon, Béatrice Martinez, Magali Rouyer, Simone Mathoulin-Pelissier, Isabelle Baldi, Catherine Verdun-Esquer, Mireille Canal-Raffin

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 8/2021

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Abstract

Objective

The aim of this study was to assess internal antineoplastic drugs (ADs) contamination in the nursing staff in French hospital centers, using highly sensitive analytical methods.

Methods

This cross-sectional study included nurses practicing in care departments where at least one of the five ADs studied was handled (5-fluorouracil, cyclophosphamide, doxorubicin, ifosfamide, methotrexate). The nurses study participation lasted 24 h including collection of three urine samples and one self-questionnaire. All urine samples were assayed by ultra-high-performance liquid chromatography–tandem mass spectrometry methods with very low value of the lower limit of quantification (LLOQ).

Results

74 nurses were included, 222 urine samples and 74 self-questionnaires were collected; 1092 urine assays were performed. The percentage of nurses with internal AD contamination was 60.8% and low levels of urinary concentrations were measured. Regarding nurses with internal contamination (n = 45), 42.2% presented internal contamination by methotrexate, 37.8% by cyclophosphamide, 33.3% by ifosfamide, 17.8% by 5-fluorouracil metabolite and 6.7% by doxorubicine. Among the positive assays, 17.9% (n = 26/145) were not explained by exposure data from the self-questionnaire but this could be due to the skin contact of nurses with contaminated work surfaces.

Conclusions

This study reported high percentage of nurses with internal ADs contamination. The low LLOQ values of the used analytical methods, allowed the detection of ADs that would not have been detected with the current published methods: the percentage of contamination would have been 17.6% instead of the 60.8% reported here. Pending toxicological reference values, urine ADs concentrations should be reduced as low as reasonably achievable (ALARA principle).

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Titel: Nurses’ internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study
verfasst von: Antoine Villa
Mathieu Molimard
Dunia Sakr
Régis Lassalle
Emmanuelle Bignon
Béatrice Martinez
Magali Rouyer
Simone Mathoulin-Pelissier
Isabelle Baldi
Catherine Verdun-Esquer
Mireille Canal-Raffin
Publikationsdatum: 22.05.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 8/2021
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-021-01706-x

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Nurses’ internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study

Abstract

Objective

Methods

Results

Conclusions

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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