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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.03.2014

Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins

verfasst von: Nicolas Montalbetti, Marianela G. Dalghi, Christiane Albrecht, Matthias A. Hediger

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 1/2014

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Abstract

Milk nutrients are secreted by epithelial cells in the alveoli of the mammary gland by several complex and highly coordinated systems. Many of these nutrients are transported from the blood to the milk via transcellular pathways that involve the concerted activity of transport proteins on the apical and basolateral membranes of mammary epithelial cells. In this review, we focus on transport mechanisms that contribute to the secretion of calcium, trace minerals and water soluble vitamins into milk with particular focus on the role of transporters of the SLC series as well as calcium transport proteins (ion channels and pumps). Numerous members of the SLC family are involved in the regulation of essential nutrients in the milk, such as the divalent metal transporter-1 (SLC11A2), ferroportin-1 (SLC40A1) and the copper transporter CTR1 (SLC31A1). A deeper understanding of the physiology and pathophysiology of these transporters will be of great value for drug discovery and treatment of breast diseases.

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Titel: Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins
verfasst von: Nicolas Montalbetti
Marianela G. Dalghi
Christiane Albrecht
Matthias A. Hediger
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 1/2014
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-014-9317-9

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Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins

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