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Erschienen in: Somnologie 1/2010

01.03.2010 | Originalien

Obstruktive Schlafapnoe bei Herzinsuffizienz

verfasst von: PD Dr. M. Arzt, R. Obermeier

Erschienen in: Somnologie | Ausgabe 1/2010

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Zusammenfassung

Die obstruktive Schlafapnoe (OSA) ist eine häufige Komorbidität der Herzinsuffizienz und trägt durch eine Erhöhung der Vor- und Nachlast sowie der Herzfrequenz bei Verminderung des Sauerstoffangebots zu deren Entstehung und Fortschreiten bei. „Continuous positive airway pressure“ (CPAP) ist die Therapie der Wahl und führt zu einer Verbesserung der linksventrikulären Funktion in dieser Patientengruppe. Die CPAP-Therapie sollte bei Patienten mit Herzinsuffizienz und OSA grundsätzlich in Erwägung gezogen, jedoch im Einzelfall hinsichtlich der erreichten kardiovaskulären Effekte, Unterdrückung der zentralen Atmungsereignisse und Änderung der Lebensqualität im Verlauf kritisch evaluiert werden. Die Frage, ob eine Indikation zur Behandlung der Schlafapnoe bei Patienten mit Herzinsuffizienz mit dem Ziel der Prognoseverbesserung gestellt werden kann, ist Gegenstand randomisierter Langzeitstudien.
Literatur
1.
Zurück zum Zitat Redfield MM, Jacobsen SJ, Burnett JC Jr et al (2003) Burden of systolic and diastolic ventricular dysfunction in the community: Appreciating the scope of the heart failure epidemic. JAMA 289:194–202CrossRefPubMed Redfield MM, Jacobsen SJ, Burnett JC Jr et al (2003) Burden of systolic and diastolic ventricular dysfunction in the community: Appreciating the scope of the heart failure epidemic. JAMA 289:194–202CrossRefPubMed
2.
Zurück zum Zitat Dickstein K, Cohen-Solal A, Filippatos G et al (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the heart failure association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 10:933–989CrossRefPubMed Dickstein K, Cohen-Solal A, Filippatos G et al (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the heart failure association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 10:933–989CrossRefPubMed
3.
Zurück zum Zitat Levy D, Kenchaiah S, Larson MG et al (2002) Long-term trends in the incidence of and survival with heart failure. N Engl J Med 347:1397–1402CrossRefPubMed Levy D, Kenchaiah S, Larson MG et al (2002) Long-term trends in the incidence of and survival with heart failure. N Engl J Med 347:1397–1402CrossRefPubMed
5.
Zurück zum Zitat Kannel WB, Levy D, Cupples LA (1987) Left ventricular hypertrophy and risk of cardiac failure: Insights from the Framingham study. J Cardiovasc Pharmacol 10(Suppl 6):S135–S140PubMed Kannel WB, Levy D, Cupples LA (1987) Left ventricular hypertrophy and risk of cardiac failure: Insights from the Framingham study. J Cardiovasc Pharmacol 10(Suppl 6):S135–S140PubMed
6.
Zurück zum Zitat McKee PA, Castelli WP, McNamara PM et al (1971) The natural history of congestive heart failure: The Framingham study. N Engl J Med 285:1441–1446PubMed McKee PA, Castelli WP, McNamara PM et al (1971) The natural history of congestive heart failure: The Framingham study. N Engl J Med 285:1441–1446PubMed
7.
Zurück zum Zitat Drager LF, Bortolotto LA, Figueiredo AC et al (2007) Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 176:706–712CrossRefPubMed Drager LF, Bortolotto LA, Figueiredo AC et al (2007) Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 176:706–712CrossRefPubMed
8.
Zurück zum Zitat Drager LF, Bortolotto LA, Lorenzi MC et al (2005) Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 172:613–618CrossRefPubMed Drager LF, Bortolotto LA, Lorenzi MC et al (2005) Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 172:613–618CrossRefPubMed
9.
Zurück zum Zitat Marin JM, Carrizo SJ, Vicente E et al (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study. Lancet 365:1046–1053PubMed Marin JM, Carrizo SJ, Vicente E et al (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study. Lancet 365:1046–1053PubMed
10.
Zurück zum Zitat Shivalkar B, Van de Heyning C, Kerremans M et al (2006) Obstructive sleep apnea syndrome: More insights on structural and functional cardiac alterations, and the effects of treatment with continuous positive airway pressure. J Am Coll Cardiol 47:1433–1439CrossRefPubMed Shivalkar B, Van de Heyning C, Kerremans M et al (2006) Obstructive sleep apnea syndrome: More insights on structural and functional cardiac alterations, and the effects of treatment with continuous positive airway pressure. J Am Coll Cardiol 47:1433–1439CrossRefPubMed
11.
Zurück zum Zitat Usui K, Parker JD, Newton GE et al (2006) Left ventricular structural adaptations to obstructive sleep apnea in dilated cardiomyopathy. Am J Respir Crit Care Med 173:1170–1175CrossRefPubMed Usui K, Parker JD, Newton GE et al (2006) Left ventricular structural adaptations to obstructive sleep apnea in dilated cardiomyopathy. Am J Respir Crit Care Med 173:1170–1175CrossRefPubMed
12.
Zurück zum Zitat Bradley TD, Floras JS (2009) Obstructive sleep apnoea and its cardiovascular consequences. Lancet 373:82–93CrossRefPubMed Bradley TD, Floras JS (2009) Obstructive sleep apnoea and its cardiovascular consequences. Lancet 373:82–93CrossRefPubMed
13.
Zurück zum Zitat Javaheri S, Parker TJ, Liming JD et al (1998) Sleep apnea in 81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations. Circulation 97:2154–2159PubMed Javaheri S, Parker TJ, Liming JD et al (1998) Sleep apnea in 81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations. Circulation 97:2154–2159PubMed
14.
Zurück zum Zitat Schulz R, Blau A, Borgel J et al (2007) Sleep apnoea in heart failure. Eur Respir J 29:1201–1205CrossRefPubMed Schulz R, Blau A, Borgel J et al (2007) Sleep apnoea in heart failure. Eur Respir J 29:1201–1205CrossRefPubMed
15.
Zurück zum Zitat Sin DD, Fitzgerald F, Parker JD et al (1999) Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure. Am J Respir Crit Care Med 160:1101–1106PubMed Sin DD, Fitzgerald F, Parker JD et al (1999) Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure. Am J Respir Crit Care Med 160:1101–1106PubMed
16.
Zurück zum Zitat Solin P, Bergin P, Richardson M et al (1999) Influence of pulmonary capillary wedge pressure on central apnea in heart failure. Circulation 99:1574–1579PubMed Solin P, Bergin P, Richardson M et al (1999) Influence of pulmonary capillary wedge pressure on central apnea in heart failure. Circulation 99:1574–1579PubMed
17.
Zurück zum Zitat Bixler EO, Vgontzas AN, Ten Have T et al (1998) Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 157:144–148PubMed Bixler EO, Vgontzas AN, Ten Have T et al (1998) Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 157:144–148PubMed
18.
Zurück zum Zitat Shahar E, Whitney CW, Redline S et al (2001) Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study. Am J Respir Crit Care Med 163:19–25PubMed Shahar E, Whitney CW, Redline S et al (2001) Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study. Am J Respir Crit Care Med 163:19–25PubMed
19.
Zurück zum Zitat Malone S, Liu PP, Holloway R et al (1991) Obstructive sleep apnoea in patients with dilated cardiomyopathy: Effects of continuous positive airway pressure. Lancet 338:1480–1484CrossRefPubMed Malone S, Liu PP, Holloway R et al (1991) Obstructive sleep apnoea in patients with dilated cardiomyopathy: Effects of continuous positive airway pressure. Lancet 338:1480–1484CrossRefPubMed
20.
Zurück zum Zitat Tolle FA, Judy WV, Yu PL et al (1983) Reduced stroke volume related to pleural pressure in obstructive sleep apnea. J Appl Physiol 55:1718–1724PubMed Tolle FA, Judy WV, Yu PL et al (1983) Reduced stroke volume related to pleural pressure in obstructive sleep apnea. J Appl Physiol 55:1718–1724PubMed
21.
Zurück zum Zitat Somers VK, Dyken ME, Clary MP et al (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96:1897–1904CrossRefPubMed Somers VK, Dyken ME, Clary MP et al (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96:1897–1904CrossRefPubMed
22.
Zurück zum Zitat Tkacova R, Rankin F, Fitzgerald FS et al (1998) Effects of continuous positive airway pressure on obstructive sleep apnea and left ventricular afterload in patients with heart failure. Circulation 98:2269–2275PubMed Tkacova R, Rankin F, Fitzgerald FS et al (1998) Effects of continuous positive airway pressure on obstructive sleep apnea and left ventricular afterload in patients with heart failure. Circulation 98:2269–2275PubMed
23.
Zurück zum Zitat Becker HF, Jerrentrup A, Ploch T et al (2003) Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 107:68–73CrossRefPubMed Becker HF, Jerrentrup A, Ploch T et al (2003) Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 107:68–73CrossRefPubMed
24.
Zurück zum Zitat Peppard PE, Young T, Palta M et al (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342:1378–1384CrossRefPubMed Peppard PE, Young T, Palta M et al (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342:1378–1384CrossRefPubMed
25.
Zurück zum Zitat Pepperell JC, Maskell NA, Jones DR et al (2003) A randomized controlled trial of adaptive ventilation for cheyne-stokes breathing in heart failure. Am J Respir Crit Care Med 168:1109–1114CrossRefPubMed Pepperell JC, Maskell NA, Jones DR et al (2003) A randomized controlled trial of adaptive ventilation for cheyne-stokes breathing in heart failure. Am J Respir Crit Care Med 168:1109–1114CrossRefPubMed
26.
Zurück zum Zitat Suzuki M, Guilleminault C, Otsuka K et al (1996) Blood pressure „dipping“ and „non-dipping“ in obstructive sleep apnea syndrome patients. Sleep 19:382–387PubMed Suzuki M, Guilleminault C, Otsuka K et al (1996) Blood pressure „dipping“ and „non-dipping“ in obstructive sleep apnea syndrome patients. Sleep 19:382–387PubMed
27.
Zurück zum Zitat Verdecchia P, Porcellati C, Reboldi G et al (2001) Left ventricular hypertrophy as an independent predictor of acute cerebrovascular events in essential hypertension. Circulation 104:2039–2044CrossRefPubMed Verdecchia P, Porcellati C, Reboldi G et al (2001) Left ventricular hypertrophy as an independent predictor of acute cerebrovascular events in essential hypertension. Circulation 104:2039–2044CrossRefPubMed
28.
Zurück zum Zitat Verdecchia P, Schillaci G, Guerrieri M et al (1990) Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation 81:528–536PubMed Verdecchia P, Schillaci G, Guerrieri M et al (1990) Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation 81:528–536PubMed
29.
Zurück zum Zitat Cintron G, Johnson G, Francis G et al (1993) Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure. The V-HeFT VA Cooperative Studies Group. Circulation 87:VI17–VI23PubMed Cintron G, Johnson G, Francis G et al (1993) Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure. The V-HeFT VA Cooperative Studies Group. Circulation 87:VI17–VI23PubMed
30.
Zurück zum Zitat Mancini DM, Eisen H, Kussmaul W et al (1991) Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 83:778–786PubMed Mancini DM, Eisen H, Kussmaul W et al (1991) Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 83:778–786PubMed
31.
Zurück zum Zitat Ponikowski P, Francis DP, Piepoli MF et al (2001) Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance: Marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis. Circulation 103:967–972PubMed Ponikowski P, Francis DP, Piepoli MF et al (2001) Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance: Marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis. Circulation 103:967–972PubMed
32.
Zurück zum Zitat Arzt M, Harth M, Luchner A et al (2003) Enhanced ventilatory response to exercise in patients with chronic heart failure and central sleep apnea. Circulation 107:1998–2003CrossRefPubMed Arzt M, Harth M, Luchner A et al (2003) Enhanced ventilatory response to exercise in patients with chronic heart failure and central sleep apnea. Circulation 107:1998–2003CrossRefPubMed
33.
Zurück zum Zitat Arzt M, Schulz M, Wensel R et al (2005) Nocturnal continuous positive airway pressure improves ventilatory efficiency during exercise in patients with chronic heart failure. Chest 127:794–802CrossRefPubMed Arzt M, Schulz M, Wensel R et al (2005) Nocturnal continuous positive airway pressure improves ventilatory efficiency during exercise in patients with chronic heart failure. Chest 127:794–802CrossRefPubMed
34.
Zurück zum Zitat Cahalin LP, Mathier MA, Semigran MJ et al (1996) The six-minute walk test predicts peak oxygen uptake and survival in patients with advanced heart failure. Chest 110:325–332CrossRefPubMed Cahalin LP, Mathier MA, Semigran MJ et al (1996) The six-minute walk test predicts peak oxygen uptake and survival in patients with advanced heart failure. Chest 110:325–332CrossRefPubMed
35.
Zurück zum Zitat Rostagno C, Olivo G, Comeglio M et al (2003) Prognostic value of 6-minute walk corridor test in patients with mild to moderate heart failure: Comparison with other methods of functional evaluation. Eur J Heart Fail 5:247–252CrossRefPubMed Rostagno C, Olivo G, Comeglio M et al (2003) Prognostic value of 6-minute walk corridor test in patients with mild to moderate heart failure: Comparison with other methods of functional evaluation. Eur J Heart Fail 5:247–252CrossRefPubMed
36.
Zurück zum Zitat Kaneko Y, Floras JS, Usui K et al (2003) Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med 348:1233–1241PubMedCrossRef Kaneko Y, Floras JS, Usui K et al (2003) Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med 348:1233–1241PubMedCrossRef
37.
Zurück zum Zitat Ruttanaumpawan P, Gilman MP, Usui K et al (2008) Sustained effect of continuous positive airway pressure on baroreflex sensitivity in congestive heart failure patients with obstructive sleep apnea. J Hypertens 26:1163–1168CrossRefPubMed Ruttanaumpawan P, Gilman MP, Usui K et al (2008) Sustained effect of continuous positive airway pressure on baroreflex sensitivity in congestive heart failure patients with obstructive sleep apnea. J Hypertens 26:1163–1168CrossRefPubMed
38.
Zurück zum Zitat Gilman MP, Floras JS, Usui K et al (2008) Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci (Lond) 114:243–249 Gilman MP, Floras JS, Usui K et al (2008) Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci (Lond) 114:243–249
39.
Zurück zum Zitat Solin P, Kaye DM, Little PJ et al (2003) Impact of sleep apnea on sympathetic nervous system activity in heart failure. Chest 123:1119–1126CrossRefPubMed Solin P, Kaye DM, Little PJ et al (2003) Impact of sleep apnea on sympathetic nervous system activity in heart failure. Chest 123:1119–1126CrossRefPubMed
40.
Zurück zum Zitat Usui K, Bradley TD, Spaak J et al (2005) Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep anea by nocturnal continuous positive airway pressure. J Am Coll Cardiol 45:2008–2011CrossRefPubMed Usui K, Bradley TD, Spaak J et al (2005) Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep anea by nocturnal continuous positive airway pressure. J Am Coll Cardiol 45:2008–2011CrossRefPubMed
41.
Zurück zum Zitat Ryan CM, Bradley TD (2005) Periodicity of obstructive sleep apnea in patients with and without heart failure. Chest 127:536–542CrossRefPubMed Ryan CM, Bradley TD (2005) Periodicity of obstructive sleep apnea in patients with and without heart failure. Chest 127:536–542CrossRefPubMed
42.
Zurück zum Zitat Tkacova R, Niroumand M, Lorenzi-Filho G et al (2001) Overnight shift from obstructive to central apneas in patients with heart failure: Role of pco2 and circulatory delay. Circulation 103:238–243PubMed Tkacova R, Niroumand M, Lorenzi-Filho G et al (2001) Overnight shift from obstructive to central apneas in patients with heart failure: Role of pco2 and circulatory delay. Circulation 103:238–243PubMed
43.
Zurück zum Zitat Ferguson KA, Cartwright R, Rogers R et al (2006) Oral appliances for snoring and obstructive sleep apnea: A review. Sleep 29:244–262PubMed Ferguson KA, Cartwright R, Rogers R et al (2006) Oral appliances for snoring and obstructive sleep apnea: A review. Sleep 29:244–262PubMed
44.
Zurück zum Zitat Gotsopoulos H, Kelly JJ, Cistulli PA (2004) Oral appliance therapy reduces blood pressure in obstructive sleep apnea: A randomized, controlled trial. Sleep 27:934–941PubMed Gotsopoulos H, Kelly JJ, Cistulli PA (2004) Oral appliance therapy reduces blood pressure in obstructive sleep apnea: A randomized, controlled trial. Sleep 27:934–941PubMed
45.
Zurück zum Zitat Eskafi M, Cline C, Israelsson B et al (2004) A mandibular advancement device reduces sleep disordered breathing in patients with congestive heart failure. Swed Dent J 28:155–163PubMed Eskafi M, Cline C, Israelsson B et al (2004) A mandibular advancement device reduces sleep disordered breathing in patients with congestive heart failure. Swed Dent J 28:155–163PubMed
46.
Zurück zum Zitat Eskafi M (2004) Sleep apnoea in patients with stable congestive heart failure an intervention study with a mandibular advancement device. Swed Dent J Suppl 1–56 Eskafi M (2004) Sleep apnoea in patients with stable congestive heart failure an intervention study with a mandibular advancement device. Swed Dent J Suppl 1–56
47.
Zurück zum Zitat Sin DD, Logan AG, Fitzgerald FS et al (2000) Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without cheyne-stokes respiration. Circulation 102:61–66PubMed Sin DD, Logan AG, Fitzgerald FS et al (2000) Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without cheyne-stokes respiration. Circulation 102:61–66PubMed
48.
Zurück zum Zitat Light RW, George RB (1983) Serial pulmonary function in patients with acute heart failure. Arch Intern Med 143:429–433CrossRefPubMed Light RW, George RB (1983) Serial pulmonary function in patients with acute heart failure. Arch Intern Med 143:429–433CrossRefPubMed
49.
Zurück zum Zitat Hosenpud JD, Stibolt TA, Atwal K et al (1990) Abnormal pulmonary function specifically related to congestive heart failure: Comparison of patients before and after cardiac transplantation. Am J Med 88:493–496CrossRefPubMed Hosenpud JD, Stibolt TA, Atwal K et al (1990) Abnormal pulmonary function specifically related to congestive heart failure: Comparison of patients before and after cardiac transplantation. Am J Med 88:493–496CrossRefPubMed
50.
Zurück zum Zitat Naum CC, Sciurba FC, Rogers RM (1992) Pulmonary function abnormalities in chronic severe cardiomyopathy preceding cardiac transplantation. Am Rev Respir Dis 145:1334–1338PubMed Naum CC, Sciurba FC, Rogers RM (1992) Pulmonary function abnormalities in chronic severe cardiomyopathy preceding cardiac transplantation. Am Rev Respir Dis 145:1334–1338PubMed
51.
Zurück zum Zitat Naughton MT, Bookman I, Floras JS et al (1995) Effect of CPAP on respiratory mechanics in heart failure. Am J Respir Crit Care Med 151:A706 Naughton MT, Bookman I, Floras JS et al (1995) Effect of CPAP on respiratory mechanics in heart failure. Am J Respir Crit Care Med 151:A706
52.
Zurück zum Zitat Krachman SL, Crocetti J, Berger TJ et al (2003) Effects of nasal continuous positive airway pressure on oxygen body stores in patients with cheyne-stokes respiration and congestive heart failure. Chest 123:59–66CrossRefPubMed Krachman SL, Crocetti J, Berger TJ et al (2003) Effects of nasal continuous positive airway pressure on oxygen body stores in patients with cheyne-stokes respiration and congestive heart failure. Chest 123:59–66CrossRefPubMed
53.
Zurück zum Zitat Barach AL, Swenson P (1939) Effect of breathing gases under positive pressure on lumens of small and medium sized bronchi. Arch Int Med 63:946–948 Barach AL, Swenson P (1939) Effect of breathing gases under positive pressure on lumens of small and medium sized bronchi. Arch Int Med 63:946–948
54.
Zurück zum Zitat Naughton MT, Rahman MA, Hara K et al (1995) Effect of continuous positive airway pressure on intrathoracic and left ventricular transmural pressures in patients with congestive heart failure. Circulation 91:1725–1731PubMed Naughton MT, Rahman MA, Hara K et al (1995) Effect of continuous positive airway pressure on intrathoracic and left ventricular transmural pressures in patients with congestive heart failure. Circulation 91:1725–1731PubMed
55.
Zurück zum Zitat Kaye DM, Mansfield D, Aggarwal A et al (2001) Acute effects of continuous positive airway pressure on cardiac sympathetic tone in congestive heart failure. Circulation 103:2336–2338PubMed Kaye DM, Mansfield D, Aggarwal A et al (2001) Acute effects of continuous positive airway pressure on cardiac sympathetic tone in congestive heart failure. Circulation 103:2336–2338PubMed
56.
Zurück zum Zitat Kaye DM, Mansfield D, Naughton MT (2004) Continuous positive airway pressure decreases myocardial oxygen consumption in heart failure. Clin Sci (Lond) 106:599–603 Kaye DM, Mansfield D, Naughton MT (2004) Continuous positive airway pressure decreases myocardial oxygen consumption in heart failure. Clin Sci (Lond) 106:599–603
57.
Zurück zum Zitat De Hoyos A, Liu PP, Benard DC et al (1995) Haemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function. Clin Sci (Lond) 88:173–178 De Hoyos A, Liu PP, Benard DC et al (1995) Haemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function. Clin Sci (Lond) 88:173–178
58.
Zurück zum Zitat Ryan CM, Usui K, Floras JS et al (2005) Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea. Thorax 60:781–785CrossRefPubMed Ryan CM, Usui K, Floras JS et al (2005) Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea. Thorax 60:781–785CrossRefPubMed
59.
Zurück zum Zitat Mansfield DR, Gollogly NC, Kaye DM et al (2004) Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 169:361–366CrossRefPubMed Mansfield DR, Gollogly NC, Kaye DM et al (2004) Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 169:361–366CrossRefPubMed
60.
Zurück zum Zitat Smith LA, Vennelle M, Gardner RS et al (2007) Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: A randomized placebo-controlled trial. Eur Heart J 28:1221–1227CrossRefPubMed Smith LA, Vennelle M, Gardner RS et al (2007) Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: A randomized placebo-controlled trial. Eur Heart J 28:1221–1227CrossRefPubMed
61.
Zurück zum Zitat Wang H, Parker JD, Newton GE et al (2007) Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol 49:1625–1631CrossRefPubMed Wang H, Parker JD, Newton GE et al (2007) Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol 49:1625–1631CrossRefPubMed
62.
Zurück zum Zitat Kasai T, Narui K, Dohi T et al (2008) Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 133:690–696CrossRefPubMed Kasai T, Narui K, Dohi T et al (2008) Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 133:690–696CrossRefPubMed
63.
Zurück zum Zitat Arias MA, Garcia-Rio F, Alonso-Fernandez A et al (2005) Obstructive sleep apnea syndrome affects left ventricular diastolic function: Effects of nasal continuous positive airway pressure in men. Circulation 112:375–383CrossRefPubMed Arias MA, Garcia-Rio F, Alonso-Fernandez A et al (2005) Obstructive sleep apnea syndrome affects left ventricular diastolic function: Effects of nasal continuous positive airway pressure in men. Circulation 112:375–383CrossRefPubMed
64.
Zurück zum Zitat Arzt M, Young T, Finn L et al (2006) Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med 166:1716–1722CrossRefPubMed Arzt M, Young T, Finn L et al (2006) Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med 166:1716–1722CrossRefPubMed
65.
Zurück zum Zitat Hastings PC, Vazir A, O’Driscoll DM et al (2006) Symptom burden of sleep-disordered breathing in mild-to-moderate congestive heart failure patients. Eur Respir J 27:748–755CrossRefPubMed Hastings PC, Vazir A, O’Driscoll DM et al (2006) Symptom burden of sleep-disordered breathing in mild-to-moderate congestive heart failure patients. Eur Respir J 27:748–755CrossRefPubMed
66.
Zurück zum Zitat Arzt M, Floras JS, Logan AG et al (2007) Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: A post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure trial (CANPAP). Circulation 115:3173–3180CrossRefPubMed Arzt M, Floras JS, Logan AG et al (2007) Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: A post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure trial (CANPAP). Circulation 115:3173–3180CrossRefPubMed
Metadaten
Titel
Obstruktive Schlafapnoe bei Herzinsuffizienz
verfasst von
PD Dr. M. Arzt
R. Obermeier
Publikationsdatum
01.03.2010
Verlag
Springer-Verlag
Erschienen in
Somnologie / Ausgabe 1/2010
Print ISSN: 1432-9123
Elektronische ISSN: 1439-054X
DOI
https://doi.org/10.1007/s11818-010-0456-y

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Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

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