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2021 | OriginalPaper | Buchkapitel

15. Okuläre Beteiligung bei Stevens-Johnson-Syndrom (SJS) und Toxisch epidermaler Nekrolyse (TEN) (engl. Stevens-Johnson syndrome, SJS, and toxic epidermal necrolysis, TEN)

verfasst von : Argyrios Chronopoulos, Maja Mockenhaupt, Uwe Pleyer

Erschienen in: Entzündliche Augenerkrankungen

Verlag: Springer Berlin Heidelberg

Zusammenfassung

ICD-10-Code L12 Pemphigoiderkrankungen, L51.1 Erythema exsudativum multiforme; Stevens-Johnson-Syndrom; Toxisch epidermale Nekrolyse
Literatur
Zurück zum Zitat Araki Y, Sotozono C, Inatomi T, Ueta M, Yokoi N, Ueda E, Kishimoto S, Kinoshita S (2009) Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset. Am J Ophthalmol 147(6):1004–1011PubMedCrossRef Araki Y, Sotozono C, Inatomi T, Ueta M, Yokoi N, Ueda E, Kishimoto S, Kinoshita S (2009) Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset. Am J Ophthalmol 147(6):1004–1011PubMedCrossRef
Zurück zum Zitat Arévalo JM, Lorente JA, González-Herrada C, Jiménez-Reyes J (2000) Treatment of toxic epidermal necrolysis with cyclosporin A. J Trauma 48:473–478PubMedCrossRef Arévalo JM, Lorente JA, González-Herrada C, Jiménez-Reyes J (2000) Treatment of toxic epidermal necrolysis with cyclosporin A. J Trauma 48:473–478PubMedCrossRef
Zurück zum Zitat Bastuji-Garin S, Fouchard N, Bertocchi M, Roujeau JC, Revuz J, Wolkenstein P (2000) SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 115:149–153PubMedCrossRef Bastuji-Garin S, Fouchard N, Bertocchi M, Roujeau JC, Revuz J, Wolkenstein P (2000) SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 115:149–153PubMedCrossRef
Zurück zum Zitat Basu S, Pillai VS, Sangwan VS (2013) Mucosal complications of modified osteoodonto keratoprosthesis in chronic Stevens–Johnson syndrome. Am J Ophthalmol 156:867–873.e2PubMedCrossRef Basu S, Pillai VS, Sangwan VS (2013) Mucosal complications of modified osteoodonto keratoprosthesis in chronic Stevens–Johnson syndrome. Am J Ophthalmol 156:867–873.e2PubMedCrossRef
Zurück zum Zitat Basu S, Shanbhag SS, Gokani A, Kedar R, Bahuguna C, Sangwan VS (2018) Chronic ocular sequelae of stevens-johnson syndrome in children: long-term impact of appropriate therapy on natural history of disease. Am J Ophthalmol 189:17–28PubMedCrossRef Basu S, Shanbhag SS, Gokani A, Kedar R, Bahuguna C, Sangwan VS (2018) Chronic ocular sequelae of stevens-johnson syndrome in children: long-term impact of appropriate therapy on natural history of disease. Am J Ophthalmol 189:17–28PubMedCrossRef
Zurück zum Zitat Bohm KJ, Ciralsky JB, Harp JL, Bajaj S, Sippel KC (2016) Cicatrizing conjunctivitis in a patient diagnosed with drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome but with features of stevens-johnson syndrome. Cornea 35:888–891PubMedCrossRef Bohm KJ, Ciralsky JB, Harp JL, Bajaj S, Sippel KC (2016) Cicatrizing conjunctivitis in a patient diagnosed with drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome but with features of stevens-johnson syndrome. Cornea 35:888–891PubMedCrossRef
Zurück zum Zitat Catt CJ, Hamilton GM, Fish J et al (2016) Ocular manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis in children. Am J Ophthalmol 166:68–75PubMedCrossRef Catt CJ, Hamilton GM, Fish J et al (2016) Ocular manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis in children. Am J Ophthalmol 166:68–75PubMedCrossRef
Zurück zum Zitat Chung WH, Hung SI et al (2008) Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 14(12):1343–1350PubMedCrossRef Chung WH, Hung SI et al (2008) Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 14(12):1343–1350PubMedCrossRef
Zurück zum Zitat Creamer D, Walsh SA, Dziewulski P et al (2016) U.K. guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016. Br J Dermatol 174:1194–1227PubMedCrossRef Creamer D, Walsh SA, Dziewulski P et al (2016) U.K. guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016. Br J Dermatol 174:1194–1227PubMedCrossRef
Zurück zum Zitat De La Paz MF, De Toledo JA, Charoenrook V et al (2011) Impact of clinical factors on the long-term functional and anatomic outcomes of osteo-odonto-keratoprosthesis and tibial bone keratoprosthesis. Am J Ophthalmol 151:829–839.e1CrossRef De La Paz MF, De Toledo JA, Charoenrook V et al (2011) Impact of clinical factors on the long-term functional and anatomic outcomes of osteo-odonto-keratoprosthesis and tibial bone keratoprosthesis. Am J Ophthalmol 151:829–839.e1CrossRef
Zurück zum Zitat De Rojas MV, Dart JK et al (2007) The natural history of Stevens Johnson syndrome: patterns of chronic ocular disease and the role of systemic immunosuppressive therapy. Br J Ophthalmol 91(8):1048–1053PubMedPubMedCentralCrossRef De Rojas MV, Dart JK et al (2007) The natural history of Stevens Johnson syndrome: patterns of chronic ocular disease and the role of systemic immunosuppressive therapy. Br J Ophthalmol 91(8):1048–1053PubMedPubMedCentralCrossRef
Zurück zum Zitat Faye O, Roujeau JC (2005) Treatment of epidermal necrolysis with high-dose intravenous im-munoglobulins (IVIG). Clinical experience to date. Drugs 65(15):2085–2090PubMedCrossRef Faye O, Roujeau JC (2005) Treatment of epidermal necrolysis with high-dose intravenous im-munoglobulins (IVIG). Clinical experience to date. Drugs 65(15):2085–2090PubMedCrossRef
Zurück zum Zitat González-Herrada C, Rodríguez-Martín S, Cachafeiro L et al (2017) Cyclosporine use in epidermal necrolysis is associated with an important mortality reduction: evidence from three different approaches. J Invest Dermatol 137:2092–2100PubMedCrossRef González-Herrada C, Rodríguez-Martín S, Cachafeiro L et al (2017) Cyclosporine use in epidermal necrolysis is associated with an important mortality reduction: evidence from three different approaches. J Invest Dermatol 137:2092–2100PubMedCrossRef
Zurück zum Zitat Gregory DG (2016) New grading system and treatment guidelines for the acute ocular manifestations of stevens-johnson syndrome. Ophthalmology 123:1653–1658PubMedCrossRef Gregory DG (2016) New grading system and treatment guidelines for the acute ocular manifestations of stevens-johnson syndrome. Ophthalmology 123:1653–1658PubMedCrossRef
Zurück zum Zitat Gueudry J, Roujeau JC, Binaghi M, Soubrane G, Muraine M (2009). Risk factors for the development of ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. Arch Dermatol 145(2):157–162. Gueudry J, Roujeau JC, Binaghi M, Soubrane G, Muraine M (2009). Risk factors for the development of ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. Arch Dermatol 145(2):157–162.
Zurück zum Zitat Gungor I, Schor K et al (2008) The Boston Scleral Lens in the treatment of pediatric patients. J AAPOS 12(3):263–267PubMedCrossRef Gungor I, Schor K et al (2008) The Boston Scleral Lens in the treatment of pediatric patients. J AAPOS 12(3):263–267PubMedCrossRef
Zurück zum Zitat Haber J, Hopman W et al (2005) Late outcomes in adult survivors of toxic epidermal necrolysis after treatment in a burn center. J Burn Care Rehabil 26(1):33–41PubMedCrossRef Haber J, Hopman W et al (2005) Late outcomes in adult survivors of toxic epidermal necrolysis after treatment in a burn center. J Burn Care Rehabil 26(1):33–41PubMedCrossRef
Zurück zum Zitat Huang Y-C, Li Y-C, Chen T-J (2012) The efficacy of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis: a systematic review and meta-analysis. Br J Dermatol 167:424–432PubMedCrossRef Huang Y-C, Li Y-C, Chen T-J (2012) The efficacy of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis: a systematic review and meta-analysis. Br J Dermatol 167:424–432PubMedCrossRef
Zurück zum Zitat Iyer G, Pillai VS, Srinivasan B et al (2010) Mucous membrane grafting for lid margin keratinization in Stevens–Johnson syndrome: results. Cornea 29:146–151PubMedCrossRef Iyer G, Pillai VS, Srinivasan B et al (2010) Mucous membrane grafting for lid margin keratinization in Stevens–Johnson syndrome: results. Cornea 29:146–151PubMedCrossRef
Zurück zum Zitat Iyer G, Srinivasan B, Agarwal S et al (2014) Comprehensive approach to ocular consequences of Stevens Johnson Syndrome – the aftermath of a systemic condition. Graefes Arch Clin Exp Ophthalmol 252:457–467PubMedCrossRef Iyer G, Srinivasan B, Agarwal S et al (2014) Comprehensive approach to ocular consequences of Stevens Johnson Syndrome – the aftermath of a systemic condition. Graefes Arch Clin Exp Ophthalmol 252:457–467PubMedCrossRef
Zurück zum Zitat Iyer G, Srinivasan B, Agarwal S et al (2016) Treatment modalities and clinical outcomes in ocular sequelae of Stevens–Johnson syndrome over 25 years – a paradigm shift. Cornea 35:46–50PubMedCrossRef Iyer G, Srinivasan B, Agarwal S et al (2016) Treatment modalities and clinical outcomes in ocular sequelae of Stevens–Johnson syndrome over 25 years – a paradigm shift. Cornea 35:46–50PubMedCrossRef
Zurück zum Zitat Jain R, Sharma N, Basu S, Iyer G (2016) Stevens-Johnson syndrome: the role of an ophthalmologist. Surv Ophthalmol 61:369–399PubMedCrossRef Jain R, Sharma N, Basu S, Iyer G (2016) Stevens-Johnson syndrome: the role of an ophthalmologist. Surv Ophthalmol 61:369–399PubMedCrossRef
Zurück zum Zitat Kim DH, Yoon KC, Seo KY et al (2015) The role of systemic immunomodulatory treatment and prognostic factors on chronic ocular complications in Stevens–Johnson syndrome. Ophthalmology 122:254–264PubMedCrossRef Kim DH, Yoon KC, Seo KY et al (2015) The role of systemic immunomodulatory treatment and prognostic factors on chronic ocular complications in Stevens–Johnson syndrome. Ophthalmology 122:254–264PubMedCrossRef
Zurück zum Zitat Kirchhof MG, Miliszewski MA, Sikora S, Papp A, Dutz JP (2014) Retrospective review of Stevens-Johnson syndrome/toxic epidermal necrolysis treatment comparing intravenous immunoglobulin with cyclosporine. J Am Acad Dermatol 71:941–947PubMedCrossRef Kirchhof MG, Miliszewski MA, Sikora S, Papp A, Dutz JP (2014) Retrospective review of Stevens-Johnson syndrome/toxic epidermal necrolysis treatment comparing intravenous immunoglobulin with cyclosporine. J Am Acad Dermatol 71:941–947PubMedCrossRef
Zurück zum Zitat Kohanim S, Palioura S, Saeed HN et al (2016) Acute and chronic ophthalmic involvement in Stevens–Johnson syndrome/toxic epidermal necrolysis – a comprehensive review and guide to therapy. II Ophthalmic disease Ocul Surf 14:168–188PubMedCrossRef Kohanim S, Palioura S, Saeed HN et al (2016) Acute and chronic ophthalmic involvement in Stevens–Johnson syndrome/toxic epidermal necrolysis – a comprehensive review and guide to therapy. II Ophthalmic disease Ocul Surf 14:168–188PubMedCrossRef
Zurück zum Zitat Kuper K, Pleyer U et al (1995) Erythema exsudativum multiforme major. Ophthalmologe 92(6):823–828PubMed Kuper K, Pleyer U et al (1995) Erythema exsudativum multiforme major. Ophthalmologe 92(6):823–828PubMed
Zurück zum Zitat Lee HY, Lim YL, Thirumoorthy T, Pang SM (2013) The role of intravenous immunoglobulin in toxic epidermal necrolysis: a retrospective analysis of 64 patients managed in a specialized centre. Br J Dermatol 169:1304–1309PubMedCrossRef Lee HY, Lim YL, Thirumoorthy T, Pang SM (2013) The role of intravenous immunoglobulin in toxic epidermal necrolysis: a retrospective analysis of 64 patients managed in a specialized centre. Br J Dermatol 169:1304–1309PubMedCrossRef
Zurück zum Zitat Lonjou C, Thomas L et al (2006) A marker for Stevens-Johnson syndrome …: ethnicity matters. Pharm J 6(4):265–268 Lonjou C, Thomas L et al (2006) A marker for Stevens-Johnson syndrome …: ethnicity matters. Pharm J 6(4):265–268
Zurück zum Zitat Lonjou C, Thomas L et al (2006) A marker for Stevens-Johnson syndrome …: ethnicity matters. Pharm J 6(4):265–268 Lonjou C, Thomas L et al (2006) A marker for Stevens-Johnson syndrome …: ethnicity matters. Pharm J 6(4):265–268
Zurück zum Zitat Lonjou C, Borot N et al (2008) A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics 18(2):99–107PubMedCrossRef Lonjou C, Borot N et al (2008) A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics 18(2):99–107PubMedCrossRef
Zurück zum Zitat Ma KN et al (2016) A novel technique for amniotic membrane transplantation in patients with acute Stevens-Johnson syndrome. Ocul Surf 14:31–36PubMedCrossRef Ma KN et al (2016) A novel technique for amniotic membrane transplantation in patients with acute Stevens-Johnson syndrome. Ocul Surf 14:31–36PubMedCrossRef
Zurück zum Zitat Mockenhaupt M (2011) The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol 7(6):814–815CrossRef Mockenhaupt M (2011) The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol 7(6):814–815CrossRef
Zurück zum Zitat Mockenhaupt M (2011) The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol 7(6):814–815CrossRef Mockenhaupt M (2011) The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol 7(6):814–815CrossRef
Zurück zum Zitat Mockenhaupt M, Roujeau JC (2019) Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. In: Kang S, Amagai M, Bruckner A, Enk AH, Margolis DJ, McMichael AJ, Orringer JS (Hrsg) Fitzpatrick’s dermatology, 9. Aufl. McGraw Hill Education, S 733–748, chapt. 44 Mockenhaupt M, Roujeau JC (2019) Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. In: Kang S, Amagai M, Bruckner A, Enk AH, Margolis DJ, McMichael AJ, Orringer JS (Hrsg) Fitzpatrick’s dermatology, 9. Aufl. McGraw Hill Education, S 733–748, chapt. 44
Zurück zum Zitat Mockenhaupt M, Viboud C et al (2008) Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 128(1):35–44PubMedCrossRef Mockenhaupt M, Viboud C et al (2008) Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 128(1):35–44PubMedCrossRef
Zurück zum Zitat Paulmann M, Mockenhaupt M (2019) Schwere Hautreaktionen: klinisches Bild, Epidemiologie, Ätiologie, Pathogenese und Therapie. Allergo J Int 28:311–326CrossRef Paulmann M, Mockenhaupt M (2019) Schwere Hautreaktionen: klinisches Bild, Epidemiologie, Ätiologie, Pathogenese und Therapie. Allergo J Int 28:311–326CrossRef
Zurück zum Zitat Oplatek A, Brown K et al (2006) Long-term follow-up of patients treated for toxic epidermal necrolysis. J Burn Care Res 27(1):26PubMedCrossRef Oplatek A, Brown K et al (2006) Long-term follow-up of patients treated for toxic epidermal necrolysis. J Burn Care Res 27(1):26PubMedCrossRef
Zurück zum Zitat Ong HS, Minassian D, Rauz S, Mehta JS, Dart JK (2019) Validation of a clinical assessment tool for cicatrising conjunctivitis. Ocul Surf pii: S1542-0124(19):30210–30211 Ong HS, Minassian D, Rauz S, Mehta JS, Dart JK (2019) Validation of a clinical assessment tool for cicatrising conjunctivitis. Ocul Surf pii: S1542-0124(19):30210–30211
Zurück zum Zitat Papakostas TD, Le HG, Chodosh J, Jacobs DS (2015) Prosthetic replacement of the ocular surface ecosystem as treatment for ocular surface disease in patients with a history of Stevens–Johnson syndrome/toxic epidermal necrolysis. Ophthalmology 122:248–253PubMedCrossRef Papakostas TD, Le HG, Chodosh J, Jacobs DS (2015) Prosthetic replacement of the ocular surface ecosystem as treatment for ocular surface disease in patients with a history of Stevens–Johnson syndrome/toxic epidermal necrolysis. Ophthalmology 122:248–253PubMedCrossRef
Zurück zum Zitat Paulmann M, Kremmler C, Sekula P, Valeyrie-Allanore L, Naldi L, Kardaun S, Mockenhaupt M for the RegiSCAR Group (2016) Long-term sequelae in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis. Allergy (Journal of the European Academy of Allergy and Clinical Immunology (EAACI)), link BioMedCentral platform 3. Paulmann M, Kremmler C, Sekula P, Valeyrie-Allanore L, Naldi L, Kardaun S, Mockenhaupt M for the RegiSCAR Group (2016) Long-term sequelae in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis. Allergy (Journal of the European Academy of Allergy and Clinical Immunology (EAACI)), link BioMedCentral platform 3.
Zurück zum Zitat Quinto GG, Campos M et al (2008) Autologous serum for ocular surface diseases. Arq Bras Oftalmol 71(6):47–54PubMedCrossRef Quinto GG, Campos M et al (2008) Autologous serum for ocular surface diseases. Arq Bras Oftalmol 71(6):47–54PubMedCrossRef
Zurück zum Zitat Romero-Rangel T, Stavrou P et al (2000) Gas-permeable scleral contact lens therapy in ocular surface disease. Am J Ophthalmol 130(1):25–32PubMedCrossRef Romero-Rangel T, Stavrou P et al (2000) Gas-permeable scleral contact lens therapy in ocular surface disease. Am J Ophthalmol 130(1):25–32PubMedCrossRef
Zurück zum Zitat Rootman DB, Kim MJ, Aldave AJ et al (2015) Ocular surface, fornix, and eyelid rehabilitation in Boston type I keratoprosthesis patients with mucous membrane disease. Ophthal Plast Reconstr Surg 31:43–49PubMedCrossRef Rootman DB, Kim MJ, Aldave AJ et al (2015) Ocular surface, fornix, and eyelid rehabilitation in Boston type I keratoprosthesis patients with mucous membrane disease. Ophthal Plast Reconstr Surg 31:43–49PubMedCrossRef
Zurück zum Zitat Roujeau JC, Huynh TN et al (1987) Genetic susceptibility to toxic epidermal necrolysis. Arch Dermatol 123(9):1171–1173PubMedCrossRef Roujeau JC, Huynh TN et al (1987) Genetic susceptibility to toxic epidermal necrolysis. Arch Dermatol 123(9):1171–1173PubMedCrossRef
Zurück zum Zitat Roujeau JC, Mockenhaupt M, Guillaume JC, Revuz J (2017) New evidence supporting cyclosporine efficacy in epidermal necrolysis. J Invest dermatol 137:2047–2049PubMedCrossRef Roujeau JC, Mockenhaupt M, Guillaume JC, Revuz J (2017) New evidence supporting cyclosporine efficacy in epidermal necrolysis. J Invest dermatol 137:2047–2049PubMedCrossRef
Zurück zum Zitat Roujeau JC, Mockenhaupt M (2019) Erythema multiforme. In: Kang S, Amagai M, Bruckner A, Enk AH, Margolis DJ, McMichael AJ, Orringer JS (Hrsg) Fitzpatrick’s dermatology, 9. Aufl. McGraw Hill Education, S 723–732, chapt. 43 Roujeau JC, Mockenhaupt M (2019) Erythema multiforme. In: Kang S, Amagai M, Bruckner A, Enk AH, Margolis DJ, McMichael AJ, Orringer JS (Hrsg) Fitzpatrick’s dermatology, 9. Aufl. McGraw Hill Education, S 723–732, chapt. 43
Zurück zum Zitat Roujeau JC, Phlippoteau C et al (1985) Sjögren-like syndrome after drug-induced toxic epidermal necrolysis. Lancet 1(8429):609–611PubMedCrossRef Roujeau JC, Phlippoteau C et al (1985) Sjögren-like syndrome after drug-induced toxic epidermal necrolysis. Lancet 1(8429):609–611PubMedCrossRef
Zurück zum Zitat Rzany B, Mockenhaupt M et al (1996) Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990–1992): structure and results of a population-based registry. J Clin Epidemiol 49(7):769–773PubMedCrossRef Rzany B, Mockenhaupt M et al (1996) Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990–1992): structure and results of a population-based registry. J Clin Epidemiol 49(7):769–773PubMedCrossRef
Zurück zum Zitat Saeed HN, Rashad R (2020) Ocular disease in Stevens-Johnson syndrome and toxic epidermal necrolysis. In: Colby K, Dana R (Hrsg) Foundations of corneal disease. Springer, Berlin, Heidelberg S 97–108 Saeed HN, Rashad R (2020) Ocular disease in Stevens-Johnson syndrome and toxic epidermal necrolysis. In: Colby K, Dana R (Hrsg) Foundations of corneal disease. Springer, Berlin, Heidelberg S 97–108
Zurück zum Zitat Sharma N, Thenarasun SA, Kaur M et al (2016) Adjuvant role of amniotic membrane transplantation in acute ocular Stevens–Johnson syndrome: a randomized control trial. Ophthalmology 123:484–491PubMedCrossRef Sharma N, Thenarasun SA, Kaur M et al (2016) Adjuvant role of amniotic membrane transplantation in acute ocular Stevens–Johnson syndrome: a randomized control trial. Ophthalmology 123:484–491PubMedCrossRef
Zurück zum Zitat Sotozono C, Ueta M, Nakatani E et al (2015) Japanese Research committee on severe cutaneous adverse reaction. Predictive factors associated with acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis. Am J Ophthalmol 160:228–237PubMedCrossRef Sotozono C, Ueta M, Nakatani E et al (2015) Japanese Research committee on severe cutaneous adverse reaction. Predictive factors associated with acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis. Am J Ophthalmol 160:228–237PubMedCrossRef
Zurück zum Zitat Sotozono C, Ueta M, Yokoi N (2018) Severe dry eye with combined mechanisms is involved in the ocular sequelae of SJS/TEN at the chronic stage. Invest Ophthalmol Vis Sci 59:DES80–DES86PubMedCrossRef Sotozono C, Ueta M, Yokoi N (2018) Severe dry eye with combined mechanisms is involved in the ocular sequelae of SJS/TEN at the chronic stage. Invest Ophthalmol Vis Sci 59:DES80–DES86PubMedCrossRef
Zurück zum Zitat Su S-C, Mockenhaupt M, Wolkenstein P et al (2017) Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis. J Invest Dermatol 137:1065–1073PubMedCrossRef Su S-C, Mockenhaupt M, Wolkenstein P et al (2017) Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis. J Invest Dermatol 137:1065–1073PubMedCrossRef
Zurück zum Zitat Tougeron-Brousseau B, Delcampe A et al (2009) Vision-related function after scleral lens fitting in ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. Am J Ophthalmol 148(6):852–859PubMedCrossRef Tougeron-Brousseau B, Delcampe A et al (2009) Vision-related function after scleral lens fitting in ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. Am J Ophthalmol 148(6):852–859PubMedCrossRef
Zurück zum Zitat Valeyrie-Allanore L, Wolkenstein P, Brochard L, Ortonne N, Maître B, Revuz J, Bagot M, Roujeau JC (2010) Open trial of ciclosporin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis. Br J Dermatol 163:847–853PubMedCrossRef Valeyrie-Allanore L, Wolkenstein P, Brochard L, Ortonne N, Maître B, Revuz J, Bagot M, Roujeau JC (2010) Open trial of ciclosporin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis. Br J Dermatol 163:847–853PubMedCrossRef
Zurück zum Zitat Wang C-W, Yang L-Y, Chen C-B et al (2018) Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions. J Clin Invest 128:985–996PubMedPubMedCentralCrossRef Wang C-W, Yang L-Y, Chen C-B et al (2018) Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions. J Clin Invest 128:985–996PubMedPubMedCentralCrossRef
Zurück zum Zitat Weber SL, de Souza RB, Gomes JA, Hofling-Lima AL (2016) The use of the esclera scleral contact lens in the treatment of moderate to severe dry eye disease. Am J Ophthalmol 163:167–173.e1CrossRef Weber SL, de Souza RB, Gomes JA, Hofling-Lima AL (2016) The use of the esclera scleral contact lens in the treatment of moderate to severe dry eye disease. Am J Ophthalmol 163:167–173.e1CrossRef
Zurück zum Zitat White KD, Abe R, Ardern-Jones M et al (2018) Special Article: SJS/TEN 2017: building multidisciplinary networks to drive science and translation. J Allergy Clin Immunol Pract 6(1):38–69PubMedPubMedCentralCrossRef White KD, Abe R, Ardern-Jones M et al (2018) Special Article: SJS/TEN 2017: building multidisciplinary networks to drive science and translation. J Allergy Clin Immunol Pract 6(1):38–69PubMedPubMedCentralCrossRef
Zurück zum Zitat Wolkenstein P, Latarjet J, Roujeau JC et al (1998) Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis. Lancet Lond Engl 352:1586–1589CrossRef Wolkenstein P, Latarjet J, Roujeau JC et al (1998) Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis. Lancet Lond Engl 352:1586–1589CrossRef
Zurück zum Zitat Yang CW, Cho YT, Chen KL, Chen YC, Song HL, Chu CY (2016) Long-term sequelae of stevens-johnson syndrome/toxic epidermal necrolysis. Acta Derm Venereol 96(4):525–529PubMedCrossRef Yang CW, Cho YT, Chen KL, Chen YC, Song HL, Chu CY (2016) Long-term sequelae of stevens-johnson syndrome/toxic epidermal necrolysis. Acta Derm Venereol 96(4):525–529PubMedCrossRef
Zurück zum Zitat Zimmermann S, Sekula P, Venhoff M, Motschall E, Knaus J, Schumacher M, Mockenhaupt M (2017) Systemic immunomodulating therapies for stevens-johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis. JAMA Dermatol 153:514–522PubMedPubMedCentralCrossRef Zimmermann S, Sekula P, Venhoff M, Motschall E, Knaus J, Schumacher M, Mockenhaupt M (2017) Systemic immunomodulating therapies for stevens-johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis. JAMA Dermatol 153:514–522PubMedPubMedCentralCrossRef
Metadaten
Titel
Okuläre Beteiligung bei und Toxisch epidermaler Nekrolyse (engl. Stevens-Johnson syndrome, SJS, and toxic epidermal necrolysis, TEN)
verfasst von
Argyrios Chronopoulos
Maja Mockenhaupt
Uwe Pleyer
Copyright-Jahr
2021
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-60399-4_15

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Die bestmögliche Wundheilung der Kornea, insbesondere ohne die Ausbildung von lichtstreuenden Narben, ist oberstes Gebot, um einer dauerhaften Schädigung der Hornhaut frühzeitig entgegenzuwirken und die Funktion des Auges zu erhalten.   

Update Augenheilkunde

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