Skip to main content
Erschienen in: Lasers in Medical Science 4/2018

21.12.2017 | Original Article

One-pot exfoliation, functionalization, and size manipulation of graphene sheets: efficient system for biomedical applications

verfasst von: Farhad Bani, Ali Bodaghi, Abbas Dadkhah, Soodabeh Movahedi, Narges Bodaghabadi, Majid Sadeghizadeh, Mohsen Adeli

Erschienen in: Lasers in Medical Science | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

In this work, we reported a facile method to produce stable aqueous graphene dispersion through direct exfoliation of graphite by modified hyperbranched polyglycerol. Size of graphene sheets was manipulated by simultaneous exfoliation and sonication of graphite, and functionalized graphene sheets with narrow size distribution were obtained. The polyglycerol-functionalized graphene sheets exhibited highly efficient cellular uptake and photothermal conversion, enabling it to serve as a photothermal agent for cancer therapy.
Literatur
2.
Zurück zum Zitat Abbasi E, Akbarzadeh A, Kouhi M, Milani M (2016) Graphene: synthesis, bio-applications, and properties. Artif Cells Nanomed Biotechnol 44(1):150–156CrossRefPubMed Abbasi E, Akbarzadeh A, Kouhi M, Milani M (2016) Graphene: synthesis, bio-applications, and properties. Artif Cells Nanomed Biotechnol 44(1):150–156CrossRefPubMed
3.
Zurück zum Zitat Eyvazzadeh N, Shakeri-Zadeh A, Fekrazad R, Amini E, Ghaznavi H, Kamrava SK (2017) Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer. Lasers Med Sci 32(152):1–9. https://doi.org/10.1007/s10103-017-2267-x Eyvazzadeh N, Shakeri-Zadeh A, Fekrazad R, Amini E, Ghaznavi H, Kamrava SK (2017) Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer. Lasers Med Sci 32(152):1–9. https://​doi.​org/​10.​1007/​s10103-017-2267-x
5.
Zurück zum Zitat Bani F, Adeli M, Movahedi S, Sadeghizadeh M (2016) Graphene–polyglycerol–curcumin hybrid as a near-infrared (NIR) laser stimuli-responsive system for chemo-photothermal cancer therapy. RSC Adv 6(66):61141–61149CrossRef Bani F, Adeli M, Movahedi S, Sadeghizadeh M (2016) Graphene–polyglycerol–curcumin hybrid as a near-infrared (NIR) laser stimuli-responsive system for chemo-photothermal cancer therapy. RSC Adv 6(66):61141–61149CrossRef
8.
Zurück zum Zitat Chen YW, Liu TY, Chen PJ, Chang PH, Chen SY (2016) A high-sensitivity and low-power theranostic nanosystem for cell SERS imaging and selectively photothermal therapy using anti-EGFR-conjugated reduced graphene oxide/mesoporous silica/AuNPs nanosheets. Small 12(11):1458–1468CrossRefPubMed Chen YW, Liu TY, Chen PJ, Chang PH, Chen SY (2016) A high-sensitivity and low-power theranostic nanosystem for cell SERS imaging and selectively photothermal therapy using anti-EGFR-conjugated reduced graphene oxide/mesoporous silica/AuNPs nanosheets. Small 12(11):1458–1468CrossRefPubMed
9.
Zurück zum Zitat Justin R, Tao K, Román S, Chen D, Xu Y, Geng X, Ross IM, Grant RT, Pearson A, Zhou G (2016) Photoluminescent and superparamagnetic reduced graphene oxide–iron oxide quantum dots for dual-modality imaging, drug delivery and photothermal therapy. Carbon 97:54–70CrossRef Justin R, Tao K, Román S, Chen D, Xu Y, Geng X, Ross IM, Grant RT, Pearson A, Zhou G (2016) Photoluminescent and superparamagnetic reduced graphene oxide–iron oxide quantum dots for dual-modality imaging, drug delivery and photothermal therapy. Carbon 97:54–70CrossRef
10.
Zurück zum Zitat Rao C, Sood A, Voggu R, Subrahmanyam K (2010) Some novel attributes of graphene. J Phys Chem Lett 1(2):572–580CrossRef Rao C, Sood A, Voggu R, Subrahmanyam K (2010) Some novel attributes of graphene. J Phys Chem Lett 1(2):572–580CrossRef
11.
Zurück zum Zitat Eda G, Fanchini G, Chhowalla M (2008) Large-area ultrathin films of reduced graphene oxide as a transparent and flexible electronic material. Nat Nanotechnol 3(5):270–274CrossRefPubMed Eda G, Fanchini G, Chhowalla M (2008) Large-area ultrathin films of reduced graphene oxide as a transparent and flexible electronic material. Nat Nanotechnol 3(5):270–274CrossRefPubMed
12.
Zurück zum Zitat Hernandez Y, Nicolosi V, Lotya M, Blighe FM, Sun Z, De S, McGovern I, Holland B, Byrne M, Gun'Ko YK (2008) High-yield production of graphene by liquid-phase exfoliation of graphite. Nat Nanotechnol 3(9):563–568CrossRefPubMed Hernandez Y, Nicolosi V, Lotya M, Blighe FM, Sun Z, De S, McGovern I, Holland B, Byrne M, Gun'Ko YK (2008) High-yield production of graphene by liquid-phase exfoliation of graphite. Nat Nanotechnol 3(9):563–568CrossRefPubMed
13.
Zurück zum Zitat Blake P, Brimicombe PD, Nair RR, Booth TJ, Jiang D, Schedin F, Ponomarenko LA, Morozov SV, Gleeson HF, Hill EW (2008) Graphene-based liquid crystal device. Nano Lett 8(6):1704–1708CrossRefPubMed Blake P, Brimicombe PD, Nair RR, Booth TJ, Jiang D, Schedin F, Ponomarenko LA, Morozov SV, Gleeson HF, Hill EW (2008) Graphene-based liquid crystal device. Nano Lett 8(6):1704–1708CrossRefPubMed
14.
Zurück zum Zitat Lotya M, King PJ, Khan U, De S, Coleman JN (2010) High-concentration, surfactant-stabilized graphene dispersions. ACS Nano 4(6):3155–3162CrossRefPubMed Lotya M, King PJ, Khan U, De S, Coleman JN (2010) High-concentration, surfactant-stabilized graphene dispersions. ACS Nano 4(6):3155–3162CrossRefPubMed
16.
Zurück zum Zitat Lotya M, Hernandez Y, King PJ, Smith RJ, Nicolosi V, Karlsson LS, Blighe FM, De S, Wang ZM, McGovern IT, Duesberg GS, Coleman JN (2009) Liquid phase production of graphene by exfoliation of graphite in surfactant/water solutions. J Am Chem Soc 131(10):3611–3620. https://doi.org/10.1021/ja807449u CrossRefPubMed Lotya M, Hernandez Y, King PJ, Smith RJ, Nicolosi V, Karlsson LS, Blighe FM, De S, Wang ZM, McGovern IT, Duesberg GS, Coleman JN (2009) Liquid phase production of graphene by exfoliation of graphite in surfactant/water solutions. J Am Chem Soc 131(10):3611–3620. https://​doi.​org/​10.​1021/​ja807449u CrossRefPubMed
17.
Zurück zum Zitat Zhang Y, Nayak TR, Hong H, Cai W (2012) Graphene: a versatile nanoplatform for biomedical applications. Nano 4(13):3833–3842 Zhang Y, Nayak TR, Hong H, Cai W (2012) Graphene: a versatile nanoplatform for biomedical applications. Nano 4(13):3833–3842
18.
Zurück zum Zitat Calderón M, Quadir MA, Sharma SK, Haag R (2010) Dendritic polyglycerols for biomedical applications. Adv Mater 22(2):190–218CrossRefPubMed Calderón M, Quadir MA, Sharma SK, Haag R (2010) Dendritic polyglycerols for biomedical applications. Adv Mater 22(2):190–218CrossRefPubMed
19.
Zurück zum Zitat Khandare J, Calderón M (2015) Dendritic polymers for smart drug delivery applications. Nano 7(9):3806–3807 Khandare J, Calderón M (2015) Dendritic polymers for smart drug delivery applications. Nano 7(9):3806–3807
21.
Zurück zum Zitat Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1):248–254CrossRefPubMed Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1):248–254CrossRefPubMed
22.
Zurück zum Zitat Turcheniuk K, Hage C-H, Heliot L, Railian S, Zaitsev V, Spadavecchia J, Boukherroub R, Szunerits S (2015) Infrared photothermal therapy with water soluble reduced graphene oxide: shape, size and reduction degree effects. Nano LIFE 5(01):1540002CrossRef Turcheniuk K, Hage C-H, Heliot L, Railian S, Zaitsev V, Spadavecchia J, Boukherroub R, Szunerits S (2015) Infrared photothermal therapy with water soluble reduced graphene oxide: shape, size and reduction degree effects. Nano LIFE 5(01):1540002CrossRef
Metadaten
Titel
One-pot exfoliation, functionalization, and size manipulation of graphene sheets: efficient system for biomedical applications
verfasst von
Farhad Bani
Ali Bodaghi
Abbas Dadkhah
Soodabeh Movahedi
Narges Bodaghabadi
Majid Sadeghizadeh
Mohsen Adeli
Publikationsdatum
21.12.2017
Verlag
Springer London
Erschienen in
Lasers in Medical Science / Ausgabe 4/2018
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-017-2422-4

Weitere Artikel der Ausgabe 4/2018

Lasers in Medical Science 4/2018 Zur Ausgabe