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Erschienen in: Current Treatment Options in Oncology 3/2014

01.09.2014 | Lower Gastrointestinal Cancers (AB Benson, Section Editor)

Optimal Treatment Strategies for Anal Cancer

verfasst von: Shahab Ahmed, MD, Cathy Eng, MD, FACP

Erschienen in: Current Treatment Options in Oncology | Ausgabe 3/2014

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Opinion statement

Squamous cell carcinoma (SCCA) of the anal canal is an underrecognized malignancy that is growing in annual incidence. Over the years, combined chemoradiation has been the mainstay of treatment for locally advanced SCCA of the anal canal. Currently, the human papilloma virus (HPV) vaccine is recommended to prevent the development of HPV and its associated precancerous lesion(s). Patients diagnosed with the human immunodeficiency virus (HIV+) are prone to develop anal cancer due to their high risk of contracting HPV infection. We will focus on the development and management of SCCA of the anal canal (both localized and metastatic), including special details on HIV-positive patients. Highlights will include the role of targeted therapy based on available literature. Our objective is to aid practicing physicians in formulating a treatment plan for both locally advanced and metastatic patients.
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Zurück zum Zitat Rubinstein P, et al. Concurrent chemoradiotherapy with 5-fluorouracil and mitomycin-C for invasive anal carcinoma in HIV-positive patients receiving highly active anti-retroviral therapy versus non-HIV patients. 2012 ASCO Annual Meeting. J Clin Oncol 30, 2012 (suppl; abstr e14590). Available from: http://meetinglibrary.asco.org/content/101205-114. This study compares the outcomes of HIV negative patients with anal cancer who receive chemoradiation versus HIV positive patients with anal cancer who receive chemoradiation and HAART. Rubinstein P, et al. Concurrent chemoradiotherapy with 5-fluorouracil and mitomycin-C for invasive anal carcinoma in HIV-positive patients receiving highly active anti-retroviral therapy versus non-HIV patients. 2012 ASCO Annual Meeting. J Clin Oncol 30, 2012 (suppl; abstr e14590). Available from: http://​meetinglibrary.​asco.​org/​content/​101205-114. This study compares the outcomes of HIV negative patients with anal cancer who receive chemoradiation versus HIV positive patients with anal cancer who receive chemoradiation and HAART.
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Zurück zum Zitat Peddada AV et al. Chemotherapy and low-dose radiotherapy in the treatment of HIV-infected patients with carcinoma of the anal canal. Int J Radiat Oncol Biol Phys. 1997;37(5):1101–5.PubMedCrossRef Peddada AV et al. Chemotherapy and low-dose radiotherapy in the treatment of HIV-infected patients with carcinoma of the anal canal. Int J Radiat Oncol Biol Phys. 1997;37(5):1101–5.PubMedCrossRef
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Zurück zum Zitat Hoffman R et al. The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys. 1999;44(1):127–31.PubMedCrossRef Hoffman R et al. The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys. 1999;44(1):127–31.PubMedCrossRef
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Zurück zum Zitat Edelman S, Johnstone PA. Combined modality therapy for HIV-infected patients with squamous cell carcinoma of the anus: outcomes and toxicities. Int J Radiat Oncol Biol Phys. 2006;66(1):206–11.PubMedCrossRef Edelman S, Johnstone PA. Combined modality therapy for HIV-infected patients with squamous cell carcinoma of the anus: outcomes and toxicities. Int J Radiat Oncol Biol Phys. 2006;66(1):206–11.PubMedCrossRef
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Zurück zum Zitat Stadler RF et al. Outcome of HIV-infected patients with invasive squamous-cell carcinoma of the anal canal in the era of highly active antiretroviral therapy. Dis Colon Rectum. 2004;47(8):1305–9.PubMedCrossRef Stadler RF et al. Outcome of HIV-infected patients with invasive squamous-cell carcinoma of the anal canal in the era of highly active antiretroviral therapy. Dis Colon Rectum. 2004;47(8):1305–9.PubMedCrossRef
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Zurück zum Zitat National Comprehensive Cancer Network, N. Anal Carcinoma, NCCN guidelines. 2014 (Version 2.2013). This refers to the current guidelines for the management of anal cancer in the United States. National Comprehensive Cancer Network, N. Anal Carcinoma, NCCN guidelines. 2014 (Version 2.2013). This refers to the current guidelines for the management of anal cancer in the United States.
Metadaten
Titel
Optimal Treatment Strategies for Anal Cancer
verfasst von
Shahab Ahmed, MD
Cathy Eng, MD, FACP
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Current Treatment Options in Oncology / Ausgabe 3/2014
Print ISSN: 1527-2729
Elektronische ISSN: 1534-6277
DOI
https://doi.org/10.1007/s11864-014-0298-0

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