The objective of this study is to analyze the treatment outcome and secondary reactions in 98 patients with stage I–III cervical carcinoma who underwent postoperative radiotherapy.
From 2006 to 2014, 98 patients with stage I–III cervical carcinoma were treated with postoperative radiotherapy. The major histological type, found in 92.86% of the patients (91 cases), was squamous cell carcinoma. Patients were staged according to the 2002 TNM guidelines. The postoperative radiotherapy methods included two-field irradiation (16 patients, 16.32%), four-field box irradiation (16 patients, 16.32%), and intensity-modulated radiotherapy (IMRT; 66 patients, 67.36%). The survival rates were represented using Kaplan-Meier curves, and prognosis analyses were performed using Cox multivariate analyses.
The 5-year overall survival and progression-free survival rates were 82.0 and 76.0%, respectively. Only one patient (1.02%) developed a grade 3 acute radiation enteritis, while grade 3 and 4 myelosuppression was noted in 17 patients (17.35%) and one patient (1.02%), respectively. Multivariate analyses showed that anemia before radiotherapy and tumor size were predictors of the OS (P = 0.008, P = 0.045) rates.
Postoperative radiotherapy for patients with risk factors of cervical cancer procured good efficacy levels with mild side effects. Anemia and tumor size were important OS predictors.
J. Ferlay, I. Soerjomataram, R. Dikshit, et al.Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int. J.Cancer 136 (2015) E359-E386.
Ohara K, Sugahara S, Kagei K, Hata M, Igaki H, Tokuuye K, et al. Retrospective comparison of clinical outcome between radiotherapy alone and surgery plus postoperative radiotherapy in the treatment of stages IB-IIB cervical squamous cell carcinoma. Radiat Med. 2004;22:42–8. PubMed
Peters WA 3rd, Liu PY, Barrett RJ 2nd, Stock RJ, Monk BJ, Berek JS, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol. 2000;18:1606–13. CrossRefPubMed
Rotman M, Sedlis A, Piedmonte MR, Bundy B, Lentz SS, Muderspach L, et al. A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features:follow-up of a gynecologic oncology group study. Int J Radiat Oncol Biol Phys. 2006;65:169–76. CrossRefPubMed
Kasuya G, Ogawa K, Iraha S, Nagai Y, Hirakawa M, Toita T, et al. Postoperative radiotherapy for uterine cervical cancer: impact of lymph node and histological type on survival. Anticancer Res. 2013;33:2199–204. PubMed
Okazawa M, Mabuchi S, Isohashi F, Suzuki O, Yoshioka Y, Sasano T, et al. Impact of the addition of concurrent chemotherapy to pelvic radiotherapy in surgically treated stage IB1-IIB cervical cancer patients with intermediate-risk or high-risk factors: a 13-year experience. Int J Gynecol Cancer. 2013;23(3):567–75. CrossRefPubMed
Wakayama A, Inamine M, Kudaka W, Nagai Y, Nakamoto T, Ooyama T, et al. Concurrent chemoradiotherapy for non-bulky stage IB/II cervical cancer without pelvic node enlargement. Anticancer Res. 2013;33:5123–6. PubMed
Lee HN, Mahajan MK, Das S, Sachdeva J, Tiwana MS. Early hematological effects of chemo-radiation therapy in cancer patients and their pattern of recovery—a prospective single institution study. Gulf J Oncolog. 2015;1:43–51. PubMed
Bishop AJ, Allen PK, Klopp AH, Meyer LA, Eifel PJ, et al. Relationship between low hemoglobin levels and outcomes after treatment with radiation or chemoradiation in patients with cervical cancer: has the impact of anemia been overstated? Int J Radiat Oncol Biol Phys. 2015;91:196–205. CrossRefPubMed
Ki EY, Lee KH, Park JS, Hur SY. A clinicopathological review of pulmonary metastasis from uterine cervical cancer. Cancer Res Treat. 2016;48:66–72. CrossRef
Agrawal A, Kumar A, Sinha AK, Kumar M, Pandey SR, Khaniya S. Intracranial metastases from carcinoma of the cervix. Singap Med J. 2007;48:154–6.
- Outcome and prognostic factors in cervical cancer patients treated with surgery and concurrent chemoradiotherapy: a retrospective study
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