Background
Methods
Study patients
Diagnosis
Ultrasound-guided local lauromacrogol injection
Hysteroscopy
Observation indicators
Statistical analysis
Results
Characteristics of study population
Parameters | Non-L group (n = 53) | L group (n = 78) | P value |
---|---|---|---|
Age (years) | 34.64 ± 4.82 | 34.13 ± 5.05 | 0.562 |
Gestational age (days) | 46.26 ± 6.99 | 45.01 ± 9.07 | 0.399 |
Fetal heartbeat positive, n (%) | 21 (39.6) | 26 (33.3) | 0.461 |
Gravidity (n) | 4.0 (3.0, 5.0) | 4.0 (3.0, 5.0) | 0.160 |
Abortion (n) | 2.0 (1.0, 3.0) | 2.0 (1.0, 3.0) | 0.677 |
Number of cesarean deliveries | 0.144 | ||
1, n (%) | 23 (43.4) | 44 (56.4) | |
≥ 2, n (%) | 30 (56.6) | 34 (43.6) | |
Time from cesarean delivery (years) | 5.0 (3.0, 9.0) | 5.0 (2.0, 8.0) | 0.285 |
Type of CSP, n (%) | 0.651 | ||
Type 1 | 36 (67.9) | 50 (64.1) | |
Type 2 | 17 (32.1) | 28 (35.9) | |
Preoperative serum hCG level (IU/L) | 19850.0 (7366.0, 48560.0) | 26790.0 (10170.0, 55730.0) | 0.137 |
Uterine scar thickness (cm) | 0.35 ± 0.16 | 0.32 ± 0.12 | 0.121 |
Mass size (cm) | 2.05 ± 0.92 | 2.39 ± 1.31 | 0.109 |
Outcomes of women with CSP treated with versus without lauromacrogol injection prior to hysteroscopy
Parameter | Non-L group (n = 53) | L group (n = 78) | P value |
---|---|---|---|
Cure rate (%) | 52 (98.1) | 77 (98.7) | 1 |
Operating time (min) | 29.87 ± 13.51 | 29.58 ± 19.99 | 0.926 |
Intraoperative blood loss (mL) | 15.0 (10.0, 20.0) | 20.0 (10.0, 30.0) | 0.105 |
Hemoglobin change | 12.0 (4.0, 16.0) | 10.5 (6.0, 17.0) | 0.952 |
Time to β-hCG normalization (days) | 28.07 ± 8.51 | 29.39 ± 9.92 | 0.586 |
Complications (%) | < 0.001* | ||
Overall | 0 (0) | 36 (46.2) | |
Abdominal pain | 0 (0) | 28 (35.9) | |
Massive bleeding | 0 (0) | 5 (6.4) | |
Bradycardia | 0 (0) | 3 (3.8) | |
Uterine packing rate (%) | 2 (3.8) | 7 (9.0) | 0.311 |
Hospital day(day) | 4.85 ± 1.12 | 5.44 ± 1.08 | 0.003* |
Hospital stay cost (¥) | 6148.75 ± 1028.71 | 9016.61 ± 1181.19 | < 0.001* |
Surgery | 1266.12 ± 282.97 | 1296.41 ± 265.14 | 0.535 |
Medical supplies | 155.9 (21.0, 819.0) | 1348.0 (1062.0, 1548.0) | < 0.001* |
Medication | 508.03 ± 225.35 | 2033.06 ± 431.73 | < 0.001* |
Ultrasound and imaging | 495.36 ± 140.62 | 709.52 ± 137.57 | < 0.001* |
Discussion
Advantages of hysteroscopic surgery over curettage in treating CSP
Parameters | Type 1(n = 86) | Type 2 (n = 45) | P |
---|---|---|---|
Age (years) | 34.1 ± 4.9 | 34.8 ± 5.0 | 0.397 |
Gravidity (n) | 4.0 (3.0, 5.0) | 4.0 (3.0, 5.0) | 0.289 |
Abortion (n) | 2.0 (1.0, 3.0) | 2.0 (1.0, 3.0) | 0.486 |
Number of cesarean deliveries (n) | 0.717 | ||
1, n (%) | 43 (50) | 24 (53.3) | |
≥ 2, n (%) | 43 (50) | 21 (46.7) | |
Fetal heartbeat positive, n (%) | 28 (32.6) | 19 (42.2) | 0.273 |
Time interval from cesarean delivery (years) | 5.0 (2.0, 8.0) | 6.0 (3.0, 9.0) | 0.232 |
Gestational age (days) | 45.5 ± 8.6 | 45.7 ± 7.8 | 0.894 |
Size of mass (cm) | 2.1 ± 1.0 | 2.6 ± 1.4 | 0.009 |
Pre-operative serum hCG level (IU/L) | 19450.0 (8572.0, 39900.0) | 33640.0 (12810.0, 66650.0) | 0.015 |
Parameters | Type 1(n = 86) | Type 2 (n = 45) | P |
---|---|---|---|
Treated by Lauromacrogol(%) | 0.651 | ||
No | 36 (41.9) | 17 (37.8) | |
Yes | 50 (58.1) | 28 (62.2) | |
Hemoglobin change(g/L) | 11.0 (4.0, 18.0) | 11.0 (7.0, 16.0) | 0.737 |
Hospital day | 5.1 ± 1.1 | 5.3 ± 1.1 | 0.323 |
Hospital stay cost (¥) | 7764.1 ± 1767.3 | 8010.2 ± 1880.2 | 0.464 |
Intraoperative blood loss (ml) | 17.5 (10.0, 20.0) | 20.0 (10.0, 40.0) | 0.138 |
Operating time (min) | 28.8 ± 12.2 | 31.5 ± 25.0 | 0.407 |
Time to β-hCG normalization (days) | 28.7 ± 9.0 | 28.6 ± 9.7 | 0.973 |
Uterine packing rate (%) | 5 (5.8) | 4 (8.9) | 0.493 |
Complications (%) | 20 (23.3) | 16 (35.6) | 0.134 |
Cure rate (%) | 86 (100) | 43 (95.6) | 0.116 |