nach oben

Erschienen in:

01.04.2012 | Reproductive Medicine

Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen

verfasst von: Thomas Freour, Damien Masson, Lionel Dessolle, Dalila Allaoua, Thomas Dejoie, Sophie Mirallie, Miguel Jean, Paul Barriere

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Smoking is known to be deleterious on female fertility and in vitro fertilization (IVF) outcome, probably partly through ovarian reserve alteration. Recently, anti-Müllerian hormone (AMH) and antral follicle count (AFC) have been shown to be the most accurate ovarian reserve markers. Here, we compared ovarian reserve markers in women undergoing IVF according to smoking status and stimulation regimen.

Methods

AFC, AMH, basal FSH, LH and estradiol, and IVF outcome were compared in 277 women undergoing IVF. Smoking status and ovarian stimulation protocol (i.e. agonists or antagonists) were recorded.

Results

Active smoking women had lower AMH and modified follicles’ size repartition in AFC compared to non-smokers. They also experienced poorer IVF outcome with decreased ovarian response and lower pregnancy rate. This remained true in both antagonist and agonist stimulation protocol groups.

Conclusion

Active smoking in infertile women is associated with ovarian reserve alteration, as reflected by AFC modification and decreased serum AMH, and leads to poor prognosis in ART cycles, whatever the stimulation protocol used. Infertile women should be strongly discouraged from smoking before they start IVF cycles.

Broer SL, Mol BW, Hendriks D, Broekmans FJ (2009) The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril 91:705–714PubMedCrossRef

Broer SL, Dólleman M, Opmeer BC, Fauser BC, Mol BW, Broekmans FJ (2011) AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update 17:46–54PubMedCrossRef

Broekmans FJ, de Ziegler D, Howles CM, Gougeon A, Trew G, Olivennes F (2010) The antral follicle count: practical recommendations for better standardization. Fertil Steril 94:1044–1051PubMedCrossRef

Grynberg M, Genro V, Gallot V, El-Ali A, Frydman R, Fanchin R (2010) Early follicle development during the luteal-follicular transition affects the predictability of serum follicle-stimulating hormone but not antimüllerian hormone levels on cycle day 3. Fertil Steril 94:1827–1831PubMedCrossRef

Waylen AL, Metwally M, Jones GL, Wilkinson AJ, Ledger WL (2009) Effects of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysis. Hum Reprod Update 15:31–44PubMedCrossRef

Freour T, Dessolle L, Jean M, Masson D, Barriere P (2010) Predictive value of ovarian reserve markers in smoking and non-smoking women undergoing IVF. Reprod Biomed Online 20:857–860PubMedCrossRef

Lambert-Messerlian GM, Harlow BL (2006) The influence of depression, body mass index, and smoking on serum inhibin B levels in late reproductive-aged women. J Clin Endocrinol Metab 91:1496–1500PubMedCrossRef

Kinney A, Kline J, Kelly A, Reuss ML, Levin B (2007) Smoking, alcohol and caffeine in relation to ovarian age during the reproductive years. Hum Reprod 22:1175–1185PubMedCrossRef

Freour T, Masson D, Mirallie S et al (2008) Active smoking compromises IVF outcome and affects ovarian reserve. Reprod Biomed Online 16:96–102PubMedCrossRef

10.

Jick H, Porter J (1977) Relation between smoking and age of natural menopause. Report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. Lancet 1:1354–1355PubMedCrossRef

11.

Mikkelsen TF, Graff-Iversen S, Sundby J, Bjertness E (2007) Early menopause, association with tobacco smoking, coffee consumption and other lifestyle factors: a cross-sectional study. BMC Public Health 7:149PubMedCrossRef

12.

Tuttle AM, Stämpfli M, Foster WG (2009) Cigarette smoke causes follicle loss in mice ovaries at concentrations representative of human exposure. Hum Reprod 24:1452–1459PubMedCrossRef

13.

Jurisicova A, Taniuchi A, Li H et al (2007) Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. J Clin Invest 117:3971–3978PubMed

14.

Fanchin R, Schonäuer LM, Righini C, Guibourdenche J, Frydman R, Taieb J (2003) Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod 18:323–327PubMedCrossRef

15.

Chang MY, Chiang CH, Hsieh TT, Soong YK, Hsu KH (1998) Use of the antral follicle count to predict the outcome of assisted reproductive technologies. Fertil Steril 69:505–510PubMedCrossRef

16.

Hendriks DJ, Kwee J, Mol BW, te Velde ER, Broekmans FJ (2007) Ultrasonography as a tool for the prediction of outcome in IVF patients: a comparative meta-analysis of ovarian volume and antral follicle count. Fertil Steril 87:764–775PubMedCrossRef

17.

Mattison DR, Singh H, Takizawa K, Thomford PJ (1989) Ovarian toxicity of benzo(a)pyrene and metabolites in mice. Reprod Toxicol 3:115–125PubMedCrossRef

18.

Shiromizu K, Mattison DR (1984) The effect of intraovarian injection of benzo(a)pyrene on primordial oocyte number and ovarian aryl hydrocarbon [benzo(a)pyrene] hydroxylase activity. Toxicol Appl Pharmacol 76:18–25PubMedCrossRef

19.

Lienesch LA, Dumont JN, Bantle JA (2000) The effect of cadmium on oogenesis in Xenopus laevis. Chemosphere 41:1651–1658PubMedCrossRef

20.

Jayaprakasan K, Hilwah N, Kendall NR et al (2007) Does 3D ultrasound offer any advantage in the pretreatment assessment of ovarian reserve and prediction of outcome after assisted reproduction treatment? Hum Reprod 22:1932–1941PubMedCrossRef

21.

Haadsma ML, Bukman A, Groen H, Roeloffzen EM, Groenewoud ER, Heineman MJ, Hoek A (2007) The number of small antral follicles (2–6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population. Hum Reprod 22:1925–1931PubMedCrossRef

22.

Santos MA, Kuijk EW, Macklon NS (2010) The impact of ovarian stimulation for IVF on the developing embryo. Reproduction 139:23–34PubMedCrossRef

23.

Al-Inany HG, Abou-Setta AM, Aboulghar M (2007) Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review. Reprod Biomed Online 14:640–649PubMedCrossRef

24.

Practice Committee of American Society for Reproductive Medicine (2008) Smoking and infertility. Fertil Steril 90(5 Suppl):S254–S259

25.

Barbieri RL (2001) The initial fertility consultation: recommendations concerning cigarette smoking, body mass index, and alcohol and caffeine consumption. Am J Obstet Gynecol 185:1168–1173PubMedCrossRef

26.

Triopon G, Tailland ML, Faillie JL et al (2006) In vitro fertilization and smoking: use of urinary cotinine and expired air carbon monoxide measurements. Gynecol Obstet Fertil 34:1043–1050PubMedCrossRef

27.

Neal MS, Hughes EG et al (2005) Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes. Hum Reprod 20:2531–2535PubMedCrossRef

Titel: Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen
verfasst von: Thomas Freour
Damien Masson
Lionel Dessolle
Dalila Allaoua
Thomas Dejoie
Sophie Mirallie
Miguel Jean
Paul Barriere
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-2172-7

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen