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Erschienen in: European Archives of Oto-Rhino-Laryngology 6/2007

01.06.2007 | Case Report

Over-expression of c-kit in a primary leiomyosarcoma of the thyroid gland

verfasst von: An-Shiou Day, Pei-Jen Lou, Wei-Chou Lin, Chi-Chun Chou

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 6/2007

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Abstract

Primary leiomyosarcoma of the thyroid gland is rare. In this paper, we report a case of high-grade leiomyosarcoma of the thyroid gland in a 43-year-old man. Lung metastasis was also noted in this patient. Despite of aggressive surgical treatment, the patient died of uncontrolled local recurrent disease 6 months after the initial operation. Immunohistochemical studies showed the tumor cells were positive for c-kit proto-oncogene product. Imatinib mesylate was used as a post-operative adjuvant treatment but the response was poor. The role of tyrosine kinase inhibitors on the treatment of thyroid leiomyosarcomas is still unclear because this is the first report of c-kit over-expression in such tumors. Nevertheless, our results show that c-kit over-expression might not be an indicator of good response to imatinib mesylate treatment in thyroid leiomyosarcomas.
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Metadaten
Titel
Over-expression of c-kit in a primary leiomyosarcoma of the thyroid gland
verfasst von
An-Shiou Day
Pei-Jen Lou
Wei-Chou Lin
Chi-Chun Chou
Publikationsdatum
01.06.2007
Verlag
Springer-Verlag
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 6/2007
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-007-0242-z

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