Erschienen in:
01.05.2007 | Adis Drug Profiles
Paliperidone Extended Release
A Viewpoint by George Simpson
verfasst von:
George Simpson
Erschienen in:
CNS Drugs
|
Ausgabe 5/2007
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Excerpt
For over 50 years, antipsychotic agents have played a key role in the treatment of schizophrenia. The simultaneous discovery of their ability to reduce or eliminate the positive symptoms of schizophrenia and at the same time cause extrapyramidal symptoms (EPS) indistinguishable from classical parkinsonism was a major advance in 20th century therapeutics. To an extent, these agents have been supplanted by atypical agents following the discovery of clozapine, with its antipsychotic effect in the absence of EPS. …