Skip to main content

2015 | OriginalPaper | Buchkapitel

38. Pankreastumoren

verfasst von : Marcus Bahra, Prof. Dr. med., Florian Lordick, Prof. Dr. med., Manfred P. Lutz, Professor Dr. med., Matthias Glanemann, Prof. Dr. med., Peter Neuhaus, Prof. Dr. med.

Erschienen in: Viszeralmedizin

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Autoren

Gastroenterologie: M. P. Lutz
Onkologie: F. Lordick
Viszeralchirurgie: M. Bahra, M. Glanemann, P. Neuhaus
Literatur
Zurück zum Zitat Adamek HE et al (2000) Pancreatic cancer detection with magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography: a prospective controlled study. Lancet 356(9225):190–193CrossRefPubMed Adamek HE et al (2000) Pancreatic cancer detection with magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography: a prospective controlled study. Lancet 356(9225):190–193CrossRefPubMed
Zurück zum Zitat Alexakis N, Halloran C et al (2004) Current standards of surgery for pancreatic cancer. Br J Surg 91(11):1410–1427CrossRefPubMed Alexakis N, Halloran C et al (2004) Current standards of surgery for pancreatic cancer. Br J Surg 91(11):1410–1427CrossRefPubMed
Zurück zum Zitat Aristu J et al (2003) Surgical resection after preoperative chemoradiotherapy benefits selected patients with unresectable pancreatic cancer. Am J Clin Oncol 26(1):30–36CrossRefPubMed Aristu J et al (2003) Surgical resection after preoperative chemoradiotherapy benefits selected patients with unresectable pancreatic cancer. Am J Clin Oncol 26(1):30–36CrossRefPubMed
Zurück zum Zitat Azria D et al (2002) Treatment of unresectable, locally advanced pancreatic adenocarcinoma with combined radiochemotherapy with 5-fluorouracil and cisplatin. Pancreas 25(4):360–365CrossRefPubMed Azria D et al (2002) Treatment of unresectable, locally advanced pancreatic adenocarcinoma with combined radiochemotherapy with 5-fluorouracil and cisplatin. Pancreas 25(4):360–365CrossRefPubMed
Zurück zum Zitat Bajetta E et al (1999) Chemoradiotherapy as preoperative treatment in locally advanced unresectable pancreatic cancer patients: results of a feasibility study. Int J Radiat Oncol Biol Phys 45(2):285–289CrossRefPubMed Bajetta E et al (1999) Chemoradiotherapy as preoperative treatment in locally advanced unresectable pancreatic cancer patients: results of a feasibility study. Int J Radiat Oncol Biol Phys 45(2):285–289CrossRefPubMed
Zurück zum Zitat Bartsch DK et al (2004) Prevalence of familial pancreatic cancer in Germany. Int J Cancer 110(6):902–906CrossRefPubMed Bartsch DK et al (2004) Prevalence of familial pancreatic cancer in Germany. Int J Cancer 110(6):902–906CrossRefPubMed
Zurück zum Zitat Berlin J, Catalano P, Thomas J et al (2002) A phase III study of gemcitabine in combination with 5-FU vs gemcitabine alone in patients with advanced pancreatic carcinoma (E2297): an Eastern Cooperative Oncology Group (ECOG) trial. J Clin Oncol 20:3270–3275CrossRefPubMed Berlin J, Catalano P, Thomas J et al (2002) A phase III study of gemcitabine in combination with 5-FU vs gemcitabine alone in patients with advanced pancreatic carcinoma (E2297): an Eastern Cooperative Oncology Group (ECOG) trial. J Clin Oncol 20:3270–3275CrossRefPubMed
Zurück zum Zitat Bronstein YL et al (2004) Detection of small pancreatic tumors with multiphasic helical CT. Am J Roentgenol 182(3):619–623CrossRef Bronstein YL et al (2004) Detection of small pancreatic tumors with multiphasic helical CT. Am J Roentgenol 182(3):619–623CrossRef
Zurück zum Zitat Brugge WR (2008) The incidental pancreatic cyst on abdominal computerizes tomography imaging: diagnosis and management. Clin Gastroenterol Hepatol 6:140–144CrossRefPubMed Brugge WR (2008) The incidental pancreatic cyst on abdominal computerizes tomography imaging: diagnosis and management. Clin Gastroenterol Hepatol 6:140–144CrossRefPubMed
Zurück zum Zitat Brunner TB et al (2000) Preoperative chemoradiation in locally advanced pancreatic carcinoma: a phase II study. Onkologie 23(5):436–442CrossRefPubMed Brunner TB et al (2000) Preoperative chemoradiation in locally advanced pancreatic carcinoma: a phase II study. Onkologie 23(5):436–442CrossRefPubMed
Zurück zum Zitat Burris HA, Moore MJ, Andersen J et al (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15:2403–2413PubMed Burris HA, Moore MJ, Andersen J et al (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15:2403–2413PubMed
Zurück zum Zitat Carpelan-Holmstrom M et al (2002) CEA, CA 19–9 and CA 72–4 improve the diagnostic accuracy in gastrointestinal cancers. Anticancer Res 22(4):2311–2316PubMed Carpelan-Holmstrom M et al (2002) CEA, CA 19–9 and CA 72–4 improve the diagnostic accuracy in gastrointestinal cancers. Anticancer Res 22(4):2311–2316PubMed
Zurück zum Zitat Chauffert B, Mornex F, Bonnetain F et al (2008) Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000–01 FFCD/SFRO study. Ann Oncol 19(9):1592–1599CrossRefPubMed Chauffert B, Mornex F, Bonnetain F et al (2008) Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000–01 FFCD/SFRO study. Ann Oncol 19(9):1592–1599CrossRefPubMed
Zurück zum Zitat Cleary SP et al (2004) Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors. J Am Coll Surg 198(5):722–731CrossRefPubMed Cleary SP et al (2004) Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors. J Am Coll Surg 198(5):722–731CrossRefPubMed
Zurück zum Zitat Conroy T, Desseigne F, Ychou M et al (2011) FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer. N Engl J Med 364:1817–1825CrossRefPubMed Conroy T, Desseigne F, Ychou M et al (2011) FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer. N Engl J Med 364:1817–1825CrossRefPubMed
Zurück zum Zitat Crane C et al (2001) Toxicity and efficacy of concurrent gemcitabine and radiotherapy for locally advanced pancreatic cancer. Int J Gastrointest Cancer 29(1):9–18CrossRefPubMed Crane C et al (2001) Toxicity and efficacy of concurrent gemcitabine and radiotherapy for locally advanced pancreatic cancer. Int J Gastrointest Cancer 29(1):9–18CrossRefPubMed
Zurück zum Zitat Ducreux M, Rougier P, Pignon J-P et al (2002) A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma. Ann Oncol 13:1185–1191CrossRefPubMed Ducreux M, Rougier P, Pignon J-P et al (2002) A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma. Ann Oncol 13:1185–1191CrossRefPubMed
Zurück zum Zitat Ekbom A et al (1994) Pancreatitis and pancreatic cancer: a population-based study. J Natl Cancer Inst 86(8):625–627CrossRefPubMed Ekbom A et al (1994) Pancreatitis and pancreatic cancer: a population-based study. J Natl Cancer Inst 86(8):625–627CrossRefPubMed
Zurück zum Zitat England RE, Martin DF (1996) Endoscopic and percutaneous intervention in malignant obstructive jaundice. Cardiovasc Intervent Radiol 19(6):381–387CrossRefPubMed England RE, Martin DF (1996) Endoscopic and percutaneous intervention in malignant obstructive jaundice. Cardiovasc Intervent Radiol 19(6):381–387CrossRefPubMed
Zurück zum Zitat Eskelinen MHU (2002) Serological tumor markers in pancreatic cancer. In: Diamandis EPFH, Lilja H, Chan DW, Schwartz MK (Hrsg) Tumor markers-physiology pathobiology, technology, and clinical applications. AACC Press, Washington DC, S 265–269 Eskelinen MHU (2002) Serological tumor markers in pancreatic cancer. In: Diamandis EPFH, Lilja H, Chan DW, Schwartz MK (Hrsg) Tumor markers-physiology pathobiology, technology, and clinical applications. AACC Press, Washington DC, S 265–269
Zurück zum Zitat Everhart J, Wright D (1995) Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis JAMA 273(20):1605–1609PubMed Everhart J, Wright D (1995) Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis JAMA 273(20):1605–1609PubMed
Zurück zum Zitat Fuchs CS et al (1996) A prospective study of cigarette smoking and the risk of pancreatic cancer. Arch Intern Med 156(19):2255–2260CrossRefPubMed Fuchs CS et al (1996) A prospective study of cigarette smoking and the risk of pancreatic cancer. Arch Intern Med 156(19):2255–2260CrossRefPubMed
Zurück zum Zitat Gaa J et al (2001) Diagnosis of pancreas tumors: MRI or multidetector spiral CT? Kongressbd Dtsch Ges Chir Kongr 118:73–77PubMed Gaa J et al (2001) Diagnosis of pancreas tumors: MRI or multidetector spiral CT? Kongressbd Dtsch Ges Chir Kongr 118:73–77PubMed
Zurück zum Zitat Geer RJ, Brennan MF (1993) Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 165(1):68–72 (discussion 72–73)CrossRefPubMed Geer RJ, Brennan MF (1993) Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 165(1):68–72 (discussion 72–73)CrossRefPubMed
Zurück zum Zitat Giardiello FM et al (2000) Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119(6):1447–1453CrossRefPubMed Giardiello FM et al (2000) Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119(6):1447–1453CrossRefPubMed
Zurück zum Zitat Gillen S, Schuster T, Meyer zum Buschenfelde C et al (2010) Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. Plos 7 e1000267 Gillen S, Schuster T, Meyer zum Buschenfelde C et al (2010) Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. Plos 7 e1000267
Zurück zum Zitat Glimelius B, Hoffman K, Sjoden PO et al (1996) Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 7:593–600CrossRefPubMed Glimelius B, Hoffman K, Sjoden PO et al (1996) Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 7:593–600CrossRefPubMed
Zurück zum Zitat Hahn SA et al (2003) BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst 95(3):214–221CrossRefPubMed Hahn SA et al (2003) BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst 95(3):214–221CrossRefPubMed
Zurück zum Zitat Hammel PR et al (2000) Pancreatic involvement in von Hippel-Lindau disease. The Groupe Francophone d‘Etude de la Maladie de von Hippel-Lindau. Gastroenterology 119(4):1087–1095CrossRefPubMed Hammel PR et al (2000) Pancreatic involvement in von Hippel-Lindau disease. The Groupe Francophone d‘Etude de la Maladie de von Hippel-Lindau. Gastroenterology 119(4):1087–1095CrossRefPubMed
Zurück zum Zitat Hecht F, Hecht BK (1990) Cancer in ataxia-telangiectasia patients. Cancer Genet Cytogenet 46(1):9–19CrossRefPubMed Hecht F, Hecht BK (1990) Cancer in ataxia-telangiectasia patients. Cancer Genet Cytogenet 46(1):9–19CrossRefPubMed
Zurück zum Zitat Hoffman JP et al (1995) A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas. Am J Surg 169(1):71–77 (discussion 77–78)CrossRefPubMed Hoffman JP et al (1995) A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas. Am J Surg 169(1):71–77 (discussion 77–78)CrossRefPubMed
Zurück zum Zitat Howe GR, Jain M, Miller AB (1990) Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study. Int J Cancer 45(4):604–608CrossRefPubMed Howe GR, Jain M, Miller AB (1990) Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study. Int J Cancer 45(4):604–608CrossRefPubMed
Zurück zum Zitat Howe GR et al (1991) Cigarette smoking and cancer of the pancreas: evidence from a population-based case-control study in Toronto, Canada. Int J Cancer 47(3):323–328CrossRefPubMed Howe GR et al (1991) Cigarette smoking and cancer of the pancreas: evidence from a population-based case-control study in Toronto, Canada. Int J Cancer 47(3):323–328CrossRefPubMed
Zurück zum Zitat Hruban RH et al (1993) K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 143(2):545–554PubMedCentralPubMed Hruban RH et al (1993) K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 143(2):545–554PubMedCentralPubMed
Zurück zum Zitat Hruban RH et al (2004) An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 28(8):977–987CrossRefPubMed Hruban RH et al (2004) An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 28(8):977–987CrossRefPubMed
Zurück zum Zitat Huang QJ et al (2002) Spiral multi-phase CT in evaluating resectability of pancreatic carcinoma. Hepatobiliary Pancreat Dis Int 1(4):614–619PubMed Huang QJ et al (2002) Spiral multi-phase CT in evaluating resectability of pancreatic carcinoma. Hepatobiliary Pancreat Dis Int 1(4):614–619PubMed
Zurück zum Zitat Hunt GC, Faigel DO (2002) Assessment of EUS for diagnosing, staging, and determining resectability of pancreatic cancer: a review. Gastrointest Endosc 55(2):232–237CrossRefPubMed Hunt GC, Faigel DO (2002) Assessment of EUS for diagnosing, staging, and determining resectability of pancreatic cancer: a review. Gastrointest Endosc 55(2):232–237CrossRefPubMed
Zurück zum Zitat Jessup JM et al (1993) Neoadjuvant therapy for unresectable pancreatic adenocarcinoma. Arch Surg 128(5):559–564CrossRefPubMed Jessup JM et al (1993) Neoadjuvant therapy for unresectable pancreatic adenocarcinoma. Arch Surg 128(5):559–564CrossRefPubMed
Zurück zum Zitat Jiang JT et al (2004) Serum level of TSGF, CA242 and CA19–9 in pancreatic cancer. World J Gastroenterol 10(11):1675–1677PubMed Jiang JT et al (2004) Serum level of TSGF, CA242 and CA19–9 in pancreatic cancer. World J Gastroenterol 10(11):1675–1677PubMed
Zurück zum Zitat Kalser MH, Ellenberg SS (1985) Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120(8):899–903CrossRefPubMed Kalser MH, Ellenberg SS (1985) Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120(8):899–903CrossRefPubMed
Zurück zum Zitat Karlson BM et al (1999) Abdominal US for diagnosis of pancreatic tumor: prospective cohort analysis. Radiology 213(1):107–111CrossRefPubMed Karlson BM et al (1999) Abdominal US for diagnosis of pancreatic tumor: prospective cohort analysis. Radiology 213(1):107–111CrossRefPubMed
Zurück zum Zitat Klinkenbijl JH et al (1999) Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230(6):776–782 (discussion 782–784)PubMedCentralCrossRefPubMed Klinkenbijl JH et al (1999) Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230(6):776–782 (discussion 782–784)PubMedCentralCrossRefPubMed
Zurück zum Zitat Kornek GV et al (2000) Treatment of unresectable, locally advanced pancreatic adenocarcinoma with combined radiochemotherapy with 5-fluorouracil, leucovorin and cisplatin. Br J Cancer 82(1):98–103PubMedCentralCrossRefPubMed Kornek GV et al (2000) Treatment of unresectable, locally advanced pancreatic adenocarcinoma with combined radiochemotherapy with 5-fluorouracil, leucovorin and cisplatin. Br J Cancer 82(1):98–103PubMedCentralCrossRefPubMed
Zurück zum Zitat La Vecchia C et al (1990) Medical history, diet and pancreatic cancer. Oncology 47(6):463–466CrossRefPubMed La Vecchia C et al (1990) Medical history, diet and pancreatic cancer. Oncology 47(6):463–466CrossRefPubMed
Zurück zum Zitat Laurent-Puig P et al (1995) Antibodies against p53 protein in serum of patients with benign or malignant pancreatic and biliary diseases. Gut 36(3):455–458PubMedCentralCrossRefPubMed Laurent-Puig P et al (1995) Antibodies against p53 protein in serum of patients with benign or malignant pancreatic and biliary diseases. Gut 36(3):455–458PubMedCentralCrossRefPubMed
Zurück zum Zitat Lemke AJ et al (2004) Retrospective digital image fusion of multidetector CT and 18 F-FDG PET: clinical value in pancreatic lesions – a prospective study with 104 patients. J Nucl Med 45(8):1279–1286PubMed Lemke AJ et al (2004) Retrospective digital image fusion of multidetector CT and 18 F-FDG PET: clinical value in pancreatic lesions – a prospective study with 104 patients. J Nucl Med 45(8):1279–1286PubMed
Zurück zum Zitat Li CP et al (2003) Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: gemcitabine versus 5-fluorouracil, a randomized controlled study. Int J Radiat Oncol Biol Phys 57(1):98–104CrossRefPubMed Li CP et al (2003) Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: gemcitabine versus 5-fluorouracil, a randomized controlled study. Int J Radiat Oncol Biol Phys 57(1):98–104CrossRefPubMed
Zurück zum Zitat Loehrer PJ, Feng Y, Cardenes H et al (2011) Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial. J Clin Oncol 29:4105–4112PubMedCentralCrossRefPubMed Loehrer PJ, Feng Y, Cardenes H et al (2011) Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial. J Clin Oncol 29:4105–4112PubMedCentralCrossRefPubMed
Zurück zum Zitat Lopez Hanninen E et al (2002) Prospective evaluation of pancreatic tumors: accuracy of MR imaging with MR cholangiopancreatography and MR angiography. Radiology 224(1):34–41CrossRefPubMed Lopez Hanninen E et al (2002) Prospective evaluation of pancreatic tumors: accuracy of MR imaging with MR cholangiopancreatography and MR angiography. Radiology 224(1):34–41CrossRefPubMed
Zurück zum Zitat Louhimo J et al (2004) Serum HCG beta and CA 72–4 are stronger prognostic factors than CEA, CA 19–9 and CA 242 in pancreatic cancer. Oncology 66(2):126–131CrossRefPubMed Louhimo J et al (2004) Serum HCG beta and CA 72–4 are stronger prognostic factors than CEA, CA 19–9 and CA 242 in pancreatic cancer. Oncology 66(2):126–131CrossRefPubMed
Zurück zum Zitat Lowenfels AB et al (1993) Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 328(20):1433–1437CrossRefPubMed Lowenfels AB et al (1993) Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 328(20):1433–1437CrossRefPubMed
Zurück zum Zitat Lynch HT, Fusaro RM (1991) Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome. Pancreas 6(2):127–131CrossRefPubMed Lynch HT, Fusaro RM (1991) Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome. Pancreas 6(2):127–131CrossRefPubMed
Zurück zum Zitat Maringhini A et al (1993) Clinical presentation and ultrasonography in the diagnosis of pancreatic cancer. Pancreas 8(2):146–150CrossRefPubMed Maringhini A et al (1993) Clinical presentation and ultrasonography in the diagnosis of pancreatic cancer. Pancreas 8(2):146–150CrossRefPubMed
Zurück zum Zitat Meyers MO et al (2004) Is reporting of recurrence data important in pancreatic cancer? Ann Surg Oncol 11(3):304–309CrossRefPubMed Meyers MO et al (2004) Is reporting of recurrence data important in pancreatic cancer? Ann Surg Oncol 11(3):304–309CrossRefPubMed
Zurück zum Zitat Michaud DS et al (2003) Dietary meat, dairy products, fat, and cholesterol and pancreatic cancer risk in a prospective study. Am J Epidemiol 157(12):1115–1125CrossRefPubMed Michaud DS et al (2003) Dietary meat, dairy products, fat, and cholesterol and pancreatic cancer risk in a prospective study. Am J Epidemiol 157(12):1115–1125CrossRefPubMed
Zurück zum Zitat Millikan KW et al (1999) Prognostic factors associated with resectable adenocarcinoma of the head of the pancreas. Am Surg 65(7):618–623 (discussion 623–624)PubMed Millikan KW et al (1999) Prognostic factors associated with resectable adenocarcinoma of the head of the pancreas. Am Surg 65(7):618–623 (discussion 623–624)PubMed
Zurück zum Zitat Mittal A et al (2004) Matched study of three methods for palliation of malignant pyloroduodenal obstruction. Br J Surg 91(2):205–209CrossRefPubMed Mittal A et al (2004) Matched study of three methods for palliation of malignant pyloroduodenal obstruction. Br J Surg 91(2):205–209CrossRefPubMed
Zurück zum Zitat Moore MJ, Goldstein D, Hamm J et al (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25(15):1960–1966CrossRefPubMed Moore MJ, Goldstein D, Hamm J et al (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25(15):1960–1966CrossRefPubMed
Zurück zum Zitat Mulcahy HE et al (1998) A prospective study of K-ras mutations in the plasma of pancreatic cancer patients. Clin Cancer Res 4(2):271–275PubMed Mulcahy HE et al (1998) A prospective study of K-ras mutations in the plasma of pancreatic cancer patients. Clin Cancer Res 4(2):271–275PubMed
Zurück zum Zitat Neoptolemos JP, Stocken DD, Friess H et al (2004) A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350:1200–1210CrossRefPubMed Neoptolemos JP, Stocken DD, Friess H et al (2004) A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350:1200–1210CrossRefPubMed
Zurück zum Zitat Neoptolemos JP, Stocken DD, Bassi C et al (2010) Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 304(10):1073–1081CrossRefPubMed Neoptolemos JP, Stocken DD, Bassi C et al (2010) Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 304(10):1073–1081CrossRefPubMed
Zurück zum Zitat Niedergethmann M, Grützmann R et al (2008) Outcome of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas (IPMN): a 10-year experience. World J Surg 32(10):2253–2260CrossRefPubMed Niedergethmann M, Grützmann R et al (2008) Outcome of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas (IPMN): a 10-year experience. World J Surg 32(10):2253–2260CrossRefPubMed
Zurück zum Zitat Norell SE et al (1986) Diet and pancreatic cancer: a case-control study. Am J Epidemiol 124(6):894–902PubMed Norell SE et al (1986) Diet and pancreatic cancer: a case-control study. Am J Epidemiol 124(6):894–902PubMed
Zurück zum Zitat Oettle H, Post S, Neuhaus P (2007) Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer a randomized controlled trial. JAMA 297:267–277CrossRefPubMed Oettle H, Post S, Neuhaus P (2007) Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer a randomized controlled trial. JAMA 297:267–277CrossRefPubMed
Zurück zum Zitat Ozkan H, Kaya M, Cengiz A (2003) Comparison of tumor marker CA 242 with CA 19-9 and carcinoembryonic antigen (CEA) in pancreatic cancer. Hepatogastroenterology 50(53):1669–1674PubMed Ozkan H, Kaya M, Cengiz A (2003) Comparison of tumor marker CA 242 with CA 19-9 and carcinoembryonic antigen (CEA) in pancreatic cancer. Hepatogastroenterology 50(53):1669–1674PubMed
Zurück zum Zitat Palesty JA, Dudrick SJ (2003) What we have learned about cachexia in gastrointestinal cancer. Dig Dis 21(3):198–213CrossRefPubMed Palesty JA, Dudrick SJ (2003) What we have learned about cachexia in gastrointestinal cancer. Dig Dis 21(3):198–213CrossRefPubMed
Zurück zum Zitat Palmer KR, Kerr M, Knowles G, Cull A, Carter DC, Leonard RC (1994) Chemotherapy prolongs survival in inoperable pancreatic carcinoma. Br J Surg 81:882–885CrossRefPubMed Palmer KR, Kerr M, Knowles G, Cull A, Carter DC, Leonard RC (1994) Chemotherapy prolongs survival in inoperable pancreatic carcinoma. Br J Surg 81:882–885CrossRefPubMed
Zurück zum Zitat Pederzoli P (1998) Phase 3 Trial of SMS 201–995 pa LAR (SMS pa LAR) vs placebo in unresectable stage II, III and IV pancreatic cancer. In: ASCO Annual Meeting Pederzoli P (1998) Phase 3 Trial of SMS 201–995 pa LAR (SMS pa LAR) vs placebo in unresectable stage II, III and IV pancreatic cancer. In: ASCO Annual Meeting
Zurück zum Zitat Pedrazzoli S, DiCarlo V et al (1998) Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg 228(4):508–517PubMedCentralCrossRefPubMed Pedrazzoli S, DiCarlo V et al (1998) Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg 228(4):508–517PubMedCentralCrossRefPubMed
Zurück zum Zitat Phillips AR et al (2002) Ethnic disparity of pancreatic cancer in New Zealand. Int J Gastrointest Cancer 31(1–3):137–145CrossRefPubMed Phillips AR et al (2002) Ethnic disparity of pancreatic cancer in New Zealand. Int J Gastrointest Cancer 31(1–3):137–145CrossRefPubMed
Zurück zum Zitat Pisters PW et al (2001) Effect of preoperative biliary decompression on pancreaticoduodenectomy-associated morbidity in 300 consecutive patients. Ann Surg 234(1):47–55PubMedCentralCrossRefPubMed Pisters PW et al (2001) Effect of preoperative biliary decompression on pancreaticoduodenectomy-associated morbidity in 300 consecutive patients. Ann Surg 234(1):47–55PubMedCentralCrossRefPubMed
Zurück zum Zitat Povoski SP et al (1999) Preoperative biliary drainage: impact on intraoperative bile cultures and infectious morbidity and mortality after pancreaticoduodenectomy. J Gastrointest Surg 3(5):496–505CrossRefPubMed Povoski SP et al (1999) Preoperative biliary drainage: impact on intraoperative bile cultures and infectious morbidity and mortality after pancreaticoduodenectomy. J Gastrointest Surg 3(5):496–505CrossRefPubMed
Zurück zum Zitat Prott FJ et al (1997) Combined modality treatment with accelerated radiotherapy and chemotherapy in patients with locally advanced inoperable carcinoma of the pancreas: results of a feasibility study. Br J Cancer 75(4):597–601PubMedCentralCrossRefPubMed Prott FJ et al (1997) Combined modality treatment with accelerated radiotherapy and chemotherapy in patients with locally advanced inoperable carcinoma of the pancreas: results of a feasibility study. Br J Cancer 75(4):597–601PubMedCentralCrossRefPubMed
Zurück zum Zitat Ren YX et al (2004) Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases. World J Gastroenterol 10(6):881–884PubMed Ren YX et al (2004) Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases. World J Gastroenterol 10(6):881–884PubMed
Zurück zum Zitat Reni M, Panucci MG, Passoni P et al (2004) Salvage chemotherapy with mitomycin, docetaxel, and irinotecan (MDI regimen) in metastatic pancreatic adenocarcinoma: a phase I and II trial. Cancer Invest 22:688–696CrossRefPubMed Reni M, Panucci MG, Passoni P et al (2004) Salvage chemotherapy with mitomycin, docetaxel, and irinotecan (MDI regimen) in metastatic pancreatic adenocarcinoma: a phase I and II trial. Cancer Invest 22:688–696CrossRefPubMed
Zurück zum Zitat Rich T et al (2004) Phase II study of external irradiation and weekly paclitaxel for nonmetastatic, unresectable pancreatic cancer: RTOG-98–12. Am J Clin Oncol 27(1):51–56CrossRefPubMed Rich T et al (2004) Phase II study of external irradiation and weekly paclitaxel for nonmetastatic, unresectable pancreatic cancer: RTOG-98–12. Am J Clin Oncol 27(1):51–56CrossRefPubMed
Zurück zum Zitat Richards DA, Kindler HL, Oettle H et al (2004) A randomized phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas. Proc Am Soc Clin Oncol 23:A4.007 Richards DA, Kindler HL, Oettle H et al (2004) A randomized phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas. Proc Am Soc Clin Oncol 23:A4.007
Zurück zum Zitat Ries LA et al (2000) The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer. Cancer 88(10):2398–2424CrossRefPubMed Ries LA et al (2000) The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer. Cancer 88(10):2398–2424CrossRefPubMed
Zurück zum Zitat Risch HA (2003) Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst 95(13):948–960CrossRefPubMed Risch HA (2003) Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst 95(13):948–960CrossRefPubMed
Zurück zum Zitat Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG (2011) Primary pancreatic cystic neoplasms revisited: Part II Mucinous cystic neoplasms. Surg Oncol 20(2):e93–101CrossRefPubMed Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG (2011) Primary pancreatic cystic neoplasms revisited: Part II Mucinous cystic neoplasms. Surg Oncol 20(2):e93–101CrossRefPubMed
Zurück zum Zitat Santo E (2004) Pancreatic cancer imaging: which method? Jop 5(4):253–257PubMed Santo E (2004) Pancreatic cancer imaging: which method? Jop 5(4):253–257PubMed
Zurück zum Zitat Schima W et al (2002) Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT. Am J Roentgenol 179(3):717–724CrossRef Schima W et al (2002) Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT. Am J Roentgenol 179(3):717–724CrossRef
Zurück zum Zitat Seufferlein T, Bachet LB, Van Cutsem E, Rougier P (2012) Pancreatic adenocarcinoma: ESMO–ESDO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vi33–vi40CrossRef Seufferlein T, Bachet LB, Van Cutsem E, Rougier P (2012) Pancreatic adenocarcinoma: ESMO–ESDO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vi33–vi40CrossRef
Zurück zum Zitat Shinchi H et al (2002) Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-fluorouracil infusion for locally unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 53(1):146–150CrossRefPubMed Shinchi H et al (2002) Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-fluorouracil infusion for locally unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 53(1):146–150CrossRefPubMed
Zurück zum Zitat Silverman DT et al (1994) Cigarette smoking and pancreas cancer: a case-control study based on direct interviews. J Natl Cancer Inst 86(20):1510–1516CrossRefPubMed Silverman DT et al (1994) Cigarette smoking and pancreas cancer: a case-control study based on direct interviews. J Natl Cancer Inst 86(20):1510–1516CrossRefPubMed
Zurück zum Zitat Slesak B et al (2004) TPS and CA 19-9 measurements in the follow-up of patients with pancreatic cancer and chronic pancreatitis. Int J Biol Markers 19(2):115–119PubMed Slesak B et al (2004) TPS and CA 19-9 measurements in the follow-up of patients with pancreatic cancer and chronic pancreatitis. Int J Biol Markers 19(2):115–119PubMed
Zurück zum Zitat Snady H et al (2000) Survival advantage of combined chemoradiotherapy compared with resection as the initial treatment of patients with regional pancreatic carcinoma. An outcomes trial. Cancer 89(2):314–327CrossRefPubMed Snady H et al (2000) Survival advantage of combined chemoradiotherapy compared with resection as the initial treatment of patients with regional pancreatic carcinoma. An outcomes trial. Cancer 89(2):314–327CrossRefPubMed
Zurück zum Zitat Sohn TA et al (2000) Do preoperative biliary stents increase postpancreaticoduodenectomy complications? J Gastrointest Surg 4(3):258–267 (discussion 267–268)CrossRefPubMed Sohn TA et al (2000) Do preoperative biliary stents increase postpancreaticoduodenectomy complications? J Gastrointest Surg 4(3):258–267 (discussion 267–268)CrossRefPubMed
Zurück zum Zitat Swift M, Chase CL, Morrell D (1990) Cancer predisposition of ataxia-telangiectasia heterozygotes. Cancer Genet Cytogenet 46(1):21–27CrossRefPubMed Swift M, Chase CL, Morrell D (1990) Cancer predisposition of ataxia-telangiectasia heterozygotes. Cancer Genet Cytogenet 46(1):21–27CrossRefPubMed
Zurück zum Zitat Varghese JC et al (1999) Role of MR cholangiopancreatography in patients with failed or inadequate ERCP. Am J Roentgenol 173(6):1527–1533CrossRef Varghese JC et al (1999) Role of MR cholangiopancreatography in patients with failed or inadequate ERCP. Am J Roentgenol 173(6):1527–1533CrossRef
Zurück zum Zitat Vyas S, Markar S, Ezzat TM, Ajit A (2011) Cystic lesions of the pancreas: current trends in approach and management. Postgrad Med J 87:207–214CrossRefPubMed Vyas S, Markar S, Ezzat TM, Ajit A (2011) Cystic lesions of the pancreas: current trends in approach and management. Postgrad Med J 87:207–214CrossRefPubMed
Zurück zum Zitat Werner JB, Bartosch-Härlid A, Andersson R (2011) Cystic pancreatic lesions: Current evidence for diagnosis and treatment. Scan J Gastroenterol 46(7–8):773–788CrossRef Werner JB, Bartosch-Härlid A, Andersson R (2011) Cystic pancreatic lesions: Current evidence for diagnosis and treatment. Scan J Gastroenterol 46(7–8):773–788CrossRef
Zurück zum Zitat Wilkowski R et al (2004) Concurrent chemoradiotherapy with gemcitabine and cisplatin after incomplete (R1) resection of locally advanced pancreatic carcinoma. Int J Radiat Oncol Biol Phys 58(3):768–772CrossRefPubMed Wilkowski R et al (2004) Concurrent chemoradiotherapy with gemcitabine and cisplatin after incomplete (R1) resection of locally advanced pancreatic carcinoma. Int J Radiat Oncol Biol Phys 58(3):768–772CrossRefPubMed
Metadaten
Titel
Pankreastumoren
verfasst von
Marcus Bahra, Prof. Dr. med.
Florian Lordick, Prof. Dr. med.
Manfred P. Lutz, Professor Dr. med.
Matthias Glanemann, Prof. Dr. med.
Peter Neuhaus, Prof. Dr. med.
Copyright-Jahr
2015
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-14301-4_38

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.