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Erschienen in: Acta Neuropathologica 5/2015

01.05.2015 | Correspondence

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

verfasst von: Kurt A. Jellinger, Irina Alafuzoff, Johannes Attems, Thomas G. Beach, Nigel J. Cairns, John F. Crary, Dennis W. Dickson, Patrick R. Hof, Bradley T. Hyman, Clifford R. Jack Jr., Gregory A. Jicha, David S. Knopman, Gabor G. Kovacs, Ian R. Mackenzie, Eliezer Masliah, Thomas J. Montine, Peter T. Nelson, Frederick Schmitt, Julie A. Schneider, Albert Serrano-Pozo, Dietmar R. Thal, Jonathan B. Toledo, John Q. Trojanowski, Juan C. Troncoso, Jean Paul Vonsattel, Thomas Wisniewski

Erschienen in: Acta Neuropathologica | Ausgabe 5/2015

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Excerpt

The relationship between primary age-related tauopathy (PART) and Alzheimer’s disease (AD) is currently a matter of discussion. Recently the term PART was referred to cases characterized by mainly allocortical neurofibrillary (NF) pathology (Braak stages 0–IV) with only few or no amyloid (Aβ) deposits (Thal Aβ phases 0–2) [49]. In addition, no elevated soluble Aβ was detected in this disorder [9, 46]. PART cases that lack any Aβ do not meet formal criteria for sporadic AD according to the NIA–AA guidelines [35]. These neurofibrillary tangle (NFT)+/Aβ-brains are commonly observed in extreme old age [9, 15, 19]. When associated with a high density of NFTs in the same distribution and some cognitive deficits, the disorder has been referred to as tangle-predominant senile dementia (TPSD) [27] or “tangle-only dementia” [55]. …
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Metadaten
Titel
PART, a distinct tauopathy, different from classical sporadic Alzheimer disease
verfasst von
Kurt A. Jellinger
Irina Alafuzoff
Johannes Attems
Thomas G. Beach
Nigel J. Cairns
John F. Crary
Dennis W. Dickson
Patrick R. Hof
Bradley T. Hyman
Clifford R. Jack Jr.
Gregory A. Jicha
David S. Knopman
Gabor G. Kovacs
Ian R. Mackenzie
Eliezer Masliah
Thomas J. Montine
Peter T. Nelson
Frederick Schmitt
Julie A. Schneider
Albert Serrano-Pozo
Dietmar R. Thal
Jonathan B. Toledo
John Q. Trojanowski
Juan C. Troncoso
Jean Paul Vonsattel
Thomas Wisniewski
Publikationsdatum
01.05.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Acta Neuropathologica / Ausgabe 5/2015
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-015-1407-2

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