Introduction
Potential biomarker of circulating miR-155 in AD
Neuropathogenesis of miR-155 in AD
MiR-155 contributes to Aβ pathology
MiR-155 contributes to Tau pathology
MiR-155 contributes to neuroinflammation
Pathogenesis of miR-155 in AD-related modifiable risk factors
MiR-155 contributes to hypertension
MiR-155 contributes to dyslipidemia
MiR-155 contributes to cerebrovascular diseases
MiR-155 contributes to depression
Pathogenesis of miR-155 in AD-related adaptive immune
Conclusion
Model | Target gene | Molecular mechanisms | Outcomes | References |
---|---|---|---|---|
Aβ1–42 oligomers-treated HT-22 cells | N/A | N/A | Serve as an AD detector | [22] |
APP/PS1 mice, Aβ1-42-treated N2a cells | SKP2 | SKP2/IKKβ pathway | Aggravating Aβ deposition | [45] |
Intravitreal injection of Aβ oligomers | N/A | TGF-β and prion diseases pathways | Regulating Aβ-induced retinal damage | [49] |
3xTg-AD mice | SOCS-1 | TNFSF10/miRNA-155/SOCS-1 network | Downregulation of the Aβ deposits and phosphorylated Tau (p-Tau) | [50] |
APPtg and TAUtg mice | MSK1, GSK3β | Repressing the expression of GSK3β | Regulating amyloid-beta production or TAU phosphorylation | [51] |
hTau mice | N/A | mTOR, MAPK, Wnt, and T-cell receptor signaling pathways | Phosphorylating tau | [30] |
DS-like neuronal deficits in Snx27 − / − mice | C/EBPβ | miR-155/C/EBPβ/SNX27 pathway | Inducing synaptic dysfunction | [60] |
3xTg-AD mice, Aβ oligomers or Aβ fibrils treated N9 microglia cells or primary astrocyte cells | SOCS1 | miR-155/SOCS1/IL-6 pathway | Enhancing the expression of pro inflammatory factors | [74] |
LPS-stimulated murine primary microglia | SOCS1, HIF1α, CEBPβ | TLR signal, NF-κB/RelA and STAT1/STAT3 signaling pathways | Inducing the M1-skewing of microglia | [75] |
Fibrillar Aβ1-42-treated primary microglia | N/A | Regulating the endolysosomal pathway | Reducing the ability of microglia to catabolize fAβ1-42 | [76] |
Intraperitoneal injection of LPS | SHIP-1 | miR-155/SHIP-1/p-AKT axis | Downregulation the expression of inflammatory factors | [77] |
A rat model of AD | N/A | Increasing the expression of IL-1β, IL-6 and TNF-α | Aggravating neuroinflammation | [79] |
Mice lacking mineralocorticoid receptors in smooth muscle cells | Cav1.2, AgtR1 | miR-155/Cav1.2/AgtR1 axis | Regulating vasoconstriction in the aging vasculature | [89] |
A pregnant hypertension rat model | FOXO3a | miR-155/ FOXO3a | Regulating placental tissue morphology, blood pressure and serum creatine level 30,402,830 | [92] |
A rat hypertension model | P27 | miR-155/P27 | Regulating Vascular smooth muscle cell proliferation 30468491 | [94] |
Two-kidney-one-clip -induced renovascular endothelial dysfunction | eNOS | NF-κB/miR-155-5p/eNOS/NO/IκB | Improving vascular endothelial function | [93] |
Atherosclerotic ApoE − / − mouse model | NoxA1 | miR-155-NoxA1-p47phox complex signaling pathway | Promoting vascular smooth muscle cells proliferation and neointima formation | [104] |
Mir155 − / − Ldlr − / − mice and Mir155 − / − Apoe − / − mice | MafB | miR-155/ MafB/IL-6 | Limiting the progression of obesity and atherosclerosis | [99] |
ApoE − / − mice | NLRP3 | ERK1/2/NF-κB/NLRP3 pathway | Aggravating inflammation and promoting the development of atherosclerosis | [105] |
ApoE − / − mice | SOCS1 | SOCS1/STAT3/PDCD4 pathway | Regulating inflammation | [106] |
Controlled cortical impact-induced experimental TBI | SOCS1 | SOCS1 rather than SHIP-1 pathway | Promoting post-traumatic neuroinflammatory responses | [110] |
Controlled cortical impact-induced experimental TBI | N/A | Promotes the type 1 IFN response | Regulating TBI pathophysiology | [111] |
Controlled cortical impact-induced experimental TBI | PGC-1α | MiR-155/PGC-1α | Suppressing mitochondrial biogenesis | [112] |
Distal middle cerebral artery occlusion (dMCAO) model | Rheb | Rheb/p-AKT/ZO-1 pathway | Destroying the integrity of BBB | [115] |
Middle cerebral artery occlusion (MCAO) model | TLR4 | TLR4/MyD88 pathway | Resulting in the development of cell damage | [116] |
Middle cerebral artery occlusion/reperfusion (MCAO/R) model | DUSP14 | NF-κB and MAPKs signaling pathways | Causing cell injury and inflammation | [117] |
Middle cerebral artery occlusion (MCAO) model | Rheb | Rheb/mTOR pathway | Resulting in significant cerebral infarct volumes and cell apoptosis | [118] |
Middle cerebral artery occlusion/reperfusion (MCAO/R) model | MafB | miR-155/ MafB | Improving the neurological function and inhibiting inflammation response | [119] |
The blood samples of major depression disorder patients, human neural progenitor cells | SIRT1 | MiR-155/ SIRT1 pathway | Mediating depression and anxiety-like behaviors | [124] |
Chronic unpredictable mild stress-induced depression model | N/A | Wnt/β-catenin signaling pathway | Promoting the release of inflammatory factors and the apoptosis of hippocampal neurons | [129] |
Chronic unpredictable mild stress-induced depression model | FGF2 | NF-κB/miR-155/FGF2 | Aggravating depression and anxiety-like behaviors | [130] |
MicroRNA-155 knockout mouse model and glioma mouse model | FoxO3a | FoxO3a/Akt/Stat5 signaling pathway | Repressing the proliferative and invasive abilities of CD8 + T cells | [145] |
Immunological diseases-related models | SOCS1, SHIP1, c-Fos, SIRT1, c-Maf, FOXO3 etc | SOCS1/Stat5, SHIP1/AKT, SIRT1Foxop3 signaling pathway | Regulating CD4 + T cells | [147] |