Ausgabe 1/2023
Inhalt (221 Artikel)
Neuropsychological test performance of former American football players
Michael L. Alosco, William B. Barr, Sarah J. Banks, Jennifer V. Wethe, Justin B. Miller, Surya Vamsi Pulukuri, Julia Culhane, Yorghos Tripodis, Charles H. Adler, Laura J. Balcer, Charles Bernick, Megan L. Mariani, Robert C. Cantu, David W. Dodick, Michael D. McClean, Rhoda Au, Jesse Mez, Robert W. Turner II, Joseph N. Palmisano, Brett Martin, Kaitlin Hartlage, Jeffrey L. Cummings, Eric M. Reiman, Martha E. Shenton, Robert A. Stern, Yi Su, Kewei Chen, Hillary Protas, Connie Boker, Lindsay Farrer, Robert Helm, Douglas I. Katz, Neil Kowall, Gustavo Mercier, James Otis, Jason Weller, Irene Simkin, Alondra Andino, Shannon Conneely, Courtney Diamond, Tessa Fagle, Olivia Haller, Tennyson Hunt, Nicole Gullotti, Brian Mayville, Kathleen McLaughlin, Mary Nanna, Taylor Platt, Fiona Rice, Madison Sestak, Douglas Annis, Christine Chaisson, Diane B. Dixon, Carolyn Finney, Kerrin Gallagher, Jun Lu, Emmanuel Ojo, Brittany Pine, Janani Ramachandran, Sylvain Bouix, Jennifer Fitzsimmons, Alexander P. Lin, Inga K. Koerte, Ofer Pasternak, Hector Arciniega, Tashrif Billah, Elena Bonke, Katherine Breedlove, Eduardo Coello, Michael J. Coleman, Leonhard Jung, Huijun Liao, Maria Loy, Elizabeth Rizzoni, Vivian Schultz, Annelise Silva, Brynn Vessey, Tim L. T. Wiegand, Aaron Ritter, Marwan Sabbagh, Raelynn de la Cruz, Jan Durant, Morgan Golceker, Nicolette Harmon, Kaeson Kaylegian, Rachelle Long, Christin Nance, Priscilla Sandoval, Kenneth L. Marek, Andrew Serrano, Yonas Geda, Bryce Falk, Amy Duffy, Marci Howard, Michelle Montague, Thomas Osgood, Debra Babcock, Patrick Bellgowan, Judith Goldberg, Thomas Wisniewski, Ivan Kirov, Yvonne Lui, Charles Marmar, Lisena Hasanaj, Liliana Serrano, Alhassan Al-Kharafi, Allan George, Sammie Martin, Edward Riley, William Runge, Elaine R. Peskind, Elizabeth Colasurdo, Daniel S. Marcus, Jenny Gurney, Richard Greenwald, Keith A. Johnson
Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer’s disease in individuals with subjective cognitive decline
María Pascual-Lucas, José Antonio Allué, Leticia Sarasa, Noelia Fandos, Sergio Castillo, Jose Terencio, Manuel Sarasa, Juan Pablo Tartari, Ángela Sanabria, Lluís Tárraga, Agustín Ruíz, Marta Marquié, Sang Won Seo, Hyemin Jang, Mercè Boada, N. Aguilera, E. Alarcón-Martín, M. Alegret, S. Alonso-Lana, M. Berthier, U. Bojayrin, M. Buendia, S. Bullich, F. Campos, A. Cano, P. Cañabate, L. Cañada, C. Cuevas, I. de Rojas, S. Diego, A. Espinosa, E. Esteban-De Antonio, A. Gailhajenet, A García-Sánchez, P. García, J. Giménez, M. Gómez-Chiari, M. Guitart, I. Hernández, M. Ibarria, A. Lafuente, N. Lleonart, F. Lomeña, E. Martín, M. Moreno, A. Morera, L. Montrreal, N. Muñoz, L. Narvaiza, A. Niñerola, A. B. Nogales, L. Núñez, A. Orellana, G. Ortega, A. Páez, A. Pancho, E. Pelejà, E. Pérez, A. Pérez-Cordon, A. Perissinotti, S. Preckler, V. Pytel, M. Ricciardi, O. Rodríguez-Gomez, N. Roé-Vellvé, M. I. Ramis, M. Rosende-Roca, S. Seguer, O. Sotolongo-Grau, A. Stephens, M. A. Tejero, M. Torres, S. Valero, L. Vargas, A. Vivas
Altered metabolic connectivity within the limbic cortico-striato-thalamo-cortical circuit in presymptomatic and symptomatic behavioral variant frontotemporal dementia
Li Liu, Min Chu, Binbin Nie, Deming Jiang, Kexin Xie, Yue Cui, Lin Liu, Yu Kong, Zhongyun Chen, Haitian Nan, Pedro Rosa-Neto, Liyong Wu
Correction: Treatment needs of dementia with Lewy bodies according to patients, caregivers, and physicians: a cross-sectional, observational, questionnaire-based study in Japan
Mamoru Hashimoto, Yuta Manabe, Takuhiro Yamaguchi, Shunji Toya, Manabu Ikeda
Dementia and psychotropic medications are associated with significantly higher mortality in geriatric patients hospitalized with COVID-19: data from the StockholmGeroCovid project
Juraj Secnik, Maria Eriksdotter, Hong Xu, Martin Annetorp, Aleksander Rytarowski, Kristina Johnell, Sara Hägg, Dorota Religa
Continuity of care (COC) and amyloid-β PET scan: the CARE-IDEAS study
Emily C. O’Brien, Cassie B. Ford, Corinna Sorenson, Eric Jutkowitz, Megan Shepherd-Banigan, Courtney Van Houtven
Leading mediators of sex differences in the incidence of dementia in community-dwelling adults in the UK Biobank: a retrospective cohort study
Xianwen Shang, Eddy Roccati, Zhuoting Zhu, Katerina Kiburg, Wei Wang, Yu Huang, Xueli Zhang, Xiayin Zhang, Jiahao Liu, Shulin Tang, Yijun Hu, Zongyuan Ge, Honghua Yu, Mingguang He
Molecular insights into sex-specific metabolic alterations in Alzheimer’s mouse brain using multi-omics approach
Abigail Strefeler, Maxime Jan, Manfredo Quadroni, Tony Teav, Nadia Rosenberg, Jean-Yves Chatton, Nicolas Guex, Hector Gallart-Ayala, Julijana Ivanisevic
Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study
Panpan He, Chun Zhou, Ziliang Ye, Mengyi Liu, Yuanyuan Zhang, Qimeng Wu, Yanjun Zhang, Sisi Yang, Gan Xiaoqin, Xianhui Qin
Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer’s Disease (EPAD) cohort
Rasha N. M. Saleh, Michael Hornberger, Craig W. Ritchie, Anne Marie Minihane
More extensive hypometabolism and higher mortality risk in patients with right- than left-predominant neurodegeneration of the anterior temporal lobe
Lars Frings, Ganna Blazhenets, Raphael Binder, Tobias Bormann, Sabine Hellwig, Philipp T. Meyer
The effects of a moderate physical activity intervention on physical fitness and cognition in healthy elderly with low levels of physical activity: a randomized controlled trial
Sara A. Galle, Jan Berend Deijen, Maarten V. Milders, Mathieu H. G. De Greef, Erik J. A. Scherder, Cornelia M. van Duijn, Madeleine L. Drent
Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Häsler, Róisín McManus, Christina Ising, Sandra Röske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Görß, Christoph Laske, Matthias H. Munk, Emrah Düzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T. Heneka
The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic
Hyemin Jang, Min Young Chun, Hee Jin Kim, Duk L. Na, Sang Won Seo
Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Hayato Odagiri, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis
Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease
Xiao Li, Deng-Feng Zhang, Rui Bi, Li-Wen Tan, Xiaogang Chen, Min Xu, Yong-Gang Yao
Correction: Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy
Jacqui T. Nimmo, Ajay Verma, Jean-Cosme Dodart, Chang Yi Wang, Jimmy Savistchenko, Ronald Melki, Roxana O. Carare, James A. R. Nicoll
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
Inés López-Cuenca, Alberto Nebreda, Alejandra García-Colomo, Elena Salobrar-García, Jaisalmer de Frutos-Lucas, Ricardo Bruña, Ana I. Ramírez, Federico Ramirez-Toraño, Juan J. Salazar, Ana Barabash, Pedro Gil, Fernando Maestú, José M. Ramírez, Rosa de Hoz
The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials
Ping-Tao Tseng, Yen-Wen Chen, Bing-Yan Zeng, Bing-Syuan Zeng, Chao-Ming Hung, Cheuk-Kwan Sun, Yu-Shian Cheng, Brendon Stubbs, Andre F. Carvalho, Andre R. Brunoni, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Che-Sheng Chu, Mein-Woei Suen, Cheng-Ta Li
Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation
Jing Xu, Yanmin Xia, Meng Meng, Fang Liu, Ping Che, Yanxin Zhang, Ying Wang, Li Cai, Wen Qin, Nan Zhang
How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model
Jaisalmer de Frutos Lucas, Kelsey R. Sewell, Alejandra García-Colomo, Shaun Markovic, Kirk I. Erickson, Belinda M. Brown
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Inès R. H. Ben-Nejma, Aneta J. Keliris, Verdi Vanreusel, Peter Ponsaerts, Annemie Van der Linden, Georgios A. Keliris
Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial
Glen Wunderlich, Zuzana Blahova, Miguel Garcia, Frank Jessen
Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit
Sterling C. Johnson, Marc Suárez-Calvet, Ivonne Suridjan, Carolina Minguillón, Juan Domingo Gispert, Erin Jonaitis, Agata Michna, Margherita Carboni, Tobias Bittner, Christina Rabe, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow
Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy
Marc Vervuurt, Anna M. de Kort, Lieke Jäkel, Iris Kersten, Wilson F. Abdo, Floris H. B. M. Schreuder, Ingeborg Rasing, Gisela M. Terwindt, Marieke J. H. Wermer, Steven M. Greenberg, Catharina J. M. Klijn, H. Bea Kuiperij, Marcel M. Verbeek
Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment
Mingxi Dang, Caishui Yang, Kewei Chen, Peng Lu, He Li, Zhanjun Zhang
Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill
Correction: Cortical microstructure in primary progressive aphasia: a multicenter study
Ignacio Illán-Gala, Victor Montal, Sergi Borrego-Écija, Maria Luisa Mandelli, Neus Falgàs, Ariane E. Welch, Jordi Pegueroles, Miguel Santos-Santos, Alexandre Bejanin, Daniel Alcolea, Oriol Dols-Icardo, Olivia Belbin, Mª. Belén Sánchez-Saudinós, Nuria Bargalló, Sofía González-Ortiz, Albert Lladó, Rafael Blesa, Bradford C. Dickerson, Howard J. Rosen, Bruce L. Miller, Alberto Lleó, Maria Luisa Gorno-Tempini, Raquel Sánchez-Valle, Juan Fortea
Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease
Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Guo
The dynamics of plasma biomarkers across the Alzheimer’s continuum
Yu Guo, Xue-Ning Shen, Hui-Fu Wang, Shi-Dong Chen, Ya-Ru Zhang, Shu-Fen Chen, Mei Cui, Wei Cheng, Qiang Dong, Tao Ma, Jin-Tai Yu
Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology
Bin Jiao, Rihui Li, Hui Zhou, Kunqiang Qing, Hui Liu, Hefu Pan, Yanqin Lei, Wenjin Fu, Xiaoan Wang, Xuewen Xiao, Xixi Liu, Qijie Yang, Xinxin Liao, Yafang Zhou, Liangjuan Fang, Yanbin Dong, Yuanhao Yang, Haiyan Jiang, Sha Huang, Lu Shen
Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse
Shang Wang, Taiyang Zhu, Wanyan Ni, Chao Zhou, Hui Zhou, Li Lin, Yuting Hu, Xiaoyu Sun, Jingjing Han, Yan Zhou, Guoliang Jin, Jie Zu, Hongjuan Shi, Xingxing Yang, Zuohui Zhang, Fang Hua
Comparison of ultrasensitive and mass spectrometry quantification of blood-based amyloid biomarkers for Alzheimer’s disease diagnosis in a memory clinic cohort
Christophe Hirtz, Germain U. Busto, Karim Bennys, Jana Kindermans, Sophie Navucet, Laurent Tiers, Simone Lista, Jérôme Vialaret, Laure-Anne Gutierrez, Yves Dauvilliers, Claudine Berr, Sylvain Lehmann, Audrey Gabelle
Choroid and choriocapillaris changes in early-stage Parkinson’s disease: a swept-source optical coherence tomography angiography-based cross-sectional study
Salih Uzun, Fatma Uzun
Letter to the Editor Authors’ Response: Choroid and choriocapillaris changes in early-stage Parkinson’s disease: a swept-source optical coherence tomography angiography-based cross-sectional study
Yifan Zhang, Yuzhu Gao, Hanyue Xu, Yi Chen, Ming Zhang
Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity
Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westman
Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease
Rebecca E. Green, Jodie Lord, Marzia A. Scelsi, Jin Xu, Andrew Wong, Sarah Naomi-James, Alex Handy, Lachlan Gilchrist, Dylan M. Williams, Thomas D. Parker, Christopher A. Lane, Ian B. Malone, David M. Cash, Carole H. Sudre, William Coath, David L. Thomas, Sarah Keuss, Richard Dobson, Cristina Legido-Quigley, Nick C. Fox, Jonathan M. Schott, Marcus Richards, Petroula Proitsi
Masitinib for mild-to-moderate Alzheimer’s disease: results from a randomized, placebo-controlled, phase 3, clinical trial
Bruno Dubois, Jesús López-Arrieta, Stanley Lipschitz, Triantafyllos Doskas, Luiza Spiru, Svitlana Moroz, Olena Venger, Patrick Vermersch, Alain Moussy, Colin D. Mansfield, Olivier Hermine, Magda Tsolaki
Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer’s disease
Meina Quan, Qi Wang, Wei Qin, Wei Wang, Fangyu Li, Tan Zhao, Tingting Li, Qiongqiong Qiu, Shuman Cao, Shiyuan Wang, Yan Wang, Hongmei Jin, Aihong Zhou, Jiliang Fang, Longfei Jia, Jianping Jia
Early tau detection in flortaucipir images: validation in autopsy-confirmed data and implications for disease progression
Vikas Kotari, Sudeepti Southekal, Michael Navitsky, Ian A. Kennedy, Ming Lu, Amanda Morris, Jennifer Ann Zimmer, Adam S. Fleisher, Mark A. Mintun, Michael D. Devous Sr, Michael J. Pontecorvo
Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment
Daniel C. Javitt, Antigona Martinez, Pejman Sehatpour, Anna Beloborodova, Christian Habeck, Yunglin Gazes, Dalton Bermudez, Qolamreza R. Razlighi, D. P. Devanand, Yaakov Stern
Brain reserve contributes to distinguishing preclinical Alzheimer’s stages 1 and 2
Zerrin Yildirim, Firuze Delen, David Berron, Hannah Baumeister, Gabriel Ziegler, Hartmut Schütze, Wenzel Glanz, Laura Dobisch, Oliver Peters, Silka Dawn Freiesleben, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn-Hendrik Schott, Dix Meiberth, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael Heneka, Frederic Brosseron, Michael Wagner, Sandra Roeske, Alfredo Ramirez, Michael Ewers, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Steffen Wolfsgruber, Renat Yakupov, Matthias Schmid, Moritz Berger, Hakan Gurvit, Frank Jessen, Emrah Duzel
Cerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
Maya Arvidsson Rådestig, Ingmar Skoog, Tobias Skillbäck, Henrik Zetterberg, Jürgen Kern, Anna Zettergren, Ulf Andreasson, Hanna Wetterberg, Silke Kern, Kaj Blennow
Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer’s disease
Angelika Caputo, Amy Racine, Ines Paule, Pierre N. Tariot, Jessica B. Langbaum, Neva Coello, Marie-Emmanuelle Riviere, J. Michael Ryan, Cristina Lopez Lopez, Ana Graf
Restless leg syndrome and risk of all-cause dementia: a nationwide retrospective cohort study
Keun You Kim, Eun Hwa Kim, Myeongjee Lee, Junghee Ha, Inkyung Jung, Eosu Kim
Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection
Mohammed D. Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E. Matthews, Li Su, Paul G. Ince, Stephen B. Wharton, Dennis Wang
Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts
Juan Lantero-Rodriguez, Agathe Vrillon, Aida Fernández-Lebrero, Paula Ortiz-Romero, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, Emmanuel Cognat, Julien Dumurgier, Albert Puig-Pijoan, Irene Navalpotro-Gómez, Greta García-Escobar, Thomas K. Karikari, Eugeen Vanmechelen, Nicholas J. Ashton, Henrik Zetterberg, Marc Suárez-Calvet, Claire Paquet, Kaj Blennow
Purpose in life promotes resilience to age-related brain burden in middle-aged adults
Kilian Abellaneda-Pérez, Gabriele Cattaneo, María Cabello-Toscano, Javier Solana-Sánchez, Lídia Mulet-Pons, Lídia Vaqué-Alcázar, Ruben Perellón-Alfonso, Cristina Solé-Padullés, Núria Bargalló, Josep M. Tormos, Alvaro Pascual-Leone, David Bartrés-Faz
Exploring the ATN classification system using brain morphology
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Göerß, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Düzel, Gabriel Ziegler
Changes in CSF sPDGFRβ level and their association with blood–brain barrier breakdown in Alzheimer’s disease with or without small cerebrovascular lesions
Xinyi Lv, Mengguo Zhang, Zhaozhao Cheng, Qiong Wang, Peng Wang, Qiang Xie, Ming Ni, Yong Shen, Qiqiang Tang, Feng Gao
Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b
Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David C. Airey, James Scherschel, Sarubini Kananathan, Brian J. Eastwood, Suchira Bose, David A. Collier, Emma Laing, David Evans, Howard Broughton, Andreas Bender
Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
Li Chen, Lei Xiong, Lingling Yao, Jinxiu Pan, Emily Arzola, Xiaojuan Zhu, Lin Mei, Wen-Cheng Xiong
Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
Jagan A. Pillai, James Bena, Lynn Bekris, Nandan Kodur, Takhar Kasumov, James B. Leverenz, Sangeeta R. Kashyap
The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults
Gilda E. Ennis, Tobey J. Betthauser, Rebecca Langhough Koscik, Nathaniel A. Chin, Bradley T. Christian, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin
Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study
Mi Hee Cho, Kyungdo Han, Seungwoo Lee, Su-Min Jeong, Jung Eun Yoo, SangYun Kim, Jinkook Lee, Sohyun Chun, Dong Wook Shin
Uncovering heterogeneous cognitive trajectories in mild cognitive impairment: a data-driven approach
Xiwu Wang, Teng Ye, Wenjun Zhou, Jie Zhang
Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration
Wencai Ding, Peng Ren, Liye Yi, Yao Si, Fan Yang, Zhipeng Li, Hongbo Bao, Shi Yan, Xinyu Zhang, Siyang Li, Xia Liang, Lifen Yao, Howard Rosen, Bradford C. Dickerson, Kimoko Domoto-Reilly, David Knopman, Bradley F. Boeve, Adam L. Boxer, John Kornak, Bruce L. Miller, William W. Seeley, Maria-Luisa Gorno-Tempini, Scott McGinnis, Maria Luisa Mandelli
Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degeneration
Claire Bridel, Juami H. M. van Gils, Suzanne S. M. Miedema, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, August B. Smit, Annemieke J. M. Rozemuller, Sanne Abeln, Charlotte E. Teunissen
Therapeutic preference for Alzheimer’s disease treatments: a discrete choice experiment with caregivers and neurologists
George Dranitsaris, Quanwu Zhang, Lin Mu, Christopher Weyrer, Erik Drysdale, Peter Neumann, Alireza Atri, Amir Abbas Tahami Monfared
Mapping the long-term delayed recall-based cortex-hippocampus network constrained by the structural and functional connectome: a case-control multimodal MRI study
Jie Ma, Mou-Xiong Zheng, Jia-Jia Wu, Xiang-Xin Xing, Yun-Ting Xiang, Dong Wei, Xin Xue, Han Zhang, Xu-Yun Hua, Qi-Hao Guo, Jian-Guang Xu
Synaptic biomarkers in the cerebrospinal fluid associate differentially with classical neuronal biomarkers in patients with Alzheimer’s disease and frontotemporal dementia
Shreyasee Das, Julie Goossens, Dirk Jacobs, Nele Dewit, Yolande A. L. Pijnenburg, Sjors G. J. G. In ‘t Veld, Charlotte E. Teunissen, Eugeen Vanmechelen
Correction: Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I‑UDSNB 1.0): development and normative data
Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricalà, Stefano Francesco Cappa
Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL−F/NL−F knock-in mouse model of Alzheimer’s disease
Emelie Andersson, Nina Schultz, Takashi Saito, Takaomi C. Saido, Kaj Blennow, Gunnar K. Gouras, Henrik Zetterberg, Oskar Hansson
The effect of music therapy on cognitive functions in patients with Alzheimer’s disease: a systematic review of randomized controlled trials
Malak Bleibel, Ali El Cheikh, Najwane Said Sadier, Linda Abou-Abbas
Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals
Corinne Pettigrew, Jurijs Nazarovs, Anja Soldan, Vikas Singh, Jiangxia Wang, Timothy Hohman, Logan Dumitrescu, Julia Libby, Brian Kunkle, Alden L. Gross, Sterling Johnson, Qiongshi Lu, Corinne Engelman, Colin L. Masters, Paul Maruff, Simon M. Laws, John C. Morris, Jason Hassenstab, Carlos Cruchaga, Susan M. Resnick, Melissa H. Kitner-Triolo, Yang An, Marilyn Albert
Ethnicity and survival after a dementia diagnosis: a retrospective cohort study using electronic health record data
Melissa Co, Christoph Mueller, Rosie Mayston, Jayati Das-Munshi, Matthew Prina
Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity
Sung Hoon Kang, Mengting Liu, Gilsoon Park, Sharon Y. Kim, Hyejoo Lee, William Matloff, Lu Zhao, Heejin Yoo, Jun Pyo Kim, Hyemin Jang, Hee Jin Kim, Neda Jahanshad, Kyumgmi Oh, Seong-Beom Koh, Duk L. Na, John Gallacher, Rebecca F. Gottesman, Sang Won Seo, Hosung Kim
Plasma β2-microglobulin and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study
Yi-Ming Huang, Ya-Hui Ma, Pei-Yang Gao, Zhi-Bo Wang, Liang-Yu Huang, Jia-Hui Hou, Lan Tan, Jin-Tai Yu
Validation study of “Santé-Cerveau”, a digital tool for early cognitive changes identification
Constance Lesoil, Stéphanie Bombois, Octave Guinebretiere, Marion Houot, Mahsa Bahrami, Marcel Levy, Rémy Genthon, Frédérique Bozon, Heidy Jean-Marie, Stéphane Epelbaum, Pierre Foulon, Nicolas Villain, Bruno Dubois
APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly
Anniina Snellman, Laura L. Ekblad, Jouni Tuisku, Mikko Koivumäki, Nicholas J. Ashton, Juan Lantero-Rodriguez, Thomas K. Karikari, Semi Helin, Marco Bucci, Eliisa Löyttyniemi, Riitta Parkkola, Mira Karrasch, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Experiences of and recommendations on clinical trial design in Alzheimer’s disease from the participant’s point of view: a mixed-methods study in two clinical trial centers in the Netherlands
Lois Ottenhoff, Everard G. B. Vijverberg, Leonie N. C. Visser, Merike Verijp, Niels D. Prins, Wiesje M. Van der Flier, Sietske A. M. Sikkes
Correction: Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study
Panpan He, Chun Zhou, Ziliang Ye, Mengyi Liu, Yuanyuan Zhang, Qimeng Wu, Yanjun Zhang, Sisi Yang, Gan Xiaoqin, Xianhui Qin
Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults
Michael Malek-Ahmadi, Yi Su, Valentina Ghisays, Ji Luo, Vivek Devadas, Yinghua Chen, Wendy Lee, Hillary Protas, Kewei Chen, Henrik Zetterberg, Kaj Blennow, Richard J. Caselli, Eric M. Reiman
The identification and cognitive correlation of perfusion patterns measured with arterial spin labeling MRI in Alzheimer’s disease
Meng Meng, Fang Liu, Yilong Ma, Wen Qin, Lining Guo, Shichun Peng, Marc L. Gordon, Yue Wang, Nan Zhang
Testing times for dementia: a community survey identifying contemporary barriers to risk reduction and screening
Nikki-Anne Wilson, Ruth Peters, Nicola T. Lautenschlager, Kaarin J. Anstey
Association between ATN profiles and mortality in a clinical cohort of patients with cognitive disorders
Mélina Régy, Aline Dugravot, Séverine Sabia, Elodie Bouaziz-Amar, Claire Paquet, Bernard Hanseeuw, Archana Singh-Manoux, Julien Dumurgier
Distinct CSF biomarker-associated DNA methylation in Alzheimer’s disease and cognitively normal subjects
Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Eden R. Martin, Lily Wang
Baseline structural MRI and plasma biomarkers predict longitudinal structural atrophy and cognitive decline in early Alzheimer’s disease
Long Xie, Sandhitsu R. Das, Laura E. M. Wisse, Ranjit Ittyerah, Robin de Flores, Leslie M. Shaw, Paul A. Yushkevich, David A. Wolk
Correction: Associations between different tau‑PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity
Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westman
Steeper memory decline after COVID-19 lockdown measures
Els D. Bakker, Stéphanie L. van der Pas, Marissa D. Zwan, Freek Gillissen, Femke H. Bouwman, Philip Scheltens, Wiesje M. van der Flier, Ingrid S. van Maurik
Functional gradients of the medial parietal cortex in a healthy cohort with family history of sporadic Alzheimer’s disease
Dániel Veréb, Mite Mijalkov, Yu-Wei Chang, Anna Canal-Garcia, Emiliano Gomez-Ruis, Anne Maass, Sylvia Villeneuve, Giovanni Volpe, Joana B. Pereira
Five-mer peptides prevent short-term spatial memory deficits in Aβ25-35-induced Alzheimer’s model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form
Rina Nakamura, Motomi Konishi, Youichirou Higashi, Motoaki Saito, Toshifumi Akizawa
Higher performance for women than men in MRI-based Alzheimer’s disease detection
Malte Klingenberg, Didem Stark, Fabian Eitel, Céline Budding, Mohamad Habes, Kerstin Ritter
Correction: Masitinib for mild-to-moderate Alzheimer’s disease: results from a randomized, placebo-controlled, phase 3, clinical trial
Bruno Dubois, Jesús López‑Arrieta, Stanley Lipschitz, Triantafyllos Doskas, Luiza Spiru, Svitlana Moroz, Olena Venger, Patrick Vermersch, Alain Moussy, Colin D. Mansfield, Olivier Hermine, Magda Tsolaki
Spatial navigation is associated with subcortical alterations and progression risk in subjective cognitive decline
Qian Chen, Futao Chen, Cong Long, Yajing Zhu, Yaoxian Jiang, Zhengyang Zhu, Jiaming Lu, Xin Zhang, Zuzana Nedelska, Jakub Hort, Bing Zhang
Digital health technologies and Alzheimer’s disease clinical trials: might decentralized clinical trials increase participation by people with cognitive impairment?
Victoire Leroy, Wassim Gana, Amal Aïdoud, Jacques-Alexis N’kodo, Anna-Chloé Balageas, Pascal Blanc, Dominique Bomia, Camille Debacq, Bertrand Fougère
Centralizing prescreening data collection to inform data-driven approaches to clinical trial recruitment
Dylan R. Kirn, Joshua D. Grill, Paul Aisen, Karin Ernstrom, Seth Gale, Judith Heidebrink, Gregory Jicha, Gustavo Jimenez-Maggiora, Leigh Johnson, Elaine Peskind, Kelly McCann, Elizabeth Shaffer, David Sultzer, Shunran Wang, Reisa Sperling, Rema Raman
A biomarker-validated time scale in years of disease progression has identified early- and late-onset subgroups in sporadic Alzheimer’s disease
Ove Almkvist, Agneta Nordberg
Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease
Tobias Gustavsson, Nicole G. Metzendorf, Elin Wik, Sahar Roshanbin, Ulrika Julku, Aikaterini Chourlia, Per Nilsson, Ken G. Andersson, Hanna Laudon, Greta Hultqvist, Stina Syvänen, Dag Sehlin
Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Sébastian Rodrigo, Philippe Gervais, Fabien Caillé, Martin Moussion, Michel Bottlaender, Marie Sarazin
Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease
Yasmine Sommerer, Valerija Dobricic, Marcel Schilling, Olena Ohlei, Sanaz Sedghpour Sabet, Tanja Wesse, Janina Fuß, Sören Franzenburg, Andre Franke, Laura Parkkinen, Christina M. Lill, Lars Bertram
Phenotype and imaging features associated with APP duplications
Lou Grangeon, Camille Charbonnier, Aline Zarea, Stephane Rousseau, Anne Rovelet-Lecrux, David Bendetowicz, Marion Lemaitre, Cécile Malrain, Muriel Quillard-Muraine, Kevin Cassinari, David Maltete, Jeremie Pariente, Olivier Moreaud, Eloi Magnin, Benjamin Cretin, Marie-Anne Mackowiak, Adeline Rollin Sillaire, Martine Vercelletto, Elsa Dionet, Olivier Felician, Pauline Rod-Olivieri, Catherine Thomas-Antérion, Gaelle Godeneche, Mathilde Sauvée, Leslie Cartz-Piver, Isabelle Le Ber, Valérie Chauvire, Therèse Jonveaux, Anna-Chloé Balageas, Annie Laquerriere, Charles Duyckaerts, Anne Vital, Andre Maues de Paula, David Meyronet, Lucie Guyant-Marechal, Didier Hannequin, Elisabeth Tournier-Lasserve, Dominique Campion, Gaël Nicolas, David Wallon
The reporting of neuropsychiatric symptoms in electronic health records of individuals with Alzheimer’s disease: a natural language processing study
Willem S. Eikelboom, Ellen H. Singleton, Esther van den Berg, Casper de Boer, Michiel Coesmans, Jeannette A. Goudzwaard, Everard G. B. Vijverberg, Michel Pan, Cornalijn Gouw, Merel O. Mol, Freek Gillissen, Jay L. P. Fieldhouse, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, John C. van Swieten, Rik Ossenkoppele, Jan A. Kors, Janne M. Papma
Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease
Marta Turri, Elisa Conti, Chiara Pavanello, Francesco Gastoldi, Marcella Palumbo, Franco Bernini, Vittoria Aprea, Francesca Re, Alberto Barbiroli, Davide Emide, Daniela Galimberti, Lucio Tremolizzo, Francesca Zimetti, Laura Calabresi, Simona Andreoni, Ildebrando Appollonio, Fulvio Da Re, Carlo Ferrarese, Aristotelis Karantzoulis, Giulia Negro, Federico Emanuele Pozzi, Giulia Remoli, Benedetta Storti, Chiara Paola Zoia
An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele
Cristiana J. Meuret, Yueming Hu, Sabrina Smadi, Mikaila Ann Bantugan, Haotian Xian, Ashley E. Martinez, Ronald M. Krauss, Qiu-Lan Ma, Dobrin Nedelkov, Hussein N. Yassine
Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study
Jose Bernal, Stefanie Schreiber, Inga Menze, Anna Ostendorf, Malte Pfister, Jonas Geisendörfer, Aditya Nemali, Anne Maass, Renat Yakupov, Oliver Peters, Lukas Preis, Luisa Schneider, Ana Lucia Herrera, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Ayda Rostamzadeh, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Peter Dechent, Klaus Scheffler, Stefan Hetzer, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Frank Jessen, Miranka Wirth, Emrah Düzel, Gabriel Ziegler
Avoiding future controversies in the Alzheimer’s disease space through understanding the aducanumab data and FDA review
Samuel P. Dickson, Sean Hennessey, Jessie Nicodemus Johnson, Newman Knowlton, Suzanne B. Hendrix
Tau accumulation in autosomal dominant Alzheimer’s disease: a longitudinal [18F]flortaucipir study
Antoinette O’Connor, David M. Cash, Teresa Poole, Pawel J. Markiewicz, Maggie R. Fraser, Ian B. Malone, Jieqing Jiao, Philip S. J. Weston, Shaney Flores, Russ Hornbeck, Eric McDade, Michael Schöll, Brian A. Gordon, Randall J. Bateman, Tammie L. S. Benzinger, Nick C. Fox
Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment
Jingshan Chen, Xue Zhao, Wenyan Zhang, Tianxiang Zhang, Siting Wu, Jinghao Shao, Fu-Dong Shi
A peripheral signature of Alzheimer’s disease featuring microbiota-gut-brain axis markers
Moira Marizzoni, Peppino Mirabelli, Elisa Mombelli, Luigi Coppola, Cristina Festari, Nicola Lopizzo, Delia Luongo, Monica Mazzelli, Daniele Naviglio, Jean-Louis Blouin, Marc Abramowicz, Marco Salvatore, Michela Pievani, Annamaria Cattaneo, Giovanni B. Frisoni
Plasma amyloid beta 42 is a biomarker for patients with hereditary, but not sporadic, cerebral amyloid angiopathy
Anna M. de Kort, H. Bea Kuiperij, Lieke Jäkel, Iris Kersten, Ingeborg Rasing, Ellis S. van Etten, Sanneke van Rooden, Matthias J. P. van Osch, Marieke J. H. Wermer, Gisela M. Terwindt, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Marcel M. Verbeek
APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia
Ashwati Vipin, Dilip Kumar, See Ann Soo, Fatin Zahra Zailan, Yi Jin Leow, Chen Ling Koh, Adeline Su Lyn Ng, Kok Pin Ng, Nagaendran Kandiah
Correction: Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I‑UDSNB 1.0): development and normative data
Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricalà, Stefano Francesco Cappa
P2X7 receptor inhibition ameliorates ubiquitin–proteasome system dysfunction associated with Alzheimer’s disease
Carolina Bianchi, Beatriz Alvarez-Castelao, Álvaro Sebastián-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Díaz-Hernández
Comparative evaluation of clinical and cerebrospinal fluid biomarker characteristics in rapidly and non-rapidly progressive Alzheimer’s disease
Janne Marieke Herden, Peter Hermann, Isabel Schmidt, Kathrin Dittmar, Sezgi Canaslan, Luise Weglage, Sabine Nuhn, Corinna Volpers, Astrid Schlung, Stefan Goebel, Fabian Kück, Anna Villar-Piqué, Christian Schmidt, Dirk Wedekind, Inga Zerr
Blood and CSF chemokines in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
Futao Zhou, Yangyan Sun, Xinhua Xie, Yushi Zhao
Body mass index and two-year change of in vivo Alzheimer’s disease pathologies in cognitively normal older adults
Seunghoon Lee, Min Soo Byun, Dahyun Yi, Min Jung Kim, Joon Hyung Jung, Nayeong Kong, Gijung Jung, Hyejin Ahn, Jun-Young Lee, Koung Mi Kang, Chul-Ho Sohn, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee
Association between polygenic risk for Alzheimer’s disease and brain structure in children and adults
Xiao-Yu He, Bang-Sheng Wu, Kevin Kuo, Wei Zhang, Qing Ma, Shi-Tong Xiang, Yu-Zhu Li, Zi-yi Wang, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Frailty in randomised controlled trials for dementia or mild cognitive impairment measured via the frailty index: prevalence and prediction of serious adverse events and attrition
Heather Wightman, Terry J. Quinn, Frances S. Mair, Jim Lewsey, David A. McAllister, Peter Hanlon
Immediate word recall in cognitive assessment can predict dementia using machine learning techniques
Michael Adebisi Fayemiwo, Toluwase Ayobami Olowookere, Oluwabunmi Omobolanle Olaniyan, Theresa Omolayo Ojewumi, Idowu Sunday Oyetade, Shannon Freeman, Piper Jackson
Nonlinear changes in delayed functional network topology in Alzheimer’s disease: relationship with amyloid and tau pathology
Mite Mijalkov, Dániel Veréb, Anna Canal-Garcia, Thomas Hinault, Giovanni Volpe, Joana B. Pereira
Shared genetic risk loci between Alzheimer’s disease and related dementias, Parkinson’s disease, and amyotrophic lateral sclerosis
Michael Wainberg, Shea J. Andrews, Shreejoy J. Tripathy
White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases
Miracle Ozzoude, Brenda Varriano, Derek Beaton, Joel Ramirez, Sabrina Adamo, Melissa F. Holmes, Christopher J. M. Scott, Fuqiang Gao, Kelly M. Sunderland, Paula McLaughlin, Maged Goubran, Donna Kwan, Angela Roberts, Robert Bartha, Sean Symons, Brian Tan, Richard H. Swartz, Agessandro Abrahao, Gustavo Saposnik, Mario Masellis, Anthony E. Lang, Connie Marras, Lorne Zinman, Christen Shoesmith, Michael Borrie, Corinne E. Fischer, Andrew Frank, Morris Freedman, Manuel Montero-Odasso, Sanjeev Kumar, Stephen Pasternak, Stephen C. Strother, Bruce G. Pollock, Tarek K. Rajji, Dallas Seitz, David F. Tang-Wai, John Turnbull, Dar Dowlatshahi, Ayman Hassan, Leanne Casaubon, Jennifer Mandzia, Demetrios Sahlas, David P. Breen, David Grimes, Mandar Jog, Thomas D. L. Steeves, Stephen R. Arnott, Sandra E. Black, Elizabeth Finger, Jennifer Rabin, Michael Strong, Peter Kleinstiver, Jane Lawrence-Dewar, Natalie Rashkovan, Susan Bronskil, Julia Fraser, Bill McIlroy, Ben Cornish, Karen Van Ooteghem, Frederico Faria, Yanina Sarquis-Adamson, Alanna Black, Barry Greenberg, Wendy Hatch, Chris Hudson, Elena Leontieva, Ed Margolin, Efrem Mandelcorn, Faryan Tayyari, Sherif Defrawy, Don Brien, Ying Chen, Brian Coe, Doug Munoz, Alisia Southwell, Dennis Bulman, Allison Ann Dilliott, Mahdi Ghani, Rob Hegele, John Robinson, Ekaterina Rogaeva, Sali Farhan, Seyyed Mohammad Hassan Haddad, Nuwan Nanayakkara, Courtney Berezuk, Malcolm Binns, Wendy Lou, Athena Theyers, Abiramy Uthirakumaran, Guangyong (GY) Zou, Sujeevini Sujanthan, Mojdeh Zamyadi, David Munoz, Roger A. Dixon, John Woulfe, Brian Levine, J. B. Orange, Alicia Peltsch, Angela Troyer, Marvin Chum, Maria Carmela Tartaglia
Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer’s disease
Monika Renuka Sanotra, Shu-Huei Kao, Ching-Kuo Lee, Chun-Hsien Hsu, Wen-Chung Huang, Tsuei-Chuan Chang, Fang-Yu Tu, I-Uen Hsu, Yung-Feng Lin
Correction: Comparative evaluation of clinical and cerebrospinal fluid biomarker characteristics in rapidly and non‑rapidly progressive Alzheimer’s disease
Janne Marieke Herden, Peter Hermann, Isabel Schmidt, Kathrin Dittmar, Sezgi Canaslan, Luise Weglage, Sabine Nuhn, Corinna Volpers, Astrid Schlung, Stefan Goebel, Fabian Kück, Anna Villar‑Piqué, Christian Schmidt, Dirk Wedekind, Inga Zerr
Differential response to donepezil in MRI subtypes of mild cognitive impairment
Patricia Diaz-Galvan, Giulia Lorenzon, Rosaleena Mohanty, Gustav Mårtensson, Enrica Cavedo, Simone Lista, Andrea Vergallo, Kejal Kantarci, Harald Hampel, Bruno Dubois, Michel J. Grothe, Daniel Ferreira, Eric Westman
Association study between drug prescriptions and Alzheimer’s disease claims in a commercial insurance database
Eric Hu, Tong Shu Li, Nathan E. Wineinger, Andrew I. Su
Plasma apolipoprotein E levels, isoform composition, and dimer profile in relation to plasma lipids in racially diverse patients with Alzheimer’s disease and mild cognitive impairment
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Jennifer C. Howell, William T. Hu, Kim Kultima, Henrietta M. Nielsen
Regional cerebral tau predicts decline in everyday functioning across the Alzheimer’s disease spectrum
Mark A. Dubbelman, Kayden J. Mimmack, Emily H. Sprague, Rebecca E. Amariglio, Patrizia Vannini, Gad A. Marshall
Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults
Emma S. Luckett, Magdalena Zielonka, Amine Kordjani, Jolien Schaeverbeke, Katarzyna Adamczuk, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen, Rik Vandenberghe
Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Jia-jia Liu, Yun-fan Long, Peng Xu, Hai-dong Guo, Guo-hong Cui
Breathing cessation events that compose the apnea–hypopnea index are distinctively associated with the adverse outcomes in Alzheimer’s disease
Adriano D. S. Targa, Iván D. Benítez, Anna Moncusí-Moix, Farida Dakterzada, Olga Minguez, Rafaela Vaca, Mireia Dalmases, Manuel Sanchez-de-la-Torre, Ferran Barbé, Gerard Piñol-Ripoll
Potential diagnostic value of CSF metabolism-related proteins across the Alzheimer’s disease continuum
Silvia Paciotti, Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Elena Chipi, Sander R. Piersma, Thang V. Pham, Lorenzo Gaetani, Connie R. Jimenez, Lucilla Parnetti, Davide Chiasserini
Prevalence and modifiable risk factors for dementia in persons with intellectual disabilities
Shintaro Takenoshita, Seishi Terada, Tomokazu Inoue, Taku Kurozumi, Norihito Yamada, Ryozo Kuwano, Shigeru Suemitsu
Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome
Breton M. Asken, Jeremy A. Tanner, Leslie S. Gaynor, Lawren VandeVrede, William G. Mantyh, Kaitlin B. Casaletto, Adam M. Staffaroni, Corrina Fonseca, Ranjani Shankar, Harli Grant, Karen Smith, Argentina Lario Lago, Haiyan Xu, Renaud La Joie, Yann Cobigo, Howie Rosen, David C. Perry, Julio C. Rojas, Bruce L. Miller, Raquel C. Gardner, Kevin K. W. Wang, Joel H. Kramer, Gil D. Rabinovici
Quantification of identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy with machine learning: a post hoc analysis of a diagnostic trial and validation of an external additional trial
Jaewon Kim, Hayeon Lee, Jinseok Lee, Sang Youl Rhee, Jae Il Shin, Seung Won Lee, Wonyoung Cho, Chanyang Min, Rosie Kwon, Jae Gwan Kim, Dong Keon Yon
Expected and diagnosed rates of mild cognitive impairment and dementia in the U.S. Medicare population: observational analysis
Soeren Mattke, Hankyung Jun, Emily Chen, Ying Liu, Andrew Becker, Christopher Wallick
Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years
Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker, Hermann Brenner
Prevalence of treated patients with Alzheimer’s disease: current trends and COVID-19 impact
Javier Olazarán, Cristóbal Carnero-Pardo, Juan Fortea, Pascual Sánchez-Juan, Guillermo García-Ribas, Félix Viñuela, Pablo Martínez-Lage, Mercè Boada
Communication about diagnosis, prognosis, and prevention in the memory clinic: perspectives of European memory clinic professionals
Heleen M. A. Hendriksen, Aniek M. van Gils, Argonde C. van Harten, Tobias Hartmann, Francesca Mangialasche, Anita Kamondi, Miia Kivipelto, Hanneke F. M. Rhodius-Meester, Ellen M. A. Smets, Wiesje M. van der Flier, Leonie N. C. Visser
Impacts of baseline biomarkers on cognitive trajectories in subjective cognitive decline: the CoSCo prospective cohort study
Yun Jeong Hong, SeongHee Ho, Jee Hyang Jeong, Kee Hyung Park, SangYun Kim, Min Jeong Wang, Seong Hye Choi, Dong Won Yang
Beta to theta power ratio in EEG periodic components as a potential biomarker in mild cognitive impairment and Alzheimer’s dementia
Hamed Azami, Christoph Zrenner, Heather Brooks, Reza Zomorrodi, Daniel M. Blumberger, Corinne E. Fischer, Alastair Flint, Nathan Herrmann, Sanjeev Kumar, Krista Lanctôt, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji
Cerebrospinal fluid lipidomic fingerprint of obstructive sleep apnoea in Alzheimer’s disease
Farida Dakterzada, Iván D. Benítez, Adriano Targa, Anna Carnes, Montse Pujol, Mariona Jové, Olga Mínguez, Rafi Vaca, Manuel Sánchez-de-la-Torre, Ferran Barbé, Reinald Pamplona, Gerard Piñol-Ripoll
Network analysis of neuropsychiatric symptoms in Alzheimer’s disease
Grace J. Goodwin, Stacey Moeller, Amy Nguyen, Jeffrey L. Cummings, Samantha E. John
Risk of dementia in primary aldosteronism compared with essential hypertension: a nationwide cohort study
Namki Hong, Kyoung Jin Kim, Min Heui Yu, Seong Ho Jeong, Seunghyun Lee, Jung Soo Lim, Yumie Rhee
Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to AppNL−G−F knock-in Alzheimer mice
Simone Tambaro, Sumonto Mitra, Ruchi Gera, Bengt Linderoth, Lars U. Wahlberg, Taher Darreh-Shori, Homira Behbahani, Per Nilsson, Maria Eriksdotter
Kidney function, albuminuria, and their modification by genetic factors and risk of incident dementia in UK Biobank
Tian-Shin Yeh, Lei Clifton, Jennifer A. Collister, Xiaonan Liu, David J. Hunter, Thomas J. Littlejohns
Correction: Repurposed agents in the Alzheimer’s disease drug development pipeline
Justin Bauzon, Garam Lee, Jeffrey Cummings
Circulating insulin-like growth factor-1 and brain health: Evidence from 369,711 participants in the UK Biobank
Zhi Cao, Jiahao Min, Qilong Tan, Keyi Si, Hongxi Yang, Chenjie Xu
A metagenomic study of gut viral markers in amyloid-positive Alzheimer’s disease patients
Mahin Ghorbani, Daniel Ferreira, Silvia Maioli
Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes
Fran C. van Heusden, Anne M. van Nifterick, Bryan C. Souza, Arthur S. C. França, Ilse M. Nauta, Cornelis J. Stam, Philip Scheltens, August B. Smit, Alida A. Gouw, Ronald E. van Kesteren
High-intensity walking in midlife is associated with improved memory in physically capable older adults
Young Min Choe, Guk-Hee Suh, Boung Chul Lee, Ihn-Geun Choi, Hyun Soo Kim, Jong Wan Kim, Jaeuk Hwang, Dahyun Yi, Jee Wook Kim
Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer’s disease: a cerebrospinal fluid and fluorodeoxyglucose-positron emission tomography study
Caterina Motta, Martina Gaia Di Donna, Chiara Giuseppina Bonomi, Martina Assogna, Agostino Chiaravalloti, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
Automating Rey Complex Figure Test scoring using a deep learning-based approach: a potential large-scale screening tool for cognitive decline
Jun Young Park, Eun Hyun Seo, Hyung-Jun Yoon, Sungho Won, Kun Ho Lee
A polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.
Tamar Sofer, Nuzulul Kurniansyah, Einat Granot-Hershkovitz, Matthew O. Goodman, Wassim Tarraf, Iris Broce, Richard B. Lipton, Martha Daviglus, Melissa Lamar, Sylvia Wassertheil-Smoller, Jianwen Cai, Charles S. DeCarli, Hector M. Gonzalez, Myriam Fornage
Prediction of post-stroke cognitive impairment after acute ischemic stroke using machine learning
Minwoo Lee, Na-Young Yeo, Hyo-Jeong Ahn, Jae-Sung Lim, Yerim Kim, Sang-Hwa Lee, Mi Sun Oh, Byung-Chul Lee, Kyung-Ho Yu, Chulho Kim
A plasma protein signature associated with cognitive function in men without severe cognitive impairment
Kanika Mehta, Mohammadreza Mohebbi, Julie A. Pasco, Lana J. Williams, Sophia X. Sui, Ken Walder, Boon Lung Ng, Veer Bala Gupta
Performance of plasma Aβ42/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status
Shogyoku Bun, Daisuke Ito, Toshiki Tezuka, Masahito Kubota, Ryo Ueda, Keisuke Takahata, Sho Moriguchi, Shin Kurose, Yuki Momota, Natsumi Suzuki, Ayaka Morimoto, Yuka Hoshino, Morinobu Seki, Yu Mimura, Ryo Shikimoto, Yasuharu Yamamoto, Takayuki Hoshino, Yoshiaki Sato, Hajime Tabuchi, Masaru Mimura
Diagnostic and prognostic value of cerebrospinal fluid SNAP-25 and neurogranin in Creutzfeldt-Jakob disease in a clinical setting cohort of rapidly progressive dementias
Giuseppe Mario Bentivenga, Simone Baiardi, Andrea Mastrangelo, Corrado Zenesini, Angela Mammana, Barbara Polischi, Sabina Capellari, Piero Parchi
REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals
Claire André, Marie-Ève Martineau-Dussault, Véronique Daneault, Hélène Blais, Sonia Frenette, Dominique Lorrain, Carol Hudon, Célyne Bastien, Dominique Petit, Alexandre Lafrenière, Cynthia Thompson, Jacques Montplaisir, Nadia Gosselin, Julie Carrier
Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population
Chun Zhou, Yanjun Zhang, Sisi Yang, Ziliang Ye, Qimeng Wu, Mengyi Liu, Panpan He, Yuanyuan Zhang, Xianhui Qin
Is later-life depression a risk factor for Alzheimer’s disease or a prodromal symptom: a study using post-mortem human brain tissue?
Lindsey I. Sinclair, Asher Mohr, Mizuki Morisaki, Martin Edmondson, Selina Chan, A. Bone-Connaughton, Gustavo Turecki, Seth Love
The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury
Shiraz Vered, Alexa S. Beiser, Liron Sulimani, Sharon Sznitman, Mitzi M. Gonzales, Hugo J. Aparicio, Charles DeCarli, Matthew R. Scott, Saptaparni Ghosh, Gil M. Lewitus, David Meiri, Sudha Seshadri, Galit Weinstein
Home-based transcranial alternating current stimulation (tACS) in Alzheimer’s disease: rationale and study design
Daniele Altomare, Alberto Benussi, Valentina Cantoni, Enrico Premi, Jasmine Rivolta, Chiara Cupidi, Alessandro Martorana, Emiliano Santarnecchi, Alessandro Padovani, Giacomo Koch, Barbara Borroni
Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease
Francheska Delgado-Peraza, Carlos Nogueras-Ortiz, Anja Hviid Simonsen, De’Larrian DeAnté Knight, Pamela J. Yao, Edward J. Goetzl, Camilla Steen Jensen, Peter Høgh, Hanne Gottrup, Karsten Vestergaard, Steen Gregers Hasselbalch, Dimitrios Kapogiannis
Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment
Nidhi S. Mundada, Julio C. Rojas, Lawren Vandevrede, Elisabeth H. Thijssen, Leonardo Iaccarino, Obiora C. Okoye, Ranjani Shankar, David N. Soleimani-Meigooni, Argentina L. Lago, Bruce L. Miller, Charlotte E. Teunissen, Hillary Heuer, Howie J. Rosen, Jeffrey L. Dage, William J. Jagust, Gil D. Rabinovici, Adam L. Boxer, Renaud La Joie
Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial
Jingsong Wu, Youze He, Shengxiang Liang, Zhizhen Liu, Jia Huang, Weilin Liu, Jing Tao, Lidian Chen, Chetwyn C. H. Chan, Tatia M. C. Lee
Cost-effectiveness of physical activity interventions for prevention and management of cognitive decline and dementia—a systematic review
Weixin Li, Kun-Woo Rafael Kim, Donglan Zhang, Bian Liu, Christine M. Dengler-Crish, Ming Wen, Lu Shi, Xi Pan, Yian Gu, Yan Li
Correction: Plasma apolipoprotein E levels, isoform composition, and dimer profile in relation to plasma lipids in racially diverse patients with Alzheimer’s disease and mild cognitive impairment
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Jennifer C. Howell, William T. Hu, Kim Kultima, Henrietta M. Nielsen
Stress, depression, and risk of dementia – a cohort study in the total population between 18 and 65 years old in Region Stockholm
Johanna Wallensten, Gunnar Ljunggren, Anna Nager, Caroline Wachtler, Nenad Bogdanovic, Predrag Petrovic, Axel C. Carlsson
Retraction Note: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis
Panchanan Maiti, Zackary Bowers, Ali Bourcier-Schultz, Jarod Morse, Gary L. Dunbar
Accuracy of plasma Aβ40, Aβ42, and p-tau181 to detect CSF Alzheimer’s pathological changes in cognitively unimpaired subjects using the Lumipulse automated platform
Francisco Martínez-Dubarbie, Armando Guerra-Ruiz, Sara López-García, Carmen Lage, Marta Fernández-Matarrubia, Jon Infante, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Pascual Sánchez-Juan, María Teresa García-Unzueta, Eloy Rodríguez-Rodríguez
Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer’s disease
Xianwei Wang, Lu Liu, Xiaohua Jiang, Jason Saredy, Hang Xi, Ramon Cueto, Danni Sigler, Mohsin Khan, Sheng Wu, Yong Ji, Nathaniel W. Snyder, Wenhui Hu, Xiaofeng Yang, Hong Wang
In vivo cortical diffusion imaging relates to Alzheimer’s disease neuropathology
Mario Torso, Gerard R. Ridgway, Michele Valotti, Ian Hardingham, Steven A. Chance, James Brewer, Oscar Lopez, Bradley Hyman, Thomas Grabowski, Mary Sano, Helena Chui, Marilyn Albert, John Morris, Jeffrey Kaye, Thomas Wisniewski, Scott Small, John Trojanowski, Charles DeCarli, Andrew Saykin, David Bennett, Roger Rosenberg, Neil Kowall, Robert Vassar, Frank LaFerla, Ronald Petersen, Eric Reiman, Bruce Miller, Allan Levey, Linda Van Eldik, Sanjay Asthana, Russell Swerdlow, Todd Golde, Stephen Strittmatter, Victor Henderson, Suzanne Craft, Henry Paulson, Sudha Seshadri, Erik Roberson, Marwan Sabbagh, Gary Rosenberg, Angela Jefferson, Heather Whitson, James Leverenz
Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project
Robert A. Stern, Diana Trujillo-Rodriguez, Yorghos Tripodis, Surya V. Pulukuri, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Charles Bernick, Zachary Baucom, Kenneth L. Marek, Michael D. McClean, Keith A. Johnson, Ann C. McKee, Thor D. Stein, Jesse Mez, Joseph N. Palmisano, Jeffrey L. Cummings, Martha E. Shenton, Eric M. Reiman, Kewei Chen, Hillary Protas, Yi Su, Connie Boker, Rhoda Au, Robert C. Cantu, Lindsay Farrer, Robert Helm, Douglas I. Katz, Neil Kowall, Gustavo Mercier, James Otis, Jason Weller, Tahlia Bragg, Irene Simkin, Suzan van Amerongen, Alondra Andino, Shannon Conneely, Courtney Diamond, Tessa Fagle, Olivia Haller, Tennyson Hunt, Nicole Gullotti, Bailey Kossow, Carrie Kugelmass, Megan Mariani, Brian Mayville, Kathleen McLaughlin, Mary Nanna, Marty DiPopolo, Taylor Platt, Fiona Rice, Madison Sestak, Douglas Annis, Christine Chaisson, Diane B. Dixon, Carolyn Finney, Kerrin Gallagher, Kaitlin Hartlage, Jun Lu, Brett Martin, Emmanuel Ojo, Brittany Pine, Janani Ramachandran, Fatima Tuz-Zahra, Eukyung Yhang, Sylvain Bouix, Jennifer Fitzsimmons, Alexander P. Lin, Inga K. Koerte, Ofer Pasternak, Hector Arciniega, Tashrif Billah, Elena Bonke, Katherine Breedlove, Holly Carrington, Eduardo Coello, Michael J. Coleman, Omar John, Leonard Jung, Huijun Liao, Maria Loy, Elizabeth Rizzoni, Vivian Schultz, Annelise Silva, Brynn Vessey, Tim L. T. Wiegand, Sarah Banks, Jason Miller, Aaron Ritter, Marwan Sabbagh, Raelynn de la Cruz, Jan Durant, Morgan Golceker, Nicolette Harmon, Jaeson Kaylegian, Rachelle Long, Christin Nance, Priscilla Sandoval, Miranda Staples, Robert W. Turner, Emma F. Clark, Andrew Serrano, David W. Dodick, Yonas Geda, Jennifer V. Wethe, Amy Duffy, Bryce Falk, Marci Howard, Michelle Montague, Thomas Osgood, Debra Babcock, Patrick Bellgowan, William Barr, Judith Goldberg, Binu Joseph, Ivan Kirov, Yvonne Lui, Charles Marmar, Thomas Wisniewski, Alhassan Al-Kharafi, Allan George, Lisena Hasanaj, Sammie Martin, Edward Riley, William Runge, Liliana Serrano, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Jeffrey Iliff, Gail Li, Deidre Janssen, James Meabon, Elaine R. Peskind, Juan Piantino, Abigail Schindler, Ronald Thomas, Elizabeth Colasurdo, Jane Shofer, Daniel S. Marcus, Jenny Gurney, Richard Greenwald
Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity
Megan E. O’Connell, Helena Kadlec, Lauren E. Griffith, Christina Wolfson, Geva Maimon, Vanessa Taler, Susan Kirkland, Parminder Raina
The therapeutic landscape of tauopathies: challenges and prospects
Jeffrey L. Cummings, M. Isabel Gonzalez, Martyn C. Pritchard, Patrick C. May, Leticia M. Toledo-Sherman, Glenn A. Harris
Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
Clément Aveneau, David Wallon, Bertrand Degos, Alexandre Obadia, Claire Hourregue, Sarah Benisty, Béatrice Garcin, Julien Dumurgier, Claire Paquet
Readthrough isoform of aquaporin-4 (AQP4) as a therapeutic target for Alzheimer’s disease and other proteinopathies
Pablo Mohaupt, Jérôme Vialaret, Christophe Hirtz, Sylvain Lehmann
Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer’s disease
Isabelle K. Gorham, Robert C. Barber, Harlan P. Jones, Nicole R. Phillips
Retinal mid-peripheral capillary free zones are enlarged in cognitively unimpaired older adults at high risk for Alzheimer’s disease
Edmund Arthur, Swetha Ravichandran, Peter J. Snyder, Jessica Alber, Jennifer Strenger, Ava K. Bittner, Rima Khankan, Stephanie L. Adams, Nicole M. Putnam, Karin R. Lypka, Juan A. Piantino, Stuart Sinoff
Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
Charles Bernick, Guogen Shan, Aaron Ritter, Nicholas J. Ashton, Kaj Blennow, Juan Lantero-Rodriguez, Anniina Snellman, Henrik Zetterberg
Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats
Audrey Hector, Chloé Provost, Benoît Delignat-Lavaud, Khadija Bouamira, Chahinez-Anissa Menaouar, Valérie Mongrain, Jonathan Brouillette
Biomarkers in Alzheimer’s disease: role in early and differential diagnosis and recognition of atypical variants
Bruno Dubois, Christine A. F. von Arnim, Nerida Burnie, Sasha Bozeat, Jeffrey Cummings
Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease
Kevin Blanco, Stefanny Salcidua, Paulina Orellana, Tania Sauma-Pérez, Tomás León, Lorena Cecilia López Steinmetz, Agustín Ibañez, Claudia Duran-Aniotz, Rolando de la Cruz
Correction: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Patricia Diaz‑Galvan, Giulia Lorenzon, Rosaleena Mohanty, Gustav Mårtensson, Enrica Cavedo, Simone Lista, Andrea Vergallo, Kejal Kantarci, Harald Hampel, Bruno Dubois, Michel J. Grothe, Daniel Ferreira, Eric Westman
Independent effect of Aβ burden on cognitive impairment in patients with small subcortical infarction
Sung Hoon Kang, Minwoong Kang, Jung Hoon Han, Eun Seong Lee, Keon-Joo Lee, Su Jin Chung, Sang-Il Suh, Seong-Beom Koh, Jae Seon Eo, Chi Kyung Kim, Kyungmi Oh
Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
Nancy R. Stallings, Melissa A. O’Neal, Jie Hu, Zhong-Jian Shen, James S. Malter
Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status
Rigina L. Gallagher, Rebecca Langhough Koscik, Jason F. Moody, Nicholas M. Vogt, Nagesh Adluru, Steven R. Kecskemeti, Carol A. Van Hulle, Nathaniel A. Chin, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Cynthia M. Carlsson, Sterling C. Johnson, Douglas C. Dean III, Henrik Zetterberg, Kaj Blennow, Andrew L. Alexander, Barbara B. Bendlin
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
Deebika Balu, Ana C. Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu, Leon M. Tai
Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials
Elliz P. Scheijbeler, Willem de Haan, Cornelis J. Stam, Jos W. R. Twisk, Alida A. Gouw
Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial
Julien Delrieu, Bruno Vellas, Sophie Guyonnet, Christelle Cantet, Vitaliy Ovod, Yan Li, James Bollinger, Randall Bateman, Sandrine Andrieu, Isabelle Carrié, Lauréane Brigitte, Catherine Faisant, Françoise Lala, Hélène Villars, Emeline Combrouze, Carole Badufle, Audrey Zueras, Christophe Morin, Gabor Abellan Van Kan, Charlotte Dupuy, Yves Rolland, Céline Caillaud, Pierre-Jean Ousset, Sherry Willis, Sylvie Belleville, Brigitte Gilbert, Francine Fontaine, Jean-François Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Marie-Noëlle-Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valérie Quipourt, Sophie Marilier, Evelyne Franon, Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valérie Faure, Michael Li Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Françoise Desclaux, Colette Blatge, Thierry Dantoine, Cécile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clément, Marie-Agnès Picat, Laurence Bernard-Bourzeix, Stéphanie Willebois, Iléana Désormais, Noëlle Cardinaud, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gédéon, Catherine Burdet, Flavien Terracol, Alain Pesce, Stéphanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristel Sudres, Nicolas Lebrun, Nadège Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurélia Romano, Lynda Touati, Cécilia Marelli, Cécile Pays, Philippe Robert, Franck Le Duff, Claire Gervais, Sébastien Gonfrier, Yannick Gasnier, Serge Bordes, Danièle Begorre, Christian Carpuat, Khaled Khales, Jean-François Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean-Pierre Salles, Nicola Coley
PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease
Qing Wang, Yue Wang, Shiping Li, Jiong Shi
Progressive mechanical and structural changes in anterior cerebral arteries with Alzheimer’s disease
Xiaozhu Liu, Samuel Halvorsen, Nathan Blanke, Margaret Downs, Thor D. Stein, Irving J. Bigio, Joseph Zaia, Yanhang Zhang
Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum
Julie Goossens, Alba Cervantes González, Nele Dewit, Laia Lidón, Juan Fortea, Daniel Alcolea, Alberto Lleó, Olivia Belbin, Eugeen Vanmechelen
Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells
Qi Ji, Yang Yang, Yun Xiong, Ying-Jie Zhang, Jun Jiang, Li-Ping Zhou, Xiao-Hui Du, Chun-Xiang Wang, Zhi-Ru Zhu
Correction: A competing risk joint model for dealing with different types of missing data in an intervention trial in prodromal Alzheimer’s disease
Floor M. van Oudenhoven, Sophie H. N. Swinkels, Hilkka Soininen, Miia Kivipelto, Tobias Hartmann, Dimitris Rizopoulos
Recruitment of pre-dementia participants: main enrollment barriers in a longitudinal amyloid-PET study
Ilse Bader, Ilona Bader, Isadora Lopes Alves, David Vállez García, Bruno Vellas, Bruno Dubois, Mercè Boada, Marta Marquié, Daniele Altomare, Philip Scheltens, Rik Vandenberghe, Bernard Hanseeuw, Michael Schöll, Giovanni B. Frisoni, Frank Jessen, Agneta Nordberg, Miia Kivipelto, Craig W. Ritchie, Oriol Grau-Rivera, José Luis Molinuevo, Lisa Ford, Andrew Stephens, Rossella Gismondi, Juan Domingo Gispert, Gill Farrar, Frederik Barkhof, Pieter Jelle Visser, Lyduine E. Collij
Clinical and biological relevance of glial fibrillary acidic protein in Alzheimer’s disease
Zhengshi Yang, Karthik Sreenivasan, Erin N. Toledano Strom, Amanda M. Leisgang Osse, Lorenzo Gabriel Pasia, Celica Glenn Cosme, Maya Rae N. Mugosa, Emma Léa Chevalier, Aaron Ritter, Justin B. Miller, Dietmar Cordes, Jeffrey L. Cummings, Jefferson W. Kinney
Identification of novel diagnostic panel for mild cognitive impairment and Alzheimer’s disease: findings based on urine proteomics and machine learning
Yuye Wang, Yu Sun, Yu Wang, Shuhong Jia, Yanan Qiao, Zhi Zhou, Wen Shao, Xiangfei Zhang, Jing Guo, Bin Zhang, Xiaoqian Niu, Yi Wang, Dantao Peng
Quantitative estimate of cognitive resilience and its medical and genetic associations
Thanaphong Phongpreecha, Dana Godrich, Eloise Berson, Camilo Espinosa, Yeasul Kim, Brenna Cholerton, Alan L. Chang, Samson Mataraso, Syed A. Bukhari, Amalia Perna, Koya Yakabi, Kathleen S. Montine, Kathleen L. Poston, Elizabeth Mormino, Lon White, Gary Beecham, Nima Aghaeepour, Thomas J. Montine
Subject classification and cross-time prediction based on functional connectivity and white matter microstructure features in a rat model of Alzheimer’s using machine learning
Yujian Diao, Bernard Lanz, Ileana Ozana Jelescu
Serum immunoglobulins and biomarkers of dementia: a population-based study
Amber Yaqub, Samer R. Khan, Meike W. Vernooij, P. Martin van Hagen, Robin P. Peeters, M. Arfan Ikram, Layal Chaker, Virgil A. S. H. Dalm
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
Lena Duchateau, Fahri Küҫükali, Arne De Roeck, Mandy M. J. Wittens, Joke Temmerman, Ilse Weets, Maarten Timmers, Sebastiaan Engelborghs, Maria Bjerke, Kristel Sleegers
A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults
Tingting Liu, Changwei Li, Ruiyuan Zhang, Eugenia Flores Millender, Hongyu Miao, Michael Ormsbee, Jinzhen Guo, Adrianna Westbrook, Yang Pan, Jing Wang, Tanika N. Kelly
Distinct effects of cholesterol profile components on amyloid and vascular burdens
Sung Hoon Kang, Heejin Yoo, Bo Kyoung Cheon, Yu Hyun Park, Soo-Jong Kim, Hongki Ham, Hyemin Jang, Hee Jin Kim, Kyungmi Oh, Seong-Beom Koh, Duk L. Na, Jun Pyo Kim, Sang Won Seo
Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
Laura Perna, Hannah Stocker, Lena Burow, Léon Beyer, Kira Trares, Carolin Kurz, Selim Gürsel, Bernd Holleczek, Maia Tatò, Konrad Beyreuther, Ute Mons, Klaus Gerwert, Robert Perneczky, Ben Schöttker, Hermann Brenner
Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
Chao Du, Mingxi Dang, Kewei Chen, Yaojing Chen, Zhanjun Zhang
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Sandar Aye, Vincent Bouteloup, Ashley Tate, Anders Wimo, Ron Handels, Delphine Jean, Bengt Winblad, Linus Jönsson
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Austin Stoner, Li Fu, LaShae Nicholson, Chao Zheng, Takuya Toyonaga, Joshua Spurrier, Will Laird, Zhengxin Cai, Stephen M. Strittmatter
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
Alexander Rau, Nils Schröter, Ganna Blazhenets, Christoph Maurer, Horst Urbach, Philipp T. Meyer, Lars Frings
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
Alba Villasán Rueda, Antonio Sánchez Cabaco, Manuel Alejandro Mejía-Ramírez, Rosa Marina Afonso, Eduardo Castillo-Riedel
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Federica Cacciamani, Ariane Bercu, Vincent Bouteloup, Leslie Grasset, Vincent Planche, Geneviève Chêne, Carole Dufouil
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
Seonjeong Byun, Hyang Jun Lee, Jun Sung Kim, Euna Choi, Subin Lee, Tae Hui Kim, Jae Hyoung Kim, Ji Won Han, Ki Woong Kim
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Lyduine E. Collij, Gill Farrar, Marissa Zwan, Elsmarieke van de Giessen, Rik Ossenkoppele, Frederik Barkhof, Annemieke J. M. Rozemuller, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Femke Bouwman
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
I. S. van Maurik, E. D. Bakker, A. A. J. M. van Unnik, H. M. Broulikova, M. D. Zwan, E. van de Giessen, J. Berkhof, F. H. Bouwman, J. E. Bosmans, W. M. van der Flier
Identification of high likelihood of dementia in population-based surveys using unsupervised clustering: a longitudinal analysis
Amin Gharbi-Meliani, François Husson, Henri Vandendriessche, Eleonore Bayen, Kristine Yaffe, Anne-Catherine Bachoud-Lévi, Laurent Cleret de Langavant
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Gustavo Patow, Leon Stefanovski, Petra Ritter, Gustavo Deco, Xenia Kobeleva
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
Gang Li, Nicola Toschi, Viswanath Devanarayan, Richard Batrla, Tommaso Boccato, Min Cho, Matteo Ferrante, Feride Frech, James E. Galvin, David Henley, Soeren Mattke, Susan De Santi, Harald Hampel
Predicting positron emission tomography brain amyloid positivity using interpretable machine learning models with wearable sensor data and lifestyle factors
Noriyuki Kimura, Tomoki Aota, Yasuhiro Aso, Kenichi Yabuuchi, Kotaro Sasaki, Teruaki Masuda, Atsuko Eguchi, Yoshitaka Maeda, Ken Aoshima, Etsuro Matsubara
Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates
Thomas Lancaster, Byron Creese, Valentina Escott-Price, Ian Driver, Georgina Menzies, Zunera Khan, Anne Corbett, Clive Ballard, Julie Williams, Kevin Murphy, Hannah Chandler
Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer’s disease and vascular dementia
Xin Ying Chua, Federico Torta, Joyce R. Chong, Narayanaswamy Venketasubramanian, Saima Hilal, Markus R. Wenk, Christopher P. Chen, Thiruma V. Arumugam, Deron R. Herr, Mitchell K. P. Lai
NeuroEPO plus (NeuralCIM®) in mild-to-moderate Alzheimer’s clinical syndrome: the ATHENEA randomized clinical trial
Saily Sosa, Giosmany Bringas, Nelky Urrutia, Ana Ivis Peñalver, Danay López, Evelio González, Ana Fernández, Zenaida Milagros Hernández, Ariel Viña, Yamile Peña, Juan Felipe Batista, Carmen Valenzuela, Kalet León, Tania Crombet, Teresita Rodríguez, Leslie Pérez, Yolanda Álvarez, Madelín Rodríguez, Nairim Vázquez, Mirelys Rodríguez, Yaniuris González, María A. Ramos, Yosvany López, Mara Hernández, Lázaro Madruga, Dianelys Carmona, Julio E. Acosta, Miriam López, Deiry Amaro, Olga L. Baños, Mariela Ortega Álvarez, Anay Cordero, Melany Betancourt, Liana Padrón, Elio Chávez, Isabel García, Yaquelin Morgan, Moraima Charles, Mónica González, Marianela de la C. Rodríguez, Yeniley León, Joe Michel López, Yanelis Acosta, Trinidad de los Ángeles Virués, Laura Pérez, Karen León, Rubén Periche, Adonisbel Valero, Yoelvis César Pozo, Greysi Horta, Rodobaldo Quesada, Elvia Luz, Leonel A. Torres, Susana Romero, María E. Rodríguez, Daymys Estévez
A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
Ana C. Valencia-Olvera, Deebika Balu, Shreya Bellur, Thomas McNally, Yaseen Saleh, Don Pham, Shivesh Ghura, Jason York, Jan O. Johansson, Mary Jo LaDu, Leon Tai
Neurophysiological markers in community-dwelling older adults with mild cognitive impairment: an EEG study
Osamu Katayama, Yaakov Stern, Christian Habeck, Sangyoon Lee, Kenji Harada, Keitaro Makino, Kouki Tomida, Masanori Morikawa, Ryo Yamaguchi, Chiharu Nishijima, Yuka Misu, Kazuya Fujii, Takayuki Kodama, Hiroyuki Shimada
White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum
Lauren R. Hirschfeld, Rachael Deardorff, Evgeny J. Chumin, Yu-Chien Wu, Brenna C. McDonald, Sha Cao, Shannon L. Risacher, Dahyun Yi, Min Soo Byun, Jun-Young Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Kwangsik Nho, Andrew J. Saykin, Dong Young Lee
The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia
Siddharth Ramanan, Ajay D. Halai, Lorna Garcia-Penton, Alistair G. Perry, Nikil Patel, Katie A. Peterson, Ruth U. Ingram, Ian Storey, Stefano F. Cappa, Eleonora Catricala, Karalyn Patterson, James B. Rowe, Peter Garrard, Matthew A. Lambon Ralph
Statins and cognitive decline in patients with Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
Bojana Petek, Henrike Häbel, Hong Xu, Marta Villa-Lopez, Irena Kalar, Minh Tuan Hoang, Silvia Maioli, Joana B. Pereira, Shayan Mostafaei, Bengt Winblad, Milica Gregoric Kramberger, Maria Eriksdotter, Sara Garcia-Ptacek
Multimodal lifestyle engagement patterns support cognitive stability beyond neuropathological burden
Emily W. Paolillo, Rowan Saloner, Anna VandeBunte, Shannon Lee, David A. Bennett, Kaitlin B. Casaletto