Introduction
Founding concepts and basic principles
The angiogenic switch
Hypoxia
Mechanisms of building a vasculature
Vasculogenesis and endothelial progenitor cells
Sprouting angiogenesis
Vessel wall (endovascular) progenitors
Intussusceptive angiogenesis
Coalescent angiogenesis
Vessel co-option
Vasculogenic mimicry
Lymphangiogenesis
Angiogenesis and anti-angiogenesis in diseases
Ischemia (stroke, vessel occlusion)
Tissue engineering
Hard-to-heal wounds
Lymphedema
Cancer
Atherosclerosis
Arthritis
Gynecological disorders and fertility
Psoriasis
Obesity
Ocular disease
Vascular malformations
COVID-19 is a vascular disease
New concepts in the field of angiogenesis
Angiocrine signals
Vessel normalization
Large data analyses in angiogenesis
Endothelial cell anergy and immune suppression
Angiogenesis inhibition and immunotherapy
Immune checkpoint inhibitor | Anti-angiogenic compound | Cancer type | Approval date | Trial registration number [reference] |
---|---|---|---|---|
Atezolizumab | Bevacizumab + chemotherapy | Advanced non-squamous NSCLC | December 6th, 2018 | NCT02366143 [332] |
Pembrolizumab | Axitinib | Renal cell carcinoma | April 19th, 2019 | NCT02853331 [156] |
Avelumab | Axitinib | Advanced renal cell carcinoma | May 14th, 2019 | NCT02684006 [331] |
Pembrolizumab | Lenvatinib | Advanced endometrial carcinoma | September 17th, 2019 | NCT02501096 [333] |
Atezolizumab | Bevacizumab | Hepatocellular carcinoma | May 29th, 2020 | NCT03434379 [157] |
Nivolumab | Cabozantinib | Renal cell carcinoma | January 22nd, 2021 | NCT03141177 [383] |
Pembrolizumab Pembrolizumab | Lenvatinib Lenvatinib | Endometrial cancer Advanced renal cell carcinoma | July 21st, 2021 August 10th, 2021 | NCT03517449 [384] NCT02811861 [385] |