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Erschienen in: BMC Cancer 1/2013

Open Access 01.12.2013 | Study protocol

Patient Activation through Counseling and Exercise – Acute Leukemia (PACE-AL) – a randomized controlled trial

verfasst von: Mary Jarden, Tom Møller, Lars Kjeldsen, Henrik Birgens, Jesper Frank Christensen, Karl Bang Christensen, Finn Diderichsen, Carsten Hendriksen, Lis Adamsen

Erschienen in: BMC Cancer | Ausgabe 1/2013

Abstract

Background

Patients with acute leukemia experience a substantial symptom burden and are at risk of developing infections throughout the course of repeated cycles of intensive chemotherapy. Physical activity in recent years has been a strategy for rehabilitation in cancer patients to remedy disease and treatment related symptoms and side effects. To date, there are no clinical practice exercise guidelines for patients with acute leukemia undergoing induction and consolidation chemotherapy. A randomized controlled trial is needed to determine if patients with acute leukemia can benefit by a structured and supervised counseling and exercise program.

Methods/design

This paper presents the study protocol: Patient Activation through Counseling and Exercise – Acute Leukemia (PACE-AL) trial, a two center, randomized controlled trial of 70 patients with acute leukemia (35 patients/study arm) following induction chemotherapy in the outpatient setting. Eligible patients will be randomized to usual care or to the 12 week exercise and counseling program. The intervention includes 3 hours + 30 minutes per week of supervised and structured aerobic training (moderate to high intensity 70 - 80%) on an ergometer cycle, strength exercises using hand weights and relaxation exercise. Individual health counseling sessions include a self directed home walk program with a step counter. The primary endpoint is functional performance/exercise capacity (6 minute walk distance). The secondary endpoints are submaximal VO2 max test, sit to stand and bicep curl test, physical activity levels, patient reported outcomes (quality of life, anxiety and depression, symptom prevalence, intensity and interference). Evaluation of clinical outcomes will be explored including incidence of infection, hospitalization days, body mass index, time to recurrence and survival. Qualitative exploration of patients’ health behavior and experiences.

Discussion

PACE-AL will provide evidence of the effect of exercise and health promotion counseling on functional and physical capacity, the symptom burden and quality of life in patients with acute leukemia during out patient management. The results will inform clinical practice exercise guidelines and rehabilitation programs for patients undergoing treatment for acute leukemia. Optimizing the treatment and care pathway may ease the transition for patients from illness to the resumption of everyday activities.

Trial registration

ClinicalTrials.gov Identifier: NCT01404520.
Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-2407-13-446) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

MJ devised the study concept and design and drafted the manuscript. LK, HB, FD and CH participated in the design of the study and revised the manuscript for important intellectual content, JFC contributed to the design of the exercise components in the intervention, KBC conducted the power calculation, devised the analytic/statistical plan and revised the manuscript for important intellectual content. TM and LA contributed to the conception and design of the study, and revised the manuscript for important intellectual content. All authors read and approved the final manuscript.
Abkürzungen
PACE-AL
Patient Activation through Exercise and Counseling – Acute Leukemia
CR
Complete remission
ACSM
American College of Sports Medicine
6MWD
6 minute walk distance
FACT-An
Functional assessment of cancer therapy-anaemia scale
SF36
36-item short form health survey
EORTC QLQ-C30
The European Organization of Research and Treatment of Cancer Quality of Life Questionnaire
MDASI
M.D. Anderson symptom inventory
BFI
Brief fatigue inventory
PA Level
Physical activity level
Leisure Time PA
Leisure time physical activity
MSPSS
Multidimensional scale of perceived social support
PAM
Patient activation measure
GSE
General self efficacy
IQR
Inter quartile range
HH
Herlev Hospital
RH
Rigshospitalet
UCSF
The University Hospital’s Centre for Health Research
CIRE
Center for Integrated Rehabilitation of Cancer Patients.

Background

Acute leukemia is a life threatening hematological malignancy, representing one percent of all cancers diagnosed annually in Denmark, which approximates to 200 new cases of acute myeloid leukemia (AML) and 50 acute lymphatic leukemia (ALL) cases in adults yearly (cancer.dk). The five-year international survival for AML is 40% for adult patients (<60 yrs) receiving curative intended treatment, and for ALL 50% (18–45 yr) and 10-30% (>45 yr) [1, 2]. The WHO performance status score of patients with AML at the time of diagnosis has been shown to have prognostic importance [3]. The primary goal of treatment for acute leukemia is to rapidly achieve complete remission attained by the initial intensive chemotherapy regimen (induction), followed by repeated cycles of intensive chemotherapy (consolidation) and if indicated, an allogeneic stem cell transplantation. Each chemotherapy cycle is followed by severe neutropenia, thrombocytopenia and anemia, with an increased risk of serious infections, mainly septicemia and pneumonia [4]. Deterioration of nutritional status and quality of life (QOL) is reported after induction treatment [5]. Patients report a substantial symptom burden including lack of energy, shortness of breath, weakness, comprised physical functioning, difficulty sleeping, pain, nausea, emesis, diarrhea, weight loss, anxiety and distress [57]. Further, clinically significant depression can be precipitated or exacerbated by a diagnosis of acute leukemia [8]. Multiple symptoms have been found to have a deteriorating effect on QOL in patients with hematologic malignancy [911].
Over the past 15 years, patient safety aspects and prolonged hospitalization have been challenged by homecare interventions and outpatient management programs triggered by the prospect of improving QOL by reducing hospital admissions [12]. Implementation of outpatient programs for patients with acute leukemia have enabled patients to be discharged to their homes while receiving mandatory antibiotic prophylaxis during neutropenic phases [13, 14]. For the patient, this requires frequent, lengthy, long term and supervised visits for treatment and follow-up care, ongoing transfusion support and close monitoring for complications including serious infections. Pharmacological strategies, as antibiotic prophylaxis, antiemetics etc. are frequently prescribed to improve tolerance to the planned chemotherapy treatment, and now physical activity in recent years has been used as a strategy for rehabilitation in cancer patients to remedy disease and treatment related symptoms and side effects. Evidence suggests that activation of cancer patients can result in healthy behaviors i.e. physical activity, and lead to better health-related outcomes and self care management [15, 16]. In addition, tailored counseling sessions have been shown to improve functioning, clinical outcomes and reduce hospitalization [17]. Feasibility, safety and beneficial effects of low to high intensity exercise and psychosocial interventions have been found in cancer patients with the majority being breast cancer, and to a much lesser extent in colon, prostate, lung and hematological malignancies [1821]. However, the complex clinical situation seen in acute leukemia has predominantly excluded patients from participating in exercise interventions. Furthermore, present clinical care practice does not incorporate health counseling and physical exercise during treatment for acute leukemia which leaves this particular patient group understudied and under recruited in existing exercise-based rehabilitation programs. In a recent review of exercise in hematological cancer survivors [22], only three small scale studies comprise patients with acute leukemia [2325], and one pilot study with a mixed population of acute leukemia and lymphoma [26], all during hospitalization while undergoing the induction phase of chemotherapy treatment. These limited findings, indicate feasibility, safety and preliminary physiological and psychosocial benefits from exercise in patients during induction treatment for acute leukemia. In our recently published pilot study (n = 20), we intervened in the outpatient management setting by building a bridge between the hospital and daily life activities of patients with acute leukemia by addressing the challenges associated with maintaining muscle, cardiovascular and emotional and general health during chemotherapy treatment [9]. This 6 week supervised and structured exercise and health counseling intervention proved feasible, safe and well tolerated with physical, functional, psychosocial and symptom benefits in a small sample of patients with acute leukemia undergoing intensive chemotherapy. However, no recommendation for exercise can be issued specifically for acute leukemia patients undergoing induction and consolidation treatment during hospitalization and outpatient treatment and care [9, 22].
This protocol paper presents our current randomized trial (PACE-AL) that aims to investigate the effect of a 12 week structured and supervised multimodal program of physical exercise and health counselling in patients with acute leukemia undergoing consolidation treatment during outpatient treatment and care. It is hypothesized that the intervention can minimize the loss of physical and functional capacity, reduce the symptom burden, improve psychosocial wellbeing and health related QOL. To our best knowledge, this is a first time study that examines a multimodal intervention of health counseling and exercise in patients with acute leukemia, initiated early in the treatment trajectory prior to consolidation treatment and conducted over a 12 week period. The long term effect of the intervention will be investigated at 6 and 12 month follow-up.

Methods/design

Participants and setting

This randomized controlled trial is a prospective, two group trial of a 12 week exercise and health counseling intervention in patients with newly diagnosed acute leukemia during the course of consolidation treatment in the outpatient clinic. 70 patients will be consecutively recruited and randomized by the research investigator and/or the nurse specialists from the Department of Hematology at two Copenhagen University hospitals: The University Hospital of Copenhagen, Rigshospitalet (RH) and Herlev Hospital (HH). Patients ≥ 18 years newly diagnosed with acute leukemia are eligible for the study upon completion of their initial induction chemotherapy with a documented complete remission (CR) status, able to read and understand Danish and can provide a signed informed written consent. The exclusion criteria are recent symptoms of cardiovascular, neurological or muscular disease, abnormal electrocardiogram and uncontrolled high blood pressure.

Study and recruitment procedures

The study flow is presented in Figure 1. Potential participants will be identified and screened for eligibility by the research investigator and/or clinical nurse specialist by weekly reviews of patient admissions and their status through medical record review and consultation with the nursing and medical staff at the Departments of Hematology, RH and HH. If eligible, the patients will be approached once the initial induction chemotherapy treatment is completed and complete remission (CR) is achieved. The patients will be provided with verbal and written information regarding the study and subsequently asked if they would like to participate. Once written consent is obtained, the patients are immediately scheduled for their baseline tests, which include four physical/exercise tests and asked to complete patient reported outcome questionnaires (PRO). Baseline tests and assessments will be repeated at 6 weeks and at completion of the intervention period (12 weeks). Selected participants (purposive sampling strategy) will be interviewed at 12 weeks by the research investigator (n = 25). Further, PRO tests will be repeated at 6 and 12 months. Three brief PRO pertaining to symptom assessment and physical activity levels will be repeated once weekly throughout the duration of the study period. To strengthen internal validity, the procedures for tests/assessments will be conducted under the same or similar conditions at all three test points at both hospitals (HH and RH). The study personnel and blinded outcome assessors will conduct tests during the morning hours (between 9 am-12 noon), utilize the same test equipment and conduct the tests/assessments in a specific order.

Randomization and group allocation

After baseline testing, patients will be randomized to one of two trial arms (intervention or control) using the computerized Clinical Trial Management System (CITMAS/HITMAS) [27] and stratified for age (<45 and >45 years), gender, and treatment facility (RH and HH). This is to ensure that the randomized groups are similar at baseline. A block design with allocation weight of 1:1 will be used to generate treatment allocation. Randomized patients will remain in the same group for the entire duration of the intervention.

Blinding

Blinding the participants or the investigators to allocation group will not be possible, however the outcome assessors and the trials statistician will be blinded to the participants study allocation. The trials statistician will have access to unblinded data, but will prepare results without knowledge of allocation to randomization coding.

Trial arm 1 (intervention protocol and general considerations)

The intervention program - exercise and counseling (Tables 1 and 2) was designed using principles for exercise suggested by the American College of Sports Medicine (ACSM) [28] and a literature review on physical activity and hematological cancer survivorship [22]. The counseling sessions and the daily guidance and motivation are theoretically based on the social cognitive model of health promotion [29], theory of planned behaviour [30] and motivational interviewing (MI) methods and principles [3134]. The intervention is a supervised hospital-based program that takes place at designated training locations at two hematology out-patient departments (RH,HH). Each session is designed to last 1hour ±10 min., 3 days weekly during the patients out-patient visit between 10 am and 12 noon beginning the first day of ambulatory care and carried out for 12 weeks. Patients who are intermittently hospitalized due to infection or other complications during the study period will be offered the intervention in their hospital room and when possible, the patient will be asked to meet at the projects designated training areas. Consecutive inclusion will enable training in small groups between 2 and 4 participants.
Table 1
The intervention program - exercise and health promotion counseling
PHYSICAL ACTIVITY
COUNSELING
 
Physical Training
Relaxation Training
Diet
Guidance and motivation
Health counseling
Supervised (out-patient facility at hospital)
Stationary cycling
Relaxation and breathing exercise with guidance and music
Protein/carbohydrate supplement 30 min. after training
Instruction and guidance in exercising, usage of step counter and walking program, short and long term motivation and symptom management
Focus:
Moderate to very hard intensity
1) Screening
   
2) Health behavior
75-80% HR max
Low intensity
e.g. chocolate milk, shake, nuts, protein bar
2) Handling of symptoms
Interval training
RPE 6-9
 
3) Social/employment
RPE 15-17
MET 2.5
  
MET 5.5 - 8
 
Protein: 16-19 g.
 
GOAL SETTING
  
Carbohyd: 1400-1900 kj.
  
Dynamic and resistance training
  
Individual
Individual
Moderate to hard
  
2 sets, 12 reps
RPE 14-16
MET 5.5
3 days/week
3 sessions 30-60 min.
Not supervised (home, outdoors, hospital corridor etc.)
Walk program with step counter
    
Daily and individual
    
Table 2
The weekly intervention program - exercise and health promotion counseling
WEEKLY PROGRAM 12 wks., 3 days/wk., 3-4 hours/wk. and daily walking
Monday
Tuesday
Wednesday
Thursday
Friday
Training program incl. relaxation (1 hr.)
 
Training program incl. relaxation (1 hr.)
 
Training program incl. relaxation (1 hr.)
Protein snack
 
Protein snack
 
Protein snack
Guidance and motivation
 
Guidance and motivation
 
Guidance and motivation
step counter
 
step counter
 
step counter
Week 1
Week 2 - 11
Week 12
Walk program with step counter
Walk program with step counter
Walk program with step counter
Establish habitual level
Maintenance or progression
Maintenance or progression
Week 6
(1) Health counseling
(2) Health counseling
(3) Health counseling
(30-60 min)
(30-60 min)
(30-60 min)

Intervention: pre-screening and safety precautions

The research investigator and/or the study’s clinical nurse specialists and physiotherapists will pre-screen the patients and supervise all sessions. If one or more of the following criteria are present prior to the intervention, the session will be either postponed or modified on that specific day; diastolic blood pressure < 45 or > 95 mmHg, pulse at rest > 100/min, signs of infection (temp > 38°C); respiration frequency at rest > 20/min and signs of bleeding (petechiae, nose bleeds, bruises). The units’ transfusion policy is for thrombocytopenia, platelets < 15 × 109/l and for anemia, hemoglobin < 7.5 - 9 g/dl. The patients will be continuously monitored with a digital heart rate monitor (Polar Model) and observed for adverse reactions/events (see Monitoring Adverse Events).
The supervised exercise component of the intervention comprises stationary cycling, and will be initiated for a period of 20-25 min for each session. A minimum of six work intervals are integrated to enable cardiovascular effect while ensuring safety and therefore aims to reach but not exceed 80% of the maximal heart rate calculated by ACSM formula (206.9 - (0.67 × age) + 75/80%) [35]. The subjective intensity of effort is evaluated by the Borg Rate of Perceived Exertion scale (RPE), a visual analogue scale ranging from 6 (light effort) to 20 (maximal exertion) [36]. Intensity effort will strive to be between 15-17 (hard to very hard). The metabolic equivalent intensity level (METS) is calculated for each physical activity component [37]. The main goal of aerobic progression is to gradually increase exercise intensity and duration. Six dynamic and resistance exercises using free hand weights will be carried out including bicep curl, shoulder press, squat, lunge, push-ups, and one core exercise for abdominal and back muscles. Exercises will be performed in 2 sets of 12 repetitions, and hand weights will be adjusted to enable 2 sets and up to 12 repetitions. Progression aims to increase weight. The exercises will be followed by relaxation training while lying supine (or sitting) on a mat following live instruction to music [3840]. At completion of each training session, the patients will consume a single or combined protein/carbohydrate supplement (16-19 g. protein and 1600–2000 kj carbohydrate) within 30 minutes of exercise to speed recovery by repairing and rebuilding muscle tissue [41, 42]. Training sessions will be accompanied by guidance and motivation by the research physiotherapists and clinical nurse specialists with special focus on topics related to the exercise program, short and long term motivation and symptom management [2934].
Counseling will be conducted three times for 30-60 min. at baseline, six and twelve weeks. Health promotion counseling sessions are schematized and carried out by the research investigator and/or clinical nurse specialists through a circular process of pre-contemplation, contemplation, preparation, action and maintenance [43]. The main principle of health counseling is to create a partnership with the patient to improve adherence to the intervention during the study period and to motivate towards positive health behavior, including maintaining or increasing physical activity during and beyond the supervised exercise sessions, and also after completion of the program. MI is a behavioral change strategy that assumes the patient possesses inherent resources and motivation that may be enhanced through the patient’s own expression of goals [2934]. Each counseling session is therefore goal oriented and offers guidance in aspects of managing treatment-related symptoms, including symptoms of stress and anxiety, and issues related to diet, smoking cessation, alcohol consumption, sleep, social and daily life function and physical activity.
At the start of the program, the participants will receive a step counter (Omron Walking Style Pro) with the motivational purpose of physical and behavioral awareness and activation [44]. The patients will be fitted with the step counter by the study physiotherapists and instructed to wear the step counter during waking hours. Results from the step counter will be electronically transferred to a laptop computer once a week for the purpose of reviewing with each patient the number of daily total steps and aerobic steps achieved during the previous week, which will result in the patient expressing physical activity and walking goals for the following week.

Trial arm 2 (control group)

The control group receives standard care and treatment that does not include supervised physical activity and/or health promotion counseling at the departments. Patients in both the intervention and control groups will receive usual care and treatment, and are not restricted from participating in other physical activity during the study period.

Study endpoints and assessments

Outcome measures will be assessed at three time points, baseline, six and twelve weeks with a 6 and 12 month follow up. Table 3 outlines the study assessment schedule. Demographic, performance status (WHO) and medical data will be collected by journal review and questionnaire. Assessments will be carried out between 9:00 am and 12:00 noon by the project outcome assessors at their respective hospitals. Patients will be instructed on proper technique for the tests, and will be advised to stop if they experience pain or extreme discomfort, nausea, or dizziness. During the test sessions, the patients will be continuously monitored with a digital heart rate monitor (Polar Model) and observed for adverse reactions/events (see Monitoring Adverse Events).
Table 3
Study assessment schedule
Data Assessment
Screening
Day -2
Day 0
Day 1
6 weeks
12 weeks
6 months
12 months
Baseline-test
  
Mid-test
Post-test
Follow-up
Follow-up
Recruitment
        
Chart review
x
       
Patient approached
x
       
Informed consent
x
       
Outcome Assessments
        
6MWD
 
x
  
x
x
  
Aastrand-Rhyming test
 
x
  
x
x
  
Sit to stand test
 
x
  
x
x
  
Biceps arm curl
 
x
  
x
x
  
Patient-reported outcomes
 
x
  
x
x
x
x
Medical chart review
 
x
   
x
x
x
Weekly assessments
        
Step counter
 
x
  
x
x
  
MDASI
 
x
  
x
x
x
x
BFI
 
x
  
x
x
x
x
PA Level
 
x
  
x
x
x
x
Randomization
  
x
     
Intervention initiation
   
x
    
Qualitative Interview
     
x
  
6MWD, 6 minute walk distance; MDASI, M.D. Anderson Symptom Inventory; BFI, Brief Fatigue Inventory; PA Level, Physical Activity Level.

Primary endpoint

Functional performance/exercise capacity: 6 minute walk distance (6MWD) which measures the sub maximal level of functional and exercise capacity and will be carried out in accordance with the American Thoracic Society (ATS) guidelines [45]. The ATS Pulmonary Function Standards Committee developed guidelines for the 6MWD in clinical settings [46]. The 6MWD was chosen because it is easy to administer in the outpatient setting, well tolerated by patients with acute leukemia, and reflects activities of daily living [47].

Secondary endpoints

Aerobic capacity. A single stage 6 min submaximal exercise test; the Aastrand-Rhyming cycle ergometer test is used to predict VO2 max values [48]. The test is based on the linear relationship between VO2 and heart rate. The patients pulse will be continually monitored using a wireless heart rate transmitter. Resistance (Watt) is increased to elicit a steady-state heart rate between 125 and 170 beats/min at a speed between 60 and 65 r.p.m. If after 6 min the HR is above 125 beats/min and stable, not fluctuating more than 5 beats/min, the test is terminated. VO2 max is determined using a nomogram with an age and body weight correction factor. VOs max is stated in ml/kg/min.
Functional performance and muscle strength comprises three endpoints: (1) Sit to stand test will be performed as a measure of strength and performance of the lower extremity muscles. The 30 second sit to stand was developed as an assessment tool to measure lower body strength [49]; (2) Biceps Arm Curl measures arm flexor strength, upper body strength and endurance [50]. The aim is to perform as many arm curls as possible in 30 seconds; and (3) Measurement of weekly steps and distance with the step counter: Omron Walking Style Pro [44].
Clinical outcomes (exploratory endpoints) will include andropometric characteristics (body mass index (wt(kg)/ht(m2)), WHO performance status, hospitalization (days), increased temperature (>38°) (days), elevated C-reactive protein (days), infections and complications (type and days), neutropenia and thrombocytopenia (days), transfusions (platelets and RBC) (number), time to relapse and survival.
Patient reported outcomes (PRO) in this study are standardized and validated questionnaires that measure physical, functional, emotional and social wellbeing, symptom prevalence, intensity including fatigue and interference in daily activities. The PRO’s will be administered and checked for completeness by the study investigator at baseline, 6 and 12 weeks, and 6 and 12 months; and coded according to the guidelines given in the questionnaires manuals: (1) The Functional Assessment of Cancer Therapy-Anemia scale (FACT-An) assesses cancer specific Health Related Quality of Life (HRQOL), the fatigue symptom subscale (An) of the FACT-An scale and the Trial Outcome Index (TOI) [51]. (2) The 36-Item Short Form Health Survey (SF-36) assesses general wellbeing using eight scales measuring different aspects of general health with two summary scales; physical and mental component scales [52]. (3) The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (C30 EORTC QLQ-C30) assesses Quality of Life (QOL) using a global health status scale, five functional scales (physical, role, emotional, cognitive and social functioning) and symptom scales (fatigue, nausea and vomiting, pain, dyspnea, insomnia, appetite loss, constipation, diarrhea) [53, 54]. (4) The Hospital Anxiety and Depression Scale (HADS) assess psychological wellbeing and is designed to measure general anxiety and depression in patients with physical illness [55]. (5) The M.D. Anderson Symptom Inventory (MDASI) assesses the severity of 13 symptoms and their impact as evaluated by six interference items [56]. The MDASI will be additionally administered once a week prior to the last training session. (6) The Brief Fatigue Inventory (BFI) assesses fatigue levels and their impact as evaluated by interference items [57]. The BFI will also be administered once a week prior to the last training session.
Physical activity, social network/relations, activation and ability, and employment (return to work) will be assessed by the (7) Leisure time physical activity [58], (8) Physical activity level [59], (9) Multidimensional Scale of Perceived Social Support (MSPSS) [60], (10) Patient Activation Measure (PAM) [61], (11) Self Efficacy Scale (GSE) [62] and (12) Employment status and ability [63].
A qualitative in-depth face-to-face semistructured interview (n = 25) at 12 weeks carried out by the study investigator will explore the patients’ perspectives on physical activity and health, health behavior, and the experiences and challenges (including barriers) of returning to daily life regarding issues of health (well-being, vitality/fatigue, strength, symptom control) and disease (treatment and management, symptoms, complications), social (network, family) and employment. Further, we would like to clarify whether and how the intervention has contributed to the patients’ experiences of physical, emotional and social wellbeing and adaptation. Moreover, we aim to describe the symptom experience from the patients’ perspective, as well as explore the effect of the intervention on the symptom burden and symptom interference. A topic and question guide will be used to aid the focus of the interviews.

Logbook

A 'monitoring logbook’ will be used to document screening, adherence to the intervention, unwanted symptoms, adverse events, and self-reported symptom assessment and activity levels. All components of the intervention performed will be recorded on-going including; exercise mode, frequency, intensity, duration and progression as well as subjective exercise response (BORG) and heart rate. Components performed beyond that prescribed in the intervention program, i.e. weekends or evenings, will be reported by the patient and then documented. For each individual component in the programme, adherence to the intervention will be measured by calculating the percentage of recommended exercise sessions performed by the patient (number of sessions performed /number of sessions prescribed). The control group will receive a modified logbook and will be asked to register activity/exercise mode, frequency and duration [59], weekly, during the study period as well as register symptom prevalence, intensity and interference (weekly) using the symptom assessment scales MDASI [56] and BFI [57].

Tracking and monitoring adverse events

Patients will be monitored for unwanted symptoms and adverse events during each intervention session and throughout the intervention period. The following study procedures will be incorporated to ensure safety: 1) Prior to each exercise session, the patient will be monitored for blood pressure, pulse, temperature and thrombocyte and hemoglobin levels according to the study’s screening criteria; 2) During each intervention session, the patients will be monitored for unwanted symptoms and adverse events and recorded in the patients study chart; 3) Symptoms experienced and adverse events will be discussed with individual patients weekly; 4) Adverse events will be a steady agenda at the weekly and monthly study group meetings; and 5) All adverse events will be reported by completing the hospitals unintended/accidental event form and will follow the hospitals procedure for reporting such events.

Ethical considerations

There are presently no rehabilitation programs available for patients with acute leukemia at the Departments of Hematology (HH, RH), however upon approval from the physician, patients may be referred to a municipality rehabilitation program. Patients in both study arms are not inhibited from exercising during the study period, as long as it is in accordance with the departments’ safety guidelines for daily physical activity and social contact. Moreover, patients allocated to both the control and intervention groups will receive usual and optimal care during the study period.

Potential risks

During the course of the trial, patients will receive two chemotherapy cycles and consequently experience two neutropenic periods, each lasting approx. 7–14 days and during this time patients are especially prone to experiencing unpleasant symptoms i.e. mucositis, fatigue, and complications i.e. bleeding and infections. Further, during the trial period, and as a requirement of usual care, patients will have an indwelling central venous catheter (CVC) placed in order to facilitate chemotherapy, transfusions and drug delivery. CVC’s have benefits (minimize extravasation risk and avoid discomfort), but are associated with certain risks (infection, thrombosis). Patients will therefore, be screened and observed (BP, P, T, platelets, hemoglobin, sign of infection or bleeding) prior to the physical tests and before and during each exercise session (see Pre-screening and safety precautions). We will integrate an adverse events procedure that includes observation, documentation, patient and study team awareness, discussion and reporting (see Tracking and monitoring adverse events). In our previous pilot study, no adverse events or injuries were observed as a result of the exercise [8], however two patients experienced aching in the hip area after increasing their walking distance and most patients reported slight soreness in their muscles the day after training. No bruising was noted. There were, however, two incidents during baseline testing of two patients, one female during the 6MWD tripped and fell to the floor, and a male patient fell forward and onto the floor during the sit-to-stand test. Both patients were not injured, and able to carry out the tests at a later time. Safety measures were then instituted immediately in the pilot study and these safety measures (using arm rests during the sit-to-stand test for weakened patients, patient information regarding wearing appropriate walking shoes) will continue during the RCT.

Approvals and registrations

Study approval is obtained for Herlev Hospital and Rigshospitalet by the Scientific Ethics Review Committee of the Capital Region of Denmark (J.no. H-4-2010-046) and the Danish Data Protection Agency (J.no. 30–0431). The study is registered at ClinicalTrials.gov Identifier: NCT01404520.

Statistical considerations

Sample size

This randomized controlled trial will include 70 acute leukemia patients over a recruitment period of 34–36 months. Sample size calculation is based on the primary endpoint; the 6 min walk distance (6MWD) and the results from our pilot study (n = 20), where n = 17 completed the study (15% lost to followup). The pilot study baseline for 6MWD was 450 m and the average change was 56.3 m effect (SD = 69.2). Assuming that there is no change in the control group, an inclusion of 70 patients (35 intervention, 35 control) will yield more than 90% power (risk of type 2 error set at 0.10) to detect a difference of this magnitude between groups using a significance level of 0.05 (risk of type 1 error set at 0.05). Should 20% be lost to followup (n = 56), the power will still be larger than 80%.

Analytic plan

Quantitative data

Data will be entered into the OpenClinica database [64] and statistical analysis will be carried out using Statistical Analysis Systems (SAS) version 9.2. Procedures for data entry and audit program have been developed to ensure accurate data entry [65]. Baseline comparisons of demographic and clinical outcomes will be performed using independent samples t-tests, and chi-squared tests will be applied for categorical variables. The primary endpoint will be reported as an independent samples t-test comparing change scores in the two randomization groups. The secondary endpoints (physical and strength tests and PRO questionnaires) will be reported as means and 95% confidence intervals and medians inter quartile range (IQR) for continuous variable, while categorical data will be reported as proportions and compared across randomization groups using chi-squared tests. The intent-to-treat principle will be applied and the significance level is set at 0.05. Additional analyses of 6 and 12 month followup data (PRO questionnaires) and of weekly symptom measurements and physical activity data will utilize linear mixed models to quantify trajectories. The trials statistician (KBC) will prepare results without knowledge of assignment to randomization coding.

Qualitative data

Upon consent from the participants, the interviews will be recorded and transcribed verbatim. Data will be anonymised and coded using computerized qualitative data analysis software (NVivo 10) [66]. Thematic analysis is a qualitative analytic method that identifies, analyzes and reports themes and patterns within and across cases [67, 68]. This study will apply an inductive, data-driven approach, which is the process of coding the data without attempting to fit it into a preexisting coding frame. The six phases of thematic analysis are as follows: (1) First, the investigator listens to the audio recordings and reads/re-reads the transcripts to become familiar with the content of the data. (2) Next, initial codes are generated from data extracts (sentences or paragraphs), (3) and from these extracts, the investigator searches for and reviews the themes, (4) generates a thematic map of the analysis, (5) defines and labels themes and finally, (6) identifies common themes. This final phase is the analysis of selected extracts/themes in relation to the initial research questions, literature and theory [67, 68].

Discussion

PACE-AL will target the special clinical and rehabilitation needs of patients with acute leukemia. Several aspects were taken into consideration in the development of PACE-AL to assure safety and tolerability, adherence and completion of study requirements. Firstly, the timing of initiation of the intervention along the treatment trajectory was considered. Once the diagnosis is established, patients are immediately hospitalized and induction chemotherapy with curative intent is rapidly initiated. The patients’ medical situation at this time is unstable with a particular risk of severe infectious complications [69, 70]. Additionally, it can be a challenge for patients to face the uncertainty of the disease and treatment while experiencing treatment-related symptoms and side effects. Being that safety is our main concern, we chose to recruit patients and initiate the intervention after completion of induction treatment, and once the patients’ condition is stabilized (CR status). After induction treatment, patients are typically managed as outpatients for months and it is during this phase in the treatment trajectory that PACE-AL trial will be initiated. Secondly, it is reported that patients with hematological malignancies undergoing intensive chemotherapy have a low level of 'naturally occurring’ physical activity, suggesting that a structured intervention may be necessary in order to promote exercise in this population [71]. However, there are no exercise guidelines available for patients with acute leukemia. Most exercise trials and rehabilitation programs institute screening parameters for participation that require platelet levels of at least 40-50 x 109/l. The units’ transfusion policy (HH, RH) for thrombocytopenia is platelets < 15 × 109/l, which on a daily basis and without platelet transfusion would exclude patients in this group from participation in existing programs. A few trials have safely carried out moderate physical exercise in patients undergoing intensive chemotherapy with platelet values ≥20 × 109/l [22, 7274] and >10 × 109/l [26]. PACE-AL will allow exercise participation with platelet values ≥15 × 109/l. [9] The safety precautions instituted in this trial include screening (platelet level, temperature, blood pressure and signs of infection and bleeding) prior to the physical tests and intervention, supervision and monitoring during the intervention, as well as a procedure for monitoring and reporting intervention-related adverse events. Thirdly, we considered the treatment setting. We chose to offer the intervention during the patients waiting time at the outpatient department to avoid prolonging the time spent at the hospital. Further, knowing that patients have difficulty initiating independent exercise during intensive chemotherapy in this setting, we decided to lengthen the intervention period from 6 weeks in our pilot study [9] to span over two chemotherapy cycles (12 weeks). The fourth aspect is the intervention type and dose. Since patients during outpatient management are required to visit the unit 3–4 days/week, an exercise intervention of 3 days/week would be realistic for the patient. Moreover, we anticipate that patients will be experiencing a relatively high symptom burden and in effect, do not want to hold the patient longer than necessary at the department. Therefore, each session will not exceed 1 hr ± 10 min. We designed the components of the intervention based on general guidelines suggested by the ACSM [28] and a literature review on physical activity and hematological cancer survivorship [22]. The exercise components in this study will include a combination of aerobic, resistance and relaxation training of low to moderate intensity 3 days/week á 3–4 hours/week. The walking program with step counter will be applied as motivation for independent activity. The step counter will be used as a means of building a bridge between hospital and daily life to improve the naturally occurring level of physical activity while at home. The step counter enables the study team to electronically review the data, and give the patient feedback about their independent activity level outside the hospital setting. Knowing that patients are at risk of losing muscle mass during treatment due to inactivity, prednisolone treatment etc., we will incorporate protein/carbohydrate supplements after each training session to prevent muscle wasting. Finally, the health counseling and daily motivation and guidance are important components in this intervention. Exercise trials for patients with hematological malignancies are primarily designed as exercise-only interventions and do not include psychosocial interventions or report the efforts made to guide and motivate participants during the individual sessions, across the intervention study period and long term [22, 25, 75].
We chose validated physical and functional capacity tests that would be feasible in this acute leukemia clinical setting. The tests reflect physical, functional and aerobic capacity and upper and lower body muscle strength. The 6MWD was chosen for the primary endpoint because it reflects activities of daily living, is easy to administer in the outpatient department and well tolerated by patients with acute leukemia undergoing chemotherapy. The gold standard of maximal oxygen uptake requires patients to perform a maximal stress test, however, wearing a mask is uncomfortable for patients recovering from stomatitis, as reported by Dimeo [76]. Therefore, oxygen uptake in this study as a secondary endpoint will be estimated by a submaximal cycle test, requiring a work intensity that will be realistic for weakened patients at all test points [48].

Summary

Inactive periods during treatment for acute leukemia are frequently related to fatigue and depression, and can lead to reduced cardio respiratory capacity, as well as impaired muscular function, affecting the ability to carry out activities of daily living. In order to optimize the treatment and care pathway, appropriate exercise guidelines and rehabilitation programs for patients undergoing treatment for acute leukemia need to be established to ease the transition from illness to the resumption of everyday activities, e.g. job/school. PACE-AL trial will study the effect of a 12 week supervised and structured exercise and health promotion counseling intervention on physical and functional capacity, symptom burden and symptom interference with daily activities, quality of life, psychosocial and clinical outcomes in patients with acute leukemia undergoing intensive chemotherapy during outpatient management.

Acknowledgements

This research is supported by grants from The Center for Integrated Rehabilitation of Cancer Patients (CIRE), a center established and supported by The Danish Cancer Society and The Novo Nordic Foundation, The University Hospitals’ Centre for Health Research (UCSF), The Lundbeck Foundation, The Novo Nordic Foundation for Clinical Nursing Research and The Danish Cancer Society. The authors acknowledge IT coordinator Knud Nelausen, clinical research unit, Dept. of Oncology, HH for developing the randomization program (CITMAS, HITMAS), physiotherapists Kira Bloomquist, (UCSF), Vivi Ann Sørensen (RH), Merete Stensen (HH), Marie Thorsager (HH) for contributions in the development of the exercise components, the hematology nursing administration; Susanne Dansholm (HH), Anette Brieghel (HH), Pernille Welinder (RH), Tina Lanther (RH), and the dieticians from HH and RH, Tanja Bak Oestergard and Berit Ipsen, respectively. The authors present this study protocol on behalf of the PACE-AL project group: clinical nurse specialists Birgit Holm (HH), Annemarie Drum (HH), Katrine Lethan (RH) and Malene Marup Jaeger (RH), and physiotherapists Maria Astrid Møller (HH), Mette Mou Nielsen (HH), Frederik Reith Bartels (RH), Eva Hollænder (RH), Linnea Waldorf Lund (RH) and outcome assessors Christina Ehrbar (HH), Pernille lund Skov Larsen (HH), Nick Smith (RH) and Sandie Bendix (RH).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

MJ devised the study concept and design and drafted the manuscript. LK, HB, FD and CH participated in the design of the study and revised the manuscript for important intellectual content, JFC contributed to the design of the exercise components in the intervention, KBC conducted the power calculation, devised the analytic/statistical plan and revised the manuscript for important intellectual content. TM and LA contributed to the conception and design of the study, and revised the manuscript for important intellectual content. All authors read and approved the final manuscript.
Anhänge

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Literatur
1.
Zurück zum Zitat Dohner H, Estey eH, Amadori S, et al: Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010, 115: 453-474. 10.1182/blood-2009-07-235358.CrossRefPubMed Dohner H, Estey eH, Amadori S, et al: Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010, 115: 453-474. 10.1182/blood-2009-07-235358.CrossRefPubMed
2.
Zurück zum Zitat Rubinitz JE, Gibson B, Smith FO: Acute myeloid leukemia. Hematol Oncol Clin North Am. 2010, 24: 35-63. 10.1016/j.hoc.2009.11.008.CrossRef Rubinitz JE, Gibson B, Smith FO: Acute myeloid leukemia. Hematol Oncol Clin North Am. 2010, 24: 35-63. 10.1016/j.hoc.2009.11.008.CrossRef
4.
Zurück zum Zitat Grigoropoulos N, Petter R, Van t Veer M, Scott M, Follows G: Leukaemia update. Part 2: managing patients with leukaemia in the community. BMJ. 2013, 346: f1932-10.1136/bmj.f1932. published 9 April 2013CrossRefPubMed Grigoropoulos N, Petter R, Van t Veer M, Scott M, Follows G: Leukaemia update. Part 2: managing patients with leukaemia in the community. BMJ. 2013, 346: f1932-10.1136/bmj.f1932. published 9 April 2013CrossRefPubMed
5.
Zurück zum Zitat Malihi Z, Kandiah M, Chan YM, Hosseinzadeh M, Sohanaki Azad M, Zarif Yeganeh M: Nutritional status and quality of life in patients with acute leukemia prior to and after induction chemotherapy in three hospitals in Tehran, Iran: a prospective study. J Hum Nutr Diet. 2013, doi:10.1111/jhn.12043. Epub ahead of print Malihi Z, Kandiah M, Chan YM, Hosseinzadeh M, Sohanaki Azad M, Zarif Yeganeh M: Nutritional status and quality of life in patients with acute leukemia prior to and after induction chemotherapy in three hospitals in Tehran, Iran: a prospective study. J Hum Nutr Diet. 2013, doi:10.1111/jhn.12043. Epub ahead of print
6.
Zurück zum Zitat Johnsen A, Tholstrup D, Petersen M, Pedersen L, Groenvold M: Health related quality of life in a nationally representative sample of haematological patients. Euro J Haematol. 2009, 83: 139-148. 10.1111/j.1600-0609.2009.01250.x.CrossRef Johnsen A, Tholstrup D, Petersen M, Pedersen L, Groenvold M: Health related quality of life in a nationally representative sample of haematological patients. Euro J Haematol. 2009, 83: 139-148. 10.1111/j.1600-0609.2009.01250.x.CrossRef
7.
Zurück zum Zitat Zimmermann C, Yuen D, Mischitelle A, Minden MD, Brandwein JM, Schimmer A, Gagliese L, Lo C, Rydall A, Rodin G: Symptom burden and supportive care in patients with acute leukemia. Leuk Res. 2013, doi:10.1016/j.leukres.2013.02.009. Epub ahead of print Zimmermann C, Yuen D, Mischitelle A, Minden MD, Brandwein JM, Schimmer A, Gagliese L, Lo C, Rydall A, Rodin G: Symptom burden and supportive care in patients with acute leukemia. Leuk Res. 2013, doi:10.1016/j.leukres.2013.02.009. Epub ahead of print
8.
Zurück zum Zitat Deschler B, Ihorst G, Platzbecker U, Germing U, Marz E, de FM, et al: Parameters detected by geriatric and quality of life assessments in 195 older patients with myeloplastic syndromes and acute myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome. Haematologica. 2013, 98: 208-216. 10.3324/haematol.2012.067892.CrossRefPubMedPubMedCentral Deschler B, Ihorst G, Platzbecker U, Germing U, Marz E, de FM, et al: Parameters detected by geriatric and quality of life assessments in 195 older patients with myeloplastic syndromes and acute myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome. Haematologica. 2013, 98: 208-216. 10.3324/haematol.2012.067892.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Jarden M, Kjeldsen L, Birgins H, Stensen M, Sørensen V, Christiansen J, Tolver A, Adamsen L, Møller T: The emerging role of exercise and health counseling in patients with acute leukemia during outpatient management. Leuk Res. 2013, 37 (2): 155-161. 10.1016/j.leukres.2012.09.001. 10.1016/j.leukres.2012.09.001. Epub 2012 Sep 27CrossRefPubMed Jarden M, Kjeldsen L, Birgins H, Stensen M, Sørensen V, Christiansen J, Tolver A, Adamsen L, Møller T: The emerging role of exercise and health counseling in patients with acute leukemia during outpatient management. Leuk Res. 2013, 37 (2): 155-161. 10.1016/j.leukres.2012.09.001. 10.1016/j.leukres.2012.09.001. Epub 2012 Sep 27CrossRefPubMed
10.
Zurück zum Zitat Santos FR, Kozasa EH, Chauffaille Mde L, Colleoni GW, Leite JR: Psychosocial adaptation and quality of life among Brazilian patients with different hematological malignancies. J Psychosom Res. 2006, 60: 505-511. 10.1016/j.jpsychores.2005.08.017.CrossRefPubMed Santos FR, Kozasa EH, Chauffaille Mde L, Colleoni GW, Leite JR: Psychosocial adaptation and quality of life among Brazilian patients with different hematological malignancies. J Psychosom Res. 2006, 60: 505-511. 10.1016/j.jpsychores.2005.08.017.CrossRefPubMed
11.
Zurück zum Zitat Pamuk GE, Harmandar F, Ermantaş N, Harmandar O, Turgut B, Demir M, Vural O: EORTC QLQ-C30 assessment in Turkish patients with hematological malignancies: association with anxiety and depression. Ann Hematol. 2008, 87: 305-310. 10.1007/s00277-008-0445-4.CrossRefPubMed Pamuk GE, Harmandar F, Ermantaş N, Harmandar O, Turgut B, Demir M, Vural O: EORTC QLQ-C30 assessment in Turkish patients with hematological malignancies: association with anxiety and depression. Ann Hematol. 2008, 87: 305-310. 10.1007/s00277-008-0445-4.CrossRefPubMed
12.
Zurück zum Zitat Møller T, Adamsen L, Appel C, Welinder P, Stage M, Jarden M, Hjerming M, Kjeldsen L: Health related quality of life and impact of infectious comorbidity in outpatient management of patients with acute leukemia. Leuk Lymphoma. 2012, Epub ahead of print Møller T, Adamsen L, Appel C, Welinder P, Stage M, Jarden M, Hjerming M, Kjeldsen L: Health related quality of life and impact of infectious comorbidity in outpatient management of patients with acute leukemia. Leuk Lymphoma. 2012, Epub ahead of print
13.
Zurück zum Zitat Savoie ML, Nevil TJ, Song KW, Forrest DL, Hogge DE, Nantel SH, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC: Shifting to outpatient management of acute myeloid leukemia: a prospective experience. Ann Oncol. 2006, 17: 763-768. 10.1093/annonc/mdl011.CrossRefPubMed Savoie ML, Nevil TJ, Song KW, Forrest DL, Hogge DE, Nantel SH, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC: Shifting to outpatient management of acute myeloid leukemia: a prospective experience. Ann Oncol. 2006, 17: 763-768. 10.1093/annonc/mdl011.CrossRefPubMed
14.
Zurück zum Zitat Møller T, Nielsen OJ, Welinder P, Dünweber A, Hjerming M, Moser C, Kjeldsen L: Safe and feasible outpatient treatment following induction and consolidation chemotherapy for patients with acute leukaemia. Eur J Haematol. 2009, 84: 316-322.CrossRefPubMed Møller T, Nielsen OJ, Welinder P, Dünweber A, Hjerming M, Moser C, Kjeldsen L: Safe and feasible outpatient treatment following induction and consolidation chemotherapy for patients with acute leukaemia. Eur J Haematol. 2009, 84: 316-322.CrossRefPubMed
15.
Zurück zum Zitat Greene J, Hibbard J: Why does parient activation matter? an examination of the relationships between patient activation and health-related outcomes. j gen intern med. 2011, 27 (5): 520-526.CrossRefPubMedCentral Greene J, Hibbard J: Why does parient activation matter? an examination of the relationships between patient activation and health-related outcomes. j gen intern med. 2011, 27 (5): 520-526.CrossRefPubMedCentral
16.
17.
Zurück zum Zitat Hibbard J, Greene J, Tusler M: Improving the outcomes of disease management by tailoring care to the patient’s level of activation. Am J Manag Care. 2009, 15 (6): 353-360.PubMed Hibbard J, Greene J, Tusler M: Improving the outcomes of disease management by tailoring care to the patient’s level of activation. Am J Manag Care. 2009, 15 (6): 353-360.PubMed
18.
Zurück zum Zitat Courneya KS, Friedenreich CM: Physical activity and cancer: an introduction. Recent Results Cancer Res. 2011, 186: 1-10.CrossRefPubMed Courneya KS, Friedenreich CM: Physical activity and cancer: an introduction. Recent Results Cancer Res. 2011, 186: 1-10.CrossRefPubMed
19.
Zurück zum Zitat Speck R, Courneya K, Mass L, Duval S, Schmitz KH: An update of controlled physical activity trials in cancer survivors: a systematic and meta-analysis. J Cancer Surviv. 2010, 4: 87-100. 10.1007/s11764-009-0110-5.CrossRefPubMed Speck R, Courneya K, Mass L, Duval S, Schmitz KH: An update of controlled physical activity trials in cancer survivors: a systematic and meta-analysis. J Cancer Surviv. 2010, 4: 87-100. 10.1007/s11764-009-0110-5.CrossRefPubMed
20.
Zurück zum Zitat Brown J, Huedo-Medina T, Pescatello L, Pescatello S, Ferrer R, Johnson B: Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011, 20: 123-133. 10.1158/1055-9965.EPI-10-0988.CrossRefPubMed Brown J, Huedo-Medina T, Pescatello L, Pescatello S, Ferrer R, Johnson B: Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011, 20: 123-133. 10.1158/1055-9965.EPI-10-0988.CrossRefPubMed
21.
Zurück zum Zitat Adamsen L, Quist M, Andersen C, et al: Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy. A randomized controlled trial. BMJ. 2009, 339: b3410-10.1136/bmj.b3410.CrossRefPubMedPubMedCentral Adamsen L, Quist M, Andersen C, et al: Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy. A randomized controlled trial. BMJ. 2009, 339: b3410-10.1136/bmj.b3410.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Battaglini CL: Physical activity and hematological cancer survivorship. Recent Results Cancer Res. 2011, 186: 275-304.CrossRefPubMed Battaglini CL: Physical activity and hematological cancer survivorship. Recent Results Cancer Res. 2011, 186: 275-304.CrossRefPubMed
23.
Zurück zum Zitat Chang PH, Lai YH, Shun SC, Lin LY, Chen ML, Yang Y, Tsai JC, Huang GS, Cheng SY: Effects of a walking intervention on fatigue-related experiences of hospitalized acute mylogenous leukemia patients undergoing chemotherapy: randomized controlled trial. J PainSymptom Manage. 2008, 35: 524-534. 10.1016/j.jpainsymman.2007.06.013.CrossRef Chang PH, Lai YH, Shun SC, Lin LY, Chen ML, Yang Y, Tsai JC, Huang GS, Cheng SY: Effects of a walking intervention on fatigue-related experiences of hospitalized acute mylogenous leukemia patients undergoing chemotherapy: randomized controlled trial. J PainSymptom Manage. 2008, 35: 524-534. 10.1016/j.jpainsymman.2007.06.013.CrossRef
24.
Zurück zum Zitat Battaglini CL, Hackney AC, Garcia R, Groff D, Evans E, Shea T: The effects of an exercise program in leukemia patients. Integr Cancer Ther. 2009, 8: 130-138. 10.1177/1534735409334266.CrossRefPubMed Battaglini CL, Hackney AC, Garcia R, Groff D, Evans E, Shea T: The effects of an exercise program in leukemia patients. Integr Cancer Ther. 2009, 8: 130-138. 10.1177/1534735409334266.CrossRefPubMed
25.
Zurück zum Zitat Alibhai S, O’Neill S, Fisher-Schlombs K, Breunis H, Brandwein JM, Timilshina N, Tomlinson G, Klepin H, Culos-Reed SN: A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy. Leuk Res. 2012, 36: 1255-1261. 10.1016/j.leukres.2012.05.016.CrossRefPubMedPubMedCentral Alibhai S, O’Neill S, Fisher-Schlombs K, Breunis H, Brandwein JM, Timilshina N, Tomlinson G, Klepin H, Culos-Reed SN: A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy. Leuk Res. 2012, 36: 1255-1261. 10.1016/j.leukres.2012.05.016.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Elter T, Stipanov M, Heuser E, von Bergwelt-Baildon M, Bloch W, Hallek M, Baumann F: Is physical exercise possible in patients with critical cytopenia undergoing intensive chemotherapy for acute leukaemia or aggressive lymphoma?. Int J Hematol. 2009, 90: 199-204. 10.1007/s12185-009-0376-4.CrossRefPubMed Elter T, Stipanov M, Heuser E, von Bergwelt-Baildon M, Bloch W, Hallek M, Baumann F: Is physical exercise possible in patients with critical cytopenia undergoing intensive chemotherapy for acute leukaemia or aggressive lymphoma?. Int J Hematol. 2009, 90: 199-204. 10.1007/s12185-009-0376-4.CrossRefPubMed
28.
Zurück zum Zitat Humphries B, Dugan EL, Doyle TLA: Muscular fitness. American College of Sports Medicine. ACSM’s Resource Manual For Guidelines For Exercise Testing and Prescription. 2006, Philadelphia: Lippincott Williams & Wilkins, 206-224. 5 Humphries B, Dugan EL, Doyle TLA: Muscular fitness. American College of Sports Medicine. ACSM’s Resource Manual For Guidelines For Exercise Testing and Prescription. 2006, Philadelphia: Lippincott Williams & Wilkins, 206-224. 5
29.
Zurück zum Zitat Bandura A: Health promotion by social cognitive means. Health Educ Behav. 2004, 31: 143-164. 10.1177/1090198104263660.CrossRefPubMed Bandura A: Health promotion by social cognitive means. Health Educ Behav. 2004, 31: 143-164. 10.1177/1090198104263660.CrossRefPubMed
30.
Zurück zum Zitat Aizen I: The theory of planned behaviour. Organ Behav Hum Decis Process. 1991, 50: 179-211. 10.1016/0749-5978(91)90020-T.CrossRef Aizen I: The theory of planned behaviour. Organ Behav Hum Decis Process. 1991, 50: 179-211. 10.1016/0749-5978(91)90020-T.CrossRef
31.
Zurück zum Zitat Jonas S: On clinician engagement and counseling. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 13-19. Jonas S: On clinician engagement and counseling. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 13-19.
32.
Zurück zum Zitat Jonas S: Mobilizing motivation: the wellness pathway and Behavior Change Pyramid. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 61-69. Jonas S: Mobilizing motivation: the wellness pathway and Behavior Change Pyramid. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 61-69.
33.
Zurück zum Zitat Jonas S: Mobilizing motivation: behavior change pyramid. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 70-83. Jonas S: Mobilizing motivation: behavior change pyramid. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 70-83.
34.
Zurück zum Zitat Rollnick S, Miller WR, Butler C: Motivational interviewing in health care: helping patients change behavior. 2008, New York: Guilford Press Rollnick S, Miller WR, Butler C: Motivational interviewing in health care: helping patients change behavior. 2008, New York: Guilford Press
35.
Zurück zum Zitat Phillips E, Capell J: The exercise prescription. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 99-133. Phillips E, Capell J: The exercise prescription. ACSM’s Exercise Is Medicine: A Clinician’s Guide to Exercise Prescription. Edited by: Jonas S, Phillips E. 2009, Philadelphia: Lippincott Williams & Wilkins, 99-133.
36.
Zurück zum Zitat Borg G: Borg’s Perceived Exertion and Pain scales. 1998, Champaign, IL: Human Kinetics Borg G: Borg’s Perceived Exertion and Pain scales. 1998, Champaign, IL: Human Kinetics
37.
Zurück zum Zitat Ainsworth BE, Haskell WL, Whitt MC, et al: Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000, 498-516. Ainsworth BE, Haskell WL, Whitt MC, et al: Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000, 498-516.
38.
Zurück zum Zitat Kim SD, Kim HS: Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs. 2005, 14: 51-55. 10.1111/j.1365-2702.2004.00938.x.CrossRefPubMed Kim SD, Kim HS: Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs. 2005, 14: 51-55. 10.1111/j.1365-2702.2004.00938.x.CrossRefPubMed
39.
Zurück zum Zitat Jacobsen E: Progressive relaxation: a physiological and clinical investigation of muscular states and their significance in psychology and medical practice. 1938, Chicago: University of Chicago Press Jacobsen E: Progressive relaxation: a physiological and clinical investigation of muscular states and their significance in psychology and medical practice. 1938, Chicago: University of Chicago Press
40.
Zurück zum Zitat Sang-Dol: Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs. 2005, 14 (1): 51-55. 10.1111/j.1365-2702.2004.00938.x.CrossRef Sang-Dol: Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs. 2005, 14 (1): 51-55. 10.1111/j.1365-2702.2004.00938.x.CrossRef
41.
Zurück zum Zitat Suzuki M: Glycemic carbohydrates consumed with amino acids or protein right after exercise enhance muscle formation. Nutr Rev. 2003, 61: 588-594.CrossRef Suzuki M: Glycemic carbohydrates consumed with amino acids or protein right after exercise enhance muscle formation. Nutr Rev. 2003, 61: 588-594.CrossRef
42.
Zurück zum Zitat Koopman R, Saris WH, Wagenmakers AJ, van Loon LJ: Nutritional interventions to promote post-exericse muscle protein synthesis. Sports Med. 2007, 37 (10): 895-906. 10.2165/00007256-200737100-00005.CrossRefPubMed Koopman R, Saris WH, Wagenmakers AJ, van Loon LJ: Nutritional interventions to promote post-exericse muscle protein synthesis. Sports Med. 2007, 37 (10): 895-906. 10.2165/00007256-200737100-00005.CrossRefPubMed
43.
Zurück zum Zitat Prochaska JO, DiClemente CC, Norcross JC: In search of how people change: applications to addictive behaviors. Am Psychol. 1992, 47 (9): 1102-1114.CrossRefPubMed Prochaska JO, DiClemente CC, Norcross JC: In search of how people change: applications to addictive behaviors. Am Psychol. 1992, 47 (9): 1102-1114.CrossRefPubMed
44.
Zurück zum Zitat Bravata DM, Smith-Spangler C, Sundaram V, Gienger AL, Lin N, Lewis R, Stave CD, Olkin I, Sirard JR: Using pedometers to increase physical activity and improve health: a systematic review. JAMA. 2007, 298: 2296-2304. 10.1001/jama.298.19.2296.CrossRefPubMed Bravata DM, Smith-Spangler C, Sundaram V, Gienger AL, Lin N, Lewis R, Stave CD, Olkin I, Sirard JR: Using pedometers to increase physical activity and improve health: a systematic review. JAMA. 2007, 298: 2296-2304. 10.1001/jama.298.19.2296.CrossRefPubMed
45.
Zurück zum Zitat Crapo R, Casaburi R, Coates A, et al: ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002, 166: 111-117.CrossRef Crapo R, Casaburi R, Coates A, et al: ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002, 166: 111-117.CrossRef
46.
Zurück zum Zitat ATS statement: guidelines for the six-minute walk test. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. Am J Respir Crit Care Med. 2002, 166 (1): 111- ATS statement: guidelines for the six-minute walk test. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. Am J Respir Crit Care Med. 2002, 166 (1): 111-
47.
Zurück zum Zitat Enright P: The six minute walk test. Respir Care. 2003, 48 (8): 783-785.PubMed Enright P: The six minute walk test. Respir Care. 2003, 48 (8): 783-785.PubMed
48.
Zurück zum Zitat Aastrand PO, Rodahl K, Dahl HA, Strømme SB: Evaluation of physical performance on the basis of tests. Textbook of work physiology: physiological bases of exercise. 2003, Champaign: Human Kinetics, 273-297. 333–364, 4 Aastrand PO, Rodahl K, Dahl HA, Strømme SB: Evaluation of physical performance on the basis of tests. Textbook of work physiology: physiological bases of exercise. 2003, Champaign: Human Kinetics, 273-297. 333–364, 4
49.
Zurück zum Zitat Jones CJ, Rikli RE, Beam W: A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport. 1999, 70: 113-119. 10.1080/02701367.1999.10608028.CrossRefPubMed Jones CJ, Rikli RE, Beam W: A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport. 1999, 70: 113-119. 10.1080/02701367.1999.10608028.CrossRefPubMed
50.
Zurück zum Zitat Osness WH, Adrian M, Clark B, Hoeger W, Raab D, Wisnell R: Functional fitness assessment for adults over 60 years (a field based assessment). 1990, Reston, VA: American Alliance for Health. Physical Education Recreation and Dance (AAHPRED) Osness WH, Adrian M, Clark B, Hoeger W, Raab D, Wisnell R: Functional fitness assessment for adults over 60 years (a field based assessment). 1990, Reston, VA: American Alliance for Health. Physical Education Recreation and Dance (AAHPRED)
51.
Zurück zum Zitat Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E: Measuring fatigue and other anemia-related symptoms with the Functional assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage. 1997, 13: 63-74.CrossRefPubMed Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E: Measuring fatigue and other anemia-related symptoms with the Functional assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage. 1997, 13: 63-74.CrossRefPubMed
52.
Zurück zum Zitat Ware JE JR, Sherbourne CD: The MOS 36-item short-form health survey (SF-36) I: conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097/00005650-199206000-00002.CrossRefPubMed Ware JE JR, Sherbourne CD: The MOS 36-item short-form health survey (SF-36) I: conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097/00005650-199206000-00002.CrossRefPubMed
53.
Zurück zum Zitat Aaronson NK, Ahmedzai S, Bergman B, et al: The European Organization for Research and Treatment of Cancer QLQ-C30: quality-og-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993, 85: 365-376. 10.1093/jnci/85.5.365.CrossRefPubMed Aaronson NK, Ahmedzai S, Bergman B, et al: The European Organization for Research and Treatment of Cancer QLQ-C30: quality-og-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993, 85: 365-376. 10.1093/jnci/85.5.365.CrossRefPubMed
54.
Zurück zum Zitat Grønvold M, Klee M, Sprangers MAG, Aaronson NK: Validation of the EORTC QLQ-C30 quality of life questionnaire through combined qualitative and quantitative assessment of patient-observer agreement. J Clin Epidemiol. 1997, 50: 441-450EORTC- Grønvold M, Klee M, Sprangers MAG, Aaronson NK: Validation of the EORTC QLQ-C30 quality of life questionnaire through combined qualitative and quantitative assessment of patient-observer agreement. J Clin Epidemiol. 1997, 50: 441-450EORTC-
55.
Zurück zum Zitat Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.CrossRefPubMed Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.CrossRefPubMed
56.
Zurück zum Zitat Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, Engstrom MC: Assessing symptom distress in cancer: the M.D. Anderson Symptoms Inventory. Cancer. 2000, 89: 1634-1646. 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V.CrossRefPubMed Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, Engstrom MC: Assessing symptom distress in cancer: the M.D. Anderson Symptoms Inventory. Cancer. 2000, 89: 1634-1646. 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V.CrossRefPubMed
57.
Zurück zum Zitat Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, Huber SL: The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999, 85 (5): 1186-1196. 10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N.CrossRefPubMed Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, Huber SL: The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999, 85 (5): 1186-1196. 10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N.CrossRefPubMed
58.
Zurück zum Zitat Saltin B, Grimby G: Physiological analysis of middle-aged and old former athletes: comparison with still active athletes of the same ages. Circulation. 1968, 38: 1104-1115. 10.1161/01.CIR.38.6.1104.CrossRefPubMed Saltin B, Grimby G: Physiological analysis of middle-aged and old former athletes: comparison with still active athletes of the same ages. Circulation. 1968, 38: 1104-1115. 10.1161/01.CIR.38.6.1104.CrossRefPubMed
59.
Zurück zum Zitat Andersen L, Groenvold M, Jørgensen T, Aadahl M: Construct validity of a revised Physical Activity Scale and testing by cognitive interviewing. Scand J Public Health. 2010, 38 (7): 707-714. 10.1177/1403494810380099.CrossRefPubMed Andersen L, Groenvold M, Jørgensen T, Aadahl M: Construct validity of a revised Physical Activity Scale and testing by cognitive interviewing. Scand J Public Health. 2010, 38 (7): 707-714. 10.1177/1403494810380099.CrossRefPubMed
60.
Zurück zum Zitat Zimet GD, Dahlem NW, Zimet SG, Farley GK: The Multidimensional Scale of Perceived Social Support. J Pers Assess. 1988, 52: 30-41. 10.1207/s15327752jpa5201_2.CrossRef Zimet GD, Dahlem NW, Zimet SG, Farley GK: The Multidimensional Scale of Perceived Social Support. J Pers Assess. 1988, 52: 30-41. 10.1207/s15327752jpa5201_2.CrossRef
61.
Zurück zum Zitat Hibbard JH, Stockard J, Mahoney ER, Tusler M: Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers. Health Serv Res. 2004, 39 (4 Pt 1): 1005-1026.CrossRefPubMedPubMedCentral Hibbard JH, Stockard J, Mahoney ER, Tusler M: Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers. Health Serv Res. 2004, 39 (4 Pt 1): 1005-1026.CrossRefPubMedPubMedCentral
62.
Zurück zum Zitat Schwarzer R, Jerusalem M: Generalized self-efficacy scale. Measures in health psychology: A user’s portfolio. Causal and control beliefs. Edited by: Weinman J, Wrigh S, Johnston M. 1995, Windsor, UK: NFER-NELSON, 35-37. Schwarzer R, Jerusalem M: Generalized self-efficacy scale. Measures in health psychology: A user’s portfolio. Causal and control beliefs. Edited by: Weinman J, Wrigh S, Johnston M. 1995, Windsor, UK: NFER-NELSON, 35-37.
63.
Zurück zum Zitat Thielen K, Nygaard E, Andersen I, Diderichsen F: Employment consequences of depressive symptoms and work demands individually and combined. 2013, Health: Eur J Publ Thielen K, Nygaard E, Andersen I, Diderichsen F: Employment consequences of depressive symptoms and work demands individually and combined. 2013, Health: Eur J Publ
65.
Zurück zum Zitat Büchele G, Och B, Bolte G, Weiland S: Single vs. double data entry. Epidemiology. 2005, 16 (1): 130-131. 10.1097/01.ede.0000147166.24478.f4.CrossRefPubMed Büchele G, Och B, Bolte G, Weiland S: Single vs. double data entry. Epidemiology. 2005, 16 (1): 130-131. 10.1097/01.ede.0000147166.24478.f4.CrossRefPubMed
66.
Zurück zum Zitat Skorkjaer Binderkrantz A, Bøge AL: Guide til NVivo 9. 2011, Copenhagen: Hans Reitzels Forlag Skorkjaer Binderkrantz A, Bøge AL: Guide til NVivo 9. 2011, Copenhagen: Hans Reitzels Forlag
67.
Zurück zum Zitat Braun V, Clarke V: Using thematic analysis in psychology. Qual Res Psychol. 2006, 3: 77-101. 10.1191/1478088706qp063oa.CrossRef Braun V, Clarke V: Using thematic analysis in psychology. Qual Res Psychol. 2006, 3: 77-101. 10.1191/1478088706qp063oa.CrossRef
68.
Zurück zum Zitat Malterud K: The art and science of clinical knowledge: evidence beyond measures and numbers. Lancet. 2001, 358: 397-400. 10.1016/S0140-6736(01)05548-9.CrossRefPubMed Malterud K: The art and science of clinical knowledge: evidence beyond measures and numbers. Lancet. 2001, 358: 397-400. 10.1016/S0140-6736(01)05548-9.CrossRefPubMed
69.
Zurück zum Zitat Cannas G, Pautas C, Raffoux E, Quesnel B, et al: Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial. Leuk Lymphoma. 2012, 53 (6): 1068-1076. 10.3109/10428194.2011.636812. doi:10.3109/10428194.2011.636812. Epub 2012 Jan 31CrossRefPubMed Cannas G, Pautas C, Raffoux E, Quesnel B, et al: Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial. Leuk Lymphoma. 2012, 53 (6): 1068-1076. 10.3109/10428194.2011.636812. doi:10.3109/10428194.2011.636812. Epub 2012 Jan 31CrossRefPubMed
70.
Zurück zum Zitat Gupta A, Singh M, Singh H, Kumar L, Sharma A, Bakhshi S: Infections in acute myeloid leukemia: an analysis of 382 febrile episodes. Med Oncol. 2010, 27 (4): 1037-1045. 10.1007/s12032-009-9330-9. doi:10.1007/s12032-009-9330-9. Epub 2009 Oct 15CrossRefPubMed Gupta A, Singh M, Singh H, Kumar L, Sharma A, Bakhshi S: Infections in acute myeloid leukemia: an analysis of 382 febrile episodes. Med Oncol. 2010, 27 (4): 1037-1045. 10.1007/s12032-009-9330-9. doi:10.1007/s12032-009-9330-9. Epub 2009 Oct 15CrossRefPubMed
71.
Zurück zum Zitat Courneya KS, Keats MR, Turner AR: Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation. Psychooncology. 2009, 9: 127-136.CrossRef Courneya KS, Keats MR, Turner AR: Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation. Psychooncology. 2009, 9: 127-136.CrossRef
72.
Zurück zum Zitat Jarden M, Baadsgaard MT, Hovgaard DJ, Boesen E, Adamsen L: A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant. 2009, 43 (9): 725-737. 10.1038/bmt.2009.27.CrossRefPubMed Jarden M, Baadsgaard MT, Hovgaard DJ, Boesen E, Adamsen L: A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant. 2009, 43 (9): 725-737. 10.1038/bmt.2009.27.CrossRefPubMed
73.
Zurück zum Zitat Baumann FT, Kraut L, Schule K, et al: A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant. 2009, 45 (2): 355-362.CrossRefPubMed Baumann FT, Kraut L, Schule K, et al: A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant. 2009, 45 (2): 355-362.CrossRefPubMed
74.
Zurück zum Zitat Wiskemann J, Dreger P, Schwerdtfeger R, Bondong A, Huber G, Kleindienst N, Ulrich CM, Bohus M: Effects of a partly self-administered exercise program before, during and after allogeneic stem cell transplantation. Blood. 2010, 117 (9): 2604-2613.CrossRefPubMed Wiskemann J, Dreger P, Schwerdtfeger R, Bondong A, Huber G, Kleindienst N, Ulrich CM, Bohus M: Effects of a partly self-administered exercise program before, during and after allogeneic stem cell transplantation. Blood. 2010, 117 (9): 2604-2613.CrossRefPubMed
75.
Zurück zum Zitat Jarden M: A systematic review of nonpharmacological exercise-based rehabilitative interventions in adults undergoing allogeneic hematopoietic stem cell transplantation. New advances in stem cell transplantation. Edited by: Demirer T. 2012, Rijeka: InTech, 558-582. Jarden M: A systematic review of nonpharmacological exercise-based rehabilitative interventions in adults undergoing allogeneic hematopoietic stem cell transplantation. New advances in stem cell transplantation. Edited by: Demirer T. 2012, Rijeka: InTech, 558-582.
76.
Zurück zum Zitat Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E: Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. Support Care Cancer. 2003, 11: 623-628. 10.1007/s00520-003-0512-2.CrossRefPubMed Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E: Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. Support Care Cancer. 2003, 11: 623-628. 10.1007/s00520-003-0512-2.CrossRefPubMed
Metadaten
Titel
Patient Activation through Counseling and Exercise – Acute Leukemia (PACE-AL) – a randomized controlled trial
verfasst von
Mary Jarden
Tom Møller
Lars Kjeldsen
Henrik Birgens
Jesper Frank Christensen
Karl Bang Christensen
Finn Diderichsen
Carsten Hendriksen
Lis Adamsen
Publikationsdatum
01.12.2013
Verlag
BioMed Central
Erschienen in
BMC Cancer / Ausgabe 1/2013
Elektronische ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-13-446

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